Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: TUMOR MICROENVIRONMENT - , . Treffer: 41

2023

Pichler, R; Siska, PJ; Tymoszuk, P; Martowicz, A; Untergasser, G; Mayr, R; Weber, F; Seeber, A; Kocher, F; Barth, DA; Pichler, M; Thurnher, M A chemokine network of T cell exhaustion and metabolic reprogramming in renal cell carcinoma.
Front Immunol. 2023; 14:1095195 Doi: 10.3389/fimmu.2023.1095195 [OPEN ACCESS]
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Sarsembayeva, A; Kienzl, M; Gruden, E; Ristic, D; Maitz, K; Valadez-Cosmes, P; Santiso, A; Hasenoehrl, C; Brcic, L; Lindenmann, J; Kargl, J; Schicho, R Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells.
Front Immunol. 2022; 13:997115 Doi: 10.3389/fimmu.2022.997115 [OPEN ACCESS]
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2022

Heidegger, I; Fotakis, G; Offermann, A; Goveia, J; Daum, S; Salcher, S; Noureen, A; Timmer-Bosscha, H; Schäfer, G; Walenkamp, A; Perner, S; Beatovic, A; Moisse, M; Plattner, C; Krogsdam, A; Haybaeck, J; Sopper, S; Thaler, S; Keller, MA; Klocker, H; Trajanoski, Z; Wolf, D; Pircher, A Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer.
Mol Cancer. 2022; 21(1): 132 Doi: 10.1186/s12943-022-01597-7 [OPEN ACCESS]
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Janisch, M; Adelsmayr, G; Müller, H; Holzinger, A; Janek, E; Talakic, E; Fuchsjäger, M; Schöllnast, H Non-contrast-enhanced CT texture analysis of primary and metastatic pancreatic ductal adenocarcinomas: value in assessment of histopathological grade and differences between primary and metastatic lesions.
Abdom Radiol (NY). 2022; 47(12):4151-4159 Doi: 10.1007/s00261-022-03646-7 [OPEN ACCESS]
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Jurmeister, P; Leitheiser, M; Wolkenstein, P; Klauschen, F; Capper, D; Brcic, L DNA methylation-based machine learning classification distinguishes pleural mesothelioma from chronic pleuritis, pleural carcinosis, and pleomorphic lung carcinomas.
Lung Cancer. 2022; 170:105-113 Doi: 10.1016/j.lungcan.2022.06.008
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Kocher, F; Puccini, A; Untergasser, G; Martowicz, A; Zimmer, K; Pircher, A; Baca, Y; Xiu, J; Haybaeck, J; Tymoszuk, P; Goldberg, RM; Petrillo, A; Shields, AF; Salem, ME; Marshall, JL; Hall, M; Korn, WM; Nabhan, C; Battaglin, F; Lenz, HJ; Lou, E; Choo, SP; Toh, CK; Gasteiger, S; Pichler, R; Wolf, D; Seeber, A Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets.
Clin Cancer Res. 2022; 28(22):4957-4967 Doi: 10.1158/1078-0432.CCR-22-0275 [OPEN ACCESS]
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Krstic, J; Schindlmaier, K; Prokesch, A Combination strategies to target metabolic flexibility in cancer.
Int Rev Cell Mol Biol. 2022; 373: 159-197. Doi: 10.1016/bs.ircmb.2022.03.001
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Neumeister, P; Schulz, E; Pansy, K; Szmyra, M; Deutsch, AJ Targeting the Microenvironment for Treating Multiple Myeloma.
Int J Mol Sci. 2022; 23(14): 7627 Doi: 10.3390/ijms23147627 [OPEN ACCESS]
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Raftopoulou, S; Valadez-Cosmes, P; Mihalic, ZN; Schicho, R; Kargl, J Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063218 [OPEN ACCESS]
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Uhl, B; Prochazka, KT; Pansy, K; Wenzl, K; Strobl, J; Baumgartner, C; Szmyra, MM; Waha, JE; Wolf, A; Tomazic, PV; Steinbauer, E; Steinwender, M; Friedl, S; Weniger, M; Küppers, R; Pichler, M; Greinix, HT; Stary, G; Ramsay, AG; Apollonio, B; Feichtinger, J; Beham-Schmid, C; Neumeister, P; Deutsch, AJ Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells.
Int J Mol Sci. 2022; 23(14): Doi: 10.3390/ijms23147874 [OPEN ACCESS]
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Valadez-Cosmes, P; Raftopoulou, S; Mihalic, ZN; Marsche, G; Kargl, J Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.
Pharmacol Ther. 2022; 236:108052 Doi: 10.1016/j.pharmthera.2021.108052
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2020

Smolle, E; Leithner, K; Olschewski, H Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations.
Thorac Cancer. 2020; 11(2):205-215 Doi: 10.1111/1759-7714.13246 [OPEN ACCESS]
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2019

Müller, M; Graf, R; Kashofer, K; Macher, S; Wölfler, A; Zebisch, A; Hrzenjak, A; Heitzer, E; Sill, H Detection of AML-specific TP53 mutations in bone marrow-derived mesenchymal stromal cells cultured under hypoxia conditions.
Ann Hematol. 2019; 98(8):2019-2020 Doi: 10.1007/s00277-019-03680-4 [OPEN ACCESS]
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2018

Li, M; Zhang, F; Su, Y; Zhou, J; Wang, W Nanoparticles designed to regulate tumor microenvironment for cancer therapy.
Life Sci. 2018; 201(10):37-44 Doi: 10.1016/j.lfs.2018.03.044
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2017

Cătană, CS; Pichler, M; Giannelli, G; Mader, RM; Berindan-Neagoe, I Non-coding RNAs, the Trojan horse in two-way communication between tumor and stroma in colorectal and hepatocellular carcinoma.
Oncotarget. 2017; 8(17):29519-29534 Doi: 10.18632/oncotarget.15706 [OPEN ACCESS]
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Mayr, C; Ocker, M; Ritter, M; Pichler, M; Neureiter, D; Kiesslich, T Biliary tract cancer stem cells - translational options and challenges.
World J Gastroenterol. 2017; 23(14):2470-2482 Doi: 10.3748/wjg.v23.i14.2470 [OPEN ACCESS]
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Roh-Johnson, M; Shah, AN; Stonick, JA; Poudel, KR; Kargl, J; Yang, GH; di Martino, J; Hernandez, RE; Gast, CE; Zarour, LR; Antoku, S; Houghton, AM; Bravo-Cordero, JJ; Wong, MH; Condeelis, J; Moens, CB Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
Dev Cell. 2017; 43(5):549-562 Doi: 10.1016/j.devcel.2017.11.003 [OPEN ACCESS]
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Smolle, MA; Calin, HN; Pichler, M; Calin, GA Noncoding RNAs and immune checkpoints-clinical implications as cancer therapeutics.
FEBS J. 2017; 284(13):1952-1966 Doi: 10.1111/febs.14030 [OPEN ACCESS]
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von der Heide, EK; Neumann, M; Vosberg, S; James, AR; Schroeder, MP; Ortiz-Tanchez, J; Isaakidis, K; Schlee, C; Luther, M; Jöhrens, K; Anagnostopoulos, I; Mochmann, LH; Nowak, D; Hofmann, WK; Greif, PA; Baldus, CD Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients.
Leukemia. 2017; 31(5): 1069-1078. Doi: 10.1038/leu.2016.324
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2016

Garg, K; Maurer, M; Griss, J; Brüggen, MC; Wolf, IH; Wagner, C; Willi, N; Mertz, KD; Wagner, SN Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome.
Hum Pathol. 2016; 54(6):157-164 Doi: 10.1016/j.humpath.2016.03.022
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Mlecnik, B; Bindea, G; Kirilovsky, A; Angell, HK; Obenauf, AC; Tosolini, M; Church, SE; Maby, P; Vasaturo, A; Angelova, M; Fredriksen, T; Mauger, S; Waldner, M; Berger, A; Speicher, MR; Pagès, F; Valge-Archer, V; Galon, J The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.
Sci Transl Med. 2016; 8(327):327ra26-327ra26 Doi: 10.1126/scitranslmed.aad6352
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Reinisch, A; Thomas, D; Corces, MR; Zhang, X; Gratzinger, D; Hong, WJ; Schallmoser, K; Strunk, D; Majeti, R A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells.
Nat Med. 2016; 22(7): 812-821. Doi: 10.1038/nm.4103 [OPEN ACCESS]
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Trivanović, D; Krstić, J; Djordjević, IO; Mojsilović, S; Santibanez, JF; Bugarski, D; Jauković, A The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation.
Mediators Inflamm. 2016; 2016(1): 7314016-7314016. Doi: 10.1155/2016/7314016 [OPEN ACCESS]
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Walsh, NM; Fleming, KE; Hanly, JG; Dakin Hache, K; Doucette, S; Ferrara, G; Cerroni, L A morphological and immunophenotypic map of the immune response in Merkel cell carcinoma.
Hum Pathol. 2016; 52(6):190-196 Doi: 10.1016/j.humpath.2016.02.002
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2015

Obenauf, AC; Zou, Y; Ji, AL; Vanharanta, S; Shu, W; Shi, H; Kong, X; Bosenberg, MC; Wiesner, T; Rosen, N; Lo, RS; Massagué, J Therapy-induced tumour secretomes promote resistance and tumour progression.
Nature. 2015; 520(7547): 368-372. Doi: 10.1038/nature14336 [OPEN ACCESS]
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2014

Al-Zoughbi, W; Al-Zhoughbi, W; Huang, J; Paramasivan, GS; Till, H; Pichler, M; Guertl-Lackner, B; Hoefler, G Tumor macroenvironment and metabolism.
Semin Oncol. 2014; 41(2):281-295 Doi: 10.1053/j.seminoncol.2014.02.005 [OPEN ACCESS]
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Becker, JC; thor Straten, P; Andersen, MH Self-reactive T cells: suppressing the suppressors.
Cancer Immunol Immunother. 2014; 63(4):313-319 Doi: 10.1007/s00262-013-1512-9
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Galon, J; Mlecnik, B; Bindea, G; Angell, HK; Berger, A; Lagorce, C; Lugli, A; Zlobec, I; Hartmann, A; Bifulco, C; Nagtegaal, ID; Palmqvist, R; Masucci, GV; Botti, G; Tatangelo, F; Delrio, P; Maio, M; Laghi, L; Grizzi, F; Asslaber, M; D'Arrigo, C; Vidal-Vanaclocha, F; Zavadova, E; Chouchane, L; Ohashi, PS; Hafezi-Bakhtiari, S; Wouters, BG; Roehrl, M; Nguyen, L; Kawakami, Y; Hazama, S; Okuno, K; Ogino, S; Gibbs, P; Waring, P; Sato, N; Torigoe, T; Itoh, K; Patel, PS; Shukla, SN; Wang, Y; Kopetz, S; Sinicrope, FA; Scripcariu, V; Ascierto, PA; Marincola, FM; Fox, BA; Pagès, F Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.
J Pathol. 2014; 232(2):199-209 Doi: 10.1002/path.4287 [OPEN ACCESS]
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Krstic, J; Santibanez, JF Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells.
ScientificWorldJournal. 2014; 2014(3): 521754-521754. Doi: 10.1155/2014/521754 [OPEN ACCESS]
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Lunardi, S; Muschel, RJ; Brunner, TB The stromal compartments in pancreatic cancer: are there any therapeutic targets?
Cancer Lett. 2014; 343(2):147-55 Doi: 10.1016/j.canlet.2013.09.039
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Miething, C; Scuoppo, C; Bosbach, B; Appelmann, I; Nakitandwe, J; Ma, J; Wu, G; Lintault, L; Auer, M; Premsrirut, PK; Teruya-Feldstein, J; Hicks, J; Benveniste, H; Speicher, MR; Downing, JR; Lowe, SW PTEN action in leukaemia dictated by the tissue microenvironment.
Nature. 2014; 510(7505):402-406 Doi: 10.1038/nature13239 [OPEN ACCESS]
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Mlecnik, B; Bindea, G; Angell, HK; Sasso, MS; Obenauf, AC; Fredriksen, T; Lafontaine, L; Bilocq, AM; Kirilovsky, A; Tosolini, M; Waldner, M; Berger, A; Fridman, WH; Rafii, A; Valge-Archer, V; Pagès, F; Speicher, MR; Galon, J Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.
Sci Transl Med. 2014; 6(228):228ra37-228ra37 Doi: 10.1126/scitranslmed.3007240 [OPEN ACCESS]
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2013

Becker, JC; Andersen, MH; Schrama, D; Thor Straten, P Immune-suppressive properties of the tumor microenvironment.
Cancer Immunol Immunother. 2013; 62(7):1137-1148 Doi: 10.1007/s00262-013-1434-6
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Bindea, G; Mlecnik, B; Tosolini, M; Kirilovsky, A; Waldner, M; Obenauf, AC; Angell, H; Fredriksen, T; Lafontaine, L; Berger, A; Bruneval, P; Fridman, WH; Becker, C; Pagès, F; Speicher, MR; Trajanoski, Z; Galon, J Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Immunity. 2013; 39(4):782-795 Doi: 10.1016/j.immuni.2013.10.003 [OPEN ACCESS]
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Svejda, B; Kidd, M; Timberlake, A; Harry, K; Kazberouk, A; Schimmack, S; Lawrence, B; Pfragner, R; Modlin, IM Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors.
Cancer Sci. 2013; 104(7):844-855 Doi: 10.1111/cas.12174 [OPEN ACCESS]
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Szkandera, J; Absenger, G; Liegl-Atzwanger, B; Pichler, M; Stotz, M; Samonigg, H; Glehr, M; Zacherl, M; Stojakovic, T; Gerger, A; Leithner, A Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients.
Br J Cancer. 2013; 108(8):1677-1683 Doi: 10.1038/bjc.2013.135 [OPEN ACCESS]
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Wölfel, T; Becker, JC; Schmitt, M Immune oncology in focus].
Onkologie. 2013; 36 Suppl 4(11):7-11 Doi: 10.1159/000350921 [OPEN ACCESS]
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2012

Brunner, TB; Kunz-Schughart, LA; Grosse-Gehling, P; Baumann, M Cancer stem cells as a predictive factor in radiotherapy.
Semin Radiat Oncol. 2012; 22(2):151-74 Doi: 10.1016/j.semradonc.2011.12.003
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Felcht, M; Heck, M; Weiss, C; Becker, JC; Dippel, E; Muller, CSL; Nashan, D; Sachse, MM; Nicolay, JP; Booken, N; Goerdt, S; Klemke, CD; Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells.
BRIT J DERMATOL. 2012; 167(2): 348-358. Doi: 10.1111/j.1365-2133.2012.10987.x
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Galon, J; Pagès, F; Marincola, FM; Angell, HK; Thurin, M; Lugli, A; Zlobec, I; Berger, A; Bifulco, C; Botti, G; Tatangelo, F; Britten, CM; Kreiter, S; Chouchane, L; Delrio, P; Arndt, H; Asslaber, M; Maio, M; Masucci, GV; Mihm, M; Vidal-Vanaclocha, F; Allison, JP; Gnjatic, S; Hakansson, L; Huber, C; Singh-Jasuja, H; Ottensmeier, C; Zwierzina, H; Laghi, L; Grizzi, F; Ohashi, PS; Shaw, PA; Clarke, BA; Wouters, BG; Kawakami, Y; Hazama, S; Okuno, K; Wang, E; O'Donnell-Tormey, J; Lagorce, C; Pawelec, G; Nishimura, MI; Hawkins, R; Lapointe, R; Lundqvist, A; Khleif, SN; Ogino, S; Gibbs, P; Waring, P; Sato, N; Torigoe, T; Itoh, K; Patel, PS; Shukla, SN; Palmqvist, R; Nagtegaal, ID; Wang, Y; D'Arrigo, C; Kopetz, S; Sinicrope, FA; Trinchieri, G; Gajewski, TF; Ascierto, PA; Fox, BA Cancer classification using the Immunoscore: a worldwide task force.
J Transl Med. 2012; 10(8):205-205 Doi: 10.1186/1479-5876-10-205 [OPEN ACCESS]
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Rausch, V; Liu, L; Apel, A; Rettig, T; Gladkich, J; Labsch, S; Kallifatidis, G; Kaczorowski, A; Groth, A; Gross, W; Gebhard, MM; Schemmer, P; Werner, J; Salnikov, AV; Zentgraf, H; Büchler, MW; Herr, I Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment.
J Pathol. 2012; 227(3):325-335 Doi: 10.1002/path.3994
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