Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: STRUCTURE-ACTIVITY RELATIONSHIP - , . Treffer: 71

2019

Schopf, FH; Huber, EM; Dodt, C; Lopez, A; Biebl, MM; Rutz, DA; Mühlhofer, M; Richter, G; Madl, T; Sattler, M; Groll, M; Buchner, J The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
MOL CELL. 2019; 74(1): 73-87. [OPEN ACCESS]
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2018

Mohsin, NU; Seebacher, W; Faist, J; Hochegger, P; Kaiser, M; Mäser, P; Belaj, F; Saf, R; Kretschmer, N; Alajlani, M; Turek, I; Brantner, A; Bauer, R; Bucar, F; Weis, R Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.
Eur J Med Chem. 2018; 143(8):97-106
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Presser, A; Lainer, G; Kretschmer, N; Schuehly, W; Saf, R; Kaiser, M; Kalt, MM Synthesis of Jacaranone-Derived Nitrogenous Cyclohexadienones and Their Antiproliferative and Antiprotozoal Activities.
Molecules. 2018; 23(11): [OPEN ACCESS]
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2017

Lebl, R; Thonhofer, M; Tysoe, C; Pabst, BM; Schalli, M; Weber, P; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.
Carbohydr Res. 2017; 442(15):31-40
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2016

Aschauer, P; Rengachari, S; Lichtenegger, J; Schittmayer, M; Das, KM; Mayer, N; Breinbauer, R; Birner-Gruenberger, R; Gruber, CC; Zimmermann, R; Gruber, K; Oberer, M Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p.
Biochim Biophys Acta. 2016; 1861(5):462-470 [OPEN ACCESS]
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Scharinger, B; Messner, B; Türkcan, A; Schuster, D; Vuorinen, A; Pitterl, F; Heinz, K; Arnhard, K; Laufer, G; Grimm, M; Stuppner, H; Oberacher, H; Eller, P; Ritsch, A; Bernhard, D Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.
J Mol Cell Cardiol. 2016; 99(7):35-46 [OPEN ACCESS]
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Stoschitzky, K; Stoschitzky, G; Lercher, P; Brussee, H; Lamprecht, G; Lindner, W Propafenone shows class Ic and class II antiarrhythmic effects.
Europace. 2016; 18(4):568-571 [OPEN ACCESS]
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Thonhofer, M; Gonzalez Santana, A; Fischer, R; Torvisco Gomez, A; Saf, R; Schalli, M; Stütz, AE; Withers, SG 5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease.
Carbohydr Res. 2016; 420(5): 6-12.
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Thonhofer, M; Weber, P; Santana, AG; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Bioorg Med Chem Lett. 2016; 26(5):1438-1442
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2015

Antus, C; Radnai, B; Dombovari, P; Fonai, F; Avar, P; Matyus, P; Racz, B; Sumegi, B; Veres, B Anti-inflammatory effects of a triple-bond resveratrol analog: structure and function relationship.
Eur J Pharmacol. 2015; 748(3):61-67
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Chromikova, V; Mader, A; Hofbauer, S; Göbl, C; Madl, T; Gach, JS; Bauernfried, S; Furtmüller, PG; Forthal, DN; Mach, L; Obinger, C; Kunert, R Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.
Biochim Biophys Acta. 2015; 1854(10 Pt A):1536-1544 [OPEN ACCESS]
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Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359 [OPEN ACCESS]
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Hacker, C; Christ, NA; Duchardt-Ferner, E; Korn, S; Göbl, C; Berninger, L; Düsterhus, S; Hellmich, UA; Madl, T; Kötter, P; Entian, KD; Wöhnert, J The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.
J Biol Chem. 2015; 290(48):28869-28886 [OPEN ACCESS]
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Perz, V; Zumstein, MT; Sander, M; Zitzenbacher, S; Ribitsch, D; Guebitz, GM Biomimetic Approach to Enhance Enzymatic Hydrolysis of the Synthetic Polyester Poly(1,4-butylene adipate): Fusing Binding Modules to Esterases.
Biomacromolecules. 2015; 16(12): 3889-3896.
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2014

Alza, NP; Pferschy-Wenzig, EM; Ortmann, S; Kretschmer, N; Kunert, O; Rechberger, GN; Bauer, R; Murray, AP Inhibition of NO production by Grindelia argentina and isolation of three new cytotoxic saponins.
Chem Biodivers. 2014; 11(2):311-322
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Lichtenegger, M; Groschner, K TRPC3: a multifunctional signaling molecule.
Handb Exp Pharmacol. 2014; 222: 67-84.
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2013

Derler, I; Plenk, P; Fahrner, M; Muik, M; Jardin, I; Schindl, R; Gruber, HJ; Groschner, K; Romanin, C The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
J Biol Chem. 2013; 288(40):29025-29034 [OPEN ACCESS]
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Müller, R; Gräwert, MA; Kern, T; Madl, T; Peschek, J; Sattler, M; Groll, M; Buchner, J High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.
Proc Natl Acad Sci U S A. 2013; 110(25): 10183-10188. [OPEN ACCESS]
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Rengachari, S; Aschauer, P; Schittmayer, M; Mayer, N; Gruber, K; Breinbauer, R; Birner-Gruenberger, R; Dreveny, I; Oberer, M Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase.
J Biol Chem. 2013; 288(43):31093-31104 [OPEN ACCESS]
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Veit, F; Pak, O; Egemnazarov, B; Roth, M; Kosanovic, D; Seimetz, M; Sommer, N; Ghofrani, HA; Seeger, W; Grimminger, F; Brandes, RP; Schermuly, RT; Weissmann, N Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling.
Antioxid Redox Signal. 2013; 19(18):2213-2231
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2012

Brkić, L; Riederer, M; Graier, WF; Malli, R; Frank, S Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells.
Atherosclerosis. 2012; 224(2):348-354 [OPEN ACCESS]
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Fröhlich, E The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.
Int J Nanomedicine. 2012; 7(3):5577-5591 [OPEN ACCESS]
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Kosol, S; Schrank, E; Krajačić, MB; Wagner, GE; Meyer, NH; Göbl, C; Rechberger, GN; Zangger, K; Novak, P Probing the interactions of macrolide antibiotics with membrane-mimetics by NMR spectroscopy.
J Med Chem. 2012; 55(11): 5632-5636. [OPEN ACCESS]
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2010

Meyer, NH; Tripsianes, K; Vincendeau, M; Madl, T; Kateb, F; Brack-Werner, R; Sattler, M Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.
J Biol Chem. 2010; 285(37): 28893-28901. [OPEN ACCESS]
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2009

Neufeld, C; Filipp, FV; Simon, B; Neuhaus, A; Schüller, N; David, C; Kooshapur, H; Madl, T; Erdmann, R; Schliebs, W; Wilmanns, M; Sattler, M Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
EMBO J. 2009; 28(6): 745-754. [OPEN ACCESS]
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Prassl, R; Laggner, P Molecular structure of low density lipoprotein: current status and future challenges
Eur Biophys J. 2009; 38(2):145-158
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2008

Pippal, JB; Fuller, PJ Structure-function relationships in the mineralocorticoid receptor.
J Mol Endocrinol. 2008; 41(6):405-413 [OPEN ACCESS]
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Rosenkilde, MM; Smit, MJ; Waldhoer, M Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors.
Br J Pharmacol. 2008; 153 Suppl 1(3): S154-S166. [OPEN ACCESS]
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Ruckenstuhl, C; Poschenel, A; Possert, R; Baral, PK; Gruber, K; Turnowsky, F Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.
Antimicrob Agents Chemother. 2008; 52(4):1496-1499 [OPEN ACCESS]
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Schindl, R; Frischauf, I; Kahr, H; Fritsch, R; Krenn, M; Derndl, A; Vales, E; Muik, M; Derler, I; Groschner, K; Romanin, C The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.
Cell Calcium. 2008; 43(3): 260-269.
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2007

Birner-Gruenberger, R; Hermetter, A Activity-based proteomics of lipolytic enzymes.
Curr Drug Discov Technol. 2007; 4(1): 1-11.
PubMed

 

Ruckenstuhl, C; Lang, S; Poschenel, A; Eidenberger, A; Baral, PK; Kohút, P; Hapala, I; Gruber, K; Turnowsky, F Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.
Antimicrob Agents Chemother. 2007; 51(1):275-284 [OPEN ACCESS]
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2006

Deindl, E; Middeler, G; Müller, OJ; Selbert, S; Schlenke, P; Marienfeld, U; Thirion, C; Katus, HA; Franz, WM Identification of a 94-bp GC-rich element in the smooth muscle myosin heavy-chain promoter controlling vascular smooth muscle cell-specific gene expression.
Cell Biochem Biophys. 2006; 45(3):279-288
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Malle, E; Marsche, G; Panzenboeck, U; Sattler, W Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins.
ARCH BIOCHEM BIOPHYS. 2006; 445(2): 245-255.
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Schmidinger, H; Hermetter, A; Birner-Gruenberger, R Activity-based proteomics: enzymatic activity profiling in complex proteomes.
Amino Acids. 2006; 30(4): 333-350.
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2004

Arnold, C; Reisch, N; Leibold, C; Becker, S; Prüfert, K; Sautter, K; Palm, D; Jatzke, S; Buchner, S; Buchner, E Structure-function analysis of the cysteine string protein in Drosophila: cysteine string, linker and C terminus.
J Exp Biol. 2004; 207(Pt 8): 1323-1334. [OPEN ACCESS]
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2003

Beubler, E Pharmacology of cyclooxygenase 2 inhibition
Wien Med Wochenschr. 2003; 153(5-6): 95-99.
PubMed

 

Ivanina, T; Rishal, I; Varon, D; Mullner, C; Frohnwieser-Steinecke, B; Schreibmayer, W; Dessauer, CW; Dascal, N Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.
J Biol Chem. 2003; 278(31):29174-29183 [OPEN ACCESS]
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Schlede, E; Aberer, W; Fuchs, T; Gerner, I; Lessmann, H; Maurer, T; Rossbacher, R; Stropp, G; Wagner, E; Kayser, D Chemical substances and contact allergy--244 substances ranked according to allergenic potency.
Toxicology. 2003; 193(3):219-259
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Schnürer, SM; Gopp, U; Kühn, KD; Breusch, SJ Bone substitutes.
Orthopade. 2003; 32(1):2-10
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Wakabayashi, I; Groschner, K Vascular actions of anthracycline antibiotics.
Curr Med Chem. 2003; 10(5):427-436
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Wakula, P; Beullens, M; Ceulemans, H; Stalmans, W; Bollen, M Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1.
J Biol Chem. 2003; 278(21): 18817-18823. [OPEN ACCESS]
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Waldhoer, M; Casarosa, P; Rosenkilde, MM; Smit, MJ; Leurs, R; Whistler, JL; Schwartz, TW The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.
J BIOL CHEM 2003 278: 19473-19482. [OPEN ACCESS]
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Wendt, T; Karabay, A; Krebs, A; Gross, H; Walker, R; Hoenger, A A structural analysis of the interaction between ncd tail and tubulin protofilaments.
J Mol Biol. 2003; 333(3): 541-552.
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2002

Gössnitzer, E; Malli, R; Schuster, S; Favre, B; Ryder, NS Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. Part I: synthesis and antifungal activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines.
Arch Pharm (Weinheim). 2002; 335(11-12): 535-546.
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Schmidt, AG; Zhai, J; Carr, AN; Gerst, MJ; Lorenz, JN; Pollesello, P; Annila, A; Hoit, BD; Kranias, EG Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.
Cardiovasc Res. 2002; 56(2): 248-259. [OPEN ACCESS]
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2001

Caplice, NM; Panetta, C; Peterson, TE; Kleppe, LS; Mueske, CS; Kostner, GM; Broze, GJ; Simari, RD Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis.
Blood. 2001; 98(10):2980-2987 [OPEN ACCESS]
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1999

Hohoff, C; Börchers, T; Rüstow, B; Spener, F; van Tilbeurgh, H Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein.
Biochemistry. 1999; 38(38):12229-12239
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Horn, S; Aglas, F; Horina, JH Cholestasis and liver cell damage due to hypersensitivity to erythromycin stearate--recurrence following therapy with erythromycin succinate
WIEN KLIN WOCHENSCHR. 1999; 111: 76-77. (- Case Report)
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Oettl, K; Reibnegger, G Pteridines as inhibitors of xanthine oxidase: structural requirements.
BBA, PROTEIN STRUCT MOL ENZYM. 1999; 1430(2): 387-395.
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