Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: SIGNAL TRANSDUCTION - GENETICS , . Treffer: 48

2021

Berg, JL; Perfler, B; Hatzl, S; Uhl, B; Reinisch, A; Pregartner, G; Berghold, A; Penz, T; Schuster, M; Geissler, K; Prokesch, A; Müller-Tidow, C; Hoefler, G; Kashofer, K; Wölfler, A; Sill, H; Caraffini, V; Zebisch, A EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Leukemia. 2021; 35(5):1521-1526 Doi: 10.1038/s41375-021-01161-0 [OPEN ACCESS]
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2018

Teufelberger, AR; Nordengrün, M; Braun, H; Maes, T; De Grove, K; Holtappels, G; O'Brien, C; Provoost, S; Hammad, H; Gonçalves, A; Beyaert, R; Declercq, W; Vandenabeele, P; Krysko, DV; Bröker, BM; Bachert, C; Krysko, O The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.
J Allergy Clin Immunol. 2018; 141(2): 549-559. Doi: 10.1016/j.jaci.2017.05.004
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2017

Arzt, L; Halbwedl, I; Gogg-Kamerer, M; Popper, HH Signal Transducer and Activator of Transcription 1 (STAT1) Knock-down Induces Apoptosis in Malignant Pleural Mesothelioma.
Pathol Oncol Res. 2017; 23(3):595-605 Doi: 10.1007/s12253-016-0157-3 [OPEN ACCESS]
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Buerger, C; Shirsath, N; Lang, V; Berard, A; Diehl, S; Kaufmann, R; Boehncke, WH; Wolf, P Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.
PLoS One. 2017; 12(7):e0180853-e0180853 Doi: 10.1371/journal.pone.0180853 [OPEN ACCESS]
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González-Vela, MDC; Curiel-Olmo, S; Derdak, S; Beltran, S; Santibañez, M; Martínez, N; Castillo-Trujillo, A; Gut, M; Sánchez-Pacheco, R; Almaraz, C; Cereceda, L; Llombart, B; Agraz-Doblas, A; Revert-Arce, J; López Guerrero, JA; Mollejo, M; Marrón, PI; Ortiz-Romero, P; Fernandez-Cuesta, L; Varela, I; Gut, I; Cerroni, L; Piris, MÁ; Vaqué, JP Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.
J Invest Dermatol. 2017; 137(1):197-206 Doi: 10.1016/j.jid.2016.08.015 [OPEN ACCESS]
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Richtig, G; Richtig, E; Kashofer, K; Koch, L; Winter, G; Hoefler, G; Pichler, M; Ehall, B; Grübler, MR; Heinemann, A; Aigelsreiter, A Testing and clinical implications for non-V600 BRAF mutations in metastatic NRASmt melanoma.
Br J Dermatol. 2017; 177(3):860-861 Doi: 10.1111/bjd.15222
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Thangaratnarajah, C; Dinger, K; Vohlen, C; Klaudt, C; Nawabi, J; Lopez Garcia, E; Kwapiszewska, G; Dobner, J; Nüsken, KD; van Koningsbruggen-Rietschel, S; von Hörsten, S; Dötsch, J; Alejandre Alcázar, MA Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.
Am J Physiol Lung Cell Mol Physiol. 2017; 313(3):L491-L506 Doi: 10.1152/ajplung.00432.2016 [OPEN ACCESS]
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Zeitelhofer, M; Adzemovic, MZ; Gomez-Cabrero, D; Bergman, P; Hochmeister, S; N'diaye, M; Paulson, A; Ruhrmann, S; Almgren, M; Tegnér, JN; Ekström, TJ; Guerreiro-Cacais, AO; Jagodic, M Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis ‬.
Proc Natl Acad Sci U S A. 2017; 114(9):E1678-E1687 Doi: 10.1073/pnas.1615783114 [OPEN ACCESS]
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2016

Jeric, I; Maurer, G; Cavallo, AL; Raguz, J; Desideri, E; Tarkowski, B; Parrini, M; Fischer, I; Zatloukal, K; Baccarini, M A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nat Commun. 2016; 7(12):13781-13781 Doi: 10.1038/ncomms13781 [OPEN ACCESS]
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Moreno-Viedma, V; Amor, M; Sarabi, A; Bilban, M; Staffler, G; Zeyda, M; Stulnig, TM Common dysregulated pathways in obese adipose tissue and atherosclerosis.
Cardiovasc Diabetol. 2016; 15(1): 120-120. Doi: 10.1186/s12933-016-0441-2 [OPEN ACCESS]
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2015

Benhaim, L; Zhang, W; Wakatsuki, T; Yang, D; Gerger, A; Bohanes, P; Paez, D; Loupakis, F; LaBonte, MJ; Ning, Y; El-Khoueiry, R; Ladner, R; Wilson, P; Zhang, H; Giamas, G; Stebbing, J; Lenz, HJ Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer.
Pharmacogenomics J. 2015; 15(3):235-240 Doi: 10.1038/tpj.2014.58
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Joshi, S; Wels, C; Beham-Schmid, C; Fukunaga-Kalabis, M; Holmen, SL; Otte, M; Herlyn, M; Waldhoer, M; Schaider, H Gα13 mediates human cytomegalovirus-encoded chemokine receptor US28-induced cell death in melanoma.
Int J Cancer. 2015; 137(6):1503-1508 Doi: 10.1002/ijc.29506 [OPEN ACCESS]
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Kargl, S; Meissl, M; Pumberger, W Early postnatal diagnosis of Costello syndrome.
Klin Padiatr. 2015; 227(1): 45-47. Doi: 10.1055/s-0034-1377028
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Zabini, D; Crnkovic, S; Xu, H; Tscherner, M; Ghanim, B; Klepetko, W; Olschewski, A; Kwapiszewska, G; Marsh, LM High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.
J Cell Mol Med. 2015; 19(5):1151-1161 Doi: 10.1111/jcmm.12519 [OPEN ACCESS]
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2014

Arzt, L; Kothmaier, H; Halbwedl, I; Quehenberger, F; Popper, HH Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma.
Virchows Arch. 2014; 465(1):79-88 Doi: 10.1007/s00428-014-1584-8
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Friedmacher, F; Hofmann, AD; Takahashi, H; Takahashi, T; Gosemann, JH; Puri, P Disruption of THY-1 signaling in alveolar lipofibroblasts in experimentally induced congenital diaphragmatic hernia.
Pediatr Surg Int. 2014; 30(2):129-135 Doi: 10.1007/s00383-013-3444-z
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Karbiener, M; Pisani, DF; Frontini, A; Oberreiter, LM; Lang, E; Vegiopoulos, A; Mössenböck, K; Bernhardt, GA; Mayr, T; Hildner, F; Grillari, J; Ailhaud, G; Herzig, S; Cinti, S; Amri, EZ; Scheideler, M MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes.
Stem Cells. 2014; 32(6):1578-1590 Doi: 10.1002/stem.1603 [OPEN ACCESS]
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Köffel, R; Meshcheryakova, A; Warszawska, J; Hennig, A; Wagner, K; Jörgl, A; Gubi, D; Moser, D; Hladik, A; Hoffmann, U; Fischer, MB; van den Berg, W; Koenders, M; Scheinecker, C; Gesslbauer, B; Knapp, S; Strobl, H Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation.
Blood. 2014; 124(17):2713-2724 Doi: 10.1182/blood-2014-07-588178 [OPEN ACCESS]
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2013

Halilbasic, E; Baghdasaryan, A; Trauner, M Nuclear receptors as drug targets in cholestatic liver diseases.
Clin Liver Dis. 2013; 17(2):161-189 Doi: 10.1016/j.cld.2012.12.001 [OPEN ACCESS]
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Houben, R; Dreher, C; Angermeyer, S; Borst, A; Utikal, J; Haferkamp, S; Peitsch, WK; Schrama, D; Hesbacher, S Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J Invest Dermatol. 2013; 133(10):2453-2460 Doi: 10.1038/jid.2013.169 [OPEN ACCESS]
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Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; Oeaghdha, CM; Haller, T; Yang, Q; Tanaka, T; Johnson, AD; Kutalik, Z; Smith, AV; Shi, J; Struchalin, M; Middelberg, RP; Brown, MJ; Gaffo, AL; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, JH; Demirkan, A; Feitosa, MF; Liu, X; Malerba, G; Lopez, LM; van der Harst, P; Li, X; Kleber, ME; Hicks, AA; Nolte, IM; Johansson, A; Murgia, F; Wild, SH; Bakker, SJ; Peden, JF; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, LM; Lehtimäki, T; Woodward, OM; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, GA; Grotevendt, A; Gislason, GK; Harris, TB; Launer, LJ; McArdle, P; Shuldiner, AR; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, NG; Montgomery, GW; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, PB; Samani, NJ; Jacobs, DR; Liu, K; D'Adamo, P; Ulivi, S; Rotter, JI; Psaty, BM; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navarro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, KT; Langenberg, C; Wareham, NJ; Isaacs, A; Kraja, A; Zhang, Q; Wild, PS; Scott, RJ; Holliday, EG; Org, E; Viigimaa, M; Bandinelli, S; Metter, JE; Lupo, A; Trabetti, E; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, HE; Davies, G; Gow, AJ; Bruinenberg, M; LifeLines Cohort Study; Stolk, RP; Kooner, JS; Zhang, W; Winkelmann, BR; Boehm, BO; Lucae, S; Penninx, BW; Smit, JH; Curhan, G; Mudgal, P; Plenge, RM; Portas, L; Persico, I; Kirin, M; Wilson, JF; Leach, IM; van Gilst, WH; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, AG; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, MG; Nauck, M; Schurmann, C; Budde, K;Ernst, F; Farrington, SM; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, SY; Spector, TD; Sala, C; Ridker, PM; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, CP; CARDIoGRAM Consortium;DIAGRAM Consortium;ICBP Consortium MAGIC Consortium;Meschia, JF;Nalls, MA;Sharma, P;Singleton, AB;Kamatani, N;Zeller, T;Burnier, M;Attia, J;Laan, M;Klopp, N;Hillege, HL;Kloiber, S;Choi, H Pirastu, M Tore, S Probst-Hensch, NM Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, JB; Fornage, M; Gasparini, P; Siscovick, DS; Polasek, O; Campbell, H; Rudan, I; Bouatia-Naji, N; Metspalu, A; Loos, RJ; van Duijn, CM; Borecki, IB; Ferrucci, L; Gambaro, G;Deary, IJ; Wolffenbuttel, BH; Chambers, JC; März, W;Pramstaller, PP; Snieder, H; Gyllensten, U; Wright, AF; Navis, G; Watkins, H; Witteman, JCM; Sanna, S; Schipf, S; Dunlop, MG; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, DI; Raitakari, O; Kao, WHL; Ciullo, M; Fox, CS; Caulfield, M; Bochud, M; Gieger, C Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Nat Genet. 2013; 45(2): 145-154. Doi: 10.1038/ng.2500 [OPEN ACCESS]
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Rohban, R; Reinisch, A; Etchart, N; Schallmoser, K; Hofmann, NA; Szoke, K; Brinchmann, JE; Bonyadi Rad, E; Rohde, E; Strunk, D Identification of an effective early signaling signature during neo-vasculogenesis in vivo by ex vivo proteomic profiling.
PLoS One. 2013; 8(6):e66909-e66909 Doi: 10.1371/journal.pone.0066909 [OPEN ACCESS]
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Veith, C; Schmitt, S; Veit, F; Dahal, BK; Wilhelm, J; Klepetko, W; Marta, G; Seeger, W; Schermuly, RT; Grimminger, F; Ghofrani, HA; Fink, L; Weissmann, N; Kwapiszewska, G Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.
Proteomics. 2013; 13(1):75-88 Doi: 10.1002/pmic.201200206
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Wang, J; Sun, Y; Zheng, S; Zhang, XS; Zhou, H; Chen, L APG: an Active Protein-Gene network model to quantify regulatory signals in complex biological systems.
Sci Rep. 2013; 3(3): 1097-1097. Doi: 10.1038/srep01097 [OPEN ACCESS]
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2012

Marzaioli, V; McMorrow, JP; Angerer, H; Gilmore, A; Crean, D; Zocco, D; Rooney, P; Veale, D; Fearon, U; Gogarty, M; McEvoy, AN; Stradner, MH; Murphy, EP Histamine contributes to increased RANKL/OPG ratio through altered NR4A activity in human chondrocyte cells.
Arthritis Rheum. 2012; 64(10):3290-3301 Doi: 10.1002/art.34554 [OPEN ACCESS]
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Min, L; Ji, Y; Bakiri, L; Qiu, Z; Cen, J; Chen, X; Chen, L; Scheuch, H; Zheng, H; Qin, L; Zatloukal, K; Hui, L; Wagner, EF Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Nat Cell Biol. 2012; 14(11):1203-1211 Doi: 10.1038/ncb2590
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2011

Drozdov, I; Svejda, B; Gustafsson, BI; Mane, S; Pfragner, R; Kidd, M; Modlin, IM Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia.
PLoS One. 2011; 6(8):e22457-e22457 Doi: 10.1371/journal.pone.0022457 [OPEN ACCESS]
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2010

Carmona-Gutierrez, D; Ruckenstuhl, C; Bauer, MA; Eisenberg, T; Büttner, S; Madeo, F Cell death in yeast: growing applications of a dying buddy.
Cell Death Differ. 2010; 17(5):733-734 Doi: 10.1038/cdd.2010.10 [OPEN ACCESS]
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Doi, T; Ruttenstock, E; Dingemann, J; Puri, P Spatiotemporal alteration in phosphatidylinositide 3-kinase-serine/threonine protein kinase B signaling in the nitrofen-induced hypoplastic lung.
J Pediatr Surg. 2010; 45(2):366-371 Doi: 10.1016/j.jpedsurg.2009.10.075
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Kondé, E; Bourgeois, B; Tellier-Lebegue, C; Wu, W; Pérez, J; Caputo, S; Attanda, W; Gasparini, S; Charbonnier, JB; Gilquin, B; Worman, HJ; Zinn-Justin, S Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.
Biochemistry. 2010; 49(37):8020-8032 Doi: 10.1021/bi101153w
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Winder, T; Zhang, W; Yang, D; Ning, Y; Bohanes, P; Gerger, A; Wilson, P; Pohl, A; Mauro, DJ; Langer, C; Rowinsky, EK; Lenz, HJ Germline Polymorphisms in Genes Involved in the IGF1 Pathway Predict Efficacy of Cetuximab in Wild-type KRAS mCRC Patients.
Clin Cancer Res. 2010; 16(22):5591-5602 Doi: 10.1158/1078-0432.CCR-10-2092 [OPEN ACCESS]
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2009

Bilban, M; Haslinger, P; Prast, J; Klinglmüller, F; Woelfel, T; Haider, S; Sachs, A; Otterbein, LE; Desoye, G; Hiden, U; Wagner, O; Knöfler, M Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma.
Endocrinology. 2009; 150(2): 1000-1013. Doi: 10.1210/en.2008-0456 [OPEN ACCESS]
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Kallifatidis, G; Rausch, V; Baumann, B; Apel, A; Beckermann, BM; Groth, A; Mattern, J; Li, Z; Kolb, A; Moldenhauer, G; Altevogt, P; Wirth, T; Werner, J; Schemmer, P; Büchler, MW; Salnikov, AV; Herr, I Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.
Gut. 2009; 58(7):949-963 Doi: 10.1136/gut.2008.149039
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Lowin, T; Straub, RH; Neumann, E; Bosserhoff, A; Vogel, C; Moissl, C; Anders, S; Müller-Ladner, U; Schedel, J Glucocorticoids increase alpha5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion.
Arthritis Rheum. 2009; 60(12):3623-3632 Doi: 10.1002/art.24985 [OPEN ACCESS]
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Platzer, B; Richter, S; Kneidinger, D; Waltenberger, D; Woisetschläger, M; Strobl, H Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
J Immunol. 2009; 183(1):66-74 Doi: 10.4049/jimmunol.0802997 [OPEN ACCESS]
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2008

Hellwinkel, OJ; Rogmann, JP; Asong, LE; Luebke, AM; Eichelberg, C; Ahyai, S; Isbarn, H; Graefen, M; Huland, H; Schlomm, T A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
BJU Int. 2008; 101(11):1454-60 Doi: 10.1111/j.1464-410X.2008.07540.x
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Houben, R; Vetter-Kauczok, CS; Ortmann, S; Rapp, UR; Broecker, EB; Becker, JC Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.
J Invest Dermatol. 2008; 128(8):2003-2012 Doi: 10.1038/jid.2008.30 [OPEN ACCESS]
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Sarkozi, R; Perco, P; Hochegger, K; Enrich, J; Wiesinger, M; Pirklbauer, M; Eder, S; Rudnicki, M; Rosenkranz, AR; Mayer, B; Mayer, G; Schramek, H Bortezomib-induced survival signals and genes in human proximal tubular cells.
J Pharmacol Exp Ther. 2008; 327(3):645-656 Doi: 10.1124/jpet.108.142604 [OPEN ACCESS]
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2007

Das, SK; Pathak, RR; Choudhury, D; Raghuram, N Genomewide computational analysis of nitrate response elements in rice and Arabidopsis.
Mol Genet Genomics. 2007; 278(5):519-525 Doi: 10.1007/s00438-007-0268-3
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Eder, P; Poteser, M; Groschner, K TRPC3: a multifunctional, pore-forming signalling molecule.
Handb Exp Pharmacol. 2007; 77-92 Doi: 10.1007/978-3-540-34891-7_4
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Kidd, M; Modlin, IM; Pfragner, R; Eick, GN; Champaneria, MC; Chan, AK; Camp, RL; Mane, SM Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1.
CANCER. 2007; 109(12): 2420-2431. Doi: 10.1002/cncr.22725 [OPEN ACCESS]
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Zebisch, A; Czernilofsky, AP; Keri, G; Smigelskaite, J; Sill, H; Troppmair, J Signaling through RAS-RAF-MEK-ERK: from basics to bedside.
Curr Med Chem. 2007; 14(5): 601-623. Doi: 10.2174/092986707780059670
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2006

Deindl, E; Middeler, G; Müller, OJ; Selbert, S; Schlenke, P; Marienfeld, U; Thirion, C; Katus, HA; Franz, WM Identification of a 94-bp GC-rich element in the smooth muscle myosin heavy-chain promoter controlling vascular smooth muscle cell-specific gene expression.
Cell Biochem Biophys. 2006; 45(3):279-288 Doi: 10.1385/CBB:45:3:279
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Zebisch, A; Troppmair, J Back to the roots: the remarkable RAF oncogene story.
CELL MOL LIFE SCI. 2006; 63: 1314-1330. Doi: 10.1007/s00018-006-6005-y
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2003

Waldhoer, M; Casarosa, P; Rosenkilde, MM; Smit, MJ; Leurs, R; Whistler, JL; Schwartz, TW The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.
J BIOL CHEM 2003 278: 19473-19482. Doi: 10.1074/jbc.M213179200 [OPEN ACCESS]
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2000

Schäfer, U; Seibold, S; Schneider, A; Neugebauer, E Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine.
FEBS Lett. 2000; 466(1): 148-154. Doi: 10.1016/S0014-5793(99)01778-0
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Schett, G; Steiner, CW; Winkler, S; Graninger, W; Smolen, J; Xu, Q; Steiner, G Reciprocal modification of Fas activation and stress protein response decides apoptosis or resistance development of cells
Acta Med Austriaca. 2000; 27(3):94-98 Doi: 10.1046/j.1563-2571.2000.00217.x
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1998

Strohmaier, H; Noiges, R; Kotschan, S; Sawers, G; Högenauer, G; Zechner, EL; Koraimann, G Signal transduction and bacterial conjugation: characterization of the role of ArcA in regulating conjugative transfer of the resistance plasmid R1.
J Mol Biol. 1998; 277(2):309-316 Doi: 10.1006/jmbi.1997.1598
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