Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: RECOMBINANT PROTEINS - METABOLISM , . Treffer: 56

2022

Kittler, S; Ebner, J; Besleaga, M; Larsbrink, J; Darnhofer, B; Birner-Gruenberger, R; Schobesberger, S; Akhgar, CK; Schwaighofer, A; Lendl, B; Spadiut, O Recombinant Protein L: Production, Purification and Characterization of a Universal Binding Ligand.
J Biotechnol. 2022; 359:108-115 Doi: 10.1016/j.jbiotec.2022.10.002
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2017

Emmanouilidis, L; Schütz, U; Tripsianes, K; Madl, T; Radke, J; Rucktäschel, R; Wilmanns, M; Schliebs, W; Erdmann, R; Sattler, M Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Nat Commun. 2017; 8(7):14635-14635 Doi: 10.1038/ncomms14635 [OPEN ACCESS]
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Oliva, C; Sánchez-Murcia, PA; Rico, E; Bravo, A; Menéndez, M; Gago, F; Jiménez-Ruiz, A Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.
Nucleic Acids Res. 2017; 45(15):9030-9045 Doi: 10.1093/nar/gkx629 [OPEN ACCESS]
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2016

Aschauer, P; Rengachari, S; Lichtenegger, J; Schittmayer, M; Das, KM; Mayer, N; Breinbauer, R; Birner-Gruenberger, R; Gruber, CC; Zimmermann, R; Gruber, K; Oberer, M Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p.
Biochim Biophys Acta. 2016; 1861(5):462-470 Doi: 10.1016/j.bbalip.2016.02.005 [OPEN ACCESS]
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Biundo, A; Hromic, A; Pavkov-Keller, T; Gruber, K; Quartinello, F; Haernvall, K; Perz, V; Arrell, MS; Zinn, M; Ribitsch, D; Guebitz, GM Characterization of a poly(butylene adipate-co-terephthalate)- hydrolyzing lipase from Pelosinus fermentans.
Appl Microbiol Biotechnol. 2016; 100(4): 1753-1764. Doi: 10.1007/s00253-015-7031-1 [OPEN ACCESS]
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Janowski, R; Scanu, S; Niessing, D; Madl, T Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Acta Crystallogr F Struct Biol Commun. 2016; 72(Pt 10):743-749 Doi: 10.1107/S2053230X16013686 [OPEN ACCESS]
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Voith von Voithenberg, L; Sánchez-Rico, C; Kang, HS; Madl, T; Zanier, K; Barth, A; Warner, LR; Sattler, M; Lamb, DC Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
Proc Natl Acad Sci U S A. 2016; 113(46):E7169-E7175 Doi: 10.1073/pnas.1605873113 [OPEN ACCESS]
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Weinhandl, K; Ballach, M; Winkler, M; Ahmad, M; Glieder, A; Birner-Gruenberger, R; Fotheringham, I; Escalettes, F; Camattari, A Pichia pastoris mutants as host strains for efficient secretion of recombinant branched chain aminotransferase (BCAT).
J Biotechnol. 2016; 235(1):84-91 Doi: 10.1016/j.jbiotec.2016.06.004
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2015

Perz, V; Zumstein, MT; Sander, M; Zitzenbacher, S; Ribitsch, D; Guebitz, GM Biomimetic Approach to Enhance Enzymatic Hydrolysis of the Synthetic Polyester Poly(1,4-butylene adipate): Fusing Binding Modules to Esterases.
Biomacromolecules. 2015; 16(12): 3889-3896. Doi: 10.1021/acs.biomac.5b01219
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Sahu-Osen, A; Montero-Moran, G; Schittmayer, M; Fritz, K; Dinh, A; Chang, YF; McMahon, D; Boeszoermenyi, A; Cornaciu, I; Russell, D; Oberer, M; Carman, GM; Birner-Gruenberger, R; Brasaemle, DL CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization.
J Lipid Res. 2015; 56(1):109-121 Doi: 10.1194/jlr.M055004 [OPEN ACCESS]
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2014

Lorenz, OR; Freiburger, L; Rutz, DA; Krause, M; Zierer, BK; Alvira, S; Cuéllar, J; Valpuesta, JM; Madl, T; Sattler, M; Buchner, J Modulation of the Hsp90 chaperone cycle by a stringent client protein.
Mol Cell. 2014; 53(6): 941-953. Doi: 10.1016/j.molcel.2014.02.003 [OPEN ACCESS]
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2013

Gizurarson, S; Huppertz, B; Osol, G; Skarphedinsson, JO; Mandala, M; Meiri, H; Effects of Placental Protein 13 on the Cardiovascular System in Gravid and Non-Gravid Rodents.
Fetal Diagn Ther. 2013; 33(4):257-264 Doi: 10.1159/000345964
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Kitic, M; Hochmeister, S; Wimmer, I; Bauer, J; Misu, T; Mader, S; Reindl, M; Fujihara, K; Lassmann, H; Bradl, M Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats.
Acta Neuropathol Commun. 2013; 1(11):5-5 Doi: 10.1186/2051-5960-1-5 [OPEN ACCESS]
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2012

Kraus, JP; Spector, E; Venezia, S; Estes, P; Chiang, PW; Creadon-Swindell, G; Müllerleile, S; de Silva, L; Barth, M; Walter, M; Walter, K; Meissner, T; Lindner, M; Ensenauer, R; Santer, R; Bodamer, OA; Baumgartner, MR; Brunner-Krainz, M; Karall, D; Haase, C; Knerr, I; Marquardt, T; Hennermann, JB; Steinfeld, R; Beblo, S; Koch, HG; Konstantopoulou, V; Scholl-Bürgi, S; van Teeffelen-Heithoff, A; Suormala, T; Ugarte, M; Sperl, W; Superti-Furga, A; Schwab, KO; Grünert, SC; Sass, JO Mutation analysis in 54 propionic acidemia patients.
J INHERIT METAB DIS. 2012; 35(1): 51-63. Doi: 10.1007/s10545-011-9399-0
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Rengachari, S; Bezerra, GA; Riegler-Berket, L; Gruber, CC; Sturm, C; Taschler, U; Boeszoermenyi, A; Dreveny, I; Zimmermann, R; Gruber, K; Oberer, M The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes.
Biochim Biophys Acta. 2012; 1821(7): 1012-1021. Doi: 10.1016/j.bbalip.2012.04.006 [OPEN ACCESS]
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2011

Norville, IH; Breitbach, K; Eske-Pogodda, K; Harmer, NJ; Sarkar-Tyson, M; Titball, RW; Steinmetz, I A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei.
Microbiology. 2011; 157(Pt 9):2629-2638 Doi: 10.1099/mic.0.049163-0 [OPEN ACCESS]
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Pival, SL; Birner-Gruenberger, R; Krump, C; Nidetzky, B D-Xylulose kinase from Saccharomyces cerevisiae: isolation and characterization of the highly unstable enzyme, recombinantly produced in Escherichia coli.
Protein Expr Purif. 2011; 79(2):223-230 Doi: 10.1016/j.pep.2011.05.018 [OPEN ACCESS]
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2010

Gruber, A; Cornaciu, I; Lass, A; Schweiger, M; Poeschl, M; Eder, C; Kumari, M; Schoiswohl, G; Wolinski, H; Kohlwein, SD; Zechner, R; Zimmermann, R; Oberer, M The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase.
J Biol Chem. 2010; 285(16): 12289-12298. Doi: 10.1074/jbc.M109.064469 [OPEN ACCESS]
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Harmatz, P; Yu, ZF; Giugliani, R; Schwartz, IV; Guffon, N; Teles, EL; Miranda, MC; Wraith, JE; Beck, M; Arash, L; Scarpa, M; Ketteridge, D; Hopwood, JJ; Plecko, B; Steiner, R; Whitley, CB; Kaplan, P; Swiedler, SJ; Hardy, K; Berger, KI; Decker, C Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long-term pulmonary function in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase.
J Inherit Metab Dis. 2010; 33(1):51-60 Doi: 10.1007/s10545-009-9007-8 [OPEN ACCESS]
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Missiou, A; Wolf, D; Platzer, I; Ernst, S; Walter, C; Rudolf, P; Zirlik, K; Köstlin, N; Willecke, FK; Münkel, C; Schönbeck, U; Libby, P; Bode, C; Varo, N; Zirlik, A CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease.
THROMB HAEMOSTASIS. 2010; 103(4): 788-796. Doi: 10.1160/TH09-07-0463
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Prager, GW; Lackner, EM; Krauth, MT; Unseld, M; Poettler, M; Laffer, S; Cerny-Reiterer, S; Lamm, W; Kornek, GV; Binder, BR; Zielinski, CC; Valent, P Targeting of VEGF-dependent transendothelial migration of cancer cells by bevacizumab.
Mol Oncol. 2010; 4(2): 150-160. Doi: 10.1016/j.molonc.2010.01.002 [OPEN ACCESS]
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Zhang, J; Lei, T; Chen, X; Peng, Y; Long, H; Zhou, L; Huang, J; Chen, Z; Long, Q; Yang, Z Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway.
Inflammation. 2010; 33(1): 25-33. Doi: 10.1007/s10753-009-9155-x
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2009

Haybaeck, J; Zeller, N; Wolf, MJ; Weber, A; Wagner, U; Kurrer, MO; Bremer, J; Iezzi, G; Graf, R; Clavien, PA; Thimme, R; Blum, H; Nedospasov, SA; Zatloukal, K; Ramzan, M; Ciesek, S; Pietschmann, T; Marche, PN; Karin, M; Kopf, M; Browning, JL; Aguzzi, A; Heikenwalder, M A lymphotoxin-driven pathway to hepatocellular carcinoma.
CANCER CELL. 2009; 16(4): 295-308. Doi: 10.1016/j.ccr.2009.08.021 [OPEN ACCESS]
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Kawano, T; Zoga, V; Kimura, M; Liang, MY; Wu, HE; Gemes, G; McCallum, JB; Kwok, WM; Hogan, QH; Sarantopoulos, CD Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation.
Mol Pain. 2009; 5(21): 12-12. Doi: 10.1186/1744-8069-5-12 [OPEN ACCESS]
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2008

Hochrainer, K; Kroismayr, R; Baranyi, U; Binder, BR; Lipp, J Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.
Cell Mol Life Sci. 2008; 65(13):2105-2117 Doi: 10.1007/s00018-008-8148-5
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Sun, X; Yang, H; Nose, K; Nose, S; Haxhija, EQ; Koga, H; Teitelbaum, DH Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition.
Am J Physiol Gastrointest Liver Physiol. 2008; 294(1):G139-G147 Doi: 10.1152/ajpgi.00386.2007 [OPEN ACCESS]
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2004

McMullen, JR; Shioi, T; Huang, WY; Zhang, L; Tarnavski, O; Bisping, E; Schinke, M; Kong, S; Sherwood, MC; Brown, J; Riggi, L; Kang, PM; Izumo, S The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
J Biol Chem. 2004; 279(6):4782-4793 Doi: 10.1074/jbc.M310405200 [OPEN ACCESS]
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Patsouris, D; Mandard, S; Voshol, PJ; Escher, P; Tan, NS; Havekes, LM; Koenig, W; März, W; Tafuri, S; Wahli, W; Müller, M; Kersten, S PPARalpha governs glycerol metabolism.
J Clin Invest. 2004; 114(1):94-103 Doi: 10.1172/JCI200420468 [OPEN ACCESS]
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Ramamoorthy, S; Stepan, V; Todisco, A Intracellular mechanisms mediating the anti-apoptotic action of gastrin.
Biochem Biophys Res Commun. 2004; 323(1):44-48 Doi: 10.1016/j.bbrc.2004.08.059
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2003

Dressel, U; Allen, TL; Pippal, JB; Rohde, PR; Lau, P; Muscat, GE The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells.
Mol Endocrinol. 2003; 17(12):2477-2493 Doi: 10.1210/me.2003-0151 [OPEN ACCESS]
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Fragaki, K; Ferrua, B; Mograbi, B; Waldispuhl, J; Kubar, J A novel Leishmania infantum nuclear phosphoprotein Lepp12 which stimulates IL1-beta synthesis in THP-1 transfectants.
BMC MICROBIOL. 2003; 3(2): 7-7. Doi: 10.1186/1471-2180-3-7 [OPEN ACCESS]
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Ljungberg, MC; Asuni, A; Pearce, J; Dayanandan, R; März, W; Hoffmann, MM; Bertrand, P; Siest, G; Rupniak, HT; Anderton, BH; Huettinger, M; Lovestone, S Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells.
Neurosci Lett. 2003; 341(1):69-73 Doi: 10.1016%2FS0304-3940%2803%2900064-8
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2002

Gutiérrez-González, LH; Ludwig, C; Hohoff, C; Rademacher, M; Hanhoff, T; Rüterjans, H; Spener, F; Lücke, C Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).
Biochem J. 2002; 364(Pt 3):725-737 Doi: 10.1042/BJ20020039 [OPEN ACCESS]
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Panzenboeck, U; Balazs, Z; Sovic, A; Hrzenjak, A; Levak-Frank, S; Wintersperger, A; Malle, E; Sattler, W ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells.
J Biol Chem. 2002; 277(45):42781-42789 Doi: 10.1074/jbc.M207601200 [OPEN ACCESS]
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Vogel, A; Börchers, T; Marcus, K; Meyer, HE; Krebs, B; Spener, F Heterologous expression and characterization of recombinant purple acid phosphatase from red kidney bean.
Arch Biochem Biophys. 2002; 401(2):164-172 Doi: 10.1016/S0003-9861(02)00046-2
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2001

Gaiger, A; Carter, L; Greinix, H; Carter, D; McNeill, PD; Houghton, RL; Cornellison, CD; Vedvick, TS; Skeiky, YA; Cheever, MA WT1-specific serum antibodies in patients with leukemia.
Clin Cancer Res. 2001; 7(3 Suppl):761s-7765
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2000

Abbadi, A; Brummel, M; Schutt, BS; Slabaugh, MB; Schuch, R; Spener, F Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme
BIOCHEM J. 2000; 345: 153-160. Doi: 10.1042/0264-6021:3450153 [OPEN ACCESS]
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Abbadi, A; Brummel, M; Spener, F Knockout of the regulatory site of 3-ketoacyl-ACP synthase III enhances short- and medium-chain acyl-ACP synthesis.
Plant J. 2000; 24(1):1-9 Doi: 10.1046/j.1365-313x.2000.00841.x [OPEN ACCESS]
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Kepplinger, KJ; Kahr, H; Förstner, G; Sonnleitner, M; Schindler, H; Schmidt, T; Groschner, K; Soldatov, NM; Romanin, C A sequence in the carboxy-terminus of the alpha(1C) subunit important for targeting, conductance and open probability of L-type Ca(2+) channels.
FEBS Lett. 2000; 477(3):161-169 Doi: 10.1016/S0014-5793(00)01791-9 [OPEN ACCESS]
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Lintschinger, B; Balzer-Geldsetzer, M; Baskaran, T; Graier, WF; Romanin, C; Zhu, MX; Groschner, K Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.
J Biol Chem. 2000; 275(36):27799-27805 Doi: 10.1074/jbc.M002705200 [OPEN ACCESS]
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Zhai, J; Schmidt, AG; Hoit, BD; Kimura, Y; MacLennan, DH; Kranias, EG Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo.
J Biol Chem. 2000; 275(14): 10538-10544. Doi: 10.1074/jbc.275.14.10538 [OPEN ACCESS]
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1999

Buhlmann, C; Borchers, T; Pollak, M; Spener, F Fatty acid metabolism in human breast cancer cells (MCF7) transfected with heart-type fatty acid binding protein
MOL CELL BIOCHEM. MOLECULAR AND CELLULAR BIOCHEMISTRY; 199: 41-48. Doi: 10.1023/A:1006986629206
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Hohoff, C; Börchers, T; Rüstow, B; Spener, F; van Tilbeurgh, H Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein.
Biochemistry. 1999; 38(38):12229-12239 Doi: 10.1021/bi990305u
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Stepan, VM; Sawada, M; Todisco, A; Dickinson, CJ Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
Mol Med. 1999; 5(3):147-159 Doi: 10.1007/BF03402058 [OPEN ACCESS]
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Valenta, R; Vrtala, S; Focke-Tejkl, M; Bugajska-Schretter, M; Ball, T; Twardosz, A; Spitzauer, S; Grönlund, H; Kraft, D Genetically engineered and synthetic allergen derivatives: candidates for vaccination against type I allergy.
Biol Chem. 1999; 380(7-8):815-824 Doi: 10.1515/BC.1999.101
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Wolfrum, C; Ellinghaus, P; Fobker, M; Seedorf, U; Assmann, G; Börchers, T; Spener, F Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein.
J Lipid Res. 1999; 40(4):708-714 Doi: 10.1016/S0022-2275(20)32150-7 [OPEN ACCESS]
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1998

Hohenegger, M; Waldhoer, M; Beindl, W; Böing, B; Kreimeyer, A; Nickel, P; Nanoff, C; Freissmuth, M Gsalpha-selective G protein antagonists.
Proc Natl Acad Sci U S A. 1998; 95(1):346-351 Doi: 10.1073/pnas.95.1.346 [OPEN ACCESS]
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Scheib, H; Pleiss, J; Stadler, P; Kovac, A; Potthoff, AP; Haalck, L; Spener, F; Paltauf, F; Schmid, RD Rational design of Rhizopus oryzae lipase with modified stereoselectivity toward triradylglycerols.
Protein Eng. 1998; 11(8):675-682 Doi: 10.1093/protein/11.8.675 [OPEN ACCESS]
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1997

Fedorov, AA; Ball, T; Mahoney, NM; Valenta, R; Almo, SC The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin.
Structure. 1997; 5(1):33-45 Doi: 10.1016/S0969-2126(97)00164-0 [OPEN ACCESS]
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Kockskämper, J; Gisselmann, G; Glitsch, HG Comparison of ouabain-sensitive and -insensitive Na/K pumps in HEK293 cells.
Biochim Biophys Acta. 1997; 1325(2): 197-208. Doi: 10.1016/S0005-2736(96)00259-3
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