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Publikationen

Suchbegriffe: PROTEIN STRUCTURE, TERTIARY - , . Treffer: 80

2016

Derler, I; Jardin, I; Stathopulos, PB; Muik, M; Fahrner, M; Zayats, V; Pandey, SK; Poteser, M; Lackner, B; Absolonova, M; Schindl, R; Groschner, K; Ettrich, R; Ikura, M; Romanin, C Cholesterol modulates Orai1 channel function.
Sci Signal. 2016; 9(412):ra10-ra10 Doi: 10.1126/scisignal.aad7808 [OPEN ACCESS]
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Uttarkar, S; Dassé, E; Coulibaly, A; Steinmann, S; Jakobs, A; Schomburg, C; Trentmann, A; Jose, J; Schlenke, P; Berdel, WE; Schmidt, TJ; Müller-Tidow, C; Frampton, J; Klempnauer, KH Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
Blood. 2016; 127(9):1173-1182 Doi: 10.1182/blood-2015-09-668632 [OPEN ACCESS]
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2015

Gherbovet, O; Sánchez-Murcia, PA; García Alvarez, MC; Bignon, J; Thoret, S; Gago, F; Roussi, F Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.
Org Biomol Chem. 2015; 13(10):3144-3154 Doi: 10.1039/c4ob02114b
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Hacker, C; Christ, NA; Duchardt-Ferner, E; Korn, S; Göbl, C; Berninger, L; Düsterhus, S; Hellmich, UA; Madl, T; Kötter, P; Entian, KD; Wöhnert, J The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.
J Biol Chem. 2015; 290(48):28869-28886 Doi: 10.1074/jbc.M115.679969 [OPEN ACCESS]
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Hocking, HG; Häse, F; Madl, T; Zacharias, M; Rief, M; Žoldák, G A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain.
Biophys J. 2015; 108(3):678-686 Doi: 10.1016/j.bpj.2014.11.3482 [OPEN ACCESS]
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Houben, R; Angermeyer, S; Haferkamp, S; Aue, A; Goebeler, M; Schrama, D; Hesbacher, S Characterization of functional domains in the Merkel cell polyoma virus Large T antigen.
Int J Cancer. 2015; 136(5):E290-E300 Doi: 10.1002/ijc.29200 [OPEN ACCESS]
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Kassner, U; Salewsky, B; Wühle-Demuth, M; Szijarto, IA; Grenkowitz, T; Binner, P; März, W; Steinhagen-Thiessen, E; Demuth, I Severe hypertriglyceridemia in a patient heterozygous for a lipoprotein lipase gene allele with two novel missense variants.
Eur J Hum Genet. 2015; 23(9):1259-1261 Doi: 10.1038/ejhg.2014.295 (- Case Report) [OPEN ACCESS]
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Meyer, NH; Mayerhofer, H; Tripsianes, K; Blindow, S; Barths, D; Mewes, A; Weimar, T; Köhli, T; Bade, S; Madl, T; Frey, A; Haas, H; Mueller-Dieckmann, J; Sattler, M; Schramm, G A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation.
J Biol Chem. 2015; 290(36): 22111-22126. Doi: 10.1074/jbc.M115.675066 [OPEN ACCESS]
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Perz, V; Zumstein, MT; Sander, M; Zitzenbacher, S; Ribitsch, D; Guebitz, GM Biomimetic Approach to Enhance Enzymatic Hydrolysis of the Synthetic Polyester Poly(1,4-butylene adipate): Fusing Binding Modules to Esterases.
Biomacromolecules. 2015; 16(12): 3889-3896. Doi: 10.1021/acs.biomac.5b01219
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2014

Cavalcante Hissa, D; Arruda Bezerra, G; Birner-Gruenberger, R; Paulino Silva, L; Usón, I; Gruber, K; Maciel Melo, VM Unique crystal structure of a novel surfactant protein from the foam nest of the frog Leptodactylus vastus.
Chembiochem. 2014; 15(3):393-398 Doi: 10.1002/cbic.201300726
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Fahrner, M; Muik, M; Schindl, R; Butorac, C; Stathopulos, P; Zheng, L; Jardin, I; Ikura, M; Romanin, C A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).
J Biol Chem. 2014; 289(48): 33231-33244. Doi: 10.1074/jbc.M114.610022 [OPEN ACCESS]
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Huang, JR; Warner, LR; Sanchez, C; Gabel, F; Madl, T; Mackereth, CD; Sattler, M; Blackledge, M Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study.
J Am Chem Soc. 2014; 136(19):7068-7076 Doi: 10.1021/ja502030n
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Khan, MA; Rupp, VM; Orpinell, M; Hussain, MS; Altmüller, J; Steinmetz, MO; Enzinger, C; Thiele, H; Höhne, W; Nürnberg, G; Baig, SM; Ansar, M; Nürnberg, P; Vincent, JB; Speicher, MR; Gönczy, P; Windpassinger, C A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.
Hum Mol Genet. 2014; 23(22):5940-5949 Doi: 10.1093/hmg/ddu318 [OPEN ACCESS]
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Morisaki, T; Müller, WG; Golob, N; Mazza, D; McNally, JG Single-molecule analysis of transcription factor binding at transcription sites in live cells.
NAT COMMUN. 2014; 5: 4456-4456. Doi: 10.1038/ncomms5456 [OPEN ACCESS]
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Neuhaus, A; Kooshapur, H; Wolf, J; Meyer, NH; Madl, T; Saidowsky, J; Hambruch, E; Lazam, A; Jung, M; Sattler, M; Schliebs, W; Erdmann, R A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
J Biol Chem. 2014; 289(1): 437-448. Doi: 10.1074/jbc.M113.499707 [OPEN ACCESS]
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2013

Damgaard, RB; Fiil, BK; Speckmann, C; Yabal, M; zur Stadt, U; Bekker-Jensen, S; Jost, PJ; Ehl, S; Mailand, N; Gyrd-Hansen, M Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
EMBO Mol Med. 2013; 5(8):1278-1295 Doi: 10.1002/emmm.201303090 [OPEN ACCESS]
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Derler, I; Plenk, P; Fahrner, M; Muik, M; Jardin, I; Schindl, R; Gruber, HJ; Groschner, K; Romanin, C The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
J Biol Chem. 2013; 288(40):29025-29034 Doi: 10.1074/jbc.M113.501510 [OPEN ACCESS]
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Herrero Acero, E; Ribitsch, D; Dellacher, A; Zitzenbacher, S; Marold, A; Steinkellner, G; Gruber, K; Schwab, H; Guebitz, GM Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis.
Biotechnol Bioeng. 2013; 110(10):2581-2590 Doi: 10.1002/bit.24930
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Ho, JE; Chen, WY; Chen, MH; Larson, MG; McCabe, EL; Cheng, S; Ghorbani, A; Coglianese, E; Emilsson, V; Johnson, AD; Walter, S; Franceschini, N; O'Donnell, CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group; Dehghan, A; Lu, C; Levy, D; Newton-Cheh, C; CHARGE Heart Failure Working Group; Lin, H; Felix, JF; Schreiter, ER; Vasan, RS; Januzzi, JL; Lee, RT; Wang, TJ; Assimes, TL; Deloukas, P; Erdmann, J; Holm, H; Kathiresan, S; König, IR; McPherson, R; Reilly, MP; Roberts, R; Samani, NJ; Schunkert, H; Stewart, AF Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
J Clin Invest. 2013; 123(10): 4208-4218. Doi: 10.1172/JCI67119 [OPEN ACCESS]
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Lichtenegger, M; Stockner, T; Poteser, M; Schleifer, H; Platzer, D; Romanin, C; Groschner, K A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.
Cell Calcium. 2013; 54(3):175-185 Doi: 10.1016/j.ceca.2013.05.010 [OPEN ACCESS]
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Müller, R; Gräwert, MA; Kern, T; Madl, T; Peschek, J; Sattler, M; Groll, M; Buchner, J High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.
Proc Natl Acad Sci U S A. 2013; 110(25): 10183-10188. Doi: 10.1073/pnas.1300547110 [OPEN ACCESS]
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Prüller, F; Raggam, RB; Mangge, H; Truschnig-Wilders, M; Matzhold, EM; Weiss, EC; Hasiba, B; Summers, KL; Renner, W; Siegert, G; Kostka, H A novel factor V mutation causes a normal activated protein C ratio despite the presence of a heterozygous F5 R506Q (factor V Leiden) mutation.
Br J Haematol. 2013; 163(3):414-417 Doi: 10.1111/bjh.12506 [OPEN ACCESS]
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Rengachari, S; Aschauer, P; Schittmayer, M; Mayer, N; Gruber, K; Breinbauer, R; Birner-Gruenberger, R; Dreveny, I; Oberer, M Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase.
J Biol Chem. 2013; 288(43):31093-31104 Doi: 10.1074/jbc.M113.491415 [OPEN ACCESS]
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Walte, A; Rüben, K; Birner-Gruenberger, R; Preisinger, C; Bamberg-Lemper, S; Hilz, N; Bracher, F; Becker, W Mechanism of dual specificity kinase activity of DYRK1A.
FEBS J. 2013; 280(18):4495-4511 Doi: 10.1111/febs.12411 [OPEN ACCESS]
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2012

Muik, M; Schindl, R; Fahrner, M; Romanin, C Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.
Cell Mol Life Sci. 2012; 69(24): 4163-4176. Doi: 10.1007/s00018-012-1072-8 [OPEN ACCESS]
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2011

Frischauf, I; Schindl, R; Bergsmann, J; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Lackner, B; Groschner, K; Romanin, C Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.
J Biol Chem. 2011; 286(10):8577-8584 Doi: 10.1074/jbc.M110.187179 [OPEN ACCESS]
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Karki, P; Li, X; Schrama, D; Fliegel, L B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+ Exchanger.
J Biol Chem. 2011; 286(15): 13096-13105. Doi: 10.1074/jbc.M110.165134 [OPEN ACCESS]
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Mackereth, CD; Madl, T; Bonnal, S; Simon, B; Zanier, K; Gasch, A; Rybin, V; Valcárcel, J; Sattler, M Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.
Nature. 2011; 475(7356): 408-411. Doi: 10.1038/nature10171 [OPEN ACCESS]
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Madl, T; Güttler, T; Görlich, D; Sattler, M Structural analysis of large protein complexes using solvent paramagnetic relaxation enhancements.
Angew Chem Int Ed Engl. 2011; 50(17): 3993-3997. Doi: 10.1002/anie.201007168
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Sayers, EW; Barrett, T; Benson, DA; Bolton, E; Bryant, SH; Canese, K; Chetvernin, V; Church, DM; DiCuccio, M; Federhen, S; Feolo, M; Fingerman, IM; Geer, LY; Helmberg, W; Kapustin, Y; Landsman, D; Lipman, DJ; Lu, Z; Madden, TL; Madej, T; Maglott, DR; Marchler-Bauer, A; Miller, V; Mizrachi, I; Ostell, J; Panchenko, A; Phan, L; Pruitt, KD; Schuler, GD; Sequeira, E; Sherry, ST; Shumway, M; Sirotkin, K; Slotta, D; Souvorov, A; Starchenko, G; Tatusova, TA; Wagner, L; Wang, Y; Wilbur, WJ; Yaschenko, E; Ye, J Database resources of the National Center for Biotechnology Information.
Nucleic Acids Res. 2011; 39(Database issue):D38-D51 Doi: 10.1093/nar/gkq1172 [OPEN ACCESS]
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Tripsianes, K; Madl, T; Machyna, M; Fessas, D; Englbrecht, C; Fischer, U; Neugebauer, KM; Sattler, M Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.
Nat Struct Mol Biol. 2011; 18(12): 1414-1420. Doi: 10.1038/nsmb.2185
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Wolf, D; Hohmann, JD; Wiedemann, A; Bledzka, K; Blankenbach, H; Marchini, T; Gutte, K; Zeschky, K; Bassler, N; Hoppe, N; Rodriguez, AO; Herr, N; Hilgendorf, I; Stachon, P; Willecke, F; Duerschmied, D; von zur Muhlen, C; Soloviev, DA; Zhang, L; Bode, C; Plow, EF; Libby, P; Peter, K; Zirlik, A Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.
CIRC RES. 2011; 109(11): 1269-1279. Doi: 10.1161/CIRCRESAHA.111.247684 [OPEN ACCESS]
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Zheng, L; Stathopulos, PB; Schindl, R; Li, GY; Romanin, C; Ikura, M Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
Proc Natl Acad Sci U S A. 2011; 108(4): 1337-1342. Doi: 10.1073/pnas.1015125108 [OPEN ACCESS]
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2010

Gruber, A; Cornaciu, I; Lass, A; Schweiger, M; Poeschl, M; Eder, C; Kumari, M; Schoiswohl, G; Wolinski, H; Kohlwein, SD; Zechner, R; Zimmermann, R; Oberer, M The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase.
J Biol Chem. 2010; 285(16): 12289-12298. Doi: 10.1074/jbc.M109.064469 [OPEN ACCESS]
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Güttler, T; Madl, T; Neumann, P; Deichsel, D; Corsini, L; Monecke, T; Ficner, R; Sattler, M; Görlich, D NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nat Struct Mol Biol. 2010; 17(11): 1367-1376. Doi: 10.1038/nsmb.1931 [OPEN ACCESS]
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Meyer, NH; Tripsianes, K; Vincendeau, M; Madl, T; Kateb, F; Brack-Werner, R; Sattler, M Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.
J Biol Chem. 2010; 285(37): 28893-28901. Doi: 10.1074/jbc.M110.126185 [OPEN ACCESS]
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Ribitsch, D; Winkler, S; Gruber, K; Karl, W; Wehrschütz-Sigl, E; Eiteljörg, I; Schratl, P; Remler, P; Stehr, R; Bessler, C; Mussmann, N; Sauter, K; Maurer, KH; Schwab, H Engineering of choline oxidase from Arthrobacter nicotianae for potential use as biological bleach in detergents.
Appl Microbiol Biotechnol. 2010; 87(5): 1743-1752. Doi: 10.1007/s00253-010-2637-9
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Simon, B; Madl, T; Mackereth, CD; Nilges, M; Sattler, M An efficient protocol for NMR-spectroscopy-based structure determination of protein complexes in solution.
Angew Chem Int Ed Engl. 2010; 49(11): 1967-1970. Doi: 10.1002/anie.200906147
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2009

Derler, I; Fahrner, M; Muik, M; Lackner, B; Schindl, R; Groschner, K; Romanin, C A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.
J Biol Chem. 2009; 284(37): 24933-24938. Doi: 10.1074/jbc.C109.024083 [OPEN ACCESS]
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Eckl, KM; de Juanes, S; Kurtenbach, J; Nätebus, M; Lugassy, J; Oji, V; Traupe, H; Preil, ML; Martínez, F; Smolle, J; Harel, A; Krieg, P; Sprecher, E; Hennies, HC Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.
J Invest Dermatol. 2009; 129(6):1421-1428 Doi: 10.1038/jid.2008.409 [OPEN ACCESS]
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Frischauf, I; Muik, M; Derler, I; Bergsmann, J; Fahrner, M; Schindl, R; Groschner, K; Romanin, C Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
J Biol Chem. 2009; 284(32): 21696-21706. Doi: 10.1074/jbc.M109.018408 [OPEN ACCESS]
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Kawano, T; Zoga, V; Kimura, M; Liang, MY; Wu, HE; Gemes, G; McCallum, JB; Kwok, WM; Hogan, QH; Sarantopoulos, CD Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation.
Mol Pain. 2009; 5(21): 12-12. Doi: 10.1186/1744-8069-5-12 [OPEN ACCESS]
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Madl, T; Bermel, W; Zangger, K Use of relaxation enhancements in a paramagnetic environment for the structure determination of proteins using NMR spectroscopy.
Angew Chem Int Ed Engl. 2009; 48(44): 8259-8262. Doi: 10.1002/anie.200902561
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Madl, T; Sattler, M Adhesion dance with raver.
Structure. 2009; 17(6): 781-783. Doi: 10.1016/j.str.2009.05.004
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Pippal, JB; Yao, Y; Rogerson, FM; Fuller, PJ Structural and functional characterization of the interdomain interaction in the mineralocorticoid receptor.
Mol Endocrinol. 2009; 23(9):1360-1370 Doi: 10.1210/me.2009-0032 [OPEN ACCESS]
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Sayers, EW; Barrett, T; Benson, DA; Bryant, SH; Canese, K; Chetvernin, V; Church, DM; DiCuccio, M; Edgar, R; Federhen, S; Feolo, M; Geer, LY; Helmberg, W; Kapustin, Y; Landsman, D; Lipman, DJ; Madden, TL; Maglott, DR; Miller, V; Mizrachi, I; Ostell, J; Pruitt, KD; Schuler, GD; Sequeira, E; Sherry, ST; Shumway, M; Sirotkin, K; Souvorov, A; Starchenko, G; Tatusova, TA; Wagner, L; Yaschenko, E; Ye, J Database resources of the National Center for Biotechnology Information.
Nucleic Acids Res. 2009; 37(Database issue): D5-15. Doi: 10.1093/nar/gkn741 [OPEN ACCESS]
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Wiltgen, M; Tscheliessnigg, K; Tilz, GP The tumour necrosis factor as a mediator of vessel inflammation: importance of exposed receptor residues for its neutralization.
Hematology. 2009; 14(6):347-356 Doi: 10.1179/102453309X12473408860541
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2008

Frischauf, I; Schindl, R; Derler, I; Bergsmann, J; Fahrner, M; Romanin, C The STIM/Orai coupling machinery.
Channels (Austin). 2008; 2(4): 261-268. Doi: 10.4161/chan.2.4.6705 [OPEN ACCESS]
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Göhler, A; Xiong, G; Paulsen, S; Trentmann, G; Maser, E Testosterone-inducible regulator is a kinase that drives steroid sensing and metabolism in Comamonas testosteroni.
J Biol Chem. 2008; 283(25):17380-17390 Doi: 10.1074/jbc.M710166200 [OPEN ACCESS]
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Langsenlehner, T; Langsenlehner, U; Renner, W; Kapp, KS; Krippl, P; Hofmann, G; Clar, H; Pummer, K; Mayer, R The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastases.
Prostate. 2008; 68(3):264-268 Doi: 10.1002/pros.20682
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