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Ranek, MJ; Oeing, C; Sanchez-Hodge, R; Kokkonen-Simon, KM; Dillard, D; Aslam, MI; Rainer, PP; Mishra, S; Dunkerly-Eyring, B; Holewinski, RJ; Virus, C; Zhang, H; Mannion, MM; Agrawal, V; Hahn, V; Lee, DI; Sasaki, M; Van Eyk, JE; Willis, MS; Page, RC; Schisler, JC; Kass, DA
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.
Nat Commun. 2020; 11(1): 5237-5237.
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Eroglu, E; Saravi, SSS; Sorrentino, A; Steinhorn, B; Michel, T
Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods.
Proc Natl Acad Sci U S A. 2019; 116(40):20210-20217
Doi: 10.1073/pnas.1910942116
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Fischer, TH; Eiringhaus, J; Dybkova, N; Saadatmand, A; Pabel, S; Weber, S; Wang, Y; Köhn, M; Tirilomis, T; Ljubojevic, S; Renner, A; Gummert, J; Maier, LS; Hasenfuß, G; El-Armouche, A; Sossalla, S
Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
Eur J Heart Fail. 2018; 20(12):1673-1685
Doi: 10.1002/ejhf.1297
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Folci, A; Steinberger, A; Lee, B; Stanika, R; Scheruebel, S; Campiglio, M; Ramprecht, C; Pelzmann, B; Hell, JW; Obermair, GJ; Heine, M; Di Biase, V
Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaV1.2 calcium channels in hippocampal neurons.
J Biol Chem. 2018; 293(3):1040-1053
Doi: 10.1074/jbc.M117.799585
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Boege, Y; Malehmir, M; Healy, ME; Bettermann, K; Lorentzen, A; Vucur, M; Ahuja, AK; Böhm, F; Mertens, JC; Shimizu, Y; Frick, L; Remouchamps, C; Mutreja, K; Kähne, T; Sundaravinayagam, D; Wolf, MJ; Rehrauer, H; Koppe, C; Speicher, T; Padrissa-Altés, S; Maire, R; Schattenberg, JM; Jeong, JS; Liu, L; Zwirner, S; Boger, R; Hüser, N; Davis, RJ; Müllhaupt, B; Moch, H; Schulze-Bergkamen, H; Clavien, PA; Werner, S; Borsig, L; Luther, SA; Jost, PJ; Weinlich, R; Unger, K; Behrens, A; Hillert, L; Dillon, C; Di Virgilio, M; Wallach, D; Dejardin, E; Zender, L; Naumann, M; Walczak, H; Green, DR; Lopes, M; Lavrik, I; Luedde, T; Heikenwalder, M; Weber, A
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer Cell. 2017; 32(3):342-359
Doi: 10.1016/j.ccell.2017.08.010
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Charoensin, S; Eroglu, E; Opelt, M; Bischof, H; Madreiter-Sokolowski, CT; Kirsch, A; Depaoli, MR; Frank, S; Schrammel, A; Mayer, B; Waldeck-Weiermair, M; Graier, WF; Malli, R
Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS).
Free Radic Biol Med. 2017; 102(1):248-259
Doi: 10.1016/j.freeradbiomed.2016.11.049
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Cuppens, T; Annibali, D; Coosemans, A; Trovik, J; Ter Haar, N; Colas, E; Garcia-Jimenez, A; Van de Vijver, K; Kruitwagen, RP; Brinkhuis, M; Zikan, M; Dundr, P; Huvila, J; Carpén, O; Haybaeck, J; Moinfar, F; Salvesen, HB; Stukan, M; Mestdagh, C; Zweemer, RP; Massuger, LF; Mallmann, MR; Wardelmann, E; Mints, M; Verbist, G; Thomas, D; Gommé, E; Hermans, E; Moerman, P; Bosse, T; Amant, F
Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative.
Clin Cancer Res. 2017; 23(5):1274-1285
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Nagaraj, C; Haitchi, HM; Heinemann, A; Howarth, PH; Olschewski, A; Marsh, LM
Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.
Antioxid Redox Signal. 2017; 27(18):1460-1472
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Parakaw, T; Suknuntha, K; Vivithanaporn, P; Schlagenhauf, A; Topanurak, S; Fucharoen, S; Pattanapanyasat, K; Schechter, A; Sibmooh, N; Srihirun, S
Platelet inhibition and increased phosphorylated vasodilator-stimulated phosphoprotein following sodium nitrite inhalation.
Nitric Oxide. 2017; 66(6):10-16
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Peschel, I; Podmirseg, SR; Taschler, M; Duyster, J; Götze, KS; Sill, H; Nachbaur, D; Jäkel, H; Hengst, L
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia.
Haematologica. 2017; 102(8):1378-1389
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Plastira, I; Bernhart, E; Goeritzer, M; DeVaney, T; Reicher, H; Hammer, A; Lohberger, B; Wintersperger, A; Zucol, B; Graier, WF; Kratky, D; Malle, E; Sattler, W
Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
J Neuroinflammation. 2017; 14(1):253-253
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Windpassinger, C; Piard, J; Bonnard, C; Alfadhel, M; Lim, S; Bisteau, X; Blouin, S; Ali, NB; Ng, AYJ; Lu, H; Tohari, S; Talib, SZA; van Hul, N; Caldez, MJ; Van Maldergem, L; Yigit, G; Kayserili, H; Youssef, SA; Coppola, V; de Bruin, A; Tessarollo, L; Choi, H; Rupp, V; Roetzer, K; Roschger, P; Klaushofer, K; Altmüller, J; Roy, S; Venkatesh, B; Ganger, R; Grill, F; Ben Chehida, F; Wollnik, B; Altunoglu, U; Al Kaissi, A; Reversade, B; Kaldis, P
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Am J Hum Genet. 2017; 101(3): 391-403.
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Dernayka, L; Rauch, N; Jarboui, MA; Zebisch, A; Texier, Y; Horn, N; Romano, D; Gloeckner, CJ; Kriegsheim, Av; Ueffing, M; Kolch, W; Boldt, K
Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.
Cell Signal. 2016; 28(9):1432-1439
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Donnerer, J; Liebmann, I
ERK1/2 Phosphorylation in the Rat Supraoptic Nucleus, Dorsal Raphe Nucleus, and Locus Coeruleus Neurons Following Noxious Stimulation to the Hind Paw.
Pharmacology. 2016; 97(1-2):57-62
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Koyani, CN; Kitz, K; Rossmann, C; Bernhart, E; Huber, E; Trummer, C; Windischhofer, W; Sattler, W; Malle, E
Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
Biochem Pharmacol. 2016; 104:29-41
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Patriarchi, T; Qian, H; Di Biase, V; Malik, ZA; Chowdhury, D; Price, JL; Hammes, EA; Buonarati, OR; Westenbroek, RE; Catterall, WA; Hofmann, F; Xiang, YK; Murphy, GG; Chen, CY; Navedo, MF; Hell, JW
Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.
EMBO J. 2016; 35(12):1330-1345
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Verbrugge, SE; Al, M; Assaraf, YG; Kammerer, S; Chandrupatla, DM; Honeywell, R; Musters, RP; Giovannetti, E; O'Toole, T; Scheffer, GL; Krige, D; de Gruijl, TD; Niessen, HW; Lems, WF; Kramer, PA; Scheper, RJ; Cloos, J; Ossenkoppele, GJ; Peters, GJ; Jansen, G
Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
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Vogl, F; Humpolickova, J; Amaro, M; Koller, D; Kofeler, H; Zenzmaier, E; Hof, M; Hermetter, A
Role of protein kinase C delta in apoptotic signaling of oxidized phospholipids in RAW 264.7 macrophages
BBA-MOL CELL BIOL L. 2016; 1861(4): 320-330.
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Crescenzo, R; Abate, F; Lasorsa, E; Tabbo', F; Gaudiano, M; Chiesa, N; Di Giacomo, F; Spaccarotella, E; Barbarossa, L; Ercole, E; Todaro, M; Boi, M; Acquaviva, A; Ficarra, E; Novero, D; Rinaldi, A; Tousseyn, T; Rosenwald, A; Kenner, L; Cerroni, L; Tzankov, A; Ponzoni, M; Paulli, M; Weisenburger, D; Chan, WC; Iqbal, J; Piris, MA; Zamo', A; Ciardullo, C; Rossi, D; Gaidano, G; Pileri, S; Tiacci, E; Falini, B; Shultz, LD; Mevellec, L; Vialard, JE; Piva, R; Bertoni, F; Rabadan, R; Inghirami, G; European T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymphoma and the AIRC 5xMille Consortium “Genetics-Driven Targeted Management of Lymphoid Malignancies”
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Cancer Cell. 2015; 27(4):516-532
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Donnerer, J; Liebmann, I
pERK1/2 immunofluorescence in rat dorsal horn and paraventricular nucleus neurons as a marker for sensitization and inhibition in the pain pathway.
Tissue Cell. 2015; 47(1):55-60
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González, A; Shimobayashi, M; Eisenberg, T; Merle, DA; Pendl, T; Hall, MN; Moustafa, T
TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae.
PLoS One. 2015; 10(3):e0120250-e0120250
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Koentges, C; König, A; Pfeil, K; Hölscher, ME; Schnick, T; Wende, AR; Schrepper, A; Cimolai, MC; Kersting, S; Hoffmann, MM; Asal, J; Osterholt, M; Odening, KE; Doenst, T; Hein, L; Abel, ED; Bode, C; Bugger, H
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res Cardiol. 2015; 110(4): 37-37.
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Koentges, C; Pfeil, K; Schnick, T; Wiese, S; Dahlbock, R; Cimolai, MC; Meyer-Steenbuck, M; Cenkerova, K; Hoffmann, MM; Jaeger, C; Odening, KE; Kammerer, B; Hein, L; Bode, C; Bugger, H
SIRT3 deficiency impairs mitochondrial and contractile function in the heart.
Basic Res Cardiol. 2015; 110(4): 36-36.
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Röhl, A; Tippel, F; Bender, E; Schmid, AB; Richter, K; Madl, T; Buchner, J
Hop/Sti1 phosphorylation inhibits its co-chaperone function.
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Scazzocchio, B; Varì, R; Filesi, C; Del Gaudio, I; D'Archivio, M; Santangelo, C; Iacovelli, A; Galvano, F; Pluchinotta, FR; Giovannini, C; Masella, R
Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity.
Mol Nutr Food Res. 2015; 59(8):1472-1481
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Sturm, EM; Parzmair, GP; Radnai, B; Frei, RB; Sturm, GJ; Hammer, A; Schuligoi, R; Lippe, IT; Heinemann, A
Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
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Arzt, L; Kothmaier, H; Halbwedl, I; Quehenberger, F; Popper, HH
Signal transducer and activator of transcription 1 (STAT1) acts like an oncogene in malignant pleural mesothelioma.
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Biasin, V; Chwalek, K; Wilhelm, J; Best, J; Marsh, LM; Ghanim, B; Klepetko, W; Fink, L; Schermuly, RT; Weissmann, N; Olschewski, A; Kwapiszewska, G
Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.
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Folci, A; Mapelli, L; Sassone, J; Prestori, F; D'Angelo, E; Bassani, S; Passafaro, M
Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons.
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Haack, TB; Gorza, M; Danhauser, K; Mayr, JA; Haberberger, B; Wieland, T; Kremer, L; Strecker, V; Graf, E; Memari, Y; Ahting, U; Kopajtich, R; Wortmann, SB; Rodenburg, RJ; Kotzaeridou, U; Hoffmann, GF; Sperl, W; Wittig, I; Wilichowski, E; Schottmann, G; Schuelke, M; Plecko, B; Stephani, U; Strom, TM; Meitinger, T; Prokisch, H; Freisinger, P
Phenotypic spectrum of eleven patients and five novel MTFMT mutations identified by exome sequencing and candidate gene screening.
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Lichtenegger, M; Groschner, K
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Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Proc Natl Acad Sci U S A. 2014; 111(4):1551-1556
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Veith, C; Zakrzewicz, D; Dahal, BK; Bálint, Z; Murmann, K; Wygrecka, M; Seeger, W; Schermuly, RT; Weissmann, N; Kwapiszewska, G
Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
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Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.
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Anderson, CD; Biffi, A; Nalls, MA; Devan, WJ; Schwab, K; Ayres, AM; Valant, V; Ross, OA; Rost, NS; Saxena, R; Viswanathan, A; Worrall, BB; Brott, TG; Goldstein, JN; Brown, D; Broderick, JP; Norrving, B; Greenberg, SM; Silliman, SL; Hansen, BM; Tirschwell, DL; Lindgren, A; Slowik, A; Schmidt, R; Selim, M; Roquer, J; Montaner, J; Singleton, AB; Kidwell, CS; Woo, D; Furie, KL; Meschia, JF; Rosand, J; on behalf of the International Stroke Genetics Consortium
Common Variants Within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage.
Stroke. 2013; 44(3):612-619
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Bhandari, D; Zhang, J; Menon, S; Lord, C; Chen, S; Helm, JR; Thorsen, K; Corbett, KD; Hay, JC; Ferro-Novick, S
Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits.
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The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models.
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The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast.
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Doddapattar, P; Radović, B; Patankar, JV; Obrowsky, S; Jandl, K; Nusshold, C; Kolb, D; Vujić, N; Doshi, L; Chandak, PG; Goeritzer, M; Ahammer, H; Hoefler, G; Sattler, W; Kratky, D
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
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Friedmacher, F; Gosemann, JH; Takahashi, H; Corcionivoschi, N; Puri, P
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Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation.
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Jakus, PB; Kalman, N; Antus, C; Radnai, B; Tucsek, Z; Gallyas, F; Sumegi, B; Veres, B
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Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.
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Lassance, L; Miedl, H; Absenger, M; Diaz-Perez, F; Lang, U; Desoye, G; Hiden, U
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Moldvay, J; Barbai, T; Bogos, K; Piurko, V; Fillinger, J; Popper, HH; Tímár, J
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Pozo, K; Castro-Rivera, E; Tan, C; Plattner, F; Schwach, G; Siegl, V; Meyer, D; Guo, A; Gundara, J; Mettlach, G; Richer, E; Guevara, JA; Ning, L; Gupta, A; Hao, G; Tsai, LH; Sun, X; Antich, P; Sidhu, S; Robinson, BG; Chen, H; Nwariaku, FE; Pfragner, R; Richardson, JA; Bibb, JA
The role of Cdk5 in neuroendocrine thyroid cancer.
Cancer Cell. 2013; 24(4):499-511
Doi: 10.1016/j.ccr.2013.08.027
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Riehle, C; Wende, AR; Sena, S; Pires, KM; Pereira, RO; Zhu, Y; Bugger, H; Frank, D; Bevins, J; Chen, D; Perry, CN; Dong, XC; Valdez, S; Rech, M; Sheng, X; Weimer, BC; Gottlieb, RA; White, MF; Abel, ED
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
J Clin Invest. 2013; 123(12): 5319-5333.
Doi: 10.1172/JCI71171
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Rungatscher, A; Hallström, S; Giacomazzi, A; Linardi, D; Milani, E; Tessari, M; Luciani, GB; Scarabelli, TM; Mazzucco, A; Faggian, G
Role of calcium desensitization in the treatment of myocardial dysfunction after deep hypothermic circulatory arrest.
Crit Care. 2013; 17(5):R245-R245
Doi: 10.1186/cc13071
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