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Publikationen

Suchbegriffe: NEOPLASM PROTEINS - GENETICS , . Treffer: 69

2019

Müller, M; Graf, R; Kashofer, K; Macher, S; Wölfler, A; Zebisch, A; Hrzenjak, A; Heitzer, E; Sill, H Detection of AML-specific TP53 mutations in bone marrow-derived mesenchymal stromal cells cultured under hypoxia conditions.
Ann Hematol. 2019; 98(8):2019-2020 Doi: 10.1007/s00277-019-03680-4 [OPEN ACCESS]
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Schober, R; Bonhenry, D; Lunz, V; Zhu, J; Krizova, A; Frischauf, I; Fahrner, M; Zhang, M; Waldherr, L; Schmidt, T; Derler, I; Stathopulos, PB; Romanin, C; Ettrich, RH; Schindl, R Sequential activation of STIM1 links Ca²⁺ with luminal domain unfolding.
Sci Signal. 2019; 12(608): Doi: 10.1126/scisignal.aax3194
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2018

Rinaldetti, S; Pfirrmann, M; Manz, K; Guilhot, J; Dietz, C; Panagiotidis, P; Spiess, B; Seifarth, W; Fabarius, A; Müller, M; Pagoni, M; Dimou, M; Dengler, J; Waller, CF; Brümmendorf, TH; Herbst, R; Burchert, A; Janβen, C; Goebeler, ME; Jost, PJ; Hanzel, S; Schafhausen, P; Prange-Krex, G; Illmer, T; Janzen, V; Klausmann, M; Eckert, R; Büschel, G; Kiani, A; Hofmann, WK; Mahon, FX; Saussele, S Effect of ABCG2, OCT1, and ABCB1 (MDR1) Gene Expression on Treatment-Free Remission in a EURO-SKI Subtrial.
Clin Lymphoma Myeloma Leuk. 2018; 18(4):266-271 Doi: 10.1016/j.clml.2018.02.004 [OPEN ACCESS]
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2017

Frischauf, I; Litviňuková, M; Schober, R; Zayats, V; Svobodová, B; Bonhenry, D; Lunz, V; Cappello, S; Tociu, L; Reha, D; Stallinger, A; Hochreiter, A; Pammer, T; Butorac, C; Muik, M; Groschner, K; Bogeski, I; Ettrich, RH; Romanin, C; Schindl, R Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Sci Signal. 2017; 10(507): Doi: 10.1126/scisignal.aao0358 [OPEN ACCESS]
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Geuens, T; De Winter, V; Rajan, N; Achsel, T; Mateiu, L; Almeida-Souza, L; Asselbergh, B; Bouhy, D; Auer-Grumbach, M; Bagni, C; Timmerman, V Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.
Acta Neuropathol Commun. 2017; 5(1):5-5 Doi: 10.1186/s40478-016-0407-3 [OPEN ACCESS]
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Li, JQ; Qiu, YL; Gong, JY; Dou, LM; Lu, Y; Knisely, AS; Zhang, MH; Luan, WS; Wang, JS Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study.
BMC Gastroenterol. 2017; 17(1):77-77 Doi: 10.1186/s12876-017-0636-3 [OPEN ACCESS]
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Richtig, G; Hoeller, C; Kashofer, K; Aigelsreiter, A; Heinemann, A; Kwong, LN; Pichler, M; Richtig, E Beyond the BRAF^V600E hotspot: biology and clinical implications of rare BRAF gene mutations in melanoma patients.
Br J Dermatol. 2017; 177(4):936-944 Doi: 10.1111/bjd.15436
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2016

Bonin, S; Donada, M; Bussolati, G; Nardon, E; Annaratone, L; Pichler, M; Chiaravalli, AM; Capella, C; Hoefler, G; Stanta, G A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.
Tumour Biol. 2016; 37(6):7295-7303 Doi: 10.1007/s13277-015-4543-3
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Busch, SE; Hanke, ML; Kargl, J; Metz, HE; MacPherson, D; Houghton, AM Lung Cancer Subtypes Generate Unique Immune Responses.
J Immunol. 2016; 197(11):4493-4503 Doi: 10.4049/jimmunol.1600576 [OPEN ACCESS]
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Hrzenjak, A JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas.
Orphanet J Rare Dis. 2016; 11(6):15-15 Doi: 10.1186/s13023-016-0400-8 [OPEN ACCESS]
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Khan, MA; Mohan, S; Zubair, M; Windpassinger, C Homozygosity mapping identified a novel protein truncating mutation (p.Ser100Leufs*24) of the BBS9 gene in a consanguineous Pakistani family with Bardet Biedl syndrome.
BMC Med Genet. 2016; 17(6): 10-10. Doi: 10.1186/s12881-016-0271-9 [OPEN ACCESS]
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Rausch, S; Hennenlotter, J; Scharpf, M; Teepe, K; Kühs, U; Aufderklamm, S; Bier, S; Mischinger, J; Gakis, G; Stenzl, A; Schwentner, C; Todenhöfer, T Prostate tumor overexpressed 1 expression in invasive urothelial carcinoma.
J Cancer Res Clin Oncol. 2016; 142(5):937-947 Doi: 10.1007/s00432-015-2107-y
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2015

Li, C; Rezania, S; Kammerer, S; Sokolowski, A; Devaney, T; Gorischek, A; Jahn, S; Hackl, H; Groschner, K; Windpassinger, C; Malle, E; Bauernhofer, T; Schreibmayer, W Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line.
Sci Rep. 2015; 5(2):8364-8364 Doi: 10.1038/srep08364 [OPEN ACCESS]
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2014

Deak, AT; Blass, S; Khan, MJ; Groschner, LN; Waldeck-Weiermair, M; Hallström, S; Graier, WF; Malli, R IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake.
J Cell Sci. 2014; 127(Pt 13):2944-2955 Doi: 10.1242/jcs.149807 [OPEN ACCESS]
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Fahrner, M; Muik, M; Schindl, R; Butorac, C; Stathopulos, P; Zheng, L; Jardin, I; Ikura, M; Romanin, C A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).
J Biol Chem. 2014; 289(48): 33231-33244. Doi: 10.1074/jbc.M114.610022 [OPEN ACCESS]
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Heiduschka, G; Grah, A; Oberndorfer, F; Seemann, R; Kranz, A; Kornek, G; Wrba, F; Thurnher, D; Selzer, E Significance of p16 expression in head and neck cancer patients treated with radiotherapy and cetuximab.
Strahlenther Onkol. 2014; 190(9):832-838 Doi: 10.1007/s00066-014-0652-y
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Herold, T; Metzeler, KH; Vosberg, S; Hartmann, L; Röllig, C; Stölzel, F; Schneider, S; Hubmann, M; Zellmeier, E; Ksienzyk, B; Jurinovic, V; Pasalic, Z; Kakadia, PM; Dufour, A; Graf, A; Krebs, S; Blum, H; Sauerland, MC; Büchner, T; Berdel, WE; Woermann, BJ; Bornhäuser, M; Ehninger, G; Mansmann, U; Hiddemann, W; Bohlander, SK; Spiekermann, K; Greif, PA Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.
Blood. 2014; 124(8): 1304-1311. Doi: 10.1182/blood-2013-12-540716
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2013

Derler, I; Schindl, R; Fritsch, R; Heftberger, P; Riedl, MC; Begg, M; House, D; Romanin, C The action of selective CRAC channel blockers is affected by the Orai pore geometry.
Cell Calcium. 2013; 53(2): 139-151. Doi: 10.1016/j.ceca.2012.11.005 [OPEN ACCESS]
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Hofer, D; Schwach, G; Ghaffari Tabrizi-Wizsy, N; Sadjak, A; Sturm, S; Stuppner, H; Pfragner, R Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells.
Oncol Rep. 2013; 29(6):2219-2226 Doi: 10.3892/or.2013.2367 [OPEN ACCESS]
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Sbiera, S; Kroiss, M; Thamm, T; Beyer, M; Majidi, F; Kuehner, D; Wobser, M; Becker, JC; Adam, P; Ronchi, C; Allolio, B; Fassnacht, M; Survivin in Adrenocortical Tumors Pathophysiological Implications and Therapeutic Potential.
HORMONE METAB RES. 2013; 45(2): 137-146. Doi: 10.1055/s-0032-1327750 [OPEN ACCESS]
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2012

Kretschmer, N; Rinner, B; Stuendl, N; Kaltenegger, H; Wolf, E; Kunert, O; Boechzelt, H; Leithner, A; Bauer, R; Lohberger, B Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.
Planta Med. 2012; 78(16):1749-1756 Doi: 10.1055/s-0032-1315385 [OPEN ACCESS]
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Lohberger, B; Rinner, B; Stuendl, N; Absenger, M; Liegl-Atzwanger, B; Walzer, SM; Windhager, R; Leithner, A Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma.
PLoS One. 2012; 7(8):e43664-e43664 Doi: 10.1371/journal.pone.0043664 [OPEN ACCESS]
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Shirsath, NP; Manohar, SM; Joshi, KS P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines.
Mol Cancer. 2012; 11:77-77 Doi: 10.1186/1476-4598-11-77 [OPEN ACCESS]
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2011

Drozdov, I; Svejda, B; Gustafsson, BI; Mane, S; Pfragner, R; Kidd, M; Modlin, IM Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia.
PLoS One. 2011; 6(8):e22457-e22457 Doi: 10.1371/journal.pone.0022457 [OPEN ACCESS]
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Muik, M; Fahrner, M; Schindl, R; Stathopulos, P; Frischauf, I; Derler, I; Plenk, P; Lackner, B; Groschner, K; Ikura, M; Romanin, C STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.
EMBO J. 2011; 30(9): 1678-1689. Doi: 10.1038/emboj.2011.79 [OPEN ACCESS]
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Presneau, N; Shalaby, A; Ye, H; Pillay, N; Halai, D; Idowu, B; Tirabosco, R; Whitwell, D; Jacques, TS; Kindblom, LG; Brüderlein, S; Möller, P; Leithner, A; Liegl, B; Amary, FM; Athanasou, NN; Hogendoorn, PC; Mertens, F; Szuhai, K; Flanagan, AM Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.
J Pathol. 2011; 223(3): 327-335. Doi: 10.1002/path.2816
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Zheng, L; Stathopulos, PB; Schindl, R; Li, GY; Romanin, C; Ikura, M Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
Proc Natl Acad Sci U S A. 2011; 108(4): 1337-1342. Doi: 10.1073/pnas.1015125108 [OPEN ACCESS]
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2010

Naghdi, S; Waideck-Weiermair, M; Fertschai, I; Poteser, M; Graier, WF; Malli, R Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1-dependent store-operated Ca2+ entry.
J CELL SCI. 2010; 123(Pt 15): 2553-2564. Doi: 10.1242/jcs.070151 [OPEN ACCESS]
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2009

Frischauf, I; Muik, M; Derler, I; Bergsmann, J; Fahrner, M; Schindl, R; Groschner, K; Romanin, C Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
J Biol Chem. 2009; 284(32): 21696-21706. Doi: 10.1074/jbc.M109.018408 [OPEN ACCESS]
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Hermann-Kleiter, N; Ghaffari-Tabrizi, N; Blumer, MJ; Schwarzer, C; Mazur, MA; Artner, I Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.
Int J Dev Biol. 2009; 53(7): 983-991. Doi: 10.1387/ijdb.072435nh [OPEN ACCESS]
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Kamlah, F; Eul, BG; Li, S; Lang, N; Marsh, LM; Seeger, W; Grimminger, F; Rose, F; Hänze, J Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.
Cancer Gene Ther. 2009; 16(3): 195-205. Doi: 10.1038/cgt.2008.71 [OPEN ACCESS]
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Muik, M; Fahrner, M; Derler, I; Schindl, R; Bergsmann, J; Frischauf, I; Groschner, K; Romanin, C A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
J Biol Chem. 2009; 284(13):8421-8426 Doi: 10.1074/jbc.C800229200 [OPEN ACCESS]
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2008

Dierick, I; Baets, J; Irobi, J; Jacobs, A; De Vriendt, E; Deconinck, T; Merlini, L; Van den Bergh, P; Rasic, VM; Robberecht, W; Fischer, D; Morales, RJ; Mitrovic, Z; Seeman, P; Mazanec, R; Kochanski, A; Jordanova, A; Auer-Grumbach, M; Helderman-van den Enden, ATJM; Wokke, JHJ; Nelis, E; De Jonghe, P; Timmerman, V Relative contribution of mutations in genes for autosomal dominant distal hereditary motor neuropathies: a genotype-phenotype correlation study.
Brain. 2008; 131(Pt 5):1217-1227 Doi: 10.1093/brain/awn029 [OPEN ACCESS]
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Muik, M; Frischauf, I; Derler, I; Fahrner, M; Bergsmann, J; Eder, P; Schindl, R; Hesch, C; Polzinger, B; Fritsch, R; Kahr, H; Madl, J; Gruber, H; Groschner, K; Romanin, C Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
J Biol Chem. 2008; 283(12):8014-8022 Doi: 10.1074/jbc.M708898200 [OPEN ACCESS]
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Schindl, R; Bergsmann, J; Frischauf, I; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Groschner, K; Romanin, C 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
J Biol Chem. 2008; 283(29):20261-20267 Doi: 10.1074/jbc.M803101200 [OPEN ACCESS]
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2007

Deutsch, AJ; Aigelsreiter, A; Staber, PB; Beham, A; Linkesch, W; Guelly, C; Brezinschek, RI; Fruhwirth, M; Emberger, W; Buettner, M; Beham-Schmid, C; Neumeister, P MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation.
Blood. 2007; 109(8):3500-3504 Doi: 10.1182/blood-2006-06-030494 [OPEN ACCESS]
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Jost, PJ; Weiss, S; Ferch, U; Gross, O; Mak, TW; Peschel, C; Ruland, J Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.
J Immunol. 2007; 178(2):953-960 Doi: 10.4049/jimmunol.178.2.953 [OPEN ACCESS]
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Rohkamm, B; Reilly, MM; Lochmuller, H; Schlotter-Weigel, B; Barisic, N; Schols, L; Laura, M; Janecke, AR; Miltenberger-Miltenyi, G; John, E; Fischer, C; Grill, F; Wakeling, W; Davis, M; Pieber, TR; Auer-Grumbach, M; Nicholson, G; Pareyson, D Further evidence for genetic heterogeneity of distal HMN type V, CMT2 with predominant hand involvement and Silver syndrome.
J NEUROL SCI. 2007; 263(1-2): 100-106. Doi: 10.1016/j.jns.2007.06.047 [OPEN ACCESS]
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Ugurel, S; Thirumaran, RK; Bloethner, S; Gast, A; Sucker, A; Mueller-Berghaus, J; Rittgen, W; Hemminki, K; Becker, JC; Kumar, R; Schadendorf, D B-RAF and N-RAS Mutations Are Preserved during Short Time In Vitro Propagation and Differentially Impact Prognosis
PLOS ONE. 2007; 2(2): Doi: 10.1371/journal.pone.0000236 [OPEN ACCESS]
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Zakrzewicz, A; Hecker, M; Marsh, LM; Kwapiszewska, G; Nejman, B; Long, L; Seeger, W; Schermuly, RT; Morrell, NW; Morty, RE; Eickelberg, O Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.
Circulation. 2007; 115(23): 2957-2968. Doi: 10.1161/CIRCULATIONAHA.106.670026 [OPEN ACCESS]
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2006

Bloethner, S; Hemminki, K; Thirumaran, RK; Chen, B; Mueller-Berghaus, J; Ugurel, S; Schadendorf, D; Kumar, R Differences in global gene expression in melanoma cell lines with and without homozygous deletion of the CDKN2A locus genes.
Melanoma Res. 2006; 16(4):297-307 Doi: 10.1097/01.cmr.0000222597.50309.05
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Brücher, BL; Geddert, H; Langner, C; Höfler, H; Fink, U; Siewert, JR; Sarbia, M Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
Int J Cancer. 2006; 119(6): 1298-1302. Doi: 10.1002/ijc.21990 [OPEN ACCESS]
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Schneider, J; Ruschhaupt, M; Buness, A; Asslaber, M; Regitnig, P; Zatloukal, K; Schippinger, W; Ploner, F; Poustka, A; Sültmann, H Identification and meta-analysis of a small gene expression signature for the diagnosis of estrogen receptor status in invasive ductal breast cancer.
Int J Cancer. 2006; 119(12):2974-2979 Doi: 10.1002/ijc.22234 [OPEN ACCESS]
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Strehl, S; König, M; Meyer, C; Schneider, B; Harbott, J; Jäger, U; von Bergh, AR; Loncarevic, IF; Jarosova, M; Schmidt, HH; Moore, SD; Marschalek, R; Haas, OA Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants.
Genes Chromosomes Cancer. 2006; 45(11):1041-1049 Doi: 10.1002/gcc.20372
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2005

Hrzenjak, A; Moinfar, F; Tavassoli, FA; Strohmeier, B; Kremser, ML; Zatloukal, K; Denk, H JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue.
J MOL DIAGN. 2005; 7(3): 388-395. Doi: 10.1016/S1525-1578(10)60568-5 [OPEN ACCESS]
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2004

Auner, HW; Zebisch, A; Schimek, MG; Bodner, C; Hiden, K; Linkesch, W; Haas, OA; Beham-Schmid, C; Sill, H High expression of the sister-chromatid separation regulator and proto-oncogene hSecurin occurs in a subset of myeloid leukaemias but is not implicated in the pathogenesis of aneuploidy.
Leukemia. 2004; 18(2):303-308 Doi: 10.1038/sj.leu.2403235 [OPEN ACCESS]
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Evgrafov, OV; Mersiyanova, I; Irobi, J; Van Den Bosch, L; Dierick, I; Leung, CL; Schagina, O; Verpoorten, N; Van Impe, K; Fedotov, V; Dadali, E; Auer-Grumbach, M; Windpassinger, C; Wagner, K; Mitrovic, Z; Hilton-Jones, D; Talbot, K; Martin, JJ; Vasserman, N; Tverskaya, S; Polyakov, A; Liem, RK; Gettemans, J; Robberecht, W; De Jonghe, P; Timmerman, V Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Nat Genet. 2004; 36(6):602-606 Doi: 10.1038/ng1354 [OPEN ACCESS]
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Hendriks, YM; Wagner, A; Morreau, H; Menko, F; Stormorken, A; Quehenberger, F; Sandkuijl, L; Møller, P; Genuardi, M; Van Houwelingen, H; Tops, C; Van Puijenbroek, M; Verkuijlen, P; Kenter, G; Van Mil, A; Meijers-Heijboer, H; Tan, GB; Breuning, MH; Fodde, R; Wijnen, JT; Bröcker-Vriends, AH; Vasen, H Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.
Gastroenterology. 2004; 127(1):17-25 Doi: 10.1053/j.gastro.2004.03.068
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Hrzenjak, A; Tippl, M; Kremser, ML; Strohmeier, B; Guelly, C; Neumeister, D; Lax, S; Moinfar, F; Tabrizi, AD; Isadi-Moud, N; Zatloukal, K; Denk, H Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas.
J PATHOL. 2004; 204(1): 19-27. Doi: 10.1002/path.1616
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Ullmann, R; Morbini, P; Halbwedl, I; Bongiovanni, M; Gogg-Kammerer, M; Papotti, M; Gabor, S; Renner, H; Popper, HH Protein expression profiles in adenocarcinomas and squamous cell carcinomas of the lung generated using tissue microarrays.
J PATHOL. 2004; 203(3): 798-807. Doi: 10.1002/path.1584
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