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Publikationen

Suchbegriffe: MYOCYTES, CARDIAC - METABOLISM, . Treffer: 78

2023

Messerer, J; Wrede, C; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice.
J Anat. 2023; 242(1):91-101 Doi: 10.1111/joa.13618 [OPEN ACCESS]
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2022

Abdellatif, M; Trummer-Herbst, V; Heberle, AM; Humnig, A; Pendl, T; Durand, S; Cerrato, G; Hofer, SJ; Islam, M; Voglhuber, J; Ramos, Pittol, JM; Kepp, O; Hoefler, G; Schmidt, A; Rainer, PP; Scherr, D; von, Lewinski, D; Bisping, E; McMullen, JR; Diwan, A; Eisenberg, T; Madeo, F; Thedieck, K; Kroemer, G; Sedej, S Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Circulation. 2022; 145(25):1853-1866 Doi: 10.1161/CIRCULATIONAHA.122.059863 [OPEN ACCESS]
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Kuppe, C; Ramirez, Flores, RO; Li, Z; Hayat, S; Levinson, RT; Liao, X; Hannani, MT; Tanevski, J; Wünnemann, F; Nagai, JS; Halder, M; Schumacher, D; Menzel, S; Schäfer, G; Hoeft, K; Cheng, M; Ziegler, S; Zhang, X; Peisker, F; Kaesler, N; Saritas, T; Xu, Y; Kassner, A; Gummert, J; Morshuis, M; Amrute, J; Veltrop, RJA; Boor, P; Klingel, K; Van, Laake, LW; Vink, A; Hoogenboezem, RM; Bindels, EMJ; Schurgers, L; Sattler, S; Schapiro, D; Schneider, RK; Lavine, K; Milting, H; Costa, IG; Saez-Rodriguez, J; Kramann, R Spatial multi-omic map of human myocardial infarction.
Nature. 2022; 608(7924): 766-777. Doi: 10.1038/s41586-022-05060-x [OPEN ACCESS]
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Ljubojević-Holzer, S; Kraler, S; Djalinac, N; Abdellatif, M; Voglhuber, J; Schipke, J; Schmidt, M; Kling, KM; Franke, GT; Herbst, V; Zirlik, A; von, Lewinski, D; Scherr, D; Rainer, PP; Kohlhaas, M; Nickel, A; Mühlfeld, C; Maack, C; Sedej, S Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Cardiovasc Res. 2022; 118(6):1492-1505 Doi: 10.1093/cvr/cvab112 [OPEN ACCESS]
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Pabel, S; Knierim, M; Stehle, T; Alebrand, F; Paulus, M; Sieme, M; Herwig, M; Barsch, F; Körtl, T; Pöppl, A; Wenner, B; Ljubojevic-Holzer, S; Molina, CE; Dybkova, N; Camboni, D; Fischer, TH; Sedej, S; Scherr, D; Schmid, C; Brochhausen, C; Hasenfuß, G; Maier, LS; Hamdani, N; Streckfuss-Bömeke, K; Sossalla, S Effects of Atrial Fibrillation on the Human Ventricle.
Circ Res. 2022; 130(7):994-1010 Doi: 10.1161/CIRCRESAHA.121.319718 [OPEN ACCESS]
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Sohljoo, S; Kim, S; Plank, G; O'Rourke, B; Zhou, L Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias.
Methods Mol Biol. 2022; 2399: 247-259. Doi: 10.1007/978-1-0716-1831-8_11
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Voglhuber, J; Holzer, M; Radulović, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca²⁺ signalling in heart failure.
Philos Trans R Soc Lond B Biol Sci. 2022; 377(1864): 20210320 Doi: 10.1098/rstb.2021.0320 [OPEN ACCESS]
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2021

Forte, E; Panahi, M; Baxan, N; Ng, FS; Boyle, JJ; Branca, J; Bedard, O; Hasham, MG; Benson, L; Harding, SE; Rosenthal, N; Sattler, S Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.
J Cell Mol Med. 2021; 25(1): 229-243. Doi: 10.1111/jcmm.15937 [OPEN ACCESS]
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2020

Djalinac, N; Ljubojevic-Holzer, S; Matzer, I; Kolesnik, E; Jandl, K; Lohberger, B; Rainer, P; Heinemann, A; Sedej, S; von, Lewinski, D; Bisping, E The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodelling.
J Cell Mol Med. 2020; 24(15):8732-8743 Doi: 10.1111/jcmm.15504 [OPEN ACCESS]
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Kolleritsch, S; Kien, B; Schoiswohl, G; Diwoky, C; Schreiber, R; Heier, C; Maresch, LK; Schweiger, M; Eichmann, TO; Stryeck, S; Krenn, P; Tomin, T; Schittmayer, M; Kolb, D; Rülicke, T; Hoefler, G; Wolinski, H; Madl, T; Birner-Gruenberger, R; Haemmerle, G Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.
Cardiovasc Res. 2020; 116(2):339-352 Doi: 10.1093/cvr/cvz119 [OPEN ACCESS]
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2019

Bandleon, S; Strunz, PP; Pickel, S; Tiapko, O; Cellini, A; Miranda-Laferte, E; Eder-Negrin, P FKBP52 regulates TRPC3-dependent Ca²⁺ signals and the hypertrophic growth of cardiomyocyte cultures.
J Cell Sci. 2019; 132(20): Doi: 10.1242/jcs.231506 [OPEN ACCESS]
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Mardanpour, P; Nayernia, K; Khodayari, S; Khodayari, H; Molcanyi, M; Hescheler, J Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function.
Cell Physiol Biochem. 2019; 53(1): 101-120. Doi: 10.33594/000000124 [OPEN ACCESS]
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2018

Harper, SC; Johnson, J; Borghetti, G; Zhao, H; Wang, T; Wallner, M; Kubo, H; Feldsott, EA; Yang, Y; Joo, Y; Gou, X; Sabri, AK; Gupta, P; Myzithras, M; Khalil, A; Franti, M; Houser, SR GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death.
Circ Res. 2018; 123(11):1220-1231 Doi: 10.1161/CIRCRESAHA.118.312955 [OPEN ACCESS]
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Mhatre, KN; Wakula, P; Klein, O; Bisping, E; Völkl, J; Pieske, B; Heinzel, FR Crosstalk between FGF23- and angiotensin II-mediated Ca²⁺ signaling in pathological cardiac hypertrophy.
Cell Mol Life Sci. 2018; 75(23):4403-4416 Doi: 10.1007/s00018-018-2885-x
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Oravecz, K; Kormos, A; Gruber, A; Márton, Z; Kohajda, Z; Mirzaei, L; Jost, N; Levijoki, J; Pollesello, P; Koskelainen, T; Otsomaa, L; Tóth, A; Papp, JG; Nánási, PP; Antoons, G; Varró, A; Acsai, K; Nagy, N Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.
Eur J Pharmacol. 2018; 818(5):278-286 Doi: 10.1016/j.ejphar.2017.10.039 [OPEN ACCESS]
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2017

Campos, FO; Shiferaw, Y; Vigmond, EJ; Plank, G Stochastic spontaneous calcium release events and sodium channelopathies promote ventricular arrhythmias.
Chaos. 2017; 27(9):093910-093910 Doi: 10.1063/1.4999612 [OPEN ACCESS]
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Toib, A; Zhang, C; Borghetti, G; Zhang, X; Wallner, M; Yang, Y; Troupes, CD; Kubo, H; Sharp, TE; Feldsott, E; Berretta, RM; Zalavadia, N; Trappanese, DM; Harper, S; Gross, P; Chen, X; Mohsin, S; Houser, SR Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.
Am J Physiol Heart Circ Physiol. 2017; 313(3):H620-H630 Doi: 10.1152/ajpheart.00167.2017 [OPEN ACCESS]
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2016

Eroglu, E; Gottschalk, B; Charoensin, S; Blass, S; Bischof, H; Rost, R; Madreiter-Sokolowski, CT; Pelzmann, B; Bernhart, E; Sattler, W; Hallström, S; Malinski, T; Waldeck-Weiermair, M; Graier, WF; Malli, R Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics.
Nat Commun. 2016; 7(3):10623-10623 Doi: 10.1038/ncomms10623 [OPEN ACCESS]
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Gross, P; Honnorat, N; Varol, E; Wallner, M; Trappanese, DM; Sharp, TE; Starosta, T; Duran, JM; Koller, S; Davatzikos, C; Houser, SR Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.
Sci Rep. 2016; 6(7):23431-23431 Doi: 10.1038/srep23431 [OPEN ACCESS]
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Kirschmer, N; Bandleon, S; von Ehrlich-Treuenstätt, V; Hartmann, S; Schaaf, A; Lamprecht, AK; Miranda-Laferte, E; Langsenlehner, T; Ritter, O; Eder, P TRPC4α and TRPC4β Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation.
PLoS One. 2016; 11(12):e0168446-e0168446 Doi: 10.1371/journal.pone.0168446 [OPEN ACCESS]
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Kooij, V; Viswanathan, MC; Lee, DI; Rainer, PP; Schmidt, W; Kronert, WA; Harding, SE; Kass, DA; Bernstein, SI; Van Eyk, JE; Cammarato, A Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.
Cardiovasc Res. 2016; 110(2):238-248 Doi: 10.1093/cvr/cvw050 [OPEN ACCESS]
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Mangmool, S; Denkaew, T; Phosri, S; Pinthong, D; Parichatikanond, W; Shimauchi, T; Nishida, M Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.
Mol Endocrinol. 2016; 30(1):118-132 Doi: 10.1210/me.2015-1201 [OPEN ACCESS]
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Primessnig, U; Schönleitner, P; Höll, A; Pfeiffer, S; Bracic, T; Rau, T; Kapl, M; Stojakovic, T; Glasnov, T; Leineweber, K; Wakula, P; Antoons, G; Pieske, B; Heinzel, FR Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction.
Eur J Heart Fail. 2016; 18(8):987-997 Doi: 10.1002/ejhf.524 [OPEN ACCESS]
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Sysa-Shah, P; Tocchetti, CG; Gupta, M; Rainer, PP; Shen, X; Kang, BH; Belmonte, F; Li, J; Xu, Y; Guo, X; Bedja, D; Gao, WD; Paolocci, N; Rath, R; Sawyer, DB; Naga Prasad, SV; Gabrielson, K Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.
Cardiovasc Res. 2016; 109(3):358-373 Doi: 10.1093/cvr/cvv274 [OPEN ACCESS]
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Voelkl, J; Alesutan, I; Primessnig, U; Feger, M; Mia, S; Jungmann, A; Castor, T; Viereck, R; Stöckigt, F; Borst, O; Gawaz, M; Schrickel, JW; Metzler, B; Katus, HA; Müller, OJ; Pieske, B; Heinzel, FR; Lang, F AMP-activated protein kinase α1-sensitive activation of AP-1 in cardiomyocytes.
J Mol Cell Cardiol. 2016; 97(4):36-43 Doi: 10.1016/j.yjmcc.2016.04.009
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2015

Hammer, KP; Ljubojevic, S; Ripplinger, CM; Pieske, BM; Bers, DM Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.
J Mol Cell Cardiol. 2015; 84(2):1-9 Doi: 10.1016/j.yjmcc.2015.03.012 [OPEN ACCESS]
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Ljubojevic, S; Bers, DM Nuclear calcium in cardiac myocytes.
J Cardiovasc Pharmacol. 2015; 65(3):211-217 Doi: 10.1097/FJC.0000000000000174 [OPEN ACCESS]
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Mangmool, S; Hemplueksa, P; Parichatikanond, W; Chattipakorn, N Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes.
Mol Endocrinol. 2015; 29(4): 583-596. Doi: 10.1210/me.2014-1346 [OPEN ACCESS]
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Mayer, SC; Gilsbach, R; Preissl, S; Monroy Ordonez, EB; Schnick, T; Beetz, N; Lother, A; Rommel, C; Ihle, H; Bugger, H; Rühle, F; Schrepper, A; Schwarzer, M; Heilmann, C; Bönisch, U; Gupta, SK; Wilpert, J; Kretz, O; von Elverfeldt, D; Orth, J; Aktories, K; Beyersdorf, F; Bode, C; Stiller, B; Krüger, M; Thum, T; Doenst, T; Stoll, M; Hein, L Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.
Circ Res. 2015; 117(7): 622-633. Doi: 10.1161/CIRCRESAHA.115.306721 [OPEN ACCESS]
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Schwarzl, M; Hamdani, N; Seiler, S; Alogna, A; Manninger, M; Reilly, S; Zirngast, B; Kirsch, A; Steendijk, P; Verderber, J; Zweiker, D; Eller, P; Höfler, G; Schauer, S; Eller, K; Maechler, H; Pieske, BM; Linke, WA; Casadei, B; Post, H A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
Am J Physiol Heart Circ Physiol. 2015; 309(9):H1407-18 Doi: 10.1152/ajpheart.00542.2015 [OPEN ACCESS]
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2014

Ashraf, MI; Ebner, M; Wallner, C; Haller, M; Khalid, S; Schwelberger, H; Koziel, K; Enthammer, M; Hermann, M; Sickinger, S; Soleiman, A; Steger, C; Vallant, S; Sucher, R; Brandacher, G; Santer, P; Dragun, D; Troppmair, J A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.
Cell Commun Signal. 2014; 12:6 Doi: 10.1186/1478-811X-12-6 [OPEN ACCESS]
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Koyani, CN; Windischhofer, W; Rossmann, C; Jin, G; Kickmaier, S; Heinzel, FR; Groschner, K; Alavian-Ghavanini, A; Sattler, W; Malle, E 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.
Int J Cardiol. 2014; 173(3):472-480 Doi: 10.1016/j.ijcard.2014.03.086 [OPEN ACCESS]
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Ljubojevic, S; Radulovic, S; Leitinger, G; Sedej, S; Sacherer, M; Holzer, M; Winkler, C; Pritz, E; Mittler, T; Schmidt, A; Sereinigg, M; Wakula, P; Zissimopoulos, S; Bisping, E; Post, H; Marsche, G; Bossuyt, J; Bers, DM; Kockskämper, J; Pieske, B Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation. 2014; 130(3):244-255 Doi: 10.1161/CIRCULATIONAHA.114.008927 [OPEN ACCESS]
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Rainer, PP; Hao, S; Vanhoutte, D; Lee, DI; Koitabashi, N; Molkentin, JD; Kass, DA Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction.
Circ Res. 2014; 114(8):1246-1257 Doi: 10.1161/CIRCRESAHA.114.302653 [OPEN ACCESS]
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Rong, Z; Wang, M; Hu, Z; Stradner, M; Zhu, S; Kong, H; Yi, H; Goldrath, A; Yang, YG; Xu, Y; Fu, X An effective approach to prevent immune rejection of human ESC-derived allografts.
Cell Stem Cell. 2014; 14(1):121-130 Doi: 10.1016/j.stem.2013.11.014 [OPEN ACCESS]
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Scheruebel, S; Koyani, CN; Hallström, S; Lang, P; Platzer, D; Mächler, H; Lohner, K; Malle, E; Zorn-Pauly, K; Pelzmann, B I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.
J Mol Cell Cardiol. 2014; 72:64-73 Doi: 10.1016/j.yjmcc.2014.02.010 [OPEN ACCESS]
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Sedej, S; Schmidt, A; Denegri, M; Walther, S; Matovina, M; Arnstein, G; Gutschi, EM; Windhager, I; Ljubojević, S; Negri, S; Heinzel, FR; Bisping, E; Vos, MA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
J Am Coll Cardiol. 2014; 63(15):1569-1579 Doi: 10.1016/j.jacc.2013.11.010 [OPEN ACCESS]
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Walther, S; Pluteanu, F; Renz, S; Nikonova, Y; Maxwell, JT; Yang, LZ; Schmidt, K; Edwards, JN; Wakula, P; Groschner, K; Maier, LS; Spiess, J; Blatter, LA; Pieske, B; Kockskämper, J Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.
Am J Physiol Heart Circ Physiol. 2014; 307(5):H689-H700 Doi: 10.1152/ajpheart.00694.2013 [OPEN ACCESS]
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Zhou, L; Solhjoo, S; Millare, B; Plank, G; Abraham, MR; Cortassa, S; Trayanova, N; O'Rourke, B Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis.
Circ Arrhythm Electrophysiol. 2014; 7(1):143-151 Doi: 10.1161/CIRCEP.113.000600 [OPEN ACCESS]
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2013

Bourgonje, VJA; Vos, MA; Ozdemir, S; Doisne, N; Acsai, K; Varro, A; Sztojkov-Ivanov, A; Zupko, I; Rauch, E; Kattner, L; Bito, V; Houtman, M; van der Nagel, R; Beekman, JD; van Veen, TAB; Sipido, KR; Antoons, G; Combined Na+/Ca2+ Exchanger and L-Type Calcium Channel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function.
Circ Arrhythm Electrophysiol. 2013; 6(2):371-379 Doi: 10.1161/CIRCEP.113.000322 [OPEN ACCESS]
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McDowell, KS; Vadakkumpadan, F; Blake, R; Blauer, J; Plank, G; Macleod, RS; Trayanova, NA Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation.
Biophys J. 2013; 104(12):2764-2773 Doi: 10.1016/j.bpj.2013.05.025 [OPEN ACCESS]
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Riehle, C; Wende, AR; Sena, S; Pires, KM; Pereira, RO; Zhu, Y; Bugger, H; Frank, D; Bevins, J; Chen, D; Perry, CN; Dong, XC; Valdez, S; Rech, M; Sheng, X; Weimer, BC; Gottlieb, RA; White, MF; Abel, ED Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
J Clin Invest. 2013; 123(12): 5319-5333. Doi: 10.1172/JCI71171 [OPEN ACCESS]
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Sipido, KR; Acsai, K; Antoons, G; Bito, V; Macquaide, N T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Adv Exp Med Biol. 2013; 961(3):375-383 Doi: 10.1007/978-1-4614-4756-6_32
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2012

Bisping, E; Ikeda, S; Sedej, M; Wakula, P; McMullen, JR; Tarnavski, O; Sedej, S; Izumo, S; Pu, WT; Pieske, B Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.
J Biol Chem. 2012; 287(13):9827-9834 Doi: 10.1074/jbc.M111.338749 [OPEN ACCESS]
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Goonasekera, SA; Hammer, K; Auger-Messier, M; Bodi, I; Chen, X; Zhang, H; Reiken, S; Elrod, JW; Correll, RN; York, AJ; Sargent, MA; Hofmann, F; Moosmang, S; Marks, AR; Houser, SR; Bers, DM; Molkentin, JD Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.
J Clin Invest. 2012; 122(1):280-290 Doi: 10.1172/JCI58227 [OPEN ACCESS]
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Jayawardena, TM; Egemnazarov, B; Finch, EA; Zhang, L; Payne, JA; Pandya, K; Zhang, Z; Rosenberg, P; Mirotsou, M; Dzau, VJ MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
Circ Res. 2012; 110(11):1465-1473 Doi: 10.1161/CIRCRESAHA.112.269035 [OPEN ACCESS]
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Larson, JE; Rainer, PP; Watts, VL; Yang, R; Miller, KL; Phan, A; Barouch, LA Dependence of β3-adrenergic signaling on the adipokine leptin in cardiac myocytes.
Int J Obes (Lond). 2012; 36(6):876-879 Doi: 10.1038/ijo.2011.137 [OPEN ACCESS]
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Wang, N; De Bock, M; Antoons, G; Gadicherla, AK; Bol, M; Decrock, E; Evans, WH; Sipido, KR; Bukauskas, FF; Leybaert, L; Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation.
Basic Res Cardiol. 2012; 107(6):304-304 Doi: 10.1007/s00395-012-0304-2 [OPEN ACCESS]
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2011

Biesmans, L; Macquaide, N; Heinzel, FR; Bito, V; Smith, GL; Sipido, KR Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
PLoS One. 2011; 6(10):e25100-e25100 Doi: 10.1371/journal.pone.0025100 [OPEN ACCESS]
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Rosker, C; Salvarani, N; Schmutz, S; Grand, T; Rohr, S Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of á-smooth muscle actin containing stress fibers.
Circ Res. 2011; 109(10):1120-1131 Doi: 10.1161/CIRCRESAHA.111.244798 [OPEN ACCESS]
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