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Publikationen

Suchbegriffe: MYOCYTES, CARDIAC - DRUG EFFECTS , . Treffer: 44

2018

Harper, SC; Johnson, J; Borghetti, G; Zhao, H; Wang, T; Wallner, M; Kubo, H; Feldsott, EA; Yang, Y; Joo, Y; Gou, X; Sabri, AK; Gupta, P; Myzithras, M; Khalil, A; Franti, M; Houser, SR GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death.
Circ Res. 2018; 123(11):1220-1231 Doi: 10.1161/CIRCRESAHA.118.312955 [OPEN ACCESS]
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Mhatre, KN; Wakula, P; Klein, O; Bisping, E; Völkl, J; Pieske, B; Heinzel, FR Crosstalk between FGF23- and angiotensin II-mediated Ca²⁺ signaling in pathological cardiac hypertrophy.
Cell Mol Life Sci. 2018; 75(23):4403-4416 Doi: 10.1007/s00018-018-2885-x
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Oravecz, K; Kormos, A; Gruber, A; Márton, Z; Kohajda, Z; Mirzaei, L; Jost, N; Levijoki, J; Pollesello, P; Koskelainen, T; Otsomaa, L; Tóth, A; Papp, JG; Nánási, PP; Antoons, G; Varró, A; Acsai, K; Nagy, N Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.
Eur J Pharmacol. 2018; 818(5):278-286 Doi: 10.1016/j.ejphar.2017.10.039 [OPEN ACCESS]
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2016

Eisenberg, T; Abdellatif, M; Schroeder, S; Primessnig, U; Stekovic, S; Pendl, T; Harger, A; Schipke, J; Zimmermann, A; Schmidt, A; Tong, M; Ruckenstuhl, C; Dammbrueck, C; Gross, AS; Herbst, V; Magnes, C; Trausinger, G; Narath, S; Meinitzer, A; Hu, Z; Kirsch, A; Eller, K; Carmona-Gutierrez, D; Büttner, S; Pietrocola, F; Knittelfelder, O; Schrepfer, E; Rockenfeller, P; Simonini, C; Rahn, A; Horsch, M; Moreth, K; Beckers, J; Fuchs, H; Gailus-Durner, V; Neff, F; Janik, D; Rathkolb, B; Rozman, J; de Angelis, MH; Moustafa, T; Haemmerle, G; Mayr, M; Willeit, P; von Frieling-Salewsky, M; Pieske, B; Scorrano, L; Pieber, T; Pechlaner, R; Willeit, J; Sigrist, SJ; Linke, WA; Mühlfeld, C; Sadoshima, J; Dengjel, J; Kiechl, S; Kroemer, G; Sedej, S; Madeo, F Cardioprotection and lifespan extension by the natural polyamine spermidine.
Nat Med. 2016; 22(12):1428-1438 Doi: 10.1038/nm.4222 [OPEN ACCESS]
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Kooij, V; Viswanathan, MC; Lee, DI; Rainer, PP; Schmidt, W; Kronert, WA; Harding, SE; Kass, DA; Bernstein, SI; Van Eyk, JE; Cammarato, A Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.
Cardiovasc Res. 2016; 110(2):238-248 Doi: 10.1093/cvr/cvw050 [OPEN ACCESS]
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Mangmool, S; Denkaew, T; Phosri, S; Pinthong, D; Parichatikanond, W; Shimauchi, T; Nishida, M Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.
Mol Endocrinol. 2016; 30(1):118-132 Doi: 10.1210/me.2015-1201 [OPEN ACCESS]
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Primessnig, U; Schönleitner, P; Höll, A; Pfeiffer, S; Bracic, T; Rau, T; Kapl, M; Stojakovic, T; Glasnov, T; Leineweber, K; Wakula, P; Antoons, G; Pieske, B; Heinzel, FR Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction.
Eur J Heart Fail. 2016; 18(8):987-997 Doi: 10.1002/ejhf.524 [OPEN ACCESS]
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Sysa-Shah, P; Tocchetti, CG; Gupta, M; Rainer, PP; Shen, X; Kang, BH; Belmonte, F; Li, J; Xu, Y; Guo, X; Bedja, D; Gao, WD; Paolocci, N; Rath, R; Sawyer, DB; Naga Prasad, SV; Gabrielson, K Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.
Cardiovasc Res. 2016; 109(3):358-373 Doi: 10.1093/cvr/cvv274 [OPEN ACCESS]
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Wallner, M; Duran, JM; Mohsin, S; Troupes, CD; Vanhoutte, D; Borghetti, G; Vagnozzi, RJ; Gross, P; Yu, D; Trappanese, DM; Kubo, H; Toib, A; Sharp, TE; Harper, SC; Volkert, MA; Starosta, T; Feldsott, EA; Berretta, RM; Wang, T; Barbe, MF; Molkentin, JD; Houser, SR Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.
Circ Res. 2016; 119(7):865-879 Doi: 10.1161/CIRCRESAHA.116.308687 [OPEN ACCESS]
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2015

Hammer, KP; Ljubojevic, S; Ripplinger, CM; Pieske, BM; Bers, DM Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.
J Mol Cell Cardiol. 2015; 84(2):1-9 Doi: 10.1016/j.yjmcc.2015.03.012 [OPEN ACCESS]
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Mangmool, S; Hemplueksa, P; Parichatikanond, W; Chattipakorn, N Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes.
Mol Endocrinol. 2015; 29(4): 583-596. Doi: 10.1210/me.2014-1346 [OPEN ACCESS]
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2014

Koyani, CN; Windischhofer, W; Rossmann, C; Jin, G; Kickmaier, S; Heinzel, FR; Groschner, K; Alavian-Ghavanini, A; Sattler, W; Malle, E 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.
Int J Cardiol. 2014; 173(3):472-480 Doi: 10.1016/j.ijcard.2014.03.086 [OPEN ACCESS]
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Scheruebel, S; Koyani, CN; Hallström, S; Lang, P; Platzer, D; Mächler, H; Lohner, K; Malle, E; Zorn-Pauly, K; Pelzmann, B I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes.
J Mol Cell Cardiol. 2014; 72:64-73 Doi: 10.1016/j.yjmcc.2014.02.010 [OPEN ACCESS]
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2013

Ahammer, H; Scherubel, S; Arnold, R; Zorn-Pauly, K; Pelzmann, B Beat to beat variability of embryonic chick heart cells under septic conditions: application and evaluation of entropy as well as fractal measures.
Conf Proc IEEE Eng Med Biol Soc. 2013; 2013(2):5566-5569 Doi: 10.1109/EMBC.2013.6610811
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Bourgonje, VJA; Vos, MA; Ozdemir, S; Doisne, N; Acsai, K; Varro, A; Sztojkov-Ivanov, A; Zupko, I; Rauch, E; Kattner, L; Bito, V; Houtman, M; van der Nagel, R; Beekman, JD; van Veen, TAB; Sipido, KR; Antoons, G; Combined Na+/Ca2+ Exchanger and L-Type Calcium Channel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function.
Circ Arrhythm Electrophysiol. 2013; 6(2):371-379 Doi: 10.1161/CIRCEP.113.000322 [OPEN ACCESS]
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Hohendanner, F; Ljubojević, S; MacQuaide, N; Sacherer, M; Sedej, S; Biesmans, L; Wakula, P; Platzer, D; Sokolow, S; Herchuelz, A; Antoons, G; Sipido, K; Pieske, B; Heinzel, FR Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure.
Circ Res. 2013; 113(5):527-538 Doi: 10.1161/CIRCRESAHA.113.300895 [OPEN ACCESS]
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Rainer, PP; Primessnig, U; Harenkamp, S; Doleschal, B; Wallner, M; Fauler, G; Stojakovic, T; Wachter, R; Yates, A; Groschner, K; Trauner, M; Pieske, BM; von Lewinski, D Bile acids induce arrhythmias in human atrial myocardium--implications for altered serum bile acid composition in patients with atrial fibrillation.
Heart. 2013; 99(22):1685-1692 Doi: 10.1136/heartjnl-2013-304163
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Sivakumaran, V; Stanley, BA; Tocchetti, CG; Ballin, JD; Caceres, V; Zhou, L; Keceli, G; Rainer, PP; Lee, DI; Huke, S; Ziolo, MT; Kranias, EG; Toscano, JP; Wilson, GM; O'Rourke, B; Kass, DA; Mahaney, JE; Paolocci, N HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Antioxid Redox Signal. 2013; 19(11):1185-1197 Doi: 10.1089/ars.2012.5057 [OPEN ACCESS]
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2012

Bourgonje, VJ; Schoenmakers, M; Beekman, JD; van der Nagel, R; Houtman, MJ; Miedema, LF; Antoons, G; Sipido, K; de Windt, LJ; van Veen, TA; Vos, MA Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Heart Rhythm. 2012; 9(11):1875-1883 Doi: 10.1016/j.hrthm.2012.07.023
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Jayawardena, TM; Egemnazarov, B; Finch, EA; Zhang, L; Payne, JA; Pandya, K; Zhang, Z; Rosenberg, P; Mirotsou, M; Dzau, VJ MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
Circ Res. 2012; 110(11):1465-1473 Doi: 10.1161/CIRCRESAHA.112.269035 [OPEN ACCESS]
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Morel, S; Frias, MA; Rosker, C; James, RW; Rohr, S; Kwak, BR The natural cardioprotective particle HDL modulates connexin43 gap junction channels.
Cardiovasc Res. 2012; 93(1): 41-49. Doi: 10.1093/cvr/cvr257 [OPEN ACCESS]
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Sacherer, M; Sedej, S; Wakuła, P; Wallner, M; Vos, MA; Kockskämper, J; Stiegler, P; Sereinigg, M; von Lewinski, D; Antoons, G; Pieske, BM; Heinzel, FR; CONTICA investigators JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Br J Pharmacol. 2012; 167(3):493-504 Doi: 10.1111/j.1476-5381.2012.01995.x [OPEN ACCESS]
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2011

Biesmans, L; Macquaide, N; Heinzel, FR; Bito, V; Smith, GL; Sipido, KR Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
PLoS One. 2011; 6(10):e25100-e25100 Doi: 10.1371/journal.pone.0025100 [OPEN ACCESS]
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Rosker, C; Salvarani, N; Schmutz, S; Grand, T; Rohr, S Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of á-smooth muscle actin containing stress fibers.
Circ Res. 2011; 109(10):1120-1131 Doi: 10.1161/CIRCRESAHA.111.244798 [OPEN ACCESS]
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Yang, LZ; Kockskämper, J; Khan, S; Suarez, J; Walther, S; Doleschal, B; Unterer, G; Khafaga, M; Mächler, H; Heinzel, FR; Dillmann, WH; Pieske, B; Spiess, J cAMP- and Ca²(+) /calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes.
Br J Pharmacol. 2011; 162(2):544-556 Doi: 10.1111/j.1476-5381.2010.01067.x [OPEN ACCESS]
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2010

Oros, A; Houtman, MJ; Neco, P; Gomez, AM; Rajamani, S; Oosterhoff, P; Attevelt, NJ; Beekman, JD; van der Heyden, MA; Ver Donck, L; Belardinelli, L; Richard, S; Antoons, G; Vos, MA; CONTICA investigators Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Br J Pharmacol. 2010; 161(1):162-175 Doi: 10.1111/j.1476-5381.2010.00883.x [OPEN ACCESS]
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Pelzmann, B; Zorn-Pauly, K; Hallström, S; Mächler, H; Jakubowski, A; Lang, P; Koidl, B Effects of thienopyridines and thienopyrimidinones on L-type calcium current in isolated cardiomyocytes.
Naunyn Schmiedebergs Arch Pharmacol. 2010; 382(5-6):433-440 Doi: 10.1007/s00210-010-0557-y
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Sedej, S; Heinzel, FR; Walther, S; Dybkova, N; Wakula, P; Groborz, J; Gronau, P; Maier, LS; Vos, MA; Lai, FA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovasc Res. 2010; 87(1):50-59 Doi: 10.1093/cvr/cvq007 [OPEN ACCESS]
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2009

Antoons, G; Sipido, KR Dofetilide as activator of Na/Ca exchange: new perspectives on an 'old' drug. Editorial to: "Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange" by Xuan-Ping Zhang et al.
Cardiovasc Drugs Ther. 2009; 23(3): 189-192. Doi: 10.1007/s10557-009-6170-y [OPEN ACCESS]
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2008

Jacobshagen, C; Grüber, M; Teucher, N; Schmidt, AG; Unsöld, BW; Toischer, K; Nguyen, VP; Maier, LS; Kögler, H; Hasenfuss, G Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction.
Eur J Heart Fail. 2008; 10(4): 334-342. Doi: 10.1016/j.ejheart.2008.02.013 [OPEN ACCESS]
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2007

Antoons, G; Volders, PG; Stankovicova, T; Bito, V; Stengl, M; Vos, MA; Sipido, KR Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
J Physiol. 2007; 579(Pt 1):147-160 Doi: 10.1113/jphysiol.2006.124222 [OPEN ACCESS]
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Fontana, M; Olschewski, H; Olschewski, A; Schlüter, KD Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.
BRIT J PHARMACOL. 2007; 151(6): 779-786. Doi: 10.1038/sj.bjp.0707300 [OPEN ACCESS]
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Schillinger, W; Teucher, N; Sossalla, S; Kettlewell, S; Werner, C; Raddatz, D; Elgner, A; Tenderich, G; Pieske, B; Ramadori, G; Schöndube, FA; Kögler, H; Kockskämper, J; Maier, LS; Schwörer, H; Smith, GL; Hasenfuss, G Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms.
Circulation. 2007; 116(1):57-66 Doi: 10.1161/CIRCULATIONAHA.106.666008 [OPEN ACCESS]
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Zorn-Pauly, K; Pelzmann, B; Lang, P; Mächler, H; Schmidt, H; Ebelt, H; Werdan, K; Koidl, B; Müller-Werdan, U Endotoxin impairs the human pacemaker current If.
Shock. 2007; 28(6):655-661 Doi: 10.1097/shk.0b013e31812386bf [OPEN ACCESS]
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2006

Dos Santos, RW; Otaviano Campos, F; Neumann Ciuffo, L; Nygren, A; Giles, W; Koch, H ATX-II effects on the apparent location of M cells in a computational model of a human left ventricular wedge.
J Cardiovasc Electrophysiol. 2006; 17 Suppl 1: S86-S95. Doi: 10.1111/j.1540-8167.2006.00389.x
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Kobayashi, S; Lackey, T; Huang, Y; Bisping, E; Pu, WT; Boxer, LM; Liang, Q Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo.
FASEB J. 2006; 20(6):800-802 Doi: 10.1096/fj.05-5426fje [OPEN ACCESS]
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Yang, LZ; Kockskämper, J; Heinzel, FR; Hauber, M; Walther, S; Spiess, J; Pieske, B Urocortin II enhances contractility in rabbit ventricular myocytes via CRF(2) receptor-mediated stimulation of protein kinase A.
Cardiovasc Res. 2006; 69(2):402-411 Doi: 10.1016/j.cardiores.2005.10.015 [OPEN ACCESS]
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Zima, AV; Kockskämper, J; Blatter, LA Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes.
J Physiol. 2006; 577(Pt 1):281-293 Doi: 10.1113/jphysiol.2006.117242 [OPEN ACCESS]
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2005

Krogh-Madsen, T; Schaffer, P; Skriver, AD; Taylor, LK; Pelzmann, B; Koidl, B; Guevara, MR An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells.
Am J Physiol Heart Circ Physiol. 2005; 289(1):H398-H413 Doi: 10.1152/ajpheart.00683.2004 [OPEN ACCESS]
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Weisser-Thomas, J; Dieterich, E; Janssen, PM; Schmidt-Schweda, S; Maier, LS; Sumbilla, C; Pieske, B Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.
J Pharmacol Toxicol Methods. 2005; 51(2): 91-103. Doi: 10.1016/j.vascn.2004.10.005
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2004

Kockskämper, J; Ahmmed, GU; Zima, AV; Sheehan, KA; Glitsch, HG; Blatter, LA Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps.
Am J Physiol Cell Physiol. 2004; 287(2):C527-C538 Doi: 10.1152/ajpcell.00541.2003 [OPEN ACCESS]
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2003

Brittsan, AG; Ginsburg, KS; Chu, G; Yatani, A; Wolska, BM; Schmidt, AG; Asahi, M; MacLennan, DH; Bers, DM; Kranias, EG Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.
Circ Res. 2003; 92(7): 769-776. Doi: 10.1161/01.RES.0000066661.49920.59 [OPEN ACCESS]
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Jansen, J; Gres, P; Umschlag, C; Heinzel, FR; Degenhardt, H; Schluter, KD; Heusch, G; Schulz, R Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs.
Am J Physiol Heart Circ Physiol. 2003; 284(1):H49-H55 Doi: 10.1152/ajpheart.01037.2001 [OPEN ACCESS]
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Pelzmann, B; Hallström, S; Schaffer, P; Lang, P; Nadlinger, K; Birkmayer, GD; Vrecko, K; Reibnegger, G; Koidl, B NADH supplementation decreases pinacidil-primed I K ATP in ventricular cardiomyocytes by increasing intracellular ATP.
Br J Pharmacol. 2003; 139(4):749-754 Doi: 10.1038/sj.bjp.0705300 [OPEN ACCESS]
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