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Publikationen

Suchbegriffe: MYOCARDIAL CONTRACTION - DRUG EFFECTS , . Treffer: 84

2021

Cellini, A; Höfler, D; Arias-Loza, PA; Bandleon, S; Langsenlehner, T; Kohlhaas, M; Maack, C; Bauer, WR; Eder-Negrin, P The α2-isoform of the Na⁺/K⁺-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction.
Am J Physiol Heart Circ Physiol. 2021; 321(4):H650-H662 Doi: 10.1152/ajpheart.00808.2020
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2018

Harper, SC; Johnson, J; Borghetti, G; Zhao, H; Wang, T; Wallner, M; Kubo, H; Feldsott, EA; Yang, Y; Joo, Y; Gou, X; Sabri, AK; Gupta, P; Myzithras, M; Khalil, A; Franti, M; Houser, SR GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death.
Circ Res. 2018; 123(11):1220-1231 Doi: 10.1161/CIRCRESAHA.118.312955 [OPEN ACCESS]
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2017

Koyani, CN; Kolesnik, E; Wölkart, G; Shrestha, N; Scheruebel, S; Trummer, C; Zorn-Pauly, K; Hammer, A; Lang, P; Reicher, H; Maechler, H; Groschner, K; Mayer, B; Rainer, PP; Sourij, H; Sattler, W; Malle, E; Pelzmann, B; von, Lewinski, D Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.
Biochem Pharmacol. 2017; 145:64-80 Doi: 10.1016/j.bcp.2017.08.021 [OPEN ACCESS]
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2016

Müller-Edenborn, B; Kania, G; Osto, E; Jakob, P; Krasniqi, N; Beck-Schimmer, B; Blyszczuk, P; Eriksson, U Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia.
PLoS One. 2016; 11(5):e0154699 Doi: 10.1371/journal.pone.0154699 [OPEN ACCESS]
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2015

Wallner, M; Kolesnik, E; Ablasser, K; Khafaga, M; Wakula, P; Ljubojevic, S; Thon-Gutschi, EM; Sourij, H; Kapl, M; Edmunds, NJ; Kuzmiski, JB; Griffith, DA; Knez, I; Pieske, B; von Lewinski, D Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium.
J Mol Cell Cardiol. 2015; 89(Pt B):365-375 Doi: 10.1016/j.yjmcc.2015.09.018
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2014

Seo, K; Rainer, PP; Lee, DI; Hao, S; Bedja, D; Birnbaumer, L; Cingolani, OH; Kass, DA Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.
Circ Res. 2014; 114(5):823-832 Doi: 10.1161/CIRCRESAHA.114.302614 [OPEN ACCESS]
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2013

Bito, V; Biesmans, L; Gellen, B; Antoons, G; Macquaide, N; Rouet-Benzineb, P; Pezet, M; Mercadier, JJ; Sipido, KR FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.
Exp Physiol. 2013; 98(1):134-148 Doi: 10.1113/expphysiol.2011.064089 [OPEN ACCESS]
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Schwarzl, M; Seiler, S; Wallner, M; von, Lewinski, D; Huber, S; Maechler, H; Steendijk, P; Zelzer, S; Truschnig-Wilders, M; Obermayer-Pietsch, B; Lueger, A; Pieske, BM; Post, H Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia.
Crit Care Med. 2013; 41(12):e401-10 Doi: 10.1097/CCM.0b013e31829791da
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2012

Rainer, PP; Doleschal, B; Kirk, JA; Sivakumaran, V; Saad, Z; Groschner, K; Maechler, H; Hoefler, G; Bauernhofer, T; Samonigg, H; Hutterer, G; Kass, DA; Pieske, B; von, Lewinski, D; Pichler, M Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.
BJU Int. 2012; 110(10):1455-62 Doi: 10.1111/j.1464-410X.2012.11134.x [OPEN ACCESS]
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2011

Yang, LZ; Kockskämper, J; Khan, S; Suarez, J; Walther, S; Doleschal, B; Unterer, G; Khafaga, M; Mächler, H; Heinzel, FR; Dillmann, WH; Pieske, B; Spiess, J cAMP- and Ca²(+) /calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes.
Br J Pharmacol. 2011; 162(2):544-556 Doi: 10.1111/j.1476-5381.2010.01067.x [OPEN ACCESS]
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2010

von Lewinski, D; Gasser, R; Rainer, PP; Huber, MS; Wilhelm, B; Roessl, U; Haas, T; Wasler, A; Grimm, M; Bisping, E; Pieske, B Functional effects of glucose transporters in human ventricular myocardium.
Eur J Heart Fail. 2010; 12(2):106-113 Doi: 10.1093/eurjhf/hfp191 [OPEN ACCESS]
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2009

Antoons, G; Sipido, KR Dofetilide as activator of Na/Ca exchange: new perspectives on an 'old' drug. Editorial to: "Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange" by Xuan-Ping Zhang et al.
Cardiovasc Drugs Ther. 2009; 23(3): 189-192. Doi: 10.1007/s10557-009-6170-y [OPEN ACCESS]
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Deng, S; Kruger, A; Schmidt, A; Metzger, A; Yan, T; Gödtel-Armbrust, U; Hasenfuss, G; Brunner, F; Wojnowski, L Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.
Naunyn Schmiedebergs Arch Pharmacol. 2009; 380(1): 25-34. Doi: 10.1007/s00210-009-0407-y [OPEN ACCESS]
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von Lewinski, D; Kockskamper, J; Zhu, D; Post, H; Elgner, A; Pieske, B Reduced Stretch-Induced Force Response in Failing Human Myocardium Caused by Impaired Na+-Contraction Coupling
CIRC-HEART FAIL. 2009; 2(1): 47-55. Doi: 10.1161/CIRCHEARTFAILURE.108.794065 [OPEN ACCESS]
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2008

Jacobshagen, C; Grüber, M; Teucher, N; Schmidt, AG; Unsöld, BW; Toischer, K; Nguyen, VP; Maier, LS; Kögler, H; Hasenfuss, G Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction.
Eur J Heart Fail. 2008; 10(4): 334-342. Doi: 10.1016/j.ejheart.2008.02.013 [OPEN ACCESS]
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Kockskämper, J; Khafaga, M; Grimm, M; Elgner, A; Walther, S; Kockskämper, A; von Lewinski, D; Post, H; Grossmann, M; Dörge, H; Gottlieb, PA; Sachs, F; Eschenhagen, T; Schöndube, FA; Pieske, B Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.
Cardiovasc Res. 2008; 79(4):642-651 Doi: 10.1093/cvr/cvn126 [OPEN ACCESS]
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2007

Bisping, E; Tenderich, G; Barckhausen, P; Stumme, B; Bruns, S; von Lewinski, D; Pieske, B Atrial myocardium is the predominant inotropic target of adrenomedullin in the human heart.
Am J Physiol Heart Circ Physiol. 2007; 293(5):H3001-H3007 Doi: 10.1152/ajpheart.01276.2006 [OPEN ACCESS]
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Fontana, M; Olschewski, H; Olschewski, A; Schlüter, KD Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.
BRIT J PHARMACOL. 2007; 151(6): 779-786. Doi: 10.1038/sj.bjp.0707300 [OPEN ACCESS]
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Schillinger, W; Teucher, N; Sossalla, S; Kettlewell, S; Werner, C; Raddatz, D; Elgner, A; Tenderich, G; Pieske, B; Ramadori, G; Schöndube, FA; Kögler, H; Kockskämper, J; Maier, LS; Schwörer, H; Smith, GL; Hasenfuss, G Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms.
Circulation. 2007; 116(1):57-66 Doi: 10.1161/CIRCULATIONAHA.106.666008 [OPEN ACCESS]
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von Lewinski, D; Bisping, E; Elgner, A; Kockskämper, J; Pieske, B Mechanistic insight into the functional and toxic effects of Strophanthidin in the failing human myocardium.
Eur J Heart Fail. 2007; 9(11):1086-1094 Doi: 10.1016/j.ejheart.2007.08.004 [OPEN ACCESS]
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2006

Toller, WG; Stranz, C Levosimendan, a new inotropic and vasodilator agent.
ANESTHESIOLOGY. 2006; 104(3): 556-569. Doi: 10.1097/00000542-200603000-00024 [OPEN ACCESS]
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Yang, LZ; Kockskämper, J; Heinzel, FR; Hauber, M; Walther, S; Spiess, J; Pieske, B Urocortin II enhances contractility in rabbit ventricular myocytes via CRF(2) receptor-mediated stimulation of protein kinase A.
Cardiovasc Res. 2006; 69(2):402-411 Doi: 10.1016/j.cardiores.2005.10.015 [OPEN ACCESS]
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2005

Luers, C; Fialka, F; Elgner, A; Zhu, D; Kockskämper, J; von Lewinski, D; Pieske, B Stretch-dependent modulation of Na+i, Ca2+i, and pHi in rabbit myocardium--a mechanism for the slow force response.
Cardiovasc Res. 2005; 68(3):454-463 Doi: 10.1016/j.cardiores.2005.07.001 [OPEN ACCESS]
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Toller, W; Wölkart, G; Stranz, C; Metzler, H; Brunner, F Contractile action of levosimendan and epinephrine during acidosis.
EUR J PHARMACOL. 2005; 507(1-3): 199-209. Doi: 10.1016/j.ejphar.2004.11.049
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von Lewinski, D; Bruns, S; Walther, S; Kögler, H; Pieske, B Insulin causes Ca2+i-dependent and Ca2+i-independent positive inotropic effects in failing human myocardium.
Circulation. 2005; 111(20):2588-2595 Doi: 10.1161/CIRCULATIONAHA.104.497461 [OPEN ACCESS]
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Weisser-Thomas, J; Dieterich, E; Janssen, PM; Schmidt-Schweda, S; Maier, LS; Sumbilla, C; Pieske, B Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.
J Pharmacol Toxicol Methods. 2005; 51(2): 91-103. Doi: 10.1016/j.vascn.2004.10.005
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2004

Kockskämper, J; Ahmmed, GU; Zima, AV; Sheehan, KA; Glitsch, HG; Blatter, LA Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps.
Am J Physiol Cell Physiol. 2004; 287(2):C527-C538 Doi: 10.1152/ajpcell.00541.2003 [OPEN ACCESS]
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2003

Jansen, J; Gres, P; Umschlag, C; Heinzel, FR; Degenhardt, H; Schluter, KD; Heusch, G; Schulz, R Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs.
Am J Physiol Heart Circ Physiol. 2003; 284(1):H49-H55 Doi: 10.1152/ajpheart.01037.2001 [OPEN ACCESS]
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Schillinger, W; Ohler, A; Emami, S; Müller, F; Christians, C; Janssen, PM; Kögler, H; Teucher, N; Pieske, B; Seidler, T; Hasenfuss, G The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase.
Cardiovasc Res. 2003; 57(4):996-1003 Doi: 10.1016/S0008-6363(02)00829-5 [OPEN ACCESS]
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von Lewinski, D; Voss, K; Hülsmann, S; Kögler, H; Pieske, B Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium.
Circ Res. 2003; 92(2):169-176 Doi: 10.1161/01.RES.0000051885.70159.12 [OPEN ACCESS]
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2002

Hasenfuss, G; Maier, LS; Hermann, HP; Lüers, C; Hünlich, M; Zeitz, O; Janssen, PM; Pieske, B Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.
Circulation. 2002; 105(2):194-199 Doi: 10.1161/hc0202.102238 [OPEN ACCESS]
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Pieske, B; Maier, LS; Piacentino, V; Weisser, J; Hasenfuss, G; Houser, S Rate dependence of Na+i and contractility in nonfailing and failing human myocardium.
Circulation. 2002; 106(4):447-453 Doi: 10.1161/01.CIR.0000023042.50192.F4 [OPEN ACCESS]
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Weber, T; Lu, M; Andera, L; Lahm, H; Gellert, N; Fariss, MW; Korinek, V; Sattler, W; Ucker, DS; Terman, A; Schröder, A; Erl, W; Brunk, UT; Coffey, RJ; Weber, C; Neuzil, J Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.
Clin Cancer Res. 2002; 8(3):863-869 [OPEN ACCESS]
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2001

Baudet, S; Weisser, J; Janssen, AP; Beulich, K; Bieligk, U; Pieske, B; Noireaud, J; Janssen, PM; Hasenfuss, G; Prestle, J Increased basal contractility of cardiomyocytes overexpressing protein kinase C epsilon and blunted positive inotropic response to endothelin-1.
Cardiovasc Res. 2001; 50(3):486-494 Doi: 10.1016/S0008-6363(01)00225-5 [OPEN ACCESS]
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Most, P; Bernotat, J; Ehlermann, P; Pleger, ST; Reppel, M; Börries, M; Niroomand, F; Pieske, B; Janssen, PM; Eschenhagen, T; Karczewski, P; Smith, GL; Koch, WJ; Katus, HA; Remppis, A S100A1: a regulator of myocardial contractility.
Proc Natl Acad Sci U S A. 2001; 98(24):13889-13894 Doi: 10.1073/pnas.241393598 [OPEN ACCESS]
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Post, H; Schulz, R; Gres, P; Heusch, G No involvement of nitric oxide in the limitation of beta-adrenergic inotropic responsiveness during ischemia.
Am J Physiol Heart Circ Physiol. 2001; 281(6):H2392-H2397 Doi: 10.1152/ajpheart.2001.281.6.H2392 [OPEN ACCESS]
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Ver Heyen, M; Heymans, S; Antoons, G; Reed, T; Periasamy, M; Awede, B; Lebacq, J; Vangheluwe, P; Dewerchin, M; Collen, D; Sipido, K; Carmeliet, P; Wuytack, F Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circ Res. 2001; 89(9):838-846 Doi: 10.1161/hh2101.098466 [OPEN ACCESS]
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2000

Janssen, PM; Zeitz, O; Keweloh, B; Siegel, U; Maier, LS; Barckhausen, P; Pieske, B; Prestle, J; Lehnart, SE; Hasenfuss, G Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium.
Cardiovasc Res. 2000; 47(1):99-107 Doi: 10.1016/S0008-6363(00)00052-3 [OPEN ACCESS]
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Maier, LS; Schwan, C; Schillinger, W; Minami, K; Schütt, U; Pieske, B Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium.
Cardiovasc Res. 2000; 45(4):913-924 Doi: 10.1016/S0008-6363(99)00387-9 [OPEN ACCESS]
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1999

Pieske, B; Beyermann, B; Breu, V; Löffler, BM; Schlotthauer, K; Maier, LS; Schmidt-Schweda, S; Just, H; Hasenfuss, G Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium.
Circulation. 1999; 99(14):1802-1809 Doi: 10.1161/01.CIR.99.14.1802 [OPEN ACCESS]
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Sandstede, JJW; Bertsch, G; Beer, M; Kenn, W; Werner, E; Pabst, T; Lipke, C; Kretschmer, S; Neubauer, S; Hahn, D Detection of myocardial viability by low-dose dobutamine cine MR imaging
Magn Reson Imaging. 1999; 17(10):1437-1443 Doi: 10.1016/S0730-725X(99)00095-8
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Toller, WG; Montgomery, MW; Pagel, PS; Hettrick, DA; Warltier, DC; Kersten, JR Isoflurane-enhanced recovery of canine stunned myocardium: role for protein kinase C?
Anesthesiology. 1999; 91(3): 713-722. Doi: 10.1097/00000542-199909000-00024 [OPEN ACCESS]
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1998

Hasenfuss, G; Pieske, B; Castell, M; Kretschmann, B; Maier, LS; Just, H Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium.
Circulation. 1998; 98(20):2141-2147 Doi: 10.1161/01.CIR.98.20.2141 [OPEN ACCESS]
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Holubarsch, C; Lüdemann, J; Wiessner, S; Ruf, T; Schulte-Baukloh, H; Schmidt-Schweda, S; Pieske, B; Posival, H; Just, H Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: dependency of external work and force on muscle length, heart rate and inotropic stimulation.
Cardiovasc Res. 1998; 37(1):46-57 Doi: 10.1016/S0008-6363(97)00215-0 [OPEN ACCESS]
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Pieske, B; Trost, S; Schutt, K; Minami, K; Just, H; Hasenfuss, G Influence of Forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium
BASIC RES CARDIOL. 1998; 93: 66-75. Doi: 10.1007/s003950050222
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Schlotthauer, K; Schattmann, J; Bers, DM; Maier, LS; Schütt, U; Minami, K; Just, H; Hasenfuss, G; Pieske, B Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine.
J Mol Cell Cardiol. 1998; 30(7):1285-1294 Doi: 10.1006/jmcc.1998.0690
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Seinost, G; Gasser, R; Reisinger, E; Rigler, MY; Fischer, L; Keplinger, A; Dattwyler, RJ; Dunn, JJ; Klein, W Cardiac manifestations of Lyme borreliosis with special reference to contractile dysfunction
Acta Med Austriaca. 1998; 25(2):44-50
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1997

Maier, LS; Pieske, B; Allen, DG Influence of stimulation frequency on Na+i and contractile function in Langendorff-perfused rat heart.
Am J Physiol. 1997; 273(3 Pt): H1246-H1254. Doi: 10.1152/ajpheart.1997.273.3.H1246
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1996

Herzig, JW; Chiesi, M; Depersin, H; Grüninger, S; Hasenfuss, G; Kubalek, R; Leutert, T; Pieske, B; Pioch, K; Wenk, P; Holubarsch, C Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2+sensitizing agent, and (+)-5-(1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-meth yl-3, 6-dihydro-2H-1,3,4-thiadiazin-2-one on skinned fibres and isolated ventricular strips.
Arzneimittelforschung. 1996; 46(6):586-593
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Meyer, M; Lehnart, S; Pieske, B; Schlottauer, K; Munk, S; Holubarsch, C; Just, H; Hasenfuss, G Influence of endothelin 1 on human atrial myocardium--myocardial function and subcellular pathways.
Basic Res Cardiol. 1996; 91(1):86-93 Doi: 10.1007/BF00788869
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