Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: MULTIPLE SCLEROSIS, . Treffer: 355

2020

Auer, M; Bsteh, G; Hegen, H; Wurth, S; Zinganell, A; Berger, T; Deisenhammer, F; Di Pauli, F Late-onset neutropenia in a multiple sclerosis patient after first dose ocrelizumab switched from rituximab
MULT SCLER RELAT DIS. 2020; 43: 102155
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Bsteh, G; Berek, K; Hegen, H; Altmann, P; Wurth, S; Auer, M; Zinganell, A; Di Pauli, F; Rommer, P; Leutmezer, F; Deisenhammer, F; Berger, T Macular ganglion cell-inner plexiform layer thinning as a biomarker of disability progression in relapsing multiple sclerosis
MULT SCLER J. 2020; 1352458520935724
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d'Ambrosio, A; Valsasina, P; Gallo, A; De Stefano, N; Pareto, D; Barkhof, F; Ciccarelli, O; Enzinger, C; Tedeschi, G; Stromillo, ML; Arévalo, MJ; Hulst, HE; Muhlert, N; Koini, M; Filippi, M; Rocca, MA Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis.
Mult Scler. 2019; 155(5):1352458519837707-1352458519837707
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de Sitter, A; Verhoeven, T; Burggraaff, J; Liu, YO; Simoes, J; Ruggieri, S; Palotai, M; Brouwer, I; Versteeg, A; Wottschel, V; Ropele, S; Rocca, MA; Gasperini, C; Gallo, A; Yiannakas, MC; Rovira, A; Enzinger, C; Filippi, M; De Stefano, N; Kappos, L; Frederiksen, JL; Uitdehaag, BMJ; Barkhof, F; Guttmann, CRG; Vrenken, H Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort
J NEUROL. 2020;
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de Sitter, A; Visser, M; Brouwer, I; Cover, KS; van Schijndel, RA; Eijgelaar, RS; Müller, DMJ; Ropele, S; Kappos, L; Rovira, Á; Filippi, M; Enzinger, C; Frederiksen, J; Ciccarelli, O; Guttmann, CRG; Wattjes, MP; Witte, MG; de Witt Hamer, PC; Barkhof, F; Vrenken, H; MAGNIMS Study Group and Alzheimer’s Disease Neuroimaging Initiative Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods.
Eur Radiol. 2020; 30(2):1062-1074 [OPEN ACCESS]
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Geraldes, R; Juryńczyk, M; Dos Passos, G; Prichler, A; Chung, K; Hagens, M; Ruggieri, S; Huerga, E; Sastre-Garriga, J; Enzinger, C; Chard, DT; Barkhof, F; Gasperini, C; Rovira, A; DeLuca, GC; Palace, J; MAGNIMS study group Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis.
J Neurol Neurosurg Psychiatry. 2020; 91(4):388-391
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Geraldes, R; Jurynczyk, M; dos Passos, GR; Pichler, A; Chung, K; Hagens, M; Ruggieri, S; Auger, C; Sastre-Garriga, J; Enzinger, C; Chard, D; Barkhof, F; Gasperini, C; Rovira, A; DeLuca, G; Palace, J The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease
MULT SCLER J. 2020; 1352458520943777
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Guger, M; Enzinger, C; Leutmezer, F; Kraus, J; Kalcher, S; Kvas, E; Berger, T; Austrian MS Treatment Registry (AMSTR) Oral therapies for treatment of relapsing-remitting multiple sclerosis in Austria: a 2-year comparison using an inverse probability weighting method.
J Neurol. 2020; [OPEN ACCESS]
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Guger, M; Traxler, G; Drabauer, M; Leitner-Pohn, D; Enzinger, C; Leutmezer, F; Oel, D; Di Pauli, F; Berger, T; Ransmayr, G Pregnancy Outcomes in Patients With Multiple Sclerosis Exposed to Natalizumab-A Retrospective Analysis From the Austrian Multiple Sclerosis Treatment Registry
FRONT NEUROL. 2020; 11: 676 [OPEN ACCESS]
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Höftberger, R; Guo, Y; Flanagan, EP; Lopez-Chiriboga, AS; Endmayr, V; Hochmeister, S; Joldic, D; Pittock, SJ; Tillema, JM; Gorman, M; Lassmann, H; Lucchinetti, CF The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody.
Acta Neuropathol. 2020; [OPEN ACCESS]
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Leurs, CE; Twaalfhoven, H; Lissenberg-Witte, BI; van Pesch, V; Dujmovic, I; Drulovic, J; Castellazzi, M; Bellini, T; Pugliatti, M; Kuhle, J; Villar, LM; Alvarez-Cermeño, JC; Alvarez-Lafuente, R; Hegen, H; Deisenhammer, F; Walchhofer, LM; Thouvenot, E; Comabella, M; Montalban, X; Vécsei, L; Rajda, C; Galimberti, D; Scarpini, E; Altintas, A; Rejdak, K; Frederiksen, JL; Pihl-Jensen, G; Jensen, P; Khalil, M; Voortman, MM; Fazekas, F; Saiz, A; La Puma, D; Vercammen, M; Vanopdenbosch, L; Uitdehaag, B; Killestein, J; Bridel, C; Teunissen, C Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.
Mult Scler. 2019; 1352458519845844-1352458519845844 [OPEN ACCESS]
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Maretzke, F; Bechthold, A; Egert, S; Ernst, JB; Melo van Lent, D; Pilz, S; Reichrath, J; Stangl, GI; Stehle, P; Volkert, D; Wagner, M; Waizenegger, J; Zittermann, A; Linseisen, J Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.
Nutrients. 2020; 12(4): [OPEN ACCESS]
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Pichler, A; Fazekas, F Commentary on 'Spontaneous multiple cervical artery dissections after alemtuzumab'
MULT SCLER J. 2020; 26(3): 384-385.
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Pinter, D; Khalil, M; Pirpamer, L; Damulina, A; Pichler, A; Fruhwirth, V; Ropele, S; Schmidt, R; Fuchs, S; Enzinger, C Long-term course and morphological MRI correlates of cognitive function in multiple sclerosis.
Mult Scler. 2020; 11(1):1352458520941474-1352458520941474
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Sastre-Garriga, J; Pareto, D; Battaglini, M; Rocca, MA; Ciccarelli, O; Enzinger, C; Wuerfel, J; Sormani, MP; Barkhof, F; Yousry, TA; De Stefano, N; Tintoré, M; Filippi, M; Gasperini, C; Kappos, L; Río, J; Frederiksen, J; Palace, J; Vrenken, H; Montalban, X; Rovira, À; MAGNIMS study group MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice.
Nat Rev Neurol. 2020; 16(3):171-182 [OPEN ACCESS]
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2019

Bollmann, S; Kristensen, MH; Larsen, MS; Olsen, MV; Pedersen, MJ; Østergaard, LR; O'Brien, K; Langkammer, C; Fazlollahi, A; Barth, M SHARQnet - Sophisticated harmonic artifact reduction in quantitative susceptibility mapping using a deep convolutional neural network.
Z Med Phys. 2019; 29(2):139-149
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Bollmann, S; Rasmussen, KGB; Kristensen, M; Blendal, RG; Østergaard, LR; Plocharski, M; O'Brien, K; Langkammer, C; Janke, A; Barth, M DeepQSM - using deep learning to solve the dipole inversion for quantitative susceptibility mapping.
Neuroimage. 2019; 195(2):373-383
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Bridel, C; van Wieringen, WN; Zetterberg, H; Tijms, BM; Teunissen, CE; and the NFL Group; Alvarez-Cermeño, JC; Andreasson, U; Axelsson, M; Bäckström, DC; Bartos, A; Bjerke, M; Blennow, K; Boxer, A; Brundin, L; Burman, J; Christensen, T; Fialová, L; Forsgren, L; Frederiksen, JL; Gisslén, M; Gray, E; Gunnarsson, M; Hall, S; Hansson, O; Herbert, MK; Jakobsson, J; Jessen-Krut, J; Janelidze, S; Johannsson, G; Jonsson, M; Kappos, L; Khademi, M; Khalil, M; Kuhle, J; Landén, M; Leinonen, V; Logroscino, G; Lu, CH; Lycke, J; Magdalinou, NK; Malaspina, A; Mattsson, N; Meeter, LH; Mehta, SR; Modvig, S; Olsson, T; Paterson, RW; Pérez-Santiago, J; Piehl, F; Pijnenburg, YAL; Pyykkö, OT; Ragnarsson, O; Rojas, JC; Romme Christensen, J; Sandberg, L; Scherling, CS; Schott, JM; Sellebjerg, FT; Simone, IL; Skillbäck, T; Stilund, M; Sundström, P; Svenningsson, A; Tortelli, R; Tortorella, C; Trentini, A; Troiano, M; Turner, MR; van Swieten, JC; Vågberg, M; Verbeek, MM; Villar, LM; Visser, PJ; Wallin, A; Weiss, A; Wikkelsø, C; Wild, EJ Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.
JAMA Neurol. 2019; [OPEN ACCESS]
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Bsteh, G; Berek, K; Hegen, H; Buchmann, A; Voortman, MM; Auer, M; Wurth, S; Zinganell, A; Di Pauli, F; Deisenhammer, F; Khalil, M; Berger, T Serum neurofilament light levels correlate with change of olfactory function in multiple sclerosis.
Mult Scler J Exp Transl Clin. 2019; 5(4): 2055217319885987-2055217319885987. [OPEN ACCESS]
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Bsteh, G; Berek, K; Hegen, H; Teuchner, B; Buchmann, A; Voortman, MM; Auer, M; Wurth, S; Zinganell, A; Di Pauli, F; Deisenhammer, F; Khalil, M; Berger, T Serum neurofilament levels correlate with retinal nerve fiber layer thinning in multiple sclerosis.
Mult Scler. 2019; 1352458519882279-1352458519882279.
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Chatterjee, M; Koel-Simmelink, MJ; Verberk, IM; Killestein, J; Vrenken, H; Enzinger, C; Ropele, S; Fazekas, F; Khalil, M; Teunissen, CE Contactin-1 and contactin-2 in cerebrospinal fluid as potential biomarkers for axonal domain dysfunction in multiple sclerosis.
Mult Scler J Exp Transl Clin. 2019; 4(4):2055217318819535-2055217318819535 [OPEN ACCESS]
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Filippi, M; Brück, W; Chard, D; Fazekas, F; Geurts, JJG; Enzinger, C; Hametner, S; Kuhlmann, T; Preziosa, P; Rovira, À; Schmierer, K; Stadelmann, C; Rocca, MA; Attendees of the Correlation between Pathological and MRI findings in MS workshop Association between pathological and MRI findings in multiple sclerosis.
LANCET NEUROL. 2019; 18(2): 198-210.
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Fissolo, N; Cervera-Carles, L; Villar Guimerans, LM; Lleó, A; Clarimón, J; Drulovic, J; Dujmovic, I; Voortman, M; Khalil, M; Gil, E; Navarro, L; Álvarez-Cermeño, JC; Montalban, X; Comabella, M Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.
Mult Scler. 2019; 25(11):1535-1538
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Gasperini, C; Prosperini, L; Tintoré, M; Sormani, MP; Filippi, M; Rio, J; Palace, J; Rocca, MA; Ciccarelli, O; Barkhof, F; Sastre-Garriga, J; Vrenken, H; Frederiksen, JL; Yousry, TA; Enzinger, C; Rovira, A; Kappos, L; Pozzilli, C; Montalban, X; De Stefano, N; and the MAGNIMS Study Group Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.
Neurology. 2019; 92(4):180-192 [OPEN ACCESS]
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Guger, M; Enzinger, C; Leutmezer, F; Kraus, J; Kalcher, S; Kvas, E; Berger, T; Austrian MS Treatment Registry (AMSTR) Real-life use of oral disease-modifying treatments in Austria.
Acta Neurol Scand. 2019; 140(1):32-39 [OPEN ACCESS]
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Guger, M; Enzinger, C; Leutmezer, F; Kraus, J; Kalcher, S; Kvas, E; Berger, T; Austrian MS Treatment Registry (AMSTR) Switching from natalizumab to fingolimod treatment in multiple sclerosis: real life data from the Austrian MS Treatment Registry.
J Neurol. 2019; 266(11):2672-2677
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Hagens, MH; Burggraaff, J; Kilsdonk, ID; Ruggieri, S; Collorone, S; Cortese, R; Cawley, N; Sbardella, E; Andelova, M; Amann, M; Lieb, JM; Pantano, P; Lissenberg-Witte, BI; Killestein, J; Oreja-Guevara, C; Wuerfel, J; Ciccarelli, O; Gasperini, C; Lukas, C; Rovira, A; Barkhof, F; Wattjes, MP; MAGNIMS Study Group Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study.
Mult Scler. 2019; 25(3):352-360 [OPEN ACCESS]
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Haindl, MT; Köck, U; Zeitelhofer-Adzemovic, M; Fazekas, F; Hochmeister, S The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis.
Glia. 2019; 67(3):467-481 [OPEN ACCESS]
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International Multiple Sclerosis Genetics Consortium A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.
Nat Commun. 2019; 10(1): 2236-2236. [OPEN ACCESS]
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Jensen, PEH; Warnke, C; Ingenhoven, K; Piccoli, L; Gasis, M; Hermanrud, C; Fernandez-Rodriguez, BM; Ryner, M; Kramer, D; Link, J; Ramanujam, R; Auer, M; Buck, D; Grummel, V; Bertotti, E; Fissolo, N; Oliver-Martos, B; Nytrova, P; Khalil, M; Guger, M; Rathmaier, S; Sievers-Stober, C; Lindberg, RLP; Hässler, S; Bachelet, D; Aktas, O; Donnellan, N; Lawton, A; Hemmer, B; Havrdova, EK; Kieseier, B; Hartung, HP; Comabella, M; Montalban, X; Derfuss, T; Sellebjerg, F; Dönnes, P; Pallardy, M; Spindeldreher, S; Broët, P; Deisenhammer, F; Fogdell-Hahn, A; Sorensen, PS; ABIRISK Consortium Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study.
J Neuroimmunol. 2019; 326:19-27
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Kober, SE; Pinter, D; Enzinger, C; Damulina, A; Duckstein, H; Fuchs, S; Neuper, C; Wood, G Self-regulation of brain activity and its effect on cognitive function in patients with multiple sclerosis - First insights from an interventional study using neurofeedback.
Clin Neurophysiol. 2019; 130(11):2124-2131
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Kor, D; Birkl, C; Ropele, S; Doucette, J; Xu, T; Wiggermann, V; Hernández-Torres, E; Hametner, S; Rauscher, A The role of iron and myelin in orientation dependent R2* of white matter.
NMR Biomed. 2019; 32(7):e4092-e4092
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Pichler, A; Khalil, M; Langkammer, C; Pinter, D; Ropele, S; Fuchs, S; Bachmaier, G; Enzinger, C; Fazekas, F The impact of vascular risk factors on brain volume and lesion load in patients with early multiple sclerosis
MULT SCLER J. 2019; 25(1): 48-54.
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Pinter, D; Beckmann, CF; Fazekas, F; Khalil, M; Pichler, A; Gattringer, T; Ropele, S; Fuchs, S; Enzinger, C Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.
Sci Rep. 2019; 9(1):16221-16221 [OPEN ACCESS]
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Santangelo, G; Altieri, M; Enzinger, C; Gallo, A; Trojano, L Cognitive reserve and neuropsychological performance in multiple sclerosis: A meta-analysis.
Neuropsychology. 2019; 33(3):379-390
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Sinnecker, T; Clarke, MA; Meier, D; Enzinger, C; Calabrese, M; De Stefano, N; Pitiot, A; Giorgio, A; Schoonheim, MM; Paul, F; Pawlak, MA; Schmidt, R; Kappos, L; Montalban, X; Rovira, À; Evangelou, N; Wuerfel, J; MAGNIMS Study Group Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.
JAMA Neurol. 2019; 130(11): [OPEN ACCESS]
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Walleczek, NK; Frommlet, F; Bsteh, G; Eggers, C; Rauschka, H; Koppi, S; Assar, H; Ehling, R; Birkl, C; Salhofer-Polanyi, S; Baumgartner, A; Blechinger, S; Buchinger, D; Sellner, J; Kraus, J; Moser, H; Mayr, M; Guger, M; Rathmaier, S; Raber, B; Liendl, H; Hiller, MS; Parigger, S; Morgenstern, G; Kempf, I; Spiss, HK; Meister, B; Heine, M; Cisar, A; Bachler, H; Khalil, M; Fuchs, S; Enzinger, C; Fazekas, F; Leutmezer, F; Berger, T; Kristoferitsch, W; Aboulenein-Djamshidian, F Month-of-birth-effect in multiple sclerosis in Austria.
Mult Scler. 2018; 1352458518810924-1352458518810924
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Wottschel, V; Chard, DT; Enzinger, C; Filippi, M; Frederiksen, JL; Gasperini, C; Giorgio, A; Rocca, MA; Rovira, A; De Stefano, N; Tintoré, M; Alexander, DC; Barkhof, F; Ciccarelli, O; MAGNIMS study group and the EuroPOND consortium SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis.
Neuroimage Clin. 2019; 24: 102011-102011. [OPEN ACCESS]
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2018

Amiri, H; de Sitter, A; Bendfeldt, K; Battaglini, M; Gandini Wheeler-Kingshott, CAM; Calabrese, M; Geurts, JJG; Rocca, MA; Sastre-Garriga, J; Enzinger, C; de Stefano, N; Filippi, M; Rovira, Á; Barkhof, F; Vrenken, H; MAGNIMS Study Group Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI.
NEUROIMAGE-CLIN. 2018; 19(3): 466-475. [OPEN ACCESS]
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Berger, T; Adamczyk-Sowa, M; Csépány, T; Fazekas, F; Hojs Fabjan, T; Horáková, D; Illes, Z; Klimová, E; Leutmezer, F; Rejdak, K; Rozsa, C; Šega Jazbec, S; Szilasiová, J; Turčáni, P; Vachová, M; Vécsei, L; Havrdová, E Management of multiple sclerosis patients in central European countries: current needs and potential solutions.
Ther Adv Neurol Disord. 2018; 11(2):1756286418759189-1756286418759189 [OPEN ACCESS]
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Birkl, C; Carassiti, D; Hussain, F; Langkammer, C; Enzinger, C; Fazekas, F; Schmierer, K; Ropele, S Assessment of ferritin content in multiple sclerosis brains using temperature-induced R*2 changes.
Magn Reson Med. 2018; 79(3):1609-1615 [OPEN ACCESS]
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De Stefano, N; Giorgio, A; Tintoré, M; Pia Amato, M; Kappos, L; Palace, J; Yousry, T; Rocca, MA; Ciccarelli, O; Enzinger, C; Frederiksen, J; Filippi, M; Vrenken, H; Rovira, À; MAGNIMS study group Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS consensus recommendations.
Mult Scler. 2018; 24(2):214-221
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Eshaghi, A; Marinescu, RV; Young, AL; Firth, NC; Prados, F; Jorge Cardoso, M; Tur, C; De Angelis, F; Cawley, N; Brownlee, WJ; De Stefano, N; Laura Stromillo, M; Battaglini, M; Ruggieri, S; Gasperini, C; Filippi, M; Rocca, MA; Rovira, A; Sastre-Garriga, J; Geurts, JJG; Vrenken, H; Wottschel, V; Leurs, CE; Uitdehaag, B; Pirpamer, L; Enzinger, C; Ourselin, S; Gandini Wheeler-Kingshott, CA; Chard, D; Thompson, AJ; Barkhof, F; Alexander, DC; Ciccarelli, O Progression of regional grey matter atrophy in multiple sclerosis.
Brain. 2018; 141(6):1665-1677 [OPEN ACCESS]
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Eshaghi, A; Prados, F; Brownlee, WJ; Altmann, DR; Tur, C; Cardoso, MJ; De Angelis, F; van de Pavert, SH; Cawley, N; De Stefano, N; Stromillo, ML; Battaglini, M; Ruggieri, S; Gasperini, C; Filippi, M; Rocca, MA; Rovira, A; Sastre-Garriga, J; Vrenken, H; Leurs, CE; Killestein, J; Pirpamer, L; Enzinger, C; Ourselin, S; Wheeler-Kingshott, CAMG; Chard, D; Thompson, AJ; Alexander, DC; Barkhof, F; Ciccarelli, O; MAGNIMS study group Deep gray matter volume loss drives disability worsening in multiple sclerosis.
Ann Neurol. 2018; 83(2):210-222 [OPEN ACCESS]
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Fabian, E; Schiller, D; Toplak, H; Brunner-Krainz, M; Fazekas, F; Schoefl, R; Krejs, GJ Clinical-Pathological Conference Series from the Medical University of Graz : Case No 153: A 55-year-old woman with atypical multiple sclerosis and irritable bowel syndrome.
Wien Klin Wochenschr. 2018; 130(3-4):151-160 (- Case Report) [OPEN ACCESS]
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Filippi, M; Preziosa, P; Meani, A; Ciccarelli, O; Mesaros, S; Rovira, A; Frederiksen, J; Enzinger, C; Barkhof, F; Gasperini, C; Brownlee, W; Drulovic, J; Montalban, X; Cramer, SP; Pichler, A; Hagens, M; Ruggieri, S; Martinelli, V; Miszkiel, K; Tintore, M; Comi, G; Dekker, I; Uitdehaag, B; Dujmovic-Basuroski, I; Rocca, MA Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study
LANCET NEUROL. 2018; 17(2): 133-142.
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Geraldes, R; Ciccarelli, O; Barkhof, F; De Stefano, N; Enzinger, C; Filippi, M; Hofer, M; Paul, F; Preziosa, P; Rovira, A; DeLuca, GC; Kappos, L; Yousry, T; Fazekas, F; Frederiksen, J; Gasperini, C; Sastre-Garriga, J; Evangelou, N; Palace, J; MAGNIMS study group The current role of MRI in differentiating multiple sclerosis from its imaging mimics.
NAT REV NEUROL. 2018; 14(4): 199-213.
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Guger, M; Enzinger, C; Leutmezer, F; Kraus, J; Kalcher, S; Kvas, E; Berger, T Real-life clinical use of natalizumab and fingolimod in Austria.
Acta Neurol Scand. 2018; 137(2):181-187
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Khalil, M; Teunissen, CE; Otto, M; Piehl, F; Sormani, MP; Gattringer, T; Barro, C; Kappos, L; Comabella, M; Fazekas, F; Petzold, A; Blennow, K; Zetterberg, H; Kuhle, J Neurofilaments as biomarkers in neurological disorders.
Nat Rev Neurol. 2018; 14(10):577-589
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Lex, H; Weisenbach, S; Sloane, J; Syed, S; Rasky, E; Freidl, W Social-emotional aspects of quality of life in multiple sclerosis.
Psychol Health Med. 2018; 23(4): 411-423.
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