Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: MODELS, MOLECULAR - , . Treffer: 99

2019

Schopf, FH; Huber, EM; Dodt, C; Lopez, A; Biebl, MM; Rutz, DA; Mühlhofer, M; Richter, G; Madl, T; Sattler, M; Groll, M; Buchner, J The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
MOL CELL. 2019; 74(1): 73-87. [OPEN ACCESS]
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2017

Schalli, M; Tysoe, C; Fischer, R; Pabst, BM; Thonhofer, M; Paschke, E; Rappitsch, T; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.
Carbohydr Res. 2017; 443-444(15):15-22
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Wallace, PW; Haernvall, K; Ribitsch, D; Zitzenbacher, S; Schittmayer, M; Steinkellner, G; Gruber, K; Guebitz, GM; Birner-Gruenberger, R PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes.
Appl Microbiol Biotechnol. 2017; 101(6):2291-2303 [OPEN ACCESS]
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2016

Anvarian, Z; Nojima, H; van Kappel, EC; Madl, T; Spit, M; Viertler, M; Jordens, I; Low, TY; van Scherpenzeel, RC; Kuper, I; Richter, K; Heck, AJ; Boelens, R; Vincent, JP; Rüdiger, SG; Maurice, MM Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Nat Struct Mol Biol. 2016; 23(4):324-332
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Hartlmüller, C; Göbl, C; Madl, T Prediction of Protein Structure Using Surface Accessibility Data.
Angew Chem Int Ed Engl. 2016; 55(39):11970-11974 [OPEN ACCESS]
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Janowski, R; Scanu, S; Niessing, D; Madl, T Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Acta Crystallogr F Struct Biol Commun. 2016; 72(Pt 10):743-749 [OPEN ACCESS]
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Kornmueller, K; Lehofer, B; Meindl, C; Fröhlich, E; Leitinger, G; Amenitsch, H; Prassl, R Peptides at the Interface: Self-Assembly of Amphiphilic Designer Peptides and Their Membrane Interaction Propensity.
Biomacromolecules. 2016; 17(11):3591-3601 [OPEN ACCESS]
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Pavkov-Keller, T; Bakhuis, J; Steinkellner, G; Jolink, F; Keijmel, E; Birner-Gruenberger, R; Gruber, K Structures of almond hydroxynitrile lyase isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLs.
J Biotechnol. 2016; 235(7):24-31
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Perz, V; Baumschlager, A; Bleymaier, K; Zitzenbacher, S; Hromic, A; Steinkellner, G; Pairitsch, A; Łyskowski, A; Gruber, K; Sinkel, C; Küper, U; Ribitsch, D; Guebitz, GM Hydrolysis of synthetic polyesters by Clostridium botulinum esterases.
Biotechnol Bioeng. 2016; 113(5): 1024-1034.
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Redrejo-Rodríguez, M; Vigouroux, A; Mursalimov, A; Grin, I; Alili, D; Koshenov, Z; Akishev, Z; Maksimenko, A; Bissenbaev, AK; Matkarimov, BT; Saparbaev, M; Ishchenko, AA; Moréra, S Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA.
Biochimie. 2016; 128-129:20-33 [OPEN ACCESS]
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Scharinger, B; Messner, B; Türkcan, A; Schuster, D; Vuorinen, A; Pitterl, F; Heinz, K; Arnhard, K; Laufer, G; Grimm, M; Stuppner, H; Oberacher, H; Eller, P; Ritsch, A; Bernhard, D Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.
J Mol Cell Cardiol. 2016; 99(7):35-46 [OPEN ACCESS]
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Thonhofer, M; Weber, P; Santana, AG; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Bioorg Med Chem Lett. 2016; 26(5):1438-1442
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Tuller, F; Holzer, H; Schanda, K; Aboulenein-Djamshidian, F; Höftberger, R; Khalil, M; Seifert-Held, T; Leutmezer, F; Berger, T; Reindl, M Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders.
J Neuroinflammation. 2016; 13(1):176-176 [OPEN ACCESS]
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Weber, J; Bao, H; Hartlmüller, C; Wang, Z; Windhager, A; Janowski, R; Madl, T; Jin, P; Niessing, D Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
Elife. 2016; 5(7): [OPEN ACCESS]
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Wenzl, K; Hofer, S; Troppan, K; Lassnig, M; Steinbauer, E; Wiltgen, M; Zulus, B; Renner, W; Beham-Schmid, C; Neumeister, P; Deutsch, A Higher incidence of the SNP Met 788 Ile in the coding region of A20 in diffuse large B cell lymphomas.
Tumour Biol. 2016; 37(4):4785-4789 [OPEN ACCESS]
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Zierer, BK; Rübbelke, M; Tippel, F; Madl, T; Schopf, FH; Rutz, DA; Richter, K; Sattler, M; Buchner, J Importance of cycle timing for the function of the molecular chaperone Hsp90.
Nat Struct Mol Biol. 2016; 23(11):1020-1028 [OPEN ACCESS]
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2015

Hocking, HG; Häse, F; Madl, T; Zacharias, M; Rief, M; Žoldák, G A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain.
Biophys J. 2015; 108(3):678-686 [OPEN ACCESS]
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Meyer, NH; Mayerhofer, H; Tripsianes, K; Blindow, S; Barths, D; Mewes, A; Weimar, T; Köhli, T; Bade, S; Madl, T; Frey, A; Haas, H; Mueller-Dieckmann, J; Sattler, M; Schramm, G A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation.
J Biol Chem. 2015; 290(36): 22111-22126. [OPEN ACCESS]
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Paolini, A; Baldassarre, A; Del Gaudio, I; Masotti, A Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3.
Int J Mol Sci. 2015; 16(8):19631-19644 [OPEN ACCESS]
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Riedl, S; Leber, R; Rinner, B; Schaider, H; Lohner, K; Zweytick, D Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine.
Biochim Biophys Acta. 2015; 1848(11 Pt A):2918-2931 [OPEN ACCESS]
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Sena, FV; Batista, AP; Catarino, T; Brito, JA; Archer, M; Viertler, M; Madl, T; Cabrita, EJ; Pereira, MM Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction.
Mol Microbiol. 2015; 98(2):272-288 [OPEN ACCESS]
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2014

Bernkopf, M; Webersinke, G; Tongsook, C; Koyani, CN; Rafiq, MA; Ayaz, M; Müller, D; Enzinger, C; Aslam, M; Naeem, F; Schmidt, K; Gruber, K; Speicher, MR; Malle, E; Macheroux, P; Ayub, M; Vincent, JB; Windpassinger, C; Duba, HC Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.
Hum Mol Genet. 2014; 23(15):4015-4023 [OPEN ACCESS]
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Göbl, C; Madl, T; Simon, B; Sattler, M NMR approaches for structural analysis of multidomain proteins and complexes in solution.
Prog Nucl Magn Reson Spectrosc. 2014; 80(7):26-63
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Goessweiner-Mohr, N; Fercher, C; Arends, K; Birner-Gruenberger, R; Laverde-Gomez, D; Huebner, J; Grohmann, E; Keller, W The type IV secretion protein TraK from the Enterococcus conjugative plasmid pIP501 exhibits a novel fold.
Acta Crystallogr D Biol Crystallogr. 2014; 70(Pt 4):1124-1135 [OPEN ACCESS]
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Karagöz, GE; Duarte, AM; Akoury, E; Ippel, H; Biernat, J; Morán Luengo, T; Radli, M; Didenko, T; Nordhues, BA; Veprintsev, DB; Dickey, CA; Mandelkow, E; Zweckstetter, M; Boelens, R; Madl, T; Rüdiger, SG Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.
Cell. 2014; 156(5): 963-974. [OPEN ACCESS]
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Krump, C; Vogl, M; Brecker, L; Nidetzky, B; Kratzer, R Acceleration of an aldo-keto reductase by minimal loop engineering.
Protein Eng Des Sel. 2014; 27(7):245-248 [OPEN ACCESS]
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Lorenz, OR; Freiburger, L; Rutz, DA; Krause, M; Zierer, BK; Alvira, S; Cuéllar, J; Valpuesta, JM; Madl, T; Sattler, M; Buchner, J Modulation of the Hsp90 chaperone cycle by a stringent client protein.
Mol Cell. 2014; 53(6): 941-953. [OPEN ACCESS]
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Ma, X; Rousseau, V; Sun, H; Lantuejoul, S; Filipits, M; Pirker, R; Popper, H; Mendiboure, J; Vataire, AL; Le Chevalier, T; Soria, JC; Brambilla, E; Dunant, A; Hainaut, P; IALT-Bio working group Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.
Mol Oncol. 2014; 8(3):555-564 [OPEN ACCESS]
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Riedl, S; Rinner, B; Schaider, H; Lohner, K; Zweytick, D Killing of melanoma cells and their metastases by human lactoferricin derivatives requires interaction with the cancer marker phosphatidylserine.
Biometals. 2014; 27(5):981-997 [OPEN ACCESS]
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2013

Bourgeois, B; Gilquin, B; Tellier-Lebègue, C; Östlund, C; Wu, W; Pérez, J; El Hage, P; Lallemand, F; Worman, HJ; Zinn-Justin, S Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.
Sci Signal. 2013; 6(280):ra49-ra49 [OPEN ACCESS]
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Goessweiner-Mohr, N; Grumet, L; Arends, K; Pavkov-Keller, T; Gruber, CC; Gruber, K; Birner-Gruenberger, R; Kropec-Huebner, A; Huebner, J; Grohmann, E; Keller, W The 2.5 Å structure of the enterococcus conjugation protein TraM resembles VirB8 type IV secretion proteins.
J Biol Chem. 2013; 288(3):2018-2028 [OPEN ACCESS]
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Herrero Acero, E; Ribitsch, D; Dellacher, A; Zitzenbacher, S; Marold, A; Steinkellner, G; Gruber, K; Schwab, H; Guebitz, GM Surface engineering of a cutinase from Thermobifida cellulosilytica for improved polyester hydrolysis.
Biotechnol Bioeng. 2013; 110(10):2581-2590
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Ho, JE; Chen, WY; Chen, MH; Larson, MG; McCabe, EL; Cheng, S; Ghorbani, A; Coglianese, E; Emilsson, V; Johnson, AD; Walter, S; Franceschini, N; O'Donnell, CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group; Dehghan, A; Lu, C; Levy, D; Newton-Cheh, C; CHARGE Heart Failure Working Group; Lin, H; Felix, JF; Schreiter, ER; Vasan, RS; Januzzi, JL; Lee, RT; Wang, TJ; Assimes, TL; Deloukas, P; Erdmann, J; Holm, H; Kathiresan, S; König, IR; McPherson, R; Reilly, MP; Roberts, R; Samani, NJ; Schunkert, H; Stewart, AF Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
J Clin Invest. 2013; 123(10): 4208-4218. [OPEN ACCESS]
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Hocking, HG; Zangger, K; Madl, T Studying the structure and dynamics of biomolecules by using soluble paramagnetic probes.
Chemphyschem. 2013; 14(13): 3082-3094. [OPEN ACCESS]
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Kueh, JT; Choi, KW; Williams, GM; Moehle, K; Bacsa, B; Robinson, JA; Brimble, MA Synthesis of a 6,6-spiroketal amino acid and its incorporation into a peptide turn sequence using solid-phase peptide synthesis.
Chemistry. 2013; 19(12): 3807-3811.
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Lemke, JR; Lal, D; Reinthaler, EM; Steiner, I; Nothnagel, M; Alber, M; Geider, K; Laube, B; Schwake, M; Finsterwalder, K; Franke, A; Schilhabel, M; Jähn, JA; Muhle, H; Boor, R; Van Paesschen, W; Caraballo, R; Fejerman, N; Weckhuysen, S; De Jonghe, P; Larsen, J; Møller, RS; Hjalgrim, H; Addis, L; Tang, S; Hughes, E; Pal, DK; Veri, K; Vaher, U; Talvik, T; Dimova, P; Guerrero López, R; Serratosa, JM; Linnankivi, T; Lehesjoki, AE; Ruf, S; Wolff, M; Buerki, S; Wohlrab, G; Kroell, J; Datta, AN; Fiedler, B; Kurlemann, G; Kluger, G; Hahn, A; Haberlandt, DE; Kutzer, C; Sperner, J; Becker, F; Weber, YG; Feucht, M; Steinböck, H; Neophythou, B; Ronen, GM; Gruber-Sedlmayr, U; Geldner, J; Harvey, RJ; Hoffmann, P; Herms, S; Altmüller, J; Toliat, MR; Thiele, H; Nürnberg, P; Wilhelm, C; Stephani, U; Helbig, I; Lerche, H; Zimprich, F; Neubauer, BA; Biskup, S; von Spiczak, S Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.
Nat Genet. 2013; 45(9):1067-1072
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Lichtenegger, M; Stockner, T; Poteser, M; Schleifer, H; Platzer, D; Romanin, C; Groschner, K A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.
Cell Calcium. 2013; 54(3):175-185 [OPEN ACCESS]
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Müller, R; Gräwert, MA; Kern, T; Madl, T; Peschek, J; Sattler, M; Groll, M; Buchner, J High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.
Proc Natl Acad Sci U S A. 2013; 110(25): 10183-10188. [OPEN ACCESS]
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Walte, A; Rüben, K; Birner-Gruenberger, R; Preisinger, C; Bamberg-Lemper, S; Hilz, N; Bracher, F; Becker, W Mechanism of dual specificity kinase activity of DYRK1A.
FEBS J. 2013; 280(18):4495-4511 [OPEN ACCESS]
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Zhang, Y; Madl, T; Bagdiul, I; Kern, T; Kang, HS; Zou, P; Mäusbacher, N; Sieber, SA; Krämer, A; Sattler, M Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.
Nucleic Acids Res. 2013; 41(2): 1343-1354. [OPEN ACCESS]
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2012

Bassler, J; Klein, I; Schmidt, C; Kallas, M; Thomson, E; Wagner, MA; Bradatsch, B; Rechberger, G; Strohmaier, H; Hurt, E; Bergler, H; The Conserved Bud20 Zinc Finger Protein Is a New Component of the Ribosomal 60S Subunit Export Machinery.
MOL CELL BIOL. 2012; 32(24): 4898-4912. [OPEN ACCESS]
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Damm, M; Nusshold, C; Cantillo, D; Rechberger, GN; Gruber, K; Sattler, W; Kappe, CO Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols.
J Proteomics. 2012; 75(18):5533-5543 [OPEN ACCESS]
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Khafaga, M; Bossuyt, J; Mamikonian, L; Li, JC; Lee, LL; Yarov-Yarovoy, V; Despa, S; Bers, DM Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction.
Proc Natl Acad Sci U S A. 2012; 109(50):20756-20761 [OPEN ACCESS]
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Kosol, S; Schrank, E; Krajačić, MB; Wagner, GE; Meyer, NH; Göbl, C; Rechberger, GN; Zangger, K; Novak, P Probing the interactions of macrolide antibiotics with membrane-mimetics by NMR spectroscopy.
J Med Chem. 2012; 55(11): 5632-5636. [OPEN ACCESS]
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Krone, N; Reisch, N; Idkowiak, J; Dhir, V; Ivison, HE; Hughes, BA; Rose, IT; O'Neil, DM; Vijzelaar, R; Smith, MJ; MacDonald, F; Cole, TR; Adolphs, N; Barton, JS; Blair, EM; Braddock, SR; Collins, F; Cragun, DL; Dattani, MT; Day, R; Dougan, S; Feist, M; Gottschalk, ME; Gregory, JW; Haim, M; Harrison, R; Olney, AH; Hauffa, BP; Hindmarsh, PC; Hopkin, RJ; Jira, PE; Kempers, M; Kerstens, MN; Khalifa, MM; Köhler, B; Maiter, D; Nielsen, S; O'Riordan, SM; Roth, CL; Shane, KP; Silink, M; Stikkelbroeck, NM; Sweeney, E; Szarras-Czapnik, M; Waterson, JR; Williamson, L; Hartmann, MF; Taylor, NF; Wudy, SA; Malunowicz, EM; Shackleton, CH; Arlt, W Genotype-phenotype analysis in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.
J Clin Endocrinol Metab. 2012; 97(2):E257-E267 [OPEN ACCESS]
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Kumari, M; Schoiswohl, G; Chitraju, C; Paar, M; Cornaciu, I; Rangrez, AY; Wongsiriroj, N; Nagy, HM; Ivanova, PT; Scott, SA; Knittelfelder, O; Rechberger, GN; Birner-Gruenberger, R; Eder, S; Brown, HA; Haemmerle, G; Oberer, M; Lass, A; Kershaw, EE; Zimmermann, R; Zechner, R Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
Cell Metab. 2012; 15(5):691-702 [OPEN ACCESS]
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Roessl, U; Wiesbauer, J; Leitgeb, S; Birner-Gruenberger, R; Nidetzky, B Non-native aggregation of recombinant human granulocyte-colony stimulating factor under simulated process stress conditions.
Biotechnol J. 2012; 7(8):1014-1024
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Sayers, EW; Barrett, T; Benson, DA; Bolton, E; Bryant, SH; Canese, K; Chetvernin, V; Church, DM; Dicuccio, M; Federhen, S; Feolo, M; Fingerman, IM; Geer, LY; Helmberg, W; Kapustin, Y; Krasnov, S; Landsman, D; Lipman, DJ; Lu, Z; Madden, TL; Madej, T; Maglott, DR; Marchler-Bauer, A; Miller, V; Karsch-Mizrachi, I; Ostell, J; Panchenko, A; Phan, L; Pruitt, KD; Schuler, GD; Sequeira, E; Sherry, ST; Shumway, M; Sirotkin, K; Slotta, D; Souvorov, A; Starchenko, G; Tatusova, TA; Wagner, L; Wang, Y; Wilbur, WJ; Yaschenko, E; Ye, J Database resources of the National Center for Biotechnology Information.
Nucleic Acids Res. 2012; 40(Database issue):D13-D25 [OPEN ACCESS]
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Unterweger, B; Stoisser, T; Leitgeb, S; Birner-Grünberger, R; Nidetzky, B Engineering of Aerococcus viridans L-lactate oxidase for site-specific PEGylation: characterization and selective bioorthogonal modification of a S218C mutant.
Bioconjug Chem. 2012; 23(7):1406-1414
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2011

Mackereth, CD; Madl, T; Bonnal, S; Simon, B; Zanier, K; Gasch, A; Rybin, V; Valcárcel, J; Sattler, M Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.
Nature. 2011; 475(7356): 408-411. [OPEN ACCESS]
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