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Publikationen

Suchbegriffe: MITOGEN-ACTIVATED PROTEIN KINASES - METABOLISM , . Treffer: 51

2019

Bravo, A; de Lucio, H; Sánchez-Murcia, PA; Jiménez-Ruiz, A; Petrone, PM; Gago, F; Cortés Cabrera, A Identification of NEK3 and MOK as novel targets for lithium.
Chem Biol Drug Des. 2019; 93(5):965-969 Doi: 10.1111/cbdd.13487
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2017

Boege, Y; Malehmir, M; Healy, ME; Bettermann, K; Lorentzen, A; Vucur, M; Ahuja, AK; Böhm, F; Mertens, JC; Shimizu, Y; Frick, L; Remouchamps, C; Mutreja, K; Kähne, T; Sundaravinayagam, D; Wolf, MJ; Rehrauer, H; Koppe, C; Speicher, T; Padrissa-Altés, S; Maire, R; Schattenberg, JM; Jeong, JS; Liu, L; Zwirner, S; Boger, R; Hüser, N; Davis, RJ; Müllhaupt, B; Moch, H; Schulze-Bergkamen, H; Clavien, PA; Werner, S; Borsig, L; Luther, SA; Jost, PJ; Weinlich, R; Unger, K; Behrens, A; Hillert, L; Dillon, C; Di Virgilio, M; Wallach, D; Dejardin, E; Zender, L; Naumann, M; Walczak, H; Green, DR; Lopes, M; Lavrik, I; Luedde, T; Heikenwalder, M; Weber, A A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer Cell. 2017; 32(3):342-359 Doi: 10.1016/j.ccell.2017.08.010 [OPEN ACCESS]
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Lin, S; Hoffmann, K; Gao, C; Petrulionis, M; Herr, I; Schemmer, P Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.
J PINEAL RES. 2017; 62(3): Doi: 10.1111/jpi.12398
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Vahdati Hassani, F; Mehri, S; Abnous, K; Birner-Gruenberger, R; Hosseinzadeh, H Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression.
Food Chem Toxicol. 2017; 107(Pt A):395-405 Doi: 10.1016/j.fct.2017.07.007
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2016

Koyani, CN; Kitz, K; Rossmann, C; Bernhart, E; Huber, E; Trummer, C; Windischhofer, W; Sattler, W; Malle, E Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
Biochem Pharmacol. 2016; 104:29-41 Doi: 10.1016/j.bcp.2016.01.011 [OPEN ACCESS]
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Đorđević, IO; Kukolj, T; Krstić, J; Trivanović, D; Obradović, H; Santibañez, JF; Mojsilović, S; Ilić, V; Bugarski, D; Jauković, A The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs.
Int J Biochem Cell Biol. 2016; 71(3): 92-101. Doi: 10.1016/j.biocel.2015.12.007
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Wang, JY; Chen, R; Chen, SP; Gao, YH; Zhang, JL; Feng, XM; Yan, Y; Liu, JL; Gaischek, I; Litscher, D; Wang, L; Lippe, IT; Litscher, G Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats.
Neural Plast. 2016; 2016(51):6521026-6521026 Doi: 10.1155/2016/6521026 [OPEN ACCESS]
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2015

Murali, R; Chandramohan, R; Möller, I; Scholz, SL; Berger, M; Huberman, K; Viale, A; Pirun, M; Socci, ND; Bouvier, N; Bauer, S; Artl, M; Schilling, B; Schimming, T; Sucker, A; Schwindenhammer, B; Grabellus, F; Speicher, MR; Schaller, J; Hillen, U; Schadendorf, D; Mentzel, T; Cheng, DT; Wiesner, T; Griewank, KG Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.
Oncotarget. 2015; 6(34):36041-36052 Doi: 10.18632/oncotarget.5936 [OPEN ACCESS]
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Zabini, D; Crnkovic, S; Xu, H; Tscherner, M; Ghanim, B; Klepetko, W; Olschewski, A; Kwapiszewska, G; Marsh, LM High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.
J Cell Mol Med. 2015; 19(5):1151-1161 Doi: 10.1111/jcmm.12519 [OPEN ACCESS]
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Zhao, Q; Assimopoulou, AN; Klauck, SM; Damianakos, H; Chinou, I; Kretschmer, N; Rios, JL; Papageorgiou, VP; Bauer, R; Efferth, T Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.
Oncotarget. 2015; 6(36):38934-38951 Doi: 10.18632/oncotarget.5380 [OPEN ACCESS]
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Zhao, Q; Kretschmer, N; Bauer, R; Efferth, T Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.
Int J Cancer. 2015; 137(6):1446-1456 Doi: 10.1002/ijc.29483 [OPEN ACCESS]
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2014

Biasin, V; Chwalek, K; Wilhelm, J; Best, J; Marsh, LM; Ghanim, B; Klepetko, W; Fink, L; Schermuly, RT; Weissmann, N; Olschewski, A; Kwapiszewska, G Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.
Int J Biochem Cell Biol. 2014; 54(3):137-148 Doi: 10.1016/j.biocel.2014.06.020
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Bösch, F; Thomas, M; Kogler, P; Oberhuber, R; Sucher, R; Aigner, F; Semsroth, S; Wiedemann, D; Yamashita, K; Troppmair, J; Kotsch, K; Pratschke, J; Öllinger, R Bilirubin rinse of the graft ameliorates ischemia reperfusion injury in heart transplantation.
Transpl Int. 2014; 27(5):504-13 Doi: 10.1111/tri.12278
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Goldinger, SM; Zimmer, L; Schulz, C; Ugurel, S; Hoeller, C; Kaehler, KC; Schadendorf, D; Hassel, JC; Becker, J; Hauschild, A; Dummer, R; Dermatology Cooperative Oncology Group (DeCOG) Upstream mitogen-activated protein kinase (MAPK) pathway inhibition: MEK inhibitor followed by a BRAF inhibitor in advanced melanoma patients.
Eur J Cancer. 2014; 50(2):406-410 Doi: 10.1016/j.ejca.2013.09.014
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2013

Kockskamper, A; von Lewinski, D; Zhu, D; Kockskamper, J; Khafaga, M; Schmidt, AG; Post, H; Pieske, B Relevance of stretch-induced phosphorylation of MAPK and p90rsk in human myocardium.
Front Biosci (Elite Ed). 2013; 5(6):883-892 Doi: 10.2741/E667
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2012

Fröhlich, JD; Huppertz, B; Abuja, PM; König, J; Desoye, G Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia.
Am J Pathol. 2012; 180(1): 153-164. Doi: 10.1016/j.ajpath.2011.09.012 [OPEN ACCESS]
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Wygrecka, M; Zakrzewicz, D; Taborski, B; Didiasova, M; Kwapiszewska, G; Preissner, KT; Markart, P TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner.
Am J Respir Cell Mol Biol. 2012; 47(5):614-627 Doi: 10.1165/rcmb.2012-0097OC
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2011

Alge-Priglinger, CS; André, S; Schoeffl, H; Kampik, A; Strauss, RW; Kernt, M; Gabius, HJ; Priglinger, SG Negative regulation of RPE cell attachment by carbohydrate-dependent cell surface binding of galectin-3 and inhibition of the ERK-MAPK pathway.
Biochimie. 2011; 93(3):477-488 Doi: 10.1016/j.biochi.2010.10.021
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Hoffmann, K; Shibo, L; Xiao, Z; Longerich, T; Büchler, MW; Schemmer, P Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.
Anticancer Res. 2011; 31(11):3883-3890
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Tucsek, Z; Radnai, B; Racz, B; Debreceni, B; Priber, JK; Dolowschiak, T; Palkovics, T; Gallyas, F; Sumegi, B; Veres, B Suppressing LPS-induced early signal transduction in macrophages by a polyphenol degradation product: a critical role of MKP-1.
J Leukoc Biol. 2011; 89(1):105-111 Doi: 10.1189/jlb.0610355 [OPEN ACCESS]
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2010

Gil, Z; Cavel, O; Kelly, K; Brader, P; Rein, A; Gao, SP; Carlson, DL; Shah, JP; Fong, Y; Wong, RJ Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves.
J Natl Cancer Inst. 2010; 102(2):107-118 Doi: 10.1093/jnci/djp456 [OPEN ACCESS]
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Missiou, A; Wolf, D; Platzer, I; Ernst, S; Walter, C; Rudolf, P; Zirlik, K; Köstlin, N; Willecke, FK; Münkel, C; Schönbeck, U; Libby, P; Bode, C; Varo, N; Zirlik, A CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease.
THROMB HAEMOSTASIS. 2010; 103(4): 788-796. Doi: 10.1160/TH09-07-0463
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Santibáñez, JF; Kocić, J; Fabra, A; Cano, A; Quintanilla, M Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes.
FEBS Lett. 2010; 584(11): 2305-2310. Doi: 10.1016/j.febslet.2010.03.042 [OPEN ACCESS]
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2009

Drozdov, I; Kidd, M; Gustafsson, BI; Svejda, B; Joseph, R; Pfragner, R; Modlin, IM Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines.
Cancer. 2009; 115(21): 4934-4945. Doi: 10.1002/cncr.24533 [OPEN ACCESS]
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Houben, R; Voigt, H; Noelke, C; Hofmeister, V; Becker, JC; Schrama, D MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib.
Mol Cancer Ther. 2009; 8(2):433-440 Doi: 10.1158/1535-7163.MCT-08-1051 [OPEN ACCESS]
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Liang, R; Nickkholgh, A; Hoffmann, K; Kern, M; Schneider, H; Sobirey, M; Zorn, M; Büchler, MW; Schemmer, P Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation.
J Pineal Res. 2009; 46(1):8-14 Doi: 10.1111/j.1600-079X.2008.00596.x
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2008

Cabanski, M; Steinmüller, M; Marsh, LM; Surdziel, E; Seeger, W; Lohmeyer, J PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.
Am J Respir Cell Mol Biol. 2008; 38(1): 26-31. Doi: 10.1165/rcmb.2007-0010OC
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Osto, E; Matter, CM; Kouroedov, A; Malinski, T; Bachschmid, M; Camici, GG; Kilic, U; Stallmach, T; Boren, J; Iliceto, S; Lüscher, TF; Cosentino, F c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress.
Circulation. 2008; 118(20):2073-80 Doi: 10.1161/CIRCULATIONAHA.108.765032
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2007

Berna, MJ; Hoffmann, KM; Tapia, JA; Thill, M; Pace, A; Mantey, SA; Jensen, RT CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways.
Biochim Biophys Acta. 2007; 1773(4): 483-501. Doi: 10.1016/j.bbamcr.2006.12.008 [OPEN ACCESS]
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Hasselblatt, P; Rath, M; Kominenovic, V; Zatloukal, K; Wagner, EF Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.
Proc Natl Acad Sci U S A. 2007; 104(43):17105-17110 Doi: 10.1073/pnas.0706272104 [OPEN ACCESS]
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2006

Krejsgaard, T; Vetter-Kauczok, CS; Woetmann, A; Lovato, P; Labuda, T; Eriksen, KW; Zhang, Q; Becker, JC; Odum, N Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.
Leukemia. 2006; 20(10):1759-1766 Doi: 10.1038/sj.leu.2404350 [OPEN ACCESS]
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2005

Andres, RH; Ducray, AD; Huber, AW; Pérez-Bouza, A; Krebs, SH; Schlattner, U; Seiler, RW; Wallimann, T; Widmer, HR Effects of creatine treatment on survival and differentiation of GABA-ergic neurons in cultured striatal tissue.
J Neurochem. 2005; 95(1):33-45 Doi: 10.1111/j.1471-4159.2005.03337.x
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Kipmen-Korgun, D; Osibow, K; Zoratti, C; Schraml, E; Greilberger, J; Kostner, GM; Jürgens, G; Graier, WF T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca(2+)-tyrosine kinase-Erk1/2 pathway.
J CARDIOVASC PHARMACOL. 2005; 45(5): 418-430. Doi: 10.1097/01.fjc.0000157458.91433.86 [OPEN ACCESS]
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2004

Geigl, JB; Langer, S; Barwisch, S; Pfleghaar, K; Lederer, G; Speicher, MR Analysis of gene expression patterns and chromosomal changes associated with aging.
Cancer Res. 2004; 64(23):8550-8557 Doi: 10.1158/0008-5472.CAN-04-2151 [OPEN ACCESS]
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Staber, PB; Linkesch, W; Zauner, D; Beham-Schmid, C; Guelly, C; Schauer, S; Sill, H; Hoefler, G Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia.
Oncogene. 2004; 23(4):894-904 Doi: 10.1038/sj.onc.1207192 [OPEN ACCESS]
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Veres, B; Radnai, B; Gallyas, F; Varbiro, G; Berente, Z; Osz, E; Sumegi, B Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice.
J Pharmacol Exp Ther. 2004; 310(1): 247-255. Doi: 10.1124/jpet.104.065151
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2003

Egger, T; Schuligoi, R; Wintersperger, A; Amann, R; Malle, E; Sattler, W Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia.
BIOCHEM J 2003 370: 459-467. Doi: 10.1042/BJ20021358 [OPEN ACCESS]
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Köller, MD; Kiener, HP; Aringer, M; Graninger, WB; Meuer, S; Samstag, Y; Smolen, JS Functional and molecular aspects of transient T cell unresponsiveness: role of selective interleukin-2 deficiency.
Clin Exp Immunol. 2003; 132(2):225-231 Doi: 10.1046/j.1365-2249.2003.02150.x [OPEN ACCESS]
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2002

Bochkov, VN; Mechtcheriakova, D; Lucerna, M; Huber, J; Malli, R; Graier, WF; Hofer, E; Binder, BR; Leitinger, N Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.
Blood. 2002; 99(1):199-206 Doi: 10.1182/blood.V99.1.199 [OPEN ACCESS]
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Klinger, M; Kudlacek, O; Seidel, MG; Freissmuth, M; Sexl, V MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases.
J Biol Chem. 2002; 277(36):32490-32497 Doi: 10.1074/jbc.M200556200 [OPEN ACCESS]
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Maly, K; Strese, K; Kampfer, S; Ueberall, F; Baier, G; Ghaffari-Tabrizi, N; Grunicke, HH; Leitges, M Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1.
FEBS Lett. 2002; 521(1-3):205-210 Doi: 10.1016/S0014-5793(02)02867-3
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Stringaris, AK; Geisenhainer, J; Bergmann, F; Balshüsemann, C; Lee, U; Zysk, G; Mitchell, TJ; Keller, BU; Kuhnt, U; Gerber, J; Spreer, A; Bähr, M; Michel, U; Nau, R Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase.
Neurobiol Dis. 2002; 11(3):355-368 Doi: 10.1006/nbdi.2002.0561 [OPEN ACCESS]
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Waldhoer, M; Kledal, TN; Farrell, H; Schwartz, TW Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities.
J Virol. 2002; 76(16):8161-8168 Doi: 10.1128/JVI.76.16.8161-8168.2002 [OPEN ACCESS]
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Windischhofer, W; Zach, D; Fauler, G; Raspotnig, G; Köfeler, H; Leis, HJ Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells.
J Bone Miner Res. 2002; 17(10):1774-1784 Doi: 10.1359/jbmr.2002.17.10.1774 [OPEN ACCESS]
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2001

Gekle, M; Freudinger, R; Mildenberger, S; Schenk, K; Marschitz, I; Schramek, H Rapid activation of Na+/H+-exchange in MDCK cells by aldosterone involves MAP-kinase ERK1/2.
Pflugers Arch. 2001; 441(6):781-786 Doi: 10.1007/s004240000507
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Li, G; Schaider, H; Satyamoorthy, K; Hanakawa, Y; Hashimoto, K; Herlyn, M Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development.
Oncogene. 2001; 20(56):8125-8135 Doi: 10.1038/sj.onc.1205034 [OPEN ACCESS]
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Mikula, M; Schreiber, M; Husak, Z; Kucerova, L; Rüth, J; Wieser, R; Zatloukal, K; Beug, H; Wagner, EF; Baccarini, M Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene.
EMBO J. 2001; 20(8):1952-1962 Doi: 10.1093/emboj/20.8.1952 [OPEN ACCESS]
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2000

Bauer, B; Krumböck, N; Ghaffari-Tabrizi, N; Kampfer, S; Villunger, A; Wilda, M; Hameister, H; Utermann, G; Leitges, M; Uberall, F; Baier, G T cell expressed PKCtheta demonstrates cell-type selective function.
Eur J Immunol. 2000; 30(12):3645-3654 Doi: 10.1002/1521-4141(200012)30:12<3645::AID-IMMU3645>3.0.CO;2-#
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Behrends, M; Schulz, R; Post, H; Alexandrov, A; Belosjorow, S; Michel, MC; Heusch, G Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs.
Am J Physiol Heart Circ Physiol. 2000; 279(3):H1111-H1119 Doi: 10.1152/ajpheart.2000.279.3.H1111 [OPEN ACCESS]
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Pausawasdi, N; Ramamoorthy, S; Stepan, V; del Valle, J; Todisco, A Regulation and function of p38 protein kinase in isolated canine gastric parietal cells.
Am J Physiol Gastrointest Liver Physiol. 2000; 278(1):G24-G31 Doi: 10.1152/ajpgi.2000.278.1.G24 [OPEN ACCESS]
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