Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: MICE, TRANSGENIC - , . Treffer: 125

2018

Zandl-Lang, M; Fanaee-Danesh, E; Sun, Y; Albrecher, NM; Gali, CC; Čančar, I; Kober, A; Tam-Amersdorfer, C; Stracke, A; Storck, SM; Saeed, A; Stefulj, J; Pietrzik, CU; Wilson, MR; Björkhem, I; Panzenboeck, U Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(1):40-60
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2017

Dobsak, T; Heimel, P; Tangl, S; Schwarze, UY; Schett, G; Gruber, R Impaired periodontium and temporomandibular joints in tumour necrosis factor-α transgenic mice.
J Clin Periodontol. 2017; 44(12):1226-1235
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Rodriguez Camargo, DC; Tripsianes, K; Buday, K; Franko, A; Göbl, C; Hartlmüller, C; Sarkar, R; Aichler, M; Mettenleiter, G; Schulz, M; Böddrich, A; Erck, C; Martens, H; Walch, AK; Madl, T; Wanker, EE; Conrad, M; de Angelis, MH; Reif, B The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
SCI REP-UK. 2017; 7(6): 44041-44041. [OPEN ACCESS]
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Taniguchi, K; Moroishi, T; de Jong, PR; Krawczyk, M; Grebbin, BM; Luo, H; Xu, RH; Golob-Schwarzl, N; Schweiger, C; Wang, K; Di Caro, G; Feng, Y; Fearon, ER; Raz, E; Kenner, L; Farin, HF; Guan, KL; Haybaeck, J; Datz, C; Zhang, K; Karin, M YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.
Proc Natl Acad Sci U S A. 2017; 114(7):1643-1648 [OPEN ACCESS]
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2016

Busch, SE; Hanke, ML; Kargl, J; Metz, HE; MacPherson, D; Houghton, AM Lung Cancer Subtypes Generate Unique Immune Responses.
J Immunol. 2016; 197(11):4493-4503 [OPEN ACCESS]
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Grün, NG; Zeyda, K; Moreno-Viedma, V; Strohmeier, K; Staffler, G; Zeyda, M; Stulnig, TM A humanized osteopontin mouse model and its application in immunometabolic obesity studies.
Transl Res. 2016; 178(10):63-73
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Jeric, I; Maurer, G; Cavallo, AL; Raguz, J; Desideri, E; Tarkowski, B; Parrini, M; Fischer, I; Zatloukal, K; Baccarini, M A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nat Commun. 2016; 7(12):13781-13781 [OPEN ACCESS]
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Nawata, A; Noguchi, H; Mazaki, Y; Kurahashi, T; Izumi, H; Wang, KY; Guo, X; Uramoto, H; Kohno, K; Taniguchi, H; Tanaka, Y; Fujii, J; Sasaguri, Y; Tanimoto, A; Nakayama, T; Yamada, S Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
PLoS One. 2016; 11(4):e0152549-e0152549 [OPEN ACCESS]
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Sigl, V; Owusu-Boaitey, K; Joshi, PA; Kavirayani, A; Wirnsberger, G; Novatchkova, M; Kozieradzki, I; Schramek, D; Edokobi, N; Hersl, J; Sampson, A; Odai-Afotey, A; Lazaro, C; Gonzalez-Suarez, E; Pujana, MA; Cimba, F; Heyn, H; Vidal, E; Cruickshank, J; Berman, H; Sarao, R; Ticevic, M; Uribesalgo, I; Tortola, L; Rao, S; Tan, Y; Pfeiler, G; Lee, EY; Bago-Horvath, Z; Kenner, L; Popper, H; Singer, C; Khokha, R; Jones, LP; Penninger, JM RANKL/RANK control Brca1 mutation- .
Cell Res. 2016; 26(7):761-774 [OPEN ACCESS]
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Tang, Y; Fickert, P; Trauner, M; Marcus, N; Blomenkamp, K; Teckman, J Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.
Am J Physiol Gastrointest Liver Physiol. 2016; 311(1):G156-G165 [OPEN ACCESS]
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Themanns, M; Mueller, KM; Kessler, SM; Golob-Schwarzl, N; Mohr, T; Kaltenecker, D; Bourgeais, J; Paier-Pourani, J; Friedbichler, K; Schneller, D; Schlederer, M; Zebedin-Brandl, E; Terracciano, LM; Han, X; Kenner, L; Wagner, KU; Mikulits, W; Kozlov, AV; Heim, MH; Gouilleux, F; Haybaeck, J; Moriggl, R Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.
Sci Rep. 2016; 6(4):34719-34719 [OPEN ACCESS]
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Trierweiler, C; Hockenjos, B; Zatloukal, K; Thimme, R; Blum, HE; Wagner, EF; Hasselblatt, P The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.
Cell Death Differ. 2016; 23(4):576-582 [OPEN ACCESS]
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Wallner, M; Duran, JM; Mohsin, S; Troupes, CD; Vanhoutte, D; Borghetti, G; Vagnozzi, RJ; Gross, P; Yu, D; Trappanese, DM; Kubo, H; Toib, A; Sharp, TE; Harper, SC; Volkert, MA; Starosta, T; Feldsott, EA; Berretta, RM; Wang, T; Barbe, MF; Molkentin, JD; Houser, SR Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.
Circ Res. 2016; 119(7):865-879 [OPEN ACCESS]
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2015

Doleschal, B; Primessnig, U; Wölkart, G; Wolf, S; Schernthaner, M; Lichtenegger, M; Glasnov, TN; Kappe, CO; Mayer, B; Antoons, G; Heinzel, F; Poteser, M; Groschner, K TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.
Cardiovasc Res. 2015; 106(1):163-173 [OPEN ACCESS]
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Heier, C; Radner, FP; Moustafa, T; Schreiber, R; Grond, S; Eichmann, TO; Schweiger, M; Schmidt, A; Cerk, IK; Oberer, M; Theussl, HC; Wojciechowski, J; Penninger, JM; Zimmermann, R; Zechner, R G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.
J Biol Chem. 2015; 290(43):26141-26150 [OPEN ACCESS]
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Imperatore, R; Morello, G; Luongo, L; Taschler, U; Romano, R; De Gregorio, D; Belardo, C; Maione, S; Di Marzo, V; Cristino, L Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior.
J Neurochem. 2015; 135(4):799-813 [OPEN ACCESS]
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Jaeger, D; Schoiswohl, G; Hofer, P; Schreiber, R; Schweiger, M; Eichmann, TO; Pollak, NM; Poecher, N; Grabner, GF; Zierler, KA; Eder, S; Kolb, D; Radner, FP; Preiss-Landl, K; Lass, A; Zechner, R; Kershaw, EE; Haemmerle, G Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
J Hepatol. 2015; 63(2):437-445 [OPEN ACCESS]
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Kessler, SM; Laggai, S; Barghash, A; Schultheiss, CS; Lederer, E; Artl, M; Helms, V; Haybaeck, J; Kiemer, AK IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.
Cell Death Dis. 2015; 6(1):e1894-e1894 [OPEN ACCESS]
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Krassnig, S; Schweinzer, C; Taub, N; Havas, D; Auer, E; Flunkert, S; Schreibmayer, W; Hutter-Paier, B; Windisch, M Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.
Neurodegener Dis. 2015; 15(4):243-257
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Mayer, SC; Gilsbach, R; Preissl, S; Monroy Ordonez, EB; Schnick, T; Beetz, N; Lother, A; Rommel, C; Ihle, H; Bugger, H; Rühle, F; Schrepper, A; Schwarzer, M; Heilmann, C; Bönisch, U; Gupta, SK; Wilpert, J; Kretz, O; von Elverfeldt, D; Orth, J; Aktories, K; Beyersdorf, F; Bode, C; Stiller, B; Krüger, M; Thum, T; Doenst, T; Stoll, M; Hein, L Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.
Circ Res. 2015; 117(7): 622-633. [OPEN ACCESS]
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Nardone, R; Höller, Y; Tezzon, F; Christova, M; Schwenker, K; Golaszewski, S; Trinka, E; Brigo, F Neurostimulation in Alzheimer's disease: from basic research to clinical applications.
Neurol Sci. 2015; 36(5):689-700
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Ortega, M; Bhatnagar, H; Lin, AP; Wang, L; Aster, JC; Sill, H; Aguiar, RC A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies.
Leukemia. 2015; 29(4):968-976 [OPEN ACCESS]
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Schweintzger, NA; Bambach, I; Reginato, E; Mayer, G; Limón-Flores, AY; Ullrich, SE; Byrne, SN; Wolf, P Mast cells are required for phototolerance induction and scratching abatement.
Exp Dermatol. 2015; 24(7):491-496
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Szabo, S; Wögenstein, KL; Österreicher, CH; Guldiken, N; Chen, Y; Doler, C; Wiche, G; Boor, P; Haybaeck, J; Strnad, P; Fuchs, P Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.
J Hepatol. 2015; 62(6):1357-1366 [OPEN ACCESS]
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2014

Almer, G; Summers, KL; Scheicher, B; Kellner, J; Stelzer, I; Leitinger, G; Gries, A; Prassl, R; Zimmer, A; Mangge, H Interleukin 10-coated nanoparticle systems compared for molecular imaging of atherosclerotic lesions.
Int J Nanomedicine. 2014; 9(10):4211-4222 [OPEN ACCESS]
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Brahma, MK; Adam, RC; Pollak, NM; Jaeger, D; Zierler, KA; Pöcher, N; Schreiber, R; Romauch, M; Moustafa, T; Eder, S; Ruelicke, T; Preiss-Landl, K; Lass, A; Zechner, R; Haemmerle, G Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis.
J Lipid Res. 2014; 55(11):2229-2241 [OPEN ACCESS]
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D'Cruz, LM; Stradner, MH; Yang, CY; Goldrath, AW E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
J Immunol. 2014; 192(5):2227-2236 [OPEN ACCESS]
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Goeritzer, M; Schlager, S; Radovic, B; Madreiter, CT; Rainer, S; Thomas, G; Lord, CC; Sacks, J; Brown, AL; Vujic, N; Obrowsky, S; Sachdev, V; Kolb, D; Chandak, PG; Graier, WF; Sattler, W; Brown, JM; Kratky, D Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
J Lipid Res. 2014; 55(12):2562-2575 [OPEN ACCESS]
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Laggai, S; Kessler, SM; Boettcher, S; Lebrun, V; Gemperlein, K; Lederer, E; Leclercq, IA; Mueller, R; Hartmann, RW; Haybaeck, J; Kiemer, AK The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis.
J Lipid Res. 2014; 55(6):1087-1097 [OPEN ACCESS]
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Lanaya, H; Natarajan, A; Komposch, K; Li, L; Amberg, N; Chen, L; Wculek, SK; Hammer, M; Zenz, R; Peck-Radosavljevic, M; Sieghart, W; Trauner, M; Wang, H; Sibilia, M EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Nat Cell Biol. 2014; 16(10): 1- 7. [OPEN ACCESS]
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Lebrun-Julien, F; Bachmann, L; Norrmén, C; Trötzmüller, M; Köfeler, H; Rüegg, MA; Hall, MN; Suter, U Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.
J NEUROSCI. 2014; 34(25): 8432-8448. [OPEN ACCESS]
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Löffler, T; Flunkert, S; Havas, D; Schweinzer, C; Uger, M; Windisch, M; Steyrer, E; Hutter-Paier, B Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer's disease.
J Neuroinflammation. 2014; 11(7):84-84 [OPEN ACCESS]
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Maraschi, A; Ciammola, A; Folci, A; Sassone, F; Ronzitti, G; Cappelletti, G; Silani, V; Sato, S; Hattori, N; Mazzanti, M; Chieregatti, E; Mulle, C; Passafaro, M; Sassone, J Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Nat Commun. 2014; 5(3):5182-5182 [OPEN ACCESS]
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Miething, C; Scuoppo, C; Bosbach, B; Appelmann, I; Nakitandwe, J; Ma, J; Wu, G; Lintault, L; Auer, M; Premsrirut, PK; Teruya-Feldstein, J; Hicks, J; Benveniste, H; Speicher, MR; Downing, JR; Lowe, SW PTEN action in leukaemia dictated by the tissue microenvironment.
Nature. 2014; 510(7505):402-406 [OPEN ACCESS]
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Simon, Y; Kessler, SM; Gemperlein, K; Bohle, RM; Müller, R; Haybaeck, J; Kiemer, AK Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.
World J Gastroenterol. 2014; 20(47):17839-17850 [OPEN ACCESS]
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Zatloukal, B; Kufferath, I; Thueringer, A; Landegren, U; Zatloukal, K; Haybaeck, J Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.
PLoS One. 2014; 9(5):e96690-e96690 [OPEN ACCESS]
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2013

Bito, V; Biesmans, L; Gellen, B; Antoons, G; Macquaide, N; Rouet-Benzineb, P; Pezet, M; Mercadier, JJ; Sipido, KR FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.
Exp Physiol. 2013; 98(1):134-148 [OPEN ACCESS]
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Eißmann, M; Melzer, IM; Fernández, SB; Michel, G; Hrabě de Angelis, M; Hoefler, G; Finkenwirth, P; Jauch, A; Schoell, B; Grez, M; Schmidt, M; Bartholomae, CC; Newrzela, S; Haetscher, N; Rieger, MA; Zachskorn, C; Mittelbronn, M; Zörnig, M Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
Oncogene. 2013; 32(20):2586-2591
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Flunkert, S; Hierzer, M; Löffler, T; Rabl, R; Neddens, J; Duller, S; Schofield, EL; Ward, MA; Posch, M; Jungwirth, H; Windisch, M; Hutter-Paier, B Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Neurodegener Dis. 2013; 11(4):194-205
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Gautier, T; de Haan, W; Grober, J; Ye, D; Bahr, MJ; Claudel, T; Nijstad, N; Van Berkel, TJ; Havekes, LM; Manns, MP; Willems, SM; Hogendoorn, PC; Lagrost, L; Kuipers, F; Van Eck, M; Rensen, PC; Tietge, UJ Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice.
J Lipid Res. 2013; 54(8):2195-2205 [OPEN ACCESS]
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Hofrichter, J; Krohn, M; Schumacher, T; Lange, C; Feistel, B; Walbroel, B; Heinze, HJ; Crockett, S; Sharbel, TF; Pahnke, J Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
Curr Alzheimer Res. 2013; 10(10):1057-1069 [OPEN ACCESS]
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Kollmann, K; Heller, G; Schneckenleithner, C; Warsch, W; Scheicher, R; Ott, RG; Schäfer, M; Fajmann, S; Schlederer, M; Schiefer, AI; Reichart, U; Mayerhofer, M; Hoeller, C; Zöchbauer-Müller, S; Kerjaschki, D; Bock, C; Kenner, L; Hoefler, G; Freissmuth, M; Green, AR; Moriggl, R; Busslinger, M; Malumbres, M; Sexl, V A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.
Cancer Cell. 2013; 24(2):167-181 [OPEN ACCESS]
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Löffler, T; Flunkert, S; Havas, D; Sántha, M; Hutter-Paier, B; Steyrer, E; Windisch, M Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice.
Neurobiol Aging. 2013; 34(10):2379-2388
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Oberhofer, M; Tian, Q; Ruppenthal, S; Wegener, S; Reil, JC; Körbel, C; Hammer, K; Menger, M; Neuberger, HR; Kaestner, L; Lipp, P Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1.
Cell Calcium. 2013; 54(1):26-36
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Park, SH; Chen, WC; Hoffman, C; Marsh, LM; West, J; Grunig, G Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene.
PLoS One. 2013; 8(1): e55180-e55180. [OPEN ACCESS]
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Pollak, NM; Schweiger, M; Jaeger, D; Kolb, D; Kumari, M; Schreiber, R; Kolleritsch, S; Markolin, P; Grabner, GF; Heier, C; Zierler, KA; Rülicke, T; Zimmermann, R; Lass, A; Zechner, R; Haemmerle, G Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
J Lipid Res. 2013; 54(4):1092-1102 [OPEN ACCESS]
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Pozo, K; Castro-Rivera, E; Tan, C; Plattner, F; Schwach, G; Siegl, V; Meyer, D; Guo, A; Gundara, J; Mettlach, G; Richer, E; Guevara, JA; Ning, L; Gupta, A; Hao, G; Tsai, LH; Sun, X; Antich, P; Sidhu, S; Robinson, BG; Chen, H; Nwariaku, FE; Pfragner, R; Richardson, JA; Bibb, JA The role of Cdk5 in neuroendocrine thyroid cancer.
Cancer Cell. 2013; 24(4):499-511 [OPEN ACCESS]
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Singer, G; Stokes, KY; Neil Granger, D Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction.
Inflamm Res. 2013; 62(2):155-164 [OPEN ACCESS]
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Singh, TP; Schön, MP; Wallbrecht, K; Gruber-Wackernagel, A; Wang, XJ; Wolf, P Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis.
PLoS One. 2013; 8(1):e51752-e51752 [OPEN ACCESS]
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Valko, PO; Gavrilov, YV; Yamamoto, M; Reddy, H; Haybaeck, J; Mignot, E; Baumann, CR; Scammell, TE Increase of histaminergic tuberomammillary neurons in narcolepsy.
Ann Neurol. 2013; 74(6):794-804
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