Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: LIVER NEOPLASMS - GENETICS , . Treffer: 47

2022

Olthof, PB; Buettner, S; Andreatos, N; Wang, J; Løes, IM; Wagner, D; Sasaki, K; Macher-Beer, A; Kamphues, C; Pozios, I; Seeliger, H; Morioka, D; Imai, K; Kaczirek, K; Pawlik, TM; Poultsides, G; Burkhart, R; Endo, I; Baba, H; Kornprat, P; Aucejo, FN; Lønning, PE; Beyer, K; Weiss, MJ; Wolfgang, CL; Kreis, ME; Margonis, GA KRAS alterations in colorectal liver metastases: shifting to exon, codon, and point mutations.
BRIT J SURG. 2022; 109(9): 804-807. Doi: 10.1093/bjs/znac147 [OPEN ACCESS]
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2020

Sladky, VC; Knapp, K; Szabo, TG; Braun, VZ; Bongiovanni, L; van den Bos, H; Spierings, DC; Westendorp, B; Curinha, A; Stojakovic, T; Scharnagl, H; Timelthaler, G; Tsuchia, K; Pinter, M; Semmler, G; Foijer, F; de Bruin, A; Reiberger, T; Rohr-Udilova, N; Villunger, A PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
EMBO Rep. 2020; 21(12):e50893-e50893 Doi: 10.15252/embr.202050893 [OPEN ACCESS]
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Stickel, F; Lutz, P; Buch, S; Nischalke, HD; Silva, I; Rausch, V; Fischer, J; Weiss, KH; Gotthardt, D; Rosendahl, J; Marot, A; Elamly, M; Krawczyk, M; Casper, M; Lammert, F; Buckley, TWM; McQuillin, A; Spengler, U; Eyer, F; Vogel, A; Marhenke, S; von Felden, J; Wege, H; Sharma, R; Atkinson, S; Franke, A; Nehring, S; Moser, V; Schafmayer, C; Spahr, L; Lackner, C; Stauber, RE; Canbay, A; Link, A; Valenti, L; Grove, JI; Aithal, GP; Marquardt, JU; Fateen, W; Zopf, S; Dufour, JF; Trebicka, J; Datz, C; Deltenre, P; Mueller, S; Berg, T; Hampe, J; Morgan, MY Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers.
Hepatology. 2020; 72(1):88-102 Doi: 10.1002/hep.30996 [OPEN ACCESS]
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2018

Deshwar, A; Margonis, GA; Andreatos, N; Barbon, C; Wang, J; Buettner, S; Wagner, D; Sasaki, K; Beer, A; Løes, IM; Pikoulis, E; Damaskos, C; Garmpis, N; Kamphues, K; He, J; Kaczirek, K; Poultsides, G; Lønning, PE; Mischinger, HJ; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ Double KRAS and BRAF Mutations in Surgically Treated Colorectal Cancer Liver Metastases: An International, Multi-institutional Case Series.
Anticancer Res. 2018; 38(5):2891-2895 Doi: 10.21873/anticanres.12535 (- Case Report) [OPEN ACCESS]
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Li, M; Su, Y; Zhang, F; Chen, K; Xu, X; Xu, L; Zhou, J; Wang, W A dual-targeting reconstituted high density lipoprotein leveraging the synergy of sorafenib and antimiRNA21 for enhanced hepatocellular carcinoma therapy.
Acta Biomater. 2018; 75(10):413-426 Doi: 10.1016/j.actbio.2018.05.049
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2017

Cătană, CS; Pichler, M; Giannelli, G; Mader, RM; Berindan-Neagoe, I Non-coding RNAs, the Trojan horse in two-way communication between tumor and stroma in colorectal and hepatocellular carcinoma.
Oncotarget. 2017; 8(17):29519-29534 Doi: 10.18632/oncotarget.15706 [OPEN ACCESS]
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Margonis, GA; Sasaki, K; Andreatos, N; Kim, Y; Merath, K; Wagner, D; Wilson, A; Buettner, S; Amini, N; Antoniou, E; Pawlik, TM KRAS Mutation Status Dictates Optimal Surgical Margin Width in Patients Undergoing Resection of Colorectal Liver Metastases.
Ann Surg Oncol. 2017; 24(1): 264-271. Doi: 10.1245/s10434-016-5609-1
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Nelson, ME; Lahiri, S; Chow, JD; Byrne, FL; Hargett, SR; Breen, DS; Olzomer, EM; Wu, LE; Cooney, GJ; Turner, N; James, DE; Slack-Davis, JK; Lackner, C; Caldwell, SH; Hoehn, KL Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nat Commun. 2017; 8(6):14689-14689 Doi: 10.1038/ncomms14689 [OPEN ACCESS]
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Richtig, G; Aigelsreiter, A; Schwarzenbacher, D; Ress, AL; Adiprasito, JB; Stiegelbauer, V; Hoefler, G; Schauer, S; Kiesslich, T; Kornprat, P; Winder, T; Eisner, F; Gerger, A; Stoeger, H; Stauber, R; Lackner, C; Pichler, M SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
PLoS One. 2017; 12(11):e0187814-e0187814 Doi: 10.1371/journal.pone.0187814 [OPEN ACCESS]
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2016

Jeric, I; Maurer, G; Cavallo, AL; Raguz, J; Desideri, E; Tarkowski, B; Parrini, M; Fischer, I; Zatloukal, K; Baccarini, M A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nat Commun. 2016; 7(12):13781-13781 Doi: 10.1038/ncomms13781 [OPEN ACCESS]
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Miller, HC; Frampton, AE; Malczewska, A; Ottaviani, S; Stronach, EA; Flora, R; Kaemmerer, D; Schwach, G; Pfragner, R; Faiz, O; Kos-Kudła, B; Hanna, GB; Stebbing, J; Castellano, L; Frilling, A MicroRNAs associated with small bowel neuroendocrine tumours and their metastases.
Endocr Relat Cancer. 2016; 23(9):711-726 Doi: 10.1530/ERC-16-0044 [OPEN ACCESS]
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Trierweiler, C; Hockenjos, B; Zatloukal, K; Thimme, R; Blum, HE; Wagner, EF; Hasselblatt, P The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.
Cell Death Differ. 2016; 23(4):576-582 Doi: 10.1038/cdd.2015.121 [OPEN ACCESS]
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2015

Elgohary, N; Pellegrino, R; Neumann, O; Elzawahry, HM; Saber, MM; Zeeneldin, AA; Geffers, R; Ehemann, V; Schemmer, P; Schirmacher, P; Longerich, T Protumorigenic role of Timeless in hepatocellular carcinoma.
Int J Oncol. 2015; 46(2):597-606 Doi: 10.3892/ijo.2014.2751 [OPEN ACCESS]
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Kaczirek, K; Ciuleanu, TE; Vrbanec, D; Marton, E; Messinger, D; Liegl-Atzwanger, B; Wrba, F; Knittelfelder, R; Lindner, E; Zielinski, CC; Streubel, B; Brodowicz, T FOLFOX4 Plus Cetuximab for Patients With Previously Untreated Metastatic Colorectal Cancer According to Tumor RAS and BRAF Mutation Status: Updated Analysis of the CECOG/CORE 1.2.002 Study.
Clin Colorectal Cancer. 2015; 14(2):91-98 Doi: 10.1016/j.clcc.2014.12.003
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2014

Bruns, H; Petrulionis, M; Schultze, D; Al Saeedi, M; Lin, S; Yamanaka, K; Ambrazevičius, M; Strupas, K; Schemmer, P Glycine inhibits angiogenic signaling in human hepatocellular carcinoma cells.
Amino Acids. 2014; 46(4):969-976 Doi: 10.1007/s00726-013-1662-2
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Friedrich, K; Wannhoff, A; Kattner, S; Brune, M; Hov, JR; Weiss, KH; Antoni, C; Dollinger, M; Neumann-Haefelin, C; Seufferlein, T; Schemmer, P; Schirmacher, P; Stremmel, W; Gotthardt, DN PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival.
J Gastroenterol Hepatol. 2014; 29(7):1477-1484 Doi: 10.1111/jgh.12540
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Herz, C; Hertrampf, A; Zimmermann, S; Stetter, N; Wagner, M; Kleinhans, C; Erlacher, M; Schüler, J; Platz, S; Rohn, S; Mersch-Sundermann, V; Lamy, E The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC.
J Cell Mol Med. 2014; 18(12): 2393-2403. Doi: 10.1111/jcmm.12412 [OPEN ACCESS]
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Lanaya, H; Natarajan, A; Komposch, K; Li, L; Amberg, N; Chen, L; Wculek, SK; Hammer, M; Zenz, R; Peck-Radosavljevic, M; Sieghart, W; Trauner, M; Wang, H; Sibilia, M EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Nat Cell Biol. 2014; 16(10): 1- 7. Doi: 10.1038/ncb3031 [OPEN ACCESS]
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Welte, S; Urbanik, T; Elßner, C; Kautz, N; Koehler, BC; Waldburger, N; Bermejo, JL; Pinna, F; Weiss, KH; Schemmer, P; Jaeger, D; Longerich, T; Breuhahn, K; Schulze-Bergkamen, H Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma.
PLoS One. 2014; 9(10):e110591-e110591 Doi: 10.1371/journal.pone.0110591 [OPEN ACCESS]
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2013

Giovinazzo, F; Schimmack, S; Svejda, B; Alaimo, D; Pfragner, R; Modlin, I; Kidd, M Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation.
PLoS One. 2013; 8(11):e81111-e81111 Doi: 10.1371/journal.pone.0081111 [OPEN ACCESS]
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2012

Aigelsreiter, A; Haybaeck, J; Schauer, S; Kiesslich, T; Bettermann, K; Griessbacher, A; Stojakovic, T; Bauernhofer, T; Samonigg, H; Kornprat, P; Lackner, C; Pichler, M NEMO expression in human hepatocellular carcinoma and its association with clinical outcome.
Hum Pathol. 2012; 43(7):1012-1019 Doi: 10.1016/j.humpath.2011.08.009
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Bernhardt, GA; Zollner, G; Cerwenka, H; Kornprat, P; Fickert, P; Bacher, H; Werkgartner, G; Müller, G; Zatloukal, K; Mischinger, HJ; Trauner, M Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy.
Liver Int. 2012; 32(1):119-127 Doi: 10.1111/j.1478-3231.2011.02625.x
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Gilg, MM; Mrak, K; Vieth, M; Langner, C Granular cell tumor of the stomach.
Pathologe. 2012; 33(1):61-64 Doi: 10.1007/s00292-011-1547-7 (- Case Report)
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Min, L; Ji, Y; Bakiri, L; Qiu, Z; Cen, J; Chen, X; Chen, L; Scheuch, H; Zheng, H; Qin, L; Zatloukal, K; Hui, L; Wagner, EF Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.
Nat Cell Biol. 2012; 14(11):1203-1211 Doi: 10.1038/ncb2590
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Neumann, O; Kesselmeier, M; Geffers, R; Pellegrino, R; Radlwimmer, B; Hoffmann, K; Ehemann, V; Schemmer, P; Schirmacher, P; Lorenzo Bermejo, J; Longerich, T Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors.
Hepatology. 2012; 56(5):1817-1827 Doi: 10.1002/hep.25870 [OPEN ACCESS]
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Radnai, B; Antus, C; Racz, B; Engelmann, P; Priber, JK; Tucsek, Z; Veres, B; Turi, Z; Lorand, T; Sumegi, B; Gallyas, F Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Mol Cancer. 2012; 11(5): 34-34. Doi: 10.1186/1476-4598-11-34 [OPEN ACCESS]
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Rinner, B; Gallè, B; Trajanoski, S; Fischer, C; Hatz, M; Maierhofer, T; Michelitsch, G; Moinfar, F; Stelzer, I; Pfragner, R; Guelly, C Molecular evidence for the bi-clonal origin of neuroendocrine tumor derived metastases.
BMC Genomics. 2012; 13(6):594-594 Doi: 10.1186/1471-2164-13-594 [OPEN ACCESS]
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2011

Haybaeck, J; Zeller, N; Heikenwalder, M The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.
SWISS MED WKLY. 2011; 141(4): w13287-w13287. Doi: 10.4414/smw.2011.13287 [OPEN ACCESS]
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Hoffmann, K; Shibo, L; Xiao, Z; Longerich, T; Büchler, MW; Schemmer, P Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.
Anticancer Res. 2011; 31(11):3883-3890
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2010

Hoffmann, K; Franz, C; Xiao, Z; Mohr, E; Serba, S; Büchler, MW; Schemmer, P Sorafenib modulates the gene expression of multi-drug resistance mediating ATP-binding cassette proteins in experimental hepatocellular carcinoma.
Anticancer Res. 2010; 30(11):4503-4508
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Tomuleasa, C; Soritau, O; Rus-Ciuca, D; Pop, T; Todea, D; Mosteanu, O; Pintea, B; Foris, V; Susman, S; Kacsó, G; Irimie, A Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma.
J Gastrointestin Liver Dis. 2010; 19(1):61-67 [OPEN ACCESS]
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Vernadakis, S; Poetsch, M; Weber, F; Treckmann, J; Mathe, Z; Baba, HA; Paul, A; Kaiser, GM Donor origin de novo HCC in a noncirrhotic liver allograft 3 years after liver transplantation.
Transpl Int. 2010; 23(3):341-343 Doi: 10.1111/j.1432-2277.2009.00942.x (- Case Report)
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2009

Aigelsreiter, A; Janig, E; Sostaric, J; Pichler, M; Unterthor, D; Halasz, J; Lackner, C; Zatloukal, K; Denk, H Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis.
Histopathology. 2009; 54(5): 561-570. Doi: 10.1111/j.1365-2559.2009.03258.x
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Haybaeck, J; Zeller, N; Wolf, MJ; Weber, A; Wagner, U; Kurrer, MO; Bremer, J; Iezzi, G; Graf, R; Clavien, PA; Thimme, R; Blum, H; Nedospasov, SA; Zatloukal, K; Ramzan, M; Ciesek, S; Pietschmann, T; Marche, PN; Karin, M; Kopf, M; Browning, JL; Aguzzi, A; Heikenwalder, M A lymphotoxin-driven pathway to hepatocellular carcinoma.
CANCER CELL. 2009; 16(4): 295-308. Doi: 10.1016/j.ccr.2009.08.021 [OPEN ACCESS]
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Kashofer, K; Tschernatsch, MM; Mischinger, HJ; Iberer, F; Zatloukal, K The disease relevance of human hepatocellular xenograft models: molecular characterization and review of the literature.
Cancer Lett. 2009; 286(1):121-128 Doi: 10.1016/j.canlet.2008.11.011
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Mischek, D; Steinborn, R; Petznek, H; Bichler, C; Zatloukal, K; Stürzl, M; Günzburg, WH; Hohenadl, C Molecularly characterised xenograft tumour mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers.
J Biomed Biotechnol. 2009; 2009(5): 437284-437284. Doi: 10.1155/2009/437284 [OPEN ACCESS]
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2008

Trauner, M; Fickert, P; Halilbasic, E; Moustafa, T Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases.
Wien Med Wochenschr. 2008; 158(19-20):542-548 Doi: 10.1007/s10354-008-0592-1
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2007

Brader, P; Riedl, CC; Woo, Y; Ponomarev, V; Zanzonico, P; Wen, B; Cai, S; Hricak, H; Fong, Y; Blasberg, R; Serganova, I Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model.
Mol Cancer Ther. 2007; 6(11):2900-2908 Doi: 10.1158/1535-7163.MCT-07-0432 [OPEN ACCESS]
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Panzitt, K; Tschernatsch, MM; Guelly, C; Moustafa, T; Stradner, M; Strohmaier, HM; Buck, CR; Denk, H; Schroeder, R; Trauner, M; Zatloukal, K Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.
Gastroenterology. 2007; 132(1):330-342 Doi: 10.1053/j.gastro.2006.08.026
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2004

Oberkofler, H; Schraml, E; Krempler, F; Patsch, W Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha.
Biochem J. 2004; 381(Pt 2): 357-363. Doi: 10.1042/BJ20040173 [OPEN ACCESS]
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Schachtrup, C; Emmler, T; Bleck, B; Sandqvist, A; Spener, F Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.
Biochem J. 2004; 382(Pt 1):239-245 Doi: 10.1042/BJ20031340 [OPEN ACCESS]
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Schrem, H; Klempnauer, J; Borlak, J Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation.
Pharmacol Rev. 2004; 56(2): 291-330. Doi: 10.1124/pr.56.2.5
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2003

Streubel, B; Lamprecht, A; Dierlamm, J; Cerroni, L; Stolte, M; Ott, G; Raderer, M; Chott, A T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.
Blood. 2003; 101(6):2335-2339 Doi: 10.1182/blood-2002-09-2963 (- Case Report) [OPEN ACCESS]
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Terracciano, LM; Bernasconi, B; Ruck, P; Stallmach, T; Briner, J; Sauter, G; Moch, H; Vecchione, R; Pollice, L; Pettinato, G; Gürtl, B; Ratschek, M; De Krijger, R; Tornillo, L; Bruder, E Comparative genomic hybridization analysis of hepatoblastoma reveals high frequency of X-chromosome gains and similarities between epithelial and stromal components.
Hum Pathol. 2003; 34(9): 864-871. Doi: 10.1016/S0046-8177(03)00351-4
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1996

Hrascan, R; Pavelic, K; Pavicic, D; Krizanac, S; Stajcer-Sittic, V; Pecur, L; Spaventi, S; Klimpfinger, M; Pavelic, J Concomitant point mutation of tumor suppressor gene p53 and oncogene c-N-ras in malignant neuroendocrine pancreatic tumor.
Anticancer Res. 1996; 16(6B):3761-3766 (- Case Report)
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1995

Kubicka, S; Trautwein, C; Schrem, H; Tillmann, H; Manns, M Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event.
J Hepatol. 1995; 23(4):412-419 Doi: 10.1016/0168-8278(95)80199-5
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1991

Chen, GL; Balfe, A; Erwa, W; Hoefler, G; Gaertner, J; Aikawa, J; Chen, WW Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro.
Biochem Biophys Res Commun. 1991; 178(3):1084-1091 Doi: 10.1016/0006-291X(91)91003-U
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