Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: LIVER - DRUG EFFECTS , . Treffer: 120

2018

Fuchs, CD; Paumgartner, G; Mlitz, V; Kunczer, V; Halilbasic, E; Leditznig, N; Wahlström, A; Ståhlman, M; Thüringer, A; Kashofer, K; Stojakovic, T; Marschall, HU; Trauner, M Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2-/- mice by modulating composition, signalling and excretion of faecal bile acids.
Gut. 2018; 67(9):1683-1691 [OPEN ACCESS]
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Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 [OPEN ACCESS]
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Ramirez, T; Strigun, A; Verlohner, A; Huener, HA; Peter, E; Herold, M; Bordag, N; Mellert, W; Walk, T; Spitzer, M; Jiang, X; Sperber, S; Hofmann, T; Hartung, T; Kamp, H; van Ravenzwaay, B Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Arch Toxicol. 2018; 92(2): 893-906. [OPEN ACCESS]
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Tang, Y; Blomenkamp, KS; Fickert, P; Trauner, M; Teckman, JH NorUDCA promotes degradation of α1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway.
PLoS One. 2018; 13(8):e0200897-e0200897 [OPEN ACCESS]
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2017

Baar, MP; Brandt, RMC; Putavet, DA; Klein, JDD; Derks, KWJ; Bourgeois, BRM; Stryeck, S; Rijksen, Y; van Willigenburg, H; Feijtel, DA; van der Pluijm, I; Essers, J; van Cappellen, WA; van IJcken, WF; Houtsmuller, AB; Pothof, J; de Bruin, RWF; Madl, T; Hoeijmakers, JHJ; Campisi, J; de Keizer, PLJ Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell. 2017; 169(1):132-147 [OPEN ACCESS]
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Fuchs, CD; Claudel, T; Scharnagl, H; Stojakovic, T; Trauner, M FXR controls CHOP expression in steatohepatitis.
FEBS Lett. 2017; 591(20):3360-3368 [OPEN ACCESS]
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Katanić, J; Matić, S; Pferschy-Wenzig, EM; Kretschmer, N; Boroja, T; Mihailović, V; Stanković, V; Stanković, N; Mladenović, M; Stanić, S; Mihailović, M; Bauer, R Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
Food Chem Toxicol. 2017; 99(2):86-102
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Lindquist, C; Bjørndal, B; Rossmann, CR; Tusubira, D; Svardal, A; Røsland, GV; Tronstad, KJ; Hallström, S; Berge, RK Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats.
J Lipid Res. 2017; 58(7):1362-1373 [OPEN ACCESS]
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Melvin, AJ; Warshaw, M; Compagnucci, A; Saidi, Y; Harrison, L; Turkova, A; Tudor-Williams, G; Tudor-Williams, G Hepatic, Renal, Hematologic, and Inflammatory Markers in HIV-Infected Children on Long-term Suppressive Antiretroviral Therapy.
J Pediatric Infect Dis Soc. 2017; 6(3):e109-e115-e109-e115 [OPEN ACCESS]
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Nelson, ME; Lahiri, S; Chow, JD; Byrne, FL; Hargett, SR; Breen, DS; Olzomer, EM; Wu, LE; Cooney, GJ; Turner, N; James, DE; Slack-Davis, JK; Lackner, C; Caldwell, SH; Hoehn, KL Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nat Commun. 2017; 8(6):14689-14689 [OPEN ACCESS]
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Vahdati Hassani, F; Mehri, S; Abnous, K; Birner-Gruenberger, R; Hosseinzadeh, H Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression.
Food Chem Toxicol. 2017; 107(Pt A):395-405
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2016

Baghdasaryan, A; Fuchs, CD; Österreicher, CH; Lemberger, UJ; Halilbasic, E; Påhlman, I; Graffner, H; Krones, E; Fickert, P; Wahlström, A; Ståhlman, M; Paumgartner, G; Marschall, HU; Trauner, M Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.
J Hepatol. 2016; 64(3):674-681 [OPEN ACCESS]
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Scharinger, B; Messner, B; Türkcan, A; Schuster, D; Vuorinen, A; Pitterl, F; Heinz, K; Arnhard, K; Laufer, G; Grimm, M; Stuppner, H; Oberacher, H; Eller, P; Ritsch, A; Bernhard, D Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.
J Mol Cell Cardiol. 2016; 99(7):35-46 [OPEN ACCESS]
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Tang, Y; Fickert, P; Trauner, M; Marcus, N; Blomenkamp, K; Teckman, J Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.
Am J Physiol Gastrointest Liver Physiol. 2016; 311(1):G156-G165 [OPEN ACCESS]
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2015

Argo, CK; Patrie, JT; Lackner, C; Henry, TD; de Lange, EE; Weltman, AL; Shah, NL; Al-Osaimi, AM; Pramoonjago, P; Jayakumar, S; Binder, LP; Simmons-Egolf, WD; Burks, SG; Bao, Y; Taylor, AG; Rodriguez, J; Caldwell, SH Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial.
J Hepatol. 2015; 62(1):190-197 [OPEN ACCESS]
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Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359 [OPEN ACCESS]
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Healy, ME; Chow, JD; Byrne, FL; Breen, DS; Leitinger, N; Li, C; Lackner, C; Caldwell, SH; Hoehn, KL Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.
J Hepatol. 2015; 62(3):599-606 [OPEN ACCESS]
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Kremer, M; Manzini, G; Hristov, B; Polychronidis, G; Mokry, T; Sommer, CM; Mehrabi, A; Weitz, J; Büchler, MW; Schemmer, P Impact of Neoadjuvant Chemotherapy on Hypertrophy of the Future Liver Remnant after Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy.
J Am Coll Surg. 2015; 221(3):717-728
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Mueller, M; Thorell, A; Claudel, T; Jha, P; Koefeler, H; Lackner, C; Hoesel, B; Fauler, G; Stojakovic, T; Einarsson, C; Marschall, HU; Trauner, M Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.
J Hepatol. 2015; 62(6):1398-1404 [OPEN ACCESS]
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Neve, EP; Köfeler, H; Hendriks, DF; Nordling, Å; Gogvadze, V; Mkrtchian, S; Näslund, E; Ingelman-Sundberg, M Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.
PLoS One. 2015; 10(9):e0138487-e0138487 [OPEN ACCESS]
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2014

Demetz, E; Schroll, A; Auer, K; Heim, C; Patsch, JR; Eller, P; Theurl, M; Theurl, I; Theurl, M; Seifert, M; Lener, D; Stanzl, U; Haschka, D; Asshoff, M; Dichtl, S; Nairz, M; Huber, E; Stadlinger, M; Moschen, AR; Li, X; Pallweber, P; Scharnagl, H; Stojakovic, T; März, W; Kleber, ME; Garlaschelli, K; Uboldi, P; Catapano, AL; Stellaard, F; Rudling, M; Kuba, K; Imai, Y; Arita, M; Schuetz, JD; Pramstaller, PP; Tietge, UJF; Trauner, M; Norata, GD; Claudel, T; Hicks, AA; Weiss, G; Tancevski, I The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.
Cell Metab. 2014; 20(5):787-798 [OPEN ACCESS]
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Hoffmann, KM; Grabowski, M; Rödl, S; Deutschmann, A; Schwantzer, G; Sovinz, P; Strenger, V; Urban, C; Muntean, W; Hauer, AC Short-term intravenous fish-oil emulsions in pediatric oncologic patients--effect on liver parameters.
Nutr Cancer. 2014; 66(6):1070-1076
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2013

Doddapattar, P; Radović, B; Patankar, JV; Obrowsky, S; Jandl, K; Nusshold, C; Kolb, D; Vujić, N; Doshi, L; Chandak, PG; Goeritzer, M; Ahammer, H; Hoefler, G; Sattler, W; Kratky, D Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Mol Nutr Food Res. 2013; 57(10):1718-1728 [OPEN ACCESS]
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Fuchs, C; Claudel, T; Trauner, M Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342
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Huang, J; Das, SK; Jha, P; Al Zoughbi, W; Schauer, S; Claudel, T; Sexl, V; Vesely, P; Birner-Gruenberger, R; Kratky, D; Trauner, M; Hoefler, G The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.
Biochim Biophys Acta. 2013; 1831(10):1555-1565 [OPEN ACCESS]
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Lu, J; Roth, RA; Malle, E; Ganey, PE Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide.
Toxicol Sci. 2013; 136(1):51-62 [OPEN ACCESS]
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Nikam, A; Patankar, JV; Lackner, C; Schöck, E; Kratky, D; Zatloukal, K; Abuja, PM Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.
PLoS One. 2013; 8(6):e66094-e66094 [OPEN ACCESS]
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Sikiric, P; Seiwerth, S; Rucman, R; Turkovic, B; Rokotov, DS; Brcic, L; Sever, M; Klicek, R; Radic, B; Drmic, D; Ilic, S; Kolenc, D; Aralica, G; Safic, H; Suran, J; Rak, D; Dzidic, S; Vrcic, H; Sebecic, B Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157.
Curr Pharm Des. 2013; 19(1): 76-83.
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2012

Chennamsetty, I; Kostner, KM; Claudel, T; Vinod, M; Frank, S; Weiss, TS; Trauner, M; Kostner, GM Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.
J Lipid Res. 2012; 53(11):2405-2412 [OPEN ACCESS]
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Haybaeck, J; Stumptner, C; Thueringer, A; Kolbe, T; Magin, TM; Hesse, M; Fickert, P; Tsybrovskyy, O; Müller, H; Trauner, M; Zatloukal, K; Denk, H Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.
Lab Invest. 2012; 92(6):857-867 [OPEN ACCESS]
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Kumari, M; Schoiswohl, G; Chitraju, C; Paar, M; Cornaciu, I; Rangrez, AY; Wongsiriroj, N; Nagy, HM; Ivanova, PT; Scott, SA; Knittelfelder, O; Rechberger, GN; Birner-Gruenberger, R; Eder, S; Brown, HA; Haemmerle, G; Oberer, M; Lass, A; Kershaw, EE; Zimmermann, R; Zechner, R Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
Cell Metab. 2012; 15(5):691-702 [OPEN ACCESS]
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Marschall, HU; Wagner, M; Zollner, G; Fickert, P; Silbert, D; Gustafsson, U; Sahlin, S; Trauner, M Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans.
Digestion. 2012; 86(3):244-249
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Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151
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Padma, VV; Lalitha, G; Shirony, NP; Baskaran, R Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats.
Asian Pac J Trop Biomed. 2012; 2(11):910-915 [OPEN ACCESS]
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Silbernagel, G; Kovarova, M; Cegan, A; Machann, J; Schick, F; Lehmann, R; Häring, HU; Stefan, N; Schleicher, E; Fritsche, A; Peter, A High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet.
J Clin Endocrinol Metab. 2012; 97(12):E2288-E2292 [OPEN ACCESS]
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2011

Décombaz, J; Jentjens, R; Ith, M; Scheurer, E; Buehler, T; Jeukendrup, A; Boesch, C Fructose and galactose enhance postexercise human liver glycogen synthesis.
Med Sci Sports Exerc. 2011; 43(10):1964-1971
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Hoffmann, K; Büchler, MW; Schemmer, P Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation--where do we stand today?
Clin Nutr. 2011; 30(2):143-147
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Ilic, S; Drmic, D; Zarkovic, K; Kolenc, D; Brcic, L; Radic, B; Djuzel, V; Blagaic, AB; Romic, Z; Dzidic, S; Kalogjera, L; Seiwerth, S; Sikiric, P Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats.
Eur J Pharmacol. 2011; 667(1-3): 322-329.
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Liang, R; Nickkholgh, A; Kern, M; Schneider, H; Benzing, S; Zorn, M; Büchler, MW; Schemmer, P Green tea extract ameliorates reperfusion injury to rat livers after warm ischemia in a dose-dependent manner.
Mol Nutr Food Res. 2011; 55(6):855-863
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Mikalauskas, S; Mikalauskiene, L; Bruns, H; Nickkholgh, A; Hoffmann, K; Longerich, T; Strupas, K; Büchler, MW; Schemmer, P Dietary glycine protects from chemotherapy-induced hepatotoxicity.
Amino Acids. 2011; 40(4):1139-1150
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Riegler, B; Besenboeck, C; Bauer, R; Nimpf, J; Schneider, WJ Enzymes involved in hepatic acylglycerol metabolism in the chicken.
Biochem Biophys Res Commun. 2011; 406(2): 257-261.
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Silbernagel, G; Machann, J; Unmuth, S; Schick, F; Stefan, N; Häring, HU; Fritsche, A Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial.
Br J Nutr. 2011; 106(1):79-86 [OPEN ACCESS]
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Tancevski, I; Demetz, E; Eller, P Sobetirome: a selective thyromimetic for the treatment of dyslipidemia.
Recent Pat Cardiovasc Drug Discov. 2011; 6(1):16-19
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2010

Denk, GU; Maitz, S; Wimmer, R; Rust, C; Invernizzi, P; Ferdinandusse, S; Kulik, W; Fuchsbichler, A; Fickert, P; Trauner, M; Hofmann, AF; Beuers, U Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
Hepatology. 2010; 52(5): 1758-1768. [OPEN ACCESS]
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Mair, M; Zollner, G; Schneller, D; Musteanu, M; Fickert, P; Gumhold, J; Schuster, C; Fuchsbichler, A; Bilban, M; Tauber, S; Esterbauer, H; Kenner, L; Poli, V; Blaas, L; Kornfeld, JW; Casanova, E; Mikulits, W; Trauner, M; Eferl, R Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis.
Gastroenterology. 2010; 138(7):2499-2508
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Morgan, RE; Trauner, M; van Staden, CJ; Lee, PH; Ramachandran, B; Eschenberg, M; Afshari, CA; Qualls, CW; Lightfoot-Dunn, R; Hamadeh, HK Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Toxicol Sci. 2010; 118(2):485-500 [OPEN ACCESS]
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Radovic, B; Hussong, R; Gerhäuser, C; Meinl, W; Frank, N; Becker, H; Köhrle, J Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism.
Mol Nutr Food Res. 2010; 54 Suppl 2(8): S225-S235.
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Tancevski, I; Demetz, E; Eller, P; Duwensee, K; Hoefer, J; Heim, C; Stanzl, U; Wehinger, A; Auer, K; Karer, R; Huber, J; Schgoer, W; Van Eck, M; Vanhoutte, J; Fievet, C; Stellaard, F; Rudling, M; Patsch, JR; Ritsch, A The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice.
PLoS One. 2010; 5(1):e8722-e8722 [OPEN ACCESS]
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Vucur, M; Roderburg, C; Bettermann, K; Tacke, F; Heikenwalder, M; Trautwein, C; Luedde, T Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?
Oncotarget. 2010; 1(5):373-378 [OPEN ACCESS]
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Wagner, D; Kniepeiss, D; Schaffellner, S; Jakoby, E; Mueller, H; Fahrleitner-Pammer, A; Tscheliessnigg, KH; Iberer, F Sirolimus has a potential to influent viral recurrence in HCV positive liver transplant candidates.
Int Immunopharmacol. 2010; 10(8): 990-993.
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