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Publikationen

Suchbegriffe: LIPASE - GENETICS , . Treffer: 67

2021

Buch, S; Sharma, A; Ryan, E; Datz, C; Griffiths, WJH; Way, M; Buckley, TWM; Ryan, JD; Stewart, S; Wright, C; Dongiovanni, P; Fracanzani, A; Zwerina, J; Merle, U; Weiss, KH; Aigner, E; Krones, E; Dejaco, C; Fischer, J; Berg, T; Valenti, L; Zoller, H; McQuillin, A; Hampe, J; Stickel, F; Morgan, MY Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.
Aliment Pharmacol Ther. 2021; 53(7):830-843 Doi: 10.1111/apt.16252
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Tünnemann-Tarr, A; Scharnagl, H; Katzmann, JL; Stürzebecher, P; Laufs, U Familial chylomicronemia syndrome due to a heterozygous deletion of the chromosome 8 treated with the apoCIII inhibitor volanesorsen: A case report.
Medicine (Baltimore). 2021; 100(42):e27573 Doi: 10.1097/MD.0000000000027573 (- Case Report) [OPEN ACCESS]
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2019

Ramms, B; Patel, S; Nora, C; Pessentheiner, AR; Chang, MW; Green, CR; Golden, GJ; Secrest, P; Krauss, RM; Metallo, CM; Benner, C; Alexander, VJ; Witztum, JL; Tsimikas, S; Esko, JD; Gordts, PLSM ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.
J Lipid Res. 2019; 60(8): 1379-1395. Doi: 10.1194/jlr.M093740 [OPEN ACCESS]
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2018

Graffmann, N; Bohndorf, M; Ncube, A; Wruck, W; Kashofer, K; Zatloukal, K; Adjaye, J Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype.
Stem Cell Res. 2018; 31(4):131-134 Doi: 10.1016/j.scr.2018.07.011 (- Case Report) [OPEN ACCESS]
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2017

Riederer, M; Lechleitner, M; Köfeler, H; Frank, S Reduced expression of adipose triglyceride lipase decreases arachidonic acid release and prostacyclin secretion in human aortic endothelial cells.
Arch Physiol Biochem. 2017; 123(4):249-253 Doi: 10.1080/13813455.2017.1309052 [OPEN ACCESS]
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Schreiber, R; Diwoky, C; Schoiswohl, G; Feiler, U; Wongsiriroj, N; Abdellatif, M; Kolb, D; Hoeks, J; Kershaw, EE; Sedej, S; Schrauwen, P; Haemmerle, G; Zechner, R Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.
Cell Metab. 2017; 26(5):753-763 Doi: 10.1016/j.cmet.2017.09.004 [OPEN ACCESS]
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2016

Al-Zoughbi, W; Pichler, M; Gorkiewicz, G; Guertl-Lackner, B; Haybaeck, J; Jahn, SW; Lackner, C; Liegl-Atzwanger, B; Popper, H; Schauer, S; Nusshold, E; Kindt, AS; Trajanoski, Z; Speicher, MR; Haemmerle, G; Zimmermann, R; Zechner, R; Vesely, PW; Hoefler, G Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
Oncotarget. 2016; 7(23):33832-33840 Doi: 10.18632/oncotarget.9418 [OPEN ACCESS]
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Argo, CK; Ikura, Y; Lackner, C; Caldwell, SH The fat droplet in hepatocellular ballooning and implications for scoring nonalcoholic steatohepatitis therapeutic response.
Hepatology. 2016; 63(3):1056-1057 Doi: 10.1002/hep.28009 [OPEN ACCESS]
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Biundo, A; Hromic, A; Pavkov-Keller, T; Gruber, K; Quartinello, F; Haernvall, K; Perz, V; Arrell, MS; Zinn, M; Ribitsch, D; Guebitz, GM Characterization of a poly(butylene adipate-co-terephthalate)- hydrolyzing lipase from Pelosinus fermentans.
Appl Microbiol Biotechnol. 2016; 100(4): 1753-1764. Doi: 10.1007/s00253-015-7031-1 [OPEN ACCESS]
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Klein, I; Klug, L; Schmidt, C; Zandl, M; Korber, M; Daum, G; Athenstaedt, K Regulation of the yeast triacylglycerol lipases Tgl4p and Tgl5p by the presence/absence of nonpolar lipids.
Mol Biol Cell. 2016; 27(13):2014-2024 Doi: 10.1091/mbc.E15-09-0633 [OPEN ACCESS]
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2015

Boeszoermenyi, A; Nagy, HM; Arthanari, H; Pillip, CJ; Lindermuth, H; Luna, RE; Wagner, G; Zechner, R; Zangger, K; Oberer, M Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring.
J Biol Chem. 2015; 290(44):26361-26372 Doi: 10.1074/jbc.M115.682203 [OPEN ACCESS]
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Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 Doi: 10.1016/j.bbalip.2015.06.005 [OPEN ACCESS]
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Hofer, P; Boeszoermenyi, A; Jaeger, D; Feiler, U; Arthanari, H; Mayer, N; Zehender, F; Rechberger, G; Oberer, M; Zimmermann, R; Lass, A; Haemmerle, G; Breinbauer, R; Zechner, R; Preiss-Landl, K Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling.
J Biol Chem. 2015; 290(30):18438-18453 Doi: 10.1074/jbc.M114.628958 [OPEN ACCESS]
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Kassner, U; Salewsky, B; Wühle-Demuth, M; Szijarto, IA; Grenkowitz, T; Binner, P; März, W; Steinhagen-Thiessen, E; Demuth, I Severe hypertriglyceridemia in a patient heterozygous for a lipoprotein lipase gene allele with two novel missense variants.
Eur J Hum Genet. 2015; 23(9):1259-1261 Doi: 10.1038/ejhg.2014.295 (- Case Report) [OPEN ACCESS]
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Mandorfer, M; Payer, BA; Schwabl, P; Steiner, S; Ferlitsch, A; Aichelburg, MC; Stättermayer, AF; Ferenci, P; Obermayer-Pietsch, B; Grabmeier-Pfistershammer, K; Trauner, M; Peck-Radosavljevic, M; Reiberger, T Revisiting liver disease progression in HIV/HCV-coinfected patients: the influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3.
Liver Int. 2015; 35(3):876-885 Doi: 10.1111/liv.12615
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Mangge, H; Baumgartner, B; Schnedl, W Letter: PNPLA3, metabolic syndrome and NAFLD status in obese subjects--authors' reply.
Aliment Pharmacol Ther. 2015; 42(5):630-631 Doi: 10.1111/apt.13318 [OPEN ACCESS]
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Mangge, H; Baumgartner, BG; Zelzer, S; Prüller, F; Schnedl, WJ; Reininghaus, EZ; Haybaeck, J; Lackner, C; Stauber, R; Aigner, E; Weghuber, D Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.
Aliment Pharmacol Ther. 2015; 42(1):99-105 Doi: 10.1111/apt.13232 [OPEN ACCESS]
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Schreiber, R; Hofer, P; Taschler, U; Voshol, PJ; Rechberger, GN; Kotzbeck, P; Jaeger, D; Preiss-Landl, K; Lord, CC; Brown, JM; Haemmerle, G; Zimmermann, R; Vidal-Puig, A; Zechner, R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Proc Natl Acad Sci U S A. 2015; 112(45):13850-13855 Doi: 10.1073/pnas.1516004112 [OPEN ACCESS]
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Stättermayer, AF; Traussnigg, S; Dienes, HP; Aigner, E; Stauber, R; Lackner, K; Hofer, H; Stift, J; Wrba, F; Stadlmayr, A; Datz, C; Strasser, M; Maieron, A; Trauner, M; Ferenci, P Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations.
J Hepatol. 2015; 63(1):156-163 Doi: 10.1016/j.jhep.2015.01.034
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Wruck, W; Kashofer, K; Rehman, S; Daskalaki, A; Berg, D; Gralka, E; Jozefczuk, J; Drews, K; Pandey, V; Regenbrecht, C; Wierling, C; Turano, P; Korf, U; Zatloukal, K; Lehrach, H; Westerhoff, HV; Adjaye, J Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes.
Sci Data. 2015; 2(S 01):150068-150068 Doi: 10.1038/sdata.2015.68 [OPEN ACCESS]
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2014

Dichlberger, A; Schlager, S; Maaninka, K; Schneider, WJ; Kovanen, PT Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.
J Lipid Res. 2014; 55(12):2471-2478 Doi: 10.1194/jlr.M048553 [OPEN ACCESS]
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Friedrich, K; Wannhoff, A; Kattner, S; Brune, M; Hov, JR; Weiss, KH; Antoni, C; Dollinger, M; Neumann-Haefelin, C; Seufferlein, T; Schemmer, P; Schirmacher, P; Stremmel, W; Gotthardt, DN PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival.
J Gastroenterol Hepatol. 2014; 29(7):1477-1484 Doi: 10.1111/jgh.12540
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Fuchs, CD; Claudel, T; Trauner, M Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.
Trends Endocrinol Metab. 2014; 25(11):576-585 Doi: 10.1016/j.tem.2014.08.001
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Goeritzer, M; Schlager, S; Radovic, B; Madreiter, CT; Rainer, S; Thomas, G; Lord, CC; Sacks, J; Brown, AL; Vujic, N; Obrowsky, S; Sachdev, V; Kolb, D; Chandak, PG; Graier, WF; Sattler, W; Brown, JM; Kratky, D Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
J Lipid Res. 2014; 55(12):2562-2575 Doi: 10.1194/jlr.M052613 [OPEN ACCESS]
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Jha, P; Claudel, T; Baghdasaryan, A; Mueller, M; Halilbasic, E; Das, SK; Lass, A; Zimmermann, R; Zechner, R; Hoefler, G; Trauner, M Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
Hepatology. 2014; 59(3):858-869 Doi: 10.1002/hep.26732 [OPEN ACCESS]
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Karimi, E; Karkhane, AA; Yakhchali, B; Shamsara, M; Aminzadeh, S; Torktaz, I; Hosseini, M; Safari, Z Study of the effect of F17A mutation on characteristics of Bacillus thermocatenulatus lipase expressed in Pichia pastoris using in silico and experimental methods.
Biotechnol Appl Biochem. 2014; 61(3): 264-273. Doi: 10.1002/bab.1164
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Nagy, HM; Paar, M; Heier, C; Moustafa, T; Hofer, P; Haemmerle, G; Lass, A; Zechner, R; Oberer, M; Zimmermann, R Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A.
Biochim Biophys Acta. 2014; 1841(4):588-594 Doi: 10.1016/j.bbalip.2014.01.005 [OPEN ACCESS]
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Schrammel, A; Mussbacher, M; Wölkart, G; Stessel, H; Pail, K; Winkler, S; Schweiger, M; Haemmerle, G; Al Zoughbi, W; Höfler, G; Lametschwandtner, A; Zechner, R; Mayer, B Endothelial dysfunction in adipose triglyceride lipase deficiency.
Biochim Biophys Acta. 2014; 1841(6):906-917 Doi: 10.1016/j.bbalip.2014.03.005 [OPEN ACCESS]
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2013

Finkenstedt, A; Auer, C; Glodny, B; Posch, U; Steitzer, H; Lanzer, G; Pratschke, J; Biebl, M; Steurer, M; Graziadei, I; Vogel, W; Zoller, H Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis.
Clin Gastroenterol Hepatol. 2013; 11(12):1667-1672 Doi: 10.1016/j.cgh.2013.06.025
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Friedrich, K; Rupp, C; Hov, JR; Steinebrunner, N; Weiss, KH; Stiehl, A; Brune, M; Schaefer, PK; Schemmer, P; Sauer, P; Schirmacher, P; Runz, H; Karlsen, TH; Stremmel, W; Gotthardt, DN A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis.
PLoS One. 2013; 8(3):e58734-e58734 Doi: 10.1371/journal.pone.0058734 [OPEN ACCESS]
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Hosseini, M; Karkhane, AA; Yakhchali, B; Shamsara, M; Aminzadeh, S; Morshedi, D; Haghbeen, K; Torktaz, I; Karimi, E; Safari, Z In silico and experimental characterization of chimeric Bacillus thermocatenulatus lipase with the complete conserved pentapeptide of Candida rugosa lipase.
Appl Biochem Biotechnol. 2013; 169(3): 773-785. Doi: 10.1007/s12010-012-0014-0
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Ploier, B; Scharwey, M; Koch, B; Schmidt, C; Schatte, J; Rechberger, G; Kollroser, M; Hermetter, A; Daum, G Screening for hydrolytic enzymes reveals Ayr1p as a novel triacylglycerol lipase in Saccharomyces cerevisiae.
J Biol Chem. 2013; 288(50):36061-36072 Doi: 10.1074/jbc.M113.509927 [OPEN ACCESS]
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Pollak, NM; Schweiger, M; Jaeger, D; Kolb, D; Kumari, M; Schreiber, R; Kolleritsch, S; Markolin, P; Grabner, GF; Heier, C; Zierler, KA; Rülicke, T; Zimmermann, R; Lass, A; Zechner, R; Haemmerle, G Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier.
J Lipid Res. 2013; 54(4):1092-1102 Doi: 10.1194/jlr.M034710 [OPEN ACCESS]
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Porpaczy, E; Tauber, S; Bilban, M; Kostner, G; Gruber, M; Eder, S; Heintel, D; Le, T; Fleiss, K; Skrabs, C; Shehata, M; Jager, U; Vanura, K; Lipoprotein lipase in chronic lymphocytic leukaemia - Strong biomarker with lack of functional significance.
LEUK RES. 2013; 37(6): 631-636. Doi: 10.1016/j.leukres.2013.02.008 [OPEN ACCESS]
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2012

Fuchs, CD; Claudel, T; Kumari, P; Haemmerle, G; Pollheimer, MJ; Stojakovic, T; Scharnagl, H; Halilbasic, E; Gumhold, J; Silbert, D; Koefeler, H; Trauner, M Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.
Hepatology. 2012; 56(1):270-280 Doi: 10.1002/hep.25601 [OPEN ACCESS]
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Lasa, A; Schweiger, M; Kotzbeck, P; Churruca, I; Simón, E; Zechner, R; Portillo, MP Resveratrol regulates lipolysis via adipose triglyceride lipase.
J Nutr Biochem. 2012; 23(4): 379-384. Doi: 10.1016/j.jnutbio.2010.12.014
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Riederer, M; Köfeler, H; Lechleitner, M; Tritscher, M; Frank, S Impact of endothelial lipase on cellular lipid composition.
Biochim Biophys Acta. 2012; 1821(7):1003-1011 Doi: 10.1016/j.bbalip.2012.03.006 [OPEN ACCESS]
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Schweiger, M; Paar, M; Eder, C; Brandis, J; Moser, E; Gorkiewicz, G; Grond, S; Radner, FP; Cerk, I; Cornaciu, I; Oberer, M; Kersten, S; Zechner, R; Zimmermann, R; Lass, A G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase.
J Lipid Res. 2012; 53(11):2307-2317 Doi: 10.1194/jlr.M027409 [OPEN ACCESS]
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Tamilarasan, KP; Temmel, H; Das, SK; Al Zoughbi, W; Schauer, S; Vesely, PW; Hoefler, G Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity.
Cell Death Dis. 2012; 3(11):e354-e354 Doi: 10.1038/cddis.2012.91 [OPEN ACCESS]
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2011

Aflaki, E; Radovic, B; Chandak, PG; Kolb, D; Eisenberg, T; Ring, J; Fertschai, I; Uellen, A; Wolinski, H; Kohlwein, SD; Zechner, R; Levak-Frank, S; Sattler, W; Graier, WF; Malli, R; Madeo, F; Kratky, D Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages.
J Biol Chem. 2011; 286(9): 7418-7428. Doi: 10.1074/jbc.M110.175703 [OPEN ACCESS]
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Das, SK; Eder, S; Schauer, S; Diwoky, C; Temmel, H; Guertl, B; Gorkiewicz, G; Tamilarasan, KP; Kumari, P; Trauner, M; Zimmermann, R; Vesely, P; Haemmerle, G; Zechner, R; Hoefler, G Adipose triglyceride lipase contributes to cancer-associated cachexia.
Science. 2011; 333(6039):233-238 Doi: 10.1126/science.1198973 [OPEN ACCESS]
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Desoye, G; Gauster, M; Wadsack, C Placental transport in pregnancy pathologies.
Am J Clin Nutr. 2011; 94(6 Suppl):1896S-11902 Doi: 10.3945/ajcn.110.000851 [OPEN ACCESS]
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Gauster, M; Hiden, U; Vanpoppel, M; Frank, S; Wadsack, C; Hauguel-de Mouzon, S; Desoye, G Dysregulation of placental endothelial lipase in obese women with gestational diabetes mellitus.
Diabetes. 2011; 60(10): 2457-2464. Doi: 10.2337/db10-1434 [OPEN ACCESS]
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Pinent, M; Prokesch, A; Hackl, H; Voshol, PJ; Klatzer, A; Walenta, E; Panzenboeck, U; Kenner, L; Trajanoski, Z; Hoefler, G; Bogner-Strauss, JG Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice.
Endocrinology. 2011; 152(7):2678-2689 Doi: 10.1210/en.2010-1477 [OPEN ACCESS]
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Riederer, M; Lechleitner, M; Hrzenjak, A; Koefeler, H; Desoye, G; Heinemann, A; Frank, S Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells.
Atherosclerosis. 2011; 214(2):338-344 Doi: 10.1016/j.atherosclerosis.2010.11.007 [OPEN ACCESS]
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2007

Gauster, M; Hiden, U; Blaschitz, A; Frank, S; Lang, U; Alvino, G; Cetin, I; Desoye, G; Wadsack, C Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies.
J Clin Endocrinol Metab. 2007; 92(6):2256-2263 Doi: 10.1210/jc.2006-2403 [OPEN ACCESS]
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Nohara, A; Kawashiri, MA; Claudel, T; Mizuno, M; Tsuchida, M; Takata, M; Katsuda, S; Miwa, K; Inazu, A; Kuipers, F; Kobayashi, J; Koizumi, J; Yamagishi, M; Mabuchi, H High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Arterioscler Thromb Vasc Biol. 2007; 27(4): 923-928. Doi: 10.1161/01.ATV.0000258945.76141.8a [OPEN ACCESS]
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2006

Lass, A; Zimmermann, R; Haemmerle, G; Riederer, M; Schoiswohl, G; Schweiger, M; Kienesberger, P; Strauss, JG; Gorkiewicz, G; Zechner, R Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.
Cell Metab. 2006; 3(5):309-319 Doi: 10.1016/j.cmet.2006.03.005 [OPEN ACCESS]
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2005

Eller, P; Schgoer, W; Mueller, T; Tancevski, I; Wehinger, A; Ulmer, H; Foeger, B; Haltmayer, M; Ritsch, A; Patsch, JR Hepatic lipase polymorphism and increased risk of peripheral arterial disease.
J Intern Med. 2005; 258(4):344-348 Doi: 10.1111/j.1365-2796.2005.01549.x [OPEN ACCESS]
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Kratky, D; Zimmermann, R; Wagner, EM; Strauss, JG; Jin, W; Kostner, GM; Haemmerle, G; Rader, DJ; Zechner, R Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue.
J CLIN INVEST. 2005; 115(1): 161-167. Doi: 10.1172/JCI15972 [OPEN ACCESS]
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