Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: KRAS, . Treffer: 61

2020

Fakler, F; Aykutlu, U; Brcic, L; Eidenhammer, S; Thueringer, A; Kashofer, K; Kulka, J; Timens, W; Popper, H Atypical goblet cell hyperplasia occurs in CPAM 1, 2, and 3, and is a probable precursor lesion for childhood adenocarcinoma.
Virchows Arch. 2020; 476(6):843-854
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2019

Arriga, R; Caratelli, S; Lanzilli, G; Ottaviani, A; Cenciarelli, C; Sconocchia, T; Spagnoli, GC; Iezzi, G; Roselli, M; Lauro, D; Coppola, A; Dotti, G; Ferrone, S; Sconocchia, G CD16-158-valine chimeric receptor T cells overcome the resistance of KRAS-mutated colorectal carcinoma cells to cetuximab.
INT J CANCER. 2019; 14(8):
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Liebs, S; Keilholz, U; Kehler, I; Schweiger, C; Haybäck, J; Nonnenmacher, A Detection of mutations in circulating cell-free DNA in relation to disease stage in colorectal cancer.
Cancer Med. 2019; 8(8):3761-3769 [OPEN ACCESS]
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Margonis, GA; Amini, N; Andreatos, N; Sasaki, K; McVey, J; Mirza, MB; Warner, S; Buettner, S; Barbon, C; Wang, J; Pulvirenti, A; Angelou, A; Kamphues, C; Antoniou, E; Pikoulis, E; Pawlik, TM; Kaczirek, K; Poultsides, G; Wagner, D; Endo, I; Imai, K; Aucejo, F; Kreis, ME; Wolfgang, CL; Weiss, MJ KRAS mutational status impacts pathologic response to pre-hepatectomy chemotherapy: a study from the International Genetic Consortium for Liver Metastases.
HPB (Oxford). 2019; 21(11):1527-1534
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Margonis, GA; Amini, N; Buettner, S; Kim, Y; Wang, J; Andreatos, N; Wagner, D; Sasaki, K; Beer, A; Kamphues, C; Morioka, D; Løes, IM; Imai, K; He, J; Pawlik, TM; Kaczirek, K; Poultsides, G; Lønning, PE; Burkhart, R; Endo, I; Baba, H; Mischinger, HJ; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ The Prognostic Impact of Primary Tumor Site Differs According to the KRAS Mutational Status: A Study By the International Genetic Consortium for Colorectal Liver Metastasis.
Ann Surg. 2019;
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Margonis, GA; Buettner, S; Andreatos, N; Wagner, D; Sasaki, K; Barbon, C; Beer, A; Kamphues, C; Løes, IM; He, J; Pawlik, TM; Kaczirek, K; Poultsides, G; Lønning, PE; Cameron, JL; Mischinger, HJ; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ Prognostic Factors Change Over Time After Hepatectomy for Colorectal Liver Metastases: A Multi-institutional, International Analysis of 1099 Patients.
ANN SURG. 2019; 269(6): 1129-1137.
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Rao, S; Mondragón, L; Pranjic, B; Hanada, T; Stoll, G; Köcher, T; Zhang, P; Jais, A; Lercher, A; Bergthaler, A; Schramek, D; Haigh, K; Sica, V; Leduc, M; Modjtahedi, N; Pai, TP; Onji, M; Uribesalgo, I; Hanada, R; Kozieradzki, I; Koglgruber, R; Cronin, SJ; She, Z; Quehenberger, F; Popper, H; Kenner, L; Haigh, JJ; Kepp, O; Rak, M; Cai, K; Kroemer, G; Penninger, JM AIF-regulated oxidative phosphorylation supports lung cancer development.
Cell Res. 2019; [OPEN ACCESS]
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Schumacher, D; Andrieux, G; Boehnke, K; Keil, M; Silvestri, A; Silvestrov, M; Keilholz, U; Haybaeck, J; Erdmann, G; Sachse, C; Templin, M; Hoffmann, J; Boerries, M; Schäfer, R; Regenbrecht, CRA Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.
PLoS Genet. 2019; 15(3):e1008076-e1008076 [OPEN ACCESS]
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Veatch, JR; Jesernig, BL; Kargl, J; Fitzgibbon, M; Lee, SM; Baik, C; Martins, R; Houghton, AM; Riddell, SR Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations.
CANCER IMMUNOL RES. 2019; 7(6): 910-922. [OPEN ACCESS]
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2018

Al-Zoughbi, W; Schauer, S; Pichler, M; Hoefler, G Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.
Pathobiology. 2018; 85(5-6): 342-347. [OPEN ACCESS]
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Berger, AW; Raedler, K; Langner, C; Ludwig, L; Dikopoulos, N; Becker, KF; Slotta-Huspenina, J; Quante, M; Schwerdel, D; Perkhofer, L; Kleger, A; Zizer, E; Oswald, F; Seufferlein, T; Meining, A Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study.
United European Gastroenterol J. 2018; 6(2): 290-299. [OPEN ACCESS]
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Deshwar, A; Margonis, GA; Andreatos, N; Barbon, C; Wang, J; Buettner, S; Wagner, D; Sasaki, K; Beer, A; Løes, IM; Pikoulis, E; Damaskos, C; Garmpis, N; Kamphues, K; He, J; Kaczirek, K; Poultsides, G; Lønning, PE; Mischinger, HJ; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ Double KRAS and BRAF Mutations in Surgically Treated Colorectal Cancer Liver Metastases: An International, Multi-institutional Case Series.
Anticancer Res. 2018; 38(5):2891-2895 (- Case Report) [OPEN ACCESS]
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El-Heliebi, A; Hille, C; Laxman, N; Svedlund, J; Haudum, C; Ercan, E; Kroneis, T; Chen, S; Smolle, M; Rossmann, C; Krzywkowski, T; Ahlford, A; Darai, E; von Amsberg, G; Alsdorf, W; König, F; Löhr, M; de Kruijff, I; Riethdorf, S; Gorges, TM; Pantel, K; Bauernhofer, T; Nilsson, M; Sedlmayr, P In Situ Detection and Quantification of AR-V7, AR-FL, PSA, and KRAS Point Mutations in Circulating Tumor Cells.
Clin Chem. 2018; 64(3):536-546 [OPEN ACCESS]
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Margonis, GA; Buettner, S; Andreatos, N; Kim, Y; Wagner, D; Sasaki, K; Beer, A; Schwarz, C; Løes, IM; Smolle, M; Kamphues, C; He, J; Pawlik, TM; Kaczirek, K; Poultsides, G; Lønning, PE; Cameron, JL; Burkhart, RA; Gerger, A; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ Association of BRAF Mutations With Survival and Recurrence in Surgically Treated Patients With Metastatic Colorectal Liver Cancer.
JAMA Surg. 2018; 153(7): e180996-e180996. [OPEN ACCESS]
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Margonis, GA; Buettner, S; Andreatos, N; Wagner, D; Sasaki, K; Barbon, C; Beer, A; Kamphues, C; Løes, IM; He, J; Pawlik, TM; Kaczirek, K; Poultsides, G; Lønning, PE; Cameron, JL; Mischinger, HJ; Aucejo, FN; Kreis, ME; Wolfgang, CL; Weiss, MJ Prognostic Factors Change Over Time After Hepatectomy for Colorectal Liver Metastases: A Multi-institutional, International Analysis of 1099 Patients.
Ann Surg. 2018;
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Zaric, B; Brcic, L; Buder, A; Brandstetter, A; Buresch, JO; Traint, S; Kovacevic, T; Stojsic, V; Perin, B; Pirker, R; Filipits, M PD-1 and PD-L1 Protein Expression Predict Survival in Completely Resected Lung Adenocarcinoma.
Clin Lung Cancer. 2018; 19(6):e957-e963-e957-e963
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2017

Chao, MP; Gentles, AJ; Chatterjee, S; Lan, F; Reinisch, A; Corces, MR; Xavy, S; Shen, J; Haag, D; Chanda, S; Sinha, R; Morganti, RM; Nishimura, T; Ameen, M; Wu, H; Wernig, M; Wu, JC; Majeti, R Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.
Cell Stem Cell. 2017; 20(3): 329-344. [OPEN ACCESS]
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Margonis, GA; Sasaki, K; Andreatos, N; Kim, Y; Merath, K; Wagner, D; Wilson, A; Buettner, S; Amini, N; Antoniou, E; Pawlik, TM KRAS Mutation Status Dictates Optimal Surgical Margin Width in Patients Undergoing Resection of Colorectal Liver Metastases.
Ann Surg Oncol. 2017; 24(1):264-271
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Mehta, AK; Hua, K; Whipple, W; Nguyen, MT; Liu, CT; Haybaeck, J; Weidhaas, J; Settleman, J; Singh, A Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells.
Sci Signal. 2017; 10(496): [OPEN ACCESS]
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Nadal, C; Winder, T; Gerger, A; Tougeron, D Future perspectives of circulating tumor DNA in colorectal cancer.
Tumour Biol. 2017; 39(5):1010428317705749-1010428317705749 [OPEN ACCESS]
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Rao, S; Sigl, V; Wimmer, RA; Novatchkova, M; Jais, A; Wagner, G; Handschuh, S; Uribesalgo, I; Hagelkruys, A; Kozieradzki, I; Tortola, L; Nitsch, R; Cronin, SJ; Orthofer, M; Branstetter, D; Canon, J; Rossi, J; D'Arcangelo, M; Botling, J; Micke, P; Fleur, L; Edlund, K; Bergqvist, M; Ekman, S; Lendl, T; Popper, H; Takayanagi, H; Kenner, L; Hirsch, FR; Dougall, W; Penninger, JM RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Genes Dev. 2017; 31(20):2099-2112 [OPEN ACCESS]
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Saraggi, D; Salmaso, R; Valentini, E; Munari, G; Vindigni, V; Rugge, M; Fassan, M; Cerroni, L Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver.
Pathol Res Pract. 2017; 213(7):860-862 (- Case Report)
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2016

Bonin, S; Donada, M; Bussolati, G; Nardon, E; Annaratone, L; Pichler, M; Chiaravalli, AM; Capella, C; Hoefler, G; Stanta, G A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.
Tumour Biol. 2016; 37(6):7295-7303
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Brcic, L; Jakopovic, M; Misic, M; Seiwerth, F; Kern, I; Smojver-Jezek, S; Quehenberger, F; Samarzija, M; Seiwerth, S Analysis of the frequency of EGFR, KRAS and ALK mutations in patients with lung adenocarcinoma in Croatia.
Diagn Pathol. 2016; 11(1):90-90 [OPEN ACCESS]
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Busch, SE; Hanke, ML; Kargl, J; Metz, HE; MacPherson, D; Houghton, AM Lung Cancer Subtypes Generate Unique Immune Responses.
J Immunol. 2016; 197(11):4493-4503 [OPEN ACCESS]
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Metz, HE; Kargl, J; Busch, SE; Kim, KH; Kurland, BF; Abberbock, SR; Randolph-Habecker, J; Knoblaugh, SE; Kolls, JK; White, MF; Houghton, AM Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.
Proc Natl Acad Sci U S A. 2016; 113(31):8795-8800 [OPEN ACCESS]
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Pehserl, AM; Ress, AL; Stanzer, S; Resel, M; Karbiener, M; Stadelmeyer, E; Stiegelbauer, V; Gerger, A; Mayr, C; Scheideler, M; Hutterer, GC; Bauernhofer, T; Kiesslich, T; Pichler, M Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
Int J Mol Sci. 2016; 17(12): [OPEN ACCESS]
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Scheipl, S; Barnard, M; Cottone, L; Jorgensen, M; Drewry, DH; Zuercher, WJ; Turlais, F; Ye, H; Leite, AP; Smith, JA; Leithner, A; Möller, P; Brüderlein, S; Guppy, N; Amary, F; Tirabosco, R; Strauss, SJ; Pillay, N; Flanagan, AM EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J Pathol. 2016; 239(3):320-334 [OPEN ACCESS]
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2015

Geles, A; Gruber-Moesenbacher, U; Quehenberger, F; Manzl, C; Al Effah, M; Grygar, E; Juettner-Smolle, F; Popper, HH Pulmonary mucinous adenocarcinomas: architectural patterns in correlation with genetic changes, prognosis and survival.
Virchows Arch. 2015; 467(6):675-686
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Grabner, B; Schramek, D; Mueller, KM; Moll, HP; Svinka, J; Hoffmann, T; Bauer, E; Blaas, L; Hruschka, N; Zboray, K; Stiedl, P; Nivarthi, H; Bogner, E; Gruber, W; Mohr, T; Zwick, RH; Kenner, L; Poli, V; Aberger, F; Stoiber, D; Egger, G; Esterbauer, H; Zuber, J; Moriggl, R; Eferl, R; Győrffy, B; Penninger, JM; Popper, H; Casanova, E Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
Nat Commun. 2015; 6(4):6285-6285 [OPEN ACCESS]
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Jagadeeshan, S; Krishnamoorthy, YR; Singhal, M; Subramanian, A; Mavuluri, J; Lakshmi, A; Roshini, A; Baskar, G; Ravi, M; Joseph, LD; Sadasivan, K; Krishnan, A; Nair, AS; Venkatraman, G; Rayala, SK Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis.
Oncogene. 2015; 34(4):455-464
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Jakopovic, M; Brcic, L; Misic, M; Seiwerth, F; Drpa, G; Cucevic, B; Plestina, S; Kukulj, S; Roglic, M; Smojver-Jezek, S; Chalfe, N; Seiwerth, S; Janevski, Z; Samarzija, M Non-small cell lung cancer mutation analysis in purely caucasian Croatian population.
Journal of Thoracic Oncology, 2015:10 (9, Suppl 2). 2015; 10(9):S708-S708.-16th World Conference on Lung Cancer; SEP 6 - 9, 2015 ; Denver, USA. [Poster]
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Kaczirek, K; Ciuleanu, TE; Vrbanec, D; Marton, E; Messinger, D; Liegl-Atzwanger, B; Wrba, F; Knittelfelder, R; Lindner, E; Zielinski, CC; Streubel, B; Brodowicz, T FOLFOX4 Plus Cetuximab for Patients With Previously Untreated Metastatic Colorectal Cancer According to Tumor RAS and BRAF Mutation Status: Updated Analysis of the CECOG/CORE 1.2.002 Study.
Clin Colorectal Cancer. 2015; 14(2):91-98
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Langner, C Serrated and non-serrated precursor lesions of colorectal cancer.
Dig Dis. 2015; 33(1):28-37
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Murali, R; Chandramohan, R; Möller, I; Scholz, SL; Berger, M; Huberman, K; Viale, A; Pirun, M; Socci, ND; Bouvier, N; Bauer, S; Artl, M; Schilling, B; Schimming, T; Sucker, A; Schwindenhammer, B; Grabellus, F; Speicher, MR; Schaller, J; Hillen, U; Schadendorf, D; Mentzel, T; Cheng, DT; Wiesner, T; Griewank, KG Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.
Oncotarget. 2015; 6(34):36041-36052 [OPEN ACCESS]
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Ress, AL; Stiegelbauer, V; Winter, E; Schwarzenbacher, D; Kiesslich, T; Lax, S; Jahn, S; Deutsch, A; Bauernhofer, T; Ling, H; Samonigg, H; Gerger, A; Hoefler, G; Pichler, M MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.
Mol Carcinog. 2015; 54(11):1442-1450
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Setaffy, L; Langner, C Microsatellite instability in colorectal cancer: clinicopathological significance.
Pol J Pathol. 2015; 66(3):203-218 [OPEN ACCESS]
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Zopf, A; Raim, R; Danzer, M; Niklas, N; Spilka, R; Pröll, J; Gabriel, C; Nechansky, A; Roucka, M Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection.
Biotechniques. 2015; 58(3):126-134 [OPEN ACCESS]
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2014

Eisterer, W; De Vries, A; Öfner, D; Rabl, H; Koplmüller, R; Greil, R; Tschmelitsch, J; Schmid, R; Kapp, K; Lukas, P; Sedlmayer, F; Höfler, G; Gnant, M; Thaler, J; Austrian Breast and Colorectal Cancer Study Group (ABCSG) Preoperative treatment with capecitabine, cetuximab and radiotherapy for primary locally advanced rectal cancer--a phase II clinical trial.
Anticancer Res. 2014; 34(11):6767-6773
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Mohan, S; Heitzer, E; Ulz, P; Lafer, I; Lax, S; Auer, M; Pichler, M; Gerger, A; Eisner, F; Hoefler, G; Bauernhofer, T; Geigl, JB; Speicher, MR Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.
PLoS Genet. 2014; 10(3):e1004271-e1004271 [OPEN ACCESS]
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Pichler, M; Winter, E; Ress, AL; Bauernhofer, T; Gerger, A; Kiesslich, T; Lax, S; Samonigg, H; Hoefler, G miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor.
J Clin Pathol. 2014; 67(3):198-203
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Rao, S; Tortola, L; Perlot, T; Wirnsberger, G; Novatchkova, M; Nitsch, R; Sykacek, P; Frank, L; Schramek, D; Komnenovic, V; Sigl, V; Aumayr, K; Schmauss, G; Fellner, N; Handschuh, S; Glösmann, M; Pasierbek, P; Schlederer, M; Resch, GP; Ma, Y; Yang, H; Popper, H; Kenner, L; Kroemer, G; Penninger, JM A dual role for autophagy in a murine model of lung cancer.
Nat Commun. 2014; 5(5):3056-3056 [OPEN ACCESS]
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Rau, TT; Agaimy, A; Gehoff, A; Geppert, C; Jung, K; Knobloch, K; Langner, C; Lugli, A; Groenbus-Lurkin, I; Nagtegaal, ID; Rüschoff, J; Saegert, X; Sarbia, M; Schneider-Stock, R; Vieth, M; Zwarthoff, EC; Hartmann, A Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics.
Virchows Arch. 2014; 464(6):663-672
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2013

Buxhofer-Ausch, V; Ausch, C; Zeillinger, R; Oberkanins, C; Dandachi, N; Reiner-Concin, A; Kriegshäuser, G Duplex reverse-hybridization assay for the simultaneous detection of KRAS/BRAF mutations in FFPE-extracted genomic DNA from colorectal cancer specimens.
Dis Markers. 2013; 34(3):171-177 [OPEN ACCESS]
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Dijkstra, JR; Heideman, DA; Meijer, GA; Boers, JE; 't Hart, NA; Diebold, J; Hirschmann, A; Hoefler, G; Winter, G; Miltenberger-Miltenyi, G; Pereira, SV; Richman, SD; Quirke, P; Rouleau, EL; Guinebretiere, JM; Tejpar, S; Biesmans, B; van Krieken, JH KRAS mutation analysis on low percentage of colon cancer cells: the importance of quality assurance.
Virchows Arch. 2013; 462(1):39-46
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Heitzer, E; Auer, M; Gasch, C; Pichler, M; Ulz, P; Hoffmann, EM; Lax, S; Waldispuehl-Geigl, J; Mauermann, O; Lackner, C; Höfler, G; Eisner, F; Sill, H; Samonigg, H; Pantel, K; Riethdorf, S; Bauernhofer, T; Geigl, JB; Speicher, MR Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013; 73(10):2965-2975 [OPEN ACCESS]
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Moldvay, J; Barbai, T; Bogos, K; Piurko, V; Fillinger, J; Popper, HH; Tímár, J EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Diagn Mol Pathol. 2013; 22(4):204-209
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2012

Dijkstra, JR; Opdam, FJ; Boonyaratanakornkit, J; Schönbrunner, ER; Shahbazian, M; Edsjö, A; Hoefler, G; Jung, A; Kotsinas, A; Gorgoulis, VG; Lpez-Ros, F; de Stricker, K; Rouleau, E; Biesmans, B; van Krieken, JH Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.
J Mol Diagn. 2012; 14(3):187-191 [OPEN ACCESS]
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Pichler, M; Winter, E; Stotz, M; Eberhard, K; Samonigg, H; Lax, S; Hoefler, G; Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer.
Br J Cancer. 2012; 106(11):1826-1832 [OPEN ACCESS]
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2011

Betge, J; Pollheimer, MJ; Schlemmer, A; Hoefler, G; Langner, C Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis.
Oncol Rep. 2011; 26(3):567-575 [OPEN ACCESS]
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