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Suchbegriffe: HEPATOCYTES - METABOLISM , . Treffer: 54

2022

Gindlhuber, J; Schinagl, M; Liesinger, L; Darnhofer, B; Tomin, T; Schittmayer, M; Birner-Gruenberger, R Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063356 [OPEN ACCESS]
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Oster, M; Galhuber, M; Krstic, J; Steinhoff, JS; Lenihan-Geels, G; Wulff, S; Kiefer, MF; Petricek, KM; Wowro, SJ; Flores, RE; Yang, N; Li, C; Meng, Y; Reinisch, I; Sommerfeld, M; Weger, S; Habisch, H; Madl, T; Schulz, TJ; Prokesch, A; Schupp, M Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
J Biol Chem. 2022; 298(9):102287 Doi: 10.1016/j.jbc.2022.102287 [OPEN ACCESS]
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2020

Choi, S; Dong, B; Lin, CJ; Heo, MJ; Kim, KH; Sun, Z; Wagner, M; Putluri, N; Suh, JM; Wang, MC; Moore, DD Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes.
Hepatology. 2020; 71(3):1055-1069 Doi: 10.1002/hep.30884 [OPEN ACCESS]
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Olivieri, O; Speziali, G; Castagna, A; Pattini, P; Udali, S; Pizzolo, F; Liesinger, L; Gindlhuber, J; Tomin, T; Schittmayer, M; Birner-Gruenberger, R; Cecconi, D; Girelli, D; Friso, S; Martinelli, N The Positive Association between Plasma Myristic Acid and ApoCIII Concentrations in Cardiovascular Disease Patients Is Supported by the Effects of Myristic Acid in HepG2 Cells.
J Nutr. 2020; 150(10):2707-2715 Doi: 10.1093/jn/nxaa202
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Sladky, VC; Knapp, K; Soratroi, C; Heppke, J; Eichin, F; Rocamora-Reverte, L; Szabo, TG; Bongiovanni, L; Westendorp, B; Moreno, E; van Liere, EA; Bakker, B; Spierings, DCJ; Wardenaar, R; Pereyra, D; Starlinger, P; Schultze, S; Trauner, M; Stojakovic, T; Scharnagl, H; Fava, LL; Foijer, F; de Bruin, A; Villunger, A E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Dev Cell. 2020; 52(3):335-349 Doi: 10.1016/j.devcel.2019.12.016
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2018

Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 Doi: 10.1016/j.bbadis.2017.08.028 [OPEN ACCESS]
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2017

Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610 Doi: 10.1111/liv.13325
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Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Vanessa Ho, WS; Jackson, SJ; Williams, TE; Al-Izki, S; Sevastou, I; Okuyama, M; Graier, WF; Stevenson, LA; Tanner, C; Ross, R; Pertwee, RG; Henstridge, CM; Irving, AJ; Schulman, J; Powell, K; Baker, MD; Giovannoni, G; Selwood, DL Big conductance calcium-activated potassium channel openers control spasticity without sedation.
Br J Pharmacol. 2017; 174(16):2662-2681 Doi: 10.1111/bph.13889 [OPEN ACCESS]
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Fuchs, CD; Paumgartner, G; Wahlström, A; Schwabl, P; Reiberger, T; Leditznig, N; Stojakovic, T; Rohr-Udilova, N; Chiba, P; Marschall, HU; Trauner, M Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.
J Hepatol. 2017; 66(1):95-101 Doi: 10.1016/j.jhep.2016.08.017 [OPEN ACCESS]
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2016

Lemberger, UJ; Fuchs, CD; Karer, M; Haas, S; Stojakovic, T; Schöfer, C; Marschall, HU; Wrba, F; Taketo, MM; Egger, G; Trauner, M; Österreicher, CH Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.
Oncotarget. 2016; 7(52):86985-86998 Doi: 10.18632/oncotarget.13521 [OPEN ACCESS]
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Trierweiler, C; Hockenjos, B; Zatloukal, K; Thimme, R; Blum, HE; Wagner, EF; Hasselblatt, P The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.
Cell Death Differ. 2016; 23(4):576-582 Doi: 10.1038/cdd.2015.121 [OPEN ACCESS]
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2015

Neve, EP; Köfeler, H; Hendriks, DF; Nordling, Å; Gogvadze, V; Mkrtchian, S; Näslund, E; Ingelman-Sundberg, M Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.
PLoS One. 2015; 10(9):e0138487-e0138487 Doi: 10.1371/journal.pone.0138487 [OPEN ACCESS]
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Raschzok, N; Sallmon, H; Pratschke, J; Sauer, IM MicroRNAs in liver tissue engineering - New promises for failing organs.
Adv Drug Deliv Rev. 2015; 88:67-77 Doi: 10.1016/j.addr.2015.06.005
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Szabo, S; Wögenstein, KL; Österreicher, CH; Guldiken, N; Chen, Y; Doler, C; Wiche, G; Boor, P; Haybaeck, J; Strnad, P; Fuchs, P Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.
J Hepatol. 2015; 62(6):1357-1366 Doi: 10.1016/j.jhep.2015.01.007 [OPEN ACCESS]
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Werner, M; Driftmann, S; Kleinehr, K; Kaiser, GM; Mathé, Z; Treckmann, JW; Paul, A; Skibbe, K; Timm, J; Canbay, A; Gerken, G; Schlaak, JF; Broering, R All-In-One: Advanced preparation of Human Parenchymal and Non-Parenchymal Liver Cells.
PLoS One. 2015; 10(9):e0138655-e0138655 Doi: 10.1371/journal.pone.0138655 [OPEN ACCESS]
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2014

Lanaya, H; Natarajan, A; Komposch, K; Li, L; Amberg, N; Chen, L; Wculek, SK; Hammer, M; Zenz, R; Peck-Radosavljevic, M; Sieghart, W; Trauner, M; Wang, H; Sibilia, M EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Nat Cell Biol. 2014; 16(10): 1- 7. Doi: 10.1038/ncb3031 [OPEN ACCESS]
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Ramackers, W; Klose, J; Vondran, FW; Schrem, H; Kaltenborn, A; Klempnauer, J; Kleine, M Species-specific regulation of fibrinogen synthesis with implications for porcine hepatocyte xenotransplantation.
Xenotransplantation. 2014; 21(5): 444-453. Doi: 10.1111/xen.12110
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Röhrl, C; Eigner, K; Winter, K; Korbelius, M; Obrowsky, S; Kratky, D; Kovacs, WJ; Stangl, H Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells.
J Lipid Res. 2014; 55(1):94-103 Doi: 10.1194/jlr.M043299 [OPEN ACCESS]
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Vinod, M; Chennamsetty, I; Colin, S; Belloy, L; De Paoli, F; Schaider, H; Graier, WF; Frank, S; Kratky, D; Staels, B; Chinetti-Gbaguidi, G; Kostner, GM miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages.
Biochim Biophys Acta. 2014; 1841(6):827-835 Doi: 10.1016/j.bbalip.2014.02.006 [OPEN ACCESS]
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Woolbright, BL; Li, F; Xie, Y; Farhood, A; Fickert, P; Trauner, M; Jaeschke, H Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.
Toxicol Lett. 2014; 228(1):56-66 Doi: 10.1016/j.toxlet.2014.04.001 [OPEN ACCESS]
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Zatloukal, B; Kufferath, I; Thueringer, A; Landegren, U; Zatloukal, K; Haybaeck, J Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.
PLoS One. 2014; 9(5):e96690-e96690 Doi: 10.1371/journal.pone.0096690 [OPEN ACCESS]
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Zollner, G; Thueringer, A; Lackner, C; Fickert, P; Trauner, M Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury.
Digestion. 2014; 90(2):81-88 Doi: 10.1159/000365003
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2013

Strnad, P; Nuraldeen, R; Guldiken, N; Hartmann, D; Mahajan, V; Denk, H; Haybaeck, J Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.
Compr Physiol. 2013; 3(4):1393-1436 Doi: 10.1002/cphy.c120032
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Svejda, B; Kidd, M; Timberlake, A; Harry, K; Kazberouk, A; Schimmack, S; Lawrence, B; Pfragner, R; Modlin, IM Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors.
Cancer Sci. 2013; 104(7):844-855 Doi: 10.1111/cas.12174 [OPEN ACCESS]
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2012

Chennamsetty, I; Kostner, KM; Claudel, T; Vinod, M; Frank, S; Weiss, TS; Trauner, M; Kostner, GM Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.
J Lipid Res. 2012; 53(11):2405-2412 Doi: 10.1194/jlr.M029769 [OPEN ACCESS]
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Chitraju, C; Trotzmuller, M; Hartler, J; Wolinski, H; Thallinger, GG; Lass, A; Zechner, R; Zimmermann, R; Kofeler, HC; Spener, F; Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress.
J Lipid Res. 2012; 53(10):2141-2152 Doi: 10.1194/jlr.M028902 [OPEN ACCESS]
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Fuchs, CD; Claudel, T; Kumari, P; Haemmerle, G; Pollheimer, MJ; Stojakovic, T; Scharnagl, H; Halilbasic, E; Gumhold, J; Silbert, D; Koefeler, H; Trauner, M Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.
Hepatology. 2012; 56(1):270-280 Doi: 10.1002/hep.25601 [OPEN ACCESS]
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Groth, A; Ottinger, S; Kleist, C; Mohr, E; Golriz, M; Schultze, D; Bruns, H; Mehrabi, A; Schemmer, P; Büchler, MW; Herr, I Evaluation of porcine mesenchymal stem cells for therapeutic use in human liver cancer.
Int J Oncol. 2012; 40(2):391-401 Doi: 10.3892/ijo.2011.1217 [OPEN ACCESS]
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Quiroga, AD; Li, L; Trötzmüller, M; Nelson, R; Proctor, SD; Köfeler, H; Lehner, R Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.
Hepatology. 2012; 56(6):2188-2198 Doi: 10.1002/hep.25961 [OPEN ACCESS]
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2011

Claudel, T; Zollner, G; Wagner, M; Trauner, M Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.
Biochim Biophys Acta. 2011; 1812(8):867-878 Doi: 10.1016/j.bbadis.2010.12.021 [OPEN ACCESS]
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Mahajan, V; Klingstedt, T; Simon, R; Nilsson, KP; Thueringer, A; Kashofer, K; Haybaeck, J; Denk, H; Abuja, PM; Zatloukal, K Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.
Gastroenterology. 2011; 141(3):1080-1090.e1-1080-1090.e7 Doi: 10.1053/j.gastro.2011.05.039
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Zhang, Y; Lei, T; Huang, JF; Wang, SB; Zhou, LL; Yang, ZQ; Chen, XD The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes.
Mol Cell Endocrinol. 2011; 342(1-2): 41-47. Doi: 10.1016/j.mce.2011.05.003
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2010

Weber, A; Boger, R; Vick, B; Urbanik, T; Haybaeck, J; Zoller, S; Teufel, A; Krammer, PH; Opferman, JT; Galle, PR; Schuchmann, M; Heikenwalder, M; Schulze-Bergkamen, H Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice.
Hepatology. 2010; 51(4):1226-1236 Doi: 10.1002/hep.23479 [OPEN ACCESS]
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2009

Fickert, P; Fuchsbichler, A; Wagner, M; Silbert, D; Zatloukal, K; Denk, H; Trauner, M The role of the hepatocyte cytokeratin network in bile formation and resistance to bile acid challenge and cholestasis in mice.
Hepatology. 2009; 50(3):893-899 Doi: 10.1002/hep.23068 [OPEN ACCESS]
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Földes-Papp, Z; König, K; Studier, H; Bückle, R; Breunig, HG; Uchugonova, A; Kostner, GM Trafficking of mature miRNA-122 into the nucleus of live liver cells.
Curr Pharm Biotechnol. 2009; 10(6): 569-578. Doi: 10.2174/138920109789069332
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Jost, PJ; Grabow, S; Gray, D; McKenzie, MD; Nachbur, U; Huang, DC; Bouillet, P; Thomas, HE; Borner, C; Silke, J; Strasser, A; Kaufmann, T XIAP discriminates between type I and type II FAS-induced apoptosis.
Nature. 2009; 460(7258):1035-1039 Doi: 10.1038/nature08229 [OPEN ACCESS]
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Stadlbauer, V; Wright, GA; Jalan, R Role of artificial liver support in hepatic encephalopathy.
Metab Brain Dis. 2009; 24(1): 15-26. Doi: 10.1007/s11011-008-9117-2
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2008

Baghdasaryan, A; Fickert, P; Fuchsbichler, A; Silbert, D; Gumhold, J; Hörl, G; Langner, C; Moustafa, T; Halilbasic, E; Claudel, T; Trauner, M Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice.
Liver Int. 2008; 28(7):948-958 Doi: 10.1111/j.1478-3231.2008.01758.x
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Hui, L; Zatloukal, K; Scheuch, H; Stepniak, E; Wagner, EF Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.
J Clin Invest. 2008; 118(12): 3943-3953. Doi: 10.1172/JCI37156 [OPEN ACCESS]
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Theurl, M; Theurl, I; Hochegger, K; Obrist, P; Subramaniam, N; van Rooijen, N; Schuemann, K; Weiss, G Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression.
J Mol Med (Berl). 2008; 86(7):825-835 Doi: 10.1007/s00109-008-0346-y
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2007

Lenart, J; Dombrowski, F; Görlach, A; Kietzmann, T Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver.
Arch Biochem Biophys. 2007; 462(2):238-244 Doi: 10.1016/j.abb.2007.02.007
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Zatloukal, K; French, SW; Stumptner, C; Strnad, P; Harada, M; Toivola, DM; Cadrin, M; Omary, MB From Mallory to Mallory-Denk bodies: what, how and why?
EXP CELL RES. 2007; 313(10): 2033-2049. Doi: 10.1016/j.yexcr.2007.04.024
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2006

Boyer, JL; Trauner, M; Mennone, A; Soroka, CJ; Cai, SY; Moustafa, T; Zollner, G; Lee, JY; Ballatori, N Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(6):G1124-G1130 Doi: 10.1152/ajpgi.00539.2005 [OPEN ACCESS]
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Denk, H; Stumptner, C; Fuchsbichler, A; Müller, T; Farr, G; Müller, W; Terracciano, L; Zatloukal, K Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
J PATHOL. 2006; 208: 653-661. Doi: 10.1002/path.1946
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Rust, C; Bauchmuller, K; Bernt, C; Vennegeerts, T; Fickert, P; Fuchsbichler, A; Beuers, U Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.
GUT. 2006; 55(5): 719-727. Doi: 10.1136/gut.2005.077461 [OPEN ACCESS]
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Schrem, H; Kleine, M; Borlak, J; Klempnauer, J Physiological incompatibilities of porcine hepatocytes for clinical liver support.
Liver Transpl. 2006; 12(12): 1832-1840. Doi: 10.1002/lt.20918
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Zollner, G; Trauner, M Molecular mechanisms of cholestasis.
Wien Med Wochenschr. 2006; 156(13-14):380-385 Doi: 10.1007/s10354-006-0312-7
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2005

Theurl, I; Ludwiczek, S; Eller, P; Seifert, M; Artner, E; Brunner, P; Weiss, G Pathways for the regulation of body iron homeostasis in response to experimental iron overload.
J Hepatol. 2005; 43(4):711-719 Doi: 10.1016/j.jhep.2005.03.030
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Zollner, G; Wagner, M; Fickert, P; Geier, A; Fuchsbichler, A; Silbert, D; Gumhold, J; Zatloukal, K; Kaser, A; Tilg, H; Denk, H; Trauner, M Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
Am J Physiol Gastrointest Liver Physiol. 2005; 289(5):G798-G805 Doi: 10.1152/ajpgi.00319.2004 [OPEN ACCESS]
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2004

Sirvent, A; Claudel, T; Martin, G; Brozek, J; Kosykh, V; Darteil, R; Hum, DW; Fruchart, JC; Staels, B The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
FEBS Lett. 2004; 566(1-3): 173-177. Doi: 10.1016/j.febslet.2004.04.026
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