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Publikationen

Suchbegriffe: HEPG2 CELLS, . Treffer: 48

2022

Fuchs, CD; Radun, R; Dixon, ED; Mlitz, V; Timelthaler, G; Halilbasic, E; Herac, M; Jonker, JW; Ronda, OAHO; Tardelli, M; Haemmerle, G; Zimmermann, R; Scharnagl, H; Stojakovic, T; Verkade, HJ; Trauner, M Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Hepatology. 2022; 75(1):125-139 Doi: 10.1002/hep.32112
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2021

Greimel, T; Jahnel, J; Pohl, S; Strini, T; Tischitz, M; Meier-Allard, N; Holasek, S; Meinel, K; Aguiriano-Moser, V; Zobel, J; Haidl, H; Gallistl, S; Panzitt, K; Wagner, M; Schlagenhauf, A Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor.
Lab Invest. 2021; 101(10):1394-1402 Doi: 10.1038/s41374-021-00628-z [OPEN ACCESS]
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Pan, G; Diamanti, K; Cavalli, M; Lara, Gutiérrez, A; Komorowski, J; Wadelius, C Multifaceted regulation of hepatic lipid metabolism by YY1.
Life Sci Alliance. 2021; 4(7): Doi: 10.26508/lsa.202000928 [OPEN ACCESS]
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Schilcher, I; Stadler, JT; Lechleitner, M; Hrzenjak, A; Berghold, A; Pregartner, G; Lhomme, M; Holzer, M; Korbelius, M; Reichmann, F; Springer, A; Wadsack, C; Madl, T; Kratky, D; Kontush, A; Marsche, G; Frank, S Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
Int J Mol Sci. 2021; 22(2): Doi: 10.3390/ijms22020719 [OPEN ACCESS]
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2020

Dong, J; He, M; Li, J; Pessentheiner, A; Wang, C; Zhang, J; Sun, Y; Wang, WT; Zhang, Y; Liu, J; Wang, SC; Huang, PH; Gordts, PL; Yuan, ZY; Tsimikas, S; Shyy, JY microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production.
JCI Insight. 2020; 5(23): Doi: 10.1172/jci.insight.143812 [OPEN ACCESS]
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Olivieri, O; Speziali, G; Castagna, A; Pattini, P; Udali, S; Pizzolo, F; Liesinger, L; Gindlhuber, J; Tomin, T; Schittmayer, M; Birner-Gruenberger, R; Cecconi, D; Girelli, D; Friso, S; Martinelli, N The Positive Association between Plasma Myristic Acid and ApoCIII Concentrations in Cardiovascular Disease Patients Is Supported by the Effects of Myristic Acid in HepG2 Cells.
J Nutr. 2020; 150(10):2707-2715 Doi: 10.1093/jn/nxaa202
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Radulović, S; Gottschalk, B; Hörl, G; Zardoya-Laguardia, P; Schilcher, I; Hallström, S; Vujić, N; Schmidt, K; Trieb, M; Graier, WF; Malli, R; Kratky, D; Marsche, G; Frank, S Endothelial lipase increases eNOS activating capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(4):158612 Doi: 10.1016/j.bbalip.2020.158612 [OPEN ACCESS]
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2019

Schilcher, I; Ledinski, G; Radulović, S; Hallström, S; Eichmann, T; Madl, T; Zhang, F; Leitinger, G; Kolb-Lenz, D; Darnhofer, B; Birner-Gruenberger, R; Wadsack, C; Kratky, D; Marsche, G; Frank, S; Cvirn, G Endothelial lipase increases antioxidative capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019; 1864(10):1363-1374 Doi: 10.1016/j.bbalip.2019.06.011 [OPEN ACCESS]
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2018

Heil, J; Schultze, D; Schemmer, P; Bruns, H N-acetylcysteine protects hepatocytes from hypoxia-related cell injury.
Clin Exp Hepatol. 2018; 4(4): 260-266. Doi: 10.5114/ceh.2018.80128 [OPEN ACCESS]
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Ramirez, T; Strigun, A; Verlohner, A; Huener, HA; Peter, E; Herold, M; Bordag, N; Mellert, W; Walk, T; Spitzer, M; Jiang, X; Sperber, S; Hofmann, T; Hartung, T; Kamp, H; van Ravenzwaay, B Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Arch Toxicol. 2018; 92(2): 893-906. Doi: 10.1007/s00204-017-2079-6 [OPEN ACCESS]
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Speziali, G; Liesinger, L; Gindlhuber, J; Leopold, C; Pucher, B; Brandi, J; Castagna, A; Tomin, T; Krenn, P; Thallinger, GG; Olivieri, O; Martinelli, N; Kratky, D; Schittmayer, M; Birner-Gruenberger, R; Cecconi, D Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells.
J Proteomics. 2018; 181(7):118-130 Doi: 10.1016/j.jprot.2018.04.008
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2017

Fuchs, CD; Claudel, T; Scharnagl, H; Stojakovic, T; Trauner, M FXR controls CHOP expression in steatohepatitis.
FEBS Lett. 2017; 591(20):3360-3368 Doi: 10.1002/1873-3468.12845 [OPEN ACCESS]
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Görtz, M; Galli, U; Longerich, T; Zöller, M; Erb, U; Schemmer, P De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells.
Oncol Rep. 2017; 38(5):2697-2704 Doi: 10.3892/or.2017.5980 [OPEN ACCESS]
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2015

Bitter, A; Rümmele, P; Klein, K; Kandel, BA; Rieger, JK; Nüssler, AK; Zanger, UM; Trauner, M; Schwab, M; Burk, O Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
Arch Toxicol. 2015; 89(11):2089-2103 Doi: 10.1007/s00204-014-1348-x
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Kessler, SM; Laggai, S; Barghash, A; Schultheiss, CS; Lederer, E; Artl, M; Helms, V; Haybaeck, J; Kiemer, AK IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.
Cell Death Dis. 2015; 6(1):e1894-e1894 Doi: 10.1038/cddis.2015.241 [OPEN ACCESS]
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2014

Röhrl, C; Eigner, K; Winter, K; Korbelius, M; Obrowsky, S; Kratky, D; Kovacs, WJ; Stangl, H Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells.
J Lipid Res. 2014; 55(1):94-103 Doi: 10.1194/jlr.M043299 [OPEN ACCESS]
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2013

Fickert, P; Pollheimer, MJ; Silbert, D; Moustafa, T; Halilbasic, E; Krones, E; Durchschein, F; Thüringer, A; Zollner, G; Denk, H; Trauner, M Differential effects of norUDCA and UDCA in obstructive cholestasis in mice.
J Hepatol. 2013; 58(6):1201-1208 Doi: 10.1016/j.jhep.2013.01.026 [OPEN ACCESS]
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Yu, A; Zheng, Y; Zhang, R; Huang, J; Zhu, Z; Zhou, R; Jin, D; Yang, Z Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Mol Cell Endocrinol. 2013; 377(1-2):23-32 Doi: 10.1016/j.mce.2013.06.028
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2012

Chennamsetty, I; Kostner, KM; Claudel, T; Vinod, M; Frank, S; Weiss, TS; Trauner, M; Kostner, GM Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.
J Lipid Res. 2012; 53(11):2405-2412 Doi: 10.1194/jlr.M029769 [OPEN ACCESS]
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Huppke, P; Brendel, C; Kalscheuer, V; Korenke, GC; Marquardt, I; Freisinger, P; Christodoulou, J; Hillebrand, M; Pitelet, G; Wilson, C; Gruber-Sedlmayr, U; Ullmann, R; Haas, S; Elpeleg, O; Nürnberg, G; Nürnberg, P; Dad, S; Mller, LB; Kaler, SG; Gärtner, J Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin.
AM J HUM GENET. 2012; 90(1): 61-68. Doi: 10.1016/j.ajhg.2011.11.030 [OPEN ACCESS]
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Leber, B; Mayrhauser, U; Leopold, B; Koestenbauer, S; Tscheliessnigg, K; Stadlbauer, V; Stiegler, P Impact of temperature on cell death in a cell-culture model of hepatocellular carcinoma.
Anticancer Res. 2012; 32(3):915-921
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Rohrl, C; Meisslitzer-Ruppitsch, C; Bittman, R; Li, ZG; Pabst, G; Prassl, R; Strobl, W; Neumuller, J; Ellinger, A; Pavelka, M; Stangl, H Combined Light and Electron Microscopy Using Diaminobenzidine Photooxidation to Monitor Trafficking of Lipids Derived from Lipoprotein Particles
CURR PHARM BIOTECHNO. 2012; 13(2): 331-340. Doi: 10.2174/138920112799095338 [OPEN ACCESS]
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2011

Bast, A; Schmidt, IH; Brauner, P; Brix, B; Breitbach, K; Steinmetz, I Defense Mechanisms of Hepatocytes Against Burkholderia pseudomallei.
Front Microbiol. 2011; 2(5):277-277 Doi: 10.3389/fmicb.2011.00277 [OPEN ACCESS]
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Hoffmann, K; Shibo, L; Xiao, Z; Longerich, T; Büchler, MW; Schemmer, P Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.
Anticancer Res. 2011; 31(11):3883-3890
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Zhang, Y; Lei, T; Huang, JF; Wang, SB; Zhou, LL; Yang, ZQ; Chen, XD The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes.
Mol Cell Endocrinol. 2011; 342(1-2): 41-47. Doi: 10.1016/j.mce.2011.05.003
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2010

Denk, GU; Maitz, S; Wimmer, R; Rust, C; Invernizzi, P; Ferdinandusse, S; Kulik, W; Fuchsbichler, A; Fickert, P; Trauner, M; Hofmann, AF; Beuers, U Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
Hepatology. 2010; 52(5): 1758-1768. Doi: 10.1002/hep.23911 [OPEN ACCESS]
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Mullen, PJ; Lüscher, B; Scharnagl, H; Krähenbühl, S; Brecht, K Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy.
Biochem Pharmacol. 2010; 79(8): 1200-1209. Doi: 10.1016/j.bcp.2009.12.007
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2006

Boyer, JL; Trauner, M; Mennone, A; Soroka, CJ; Cai, SY; Moustafa, T; Zollner, G; Lee, JY; Ballatori, N Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(6):G1124-G1130 Doi: 10.1152/ajpgi.00539.2005 [OPEN ACCESS]
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2005

Gauster, M; Hrzenjak, A; Schick, K; Frank, S Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family.
J LIPID RES. 2005; 46(5): 977-987. Doi: 10.1194/jlr.M400500-JLR200 [OPEN ACCESS]
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2004

Oberkofler, H; Schraml, E; Krempler, F; Patsch, W Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha.
Biochem J. 2004; 381(Pt 2): 357-363. Doi: 10.1042/BJ20040173 [OPEN ACCESS]
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Schmidt, H; Aulchenko, YS; Schweighofer, N; Schmidt, R; Frank, S; Kostner, GM; Ott, E; van Duijn, C Angiotensinogen promoter B-haplotype associated with cerebral small vessel disease enhances basal transcriptional activity.
STROKE. 2004; 35: 2592-2597. Doi: 10.1161/01.STR.0000144646.96121.d2 [OPEN ACCESS]
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Sirvent, A; Claudel, T; Martin, G; Brozek, J; Kosykh, V; Darteil, R; Hum, DW; Fruchart, JC; Staels, B The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
FEBS Lett. 2004; 566(1-3): 173-177. Doi: 10.1016/j.febslet.2004.04.026
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2003

Barbier, O; Torra, IP; Sirvent, A; Claudel, T; Blanquart, C; Duran-Sandoval, D; Kuipers, F; Kosykh, V; Fruchart, JC; Staels, B FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.
Gastroenterology. 2003; 124(7): 1926-1940. Doi: 10.1016/S0016-5085(03)00388-3
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Claudel, T; Inoue, Y; Barbier, O; Duran-Sandoval, D; Kosykh, V; Fruchart, J; Fruchart, JC; Gonzalez, FJ; Staels, B Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Gastroenterology. 2003; 125(2):544-555 Doi: 10.1016/S0016-5085(03)00896-5
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Manzoni, C; Duranti, M; Eberini, I; Scharnag, H; März, W; Castiglioni, S; Lovati, MR Subcellular localization of soybean 7S globulin in HepG2 cells and LDL receptor up-regulation by its alpha' constituent subunit.
J Nutr. 2003; 133(7):2149-2155 Doi: 10.1093/jn/133.7.2149 [OPEN ACCESS]
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Pineda Torra, I; Claudel, T; Duval, C; Kosykh, V; Fruchart, JC; Staels, B Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Mol Endocrinol. 2003; 17(2):259-272 Doi: 10.1210/me.2002-0120 [OPEN ACCESS]
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Strauss, JG; Hayn, M; Zechner, R; Levak-Frank, S; Frank, S Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells.
Biochem J. 2003; 371(Pt 3):981-988 Doi: 10.1042/BJ20021437 [OPEN ACCESS]
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2002

Claudel, T; Sturm, E; Duez, H; Torra, IP; Sirvent, A; Kosykh, V; Fruchart, JC; Dallongeville, J; Hum, DW; Kuipers, F; Staels, B Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
J Clin Invest. 2002; 109(7):961-971 Doi: 10.1172/JCI14505 [OPEN ACCESS]
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Strauss, JG; Zimmermann, R; Hrzenjak, A; Zhou, Y; Kratky, D; Levak-Frank, S; Kostner, GM; Zechner, R; Frank, S Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.
Biochem J. 2002; 368(Pt 1):69-79 Doi: 10.1042/BJ20020306 [OPEN ACCESS]
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2001

Scharnagl, H; Schinker, R; Gierens, H; Nauck, M; Wieland, H; März, W Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells.
BIOCHEM PHARMACOL 2001 62: 1545-1555. Doi: 10.1016/S0006-2952(01)00790-0
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Wolfrum, C; Borrmann, CM; Borchers, T; Spener, F Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.
Proc Natl Acad Sci U S A. 2001; 98(5):2323-2328 Doi: 10.1073/pnas.051619898 [OPEN ACCESS]
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2000

Gierens, H; Nauck, M; Roth, M; Schinker, R; Schürmann, C; Scharnagl, H; Neuhaus, G; Wieland, H; März, W Interleukin-6 stimulates LDL receptor gene expression via activation of sterol-responsive and Sp1 binding elements.
ARTERIOSCLER THROMB VASC BIOL 2000 20: 1777-1783. Doi: 10.1161/01.ATV.20.7.1777 [OPEN ACCESS]
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1999

Wolfrum, C; Ellinghaus, P; Fobker, M; Seedorf, U; Assmann, G; Börchers, T; Spener, F Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein.
J Lipid Res. 1999; 40(4):708-714 Doi: 10.1016/S0022-2275(20)32150-7 [OPEN ACCESS]
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1998

Goti, D; Reicher, H; Malle, E; Kostner, GM; Panzenboeck, U; Sattler, W High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles.
Biochem J. 1998; 332 ( Pt 1)(3):57-65 Doi: 10.1042/bj3320057 [OPEN ACCESS]
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Steiner, E; Kleinhappl, B; Gutschi, A; Marth, E Analysis of hsp70 mRNA levels in HepG2 cells exposed to various metals differing in toxicity
Toxicol Lett. 1998; 96-97(2):169-176 Doi: 10.1016%2FS0378-4274%2898%2900065-4
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1997

Hofer, G; Steyrer, E; Kostner, GM; Hermetter, A LDL-mediated interaction of Lpa with HepG2 cells: a novel fluorescence microscopy approach.
J LIPID RES 1997 38: 2411-2421. Doi: 10.1016/S0022-2275(20)30026-2 [OPEN ACCESS]
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1993

Kostner, GM Interaction of Lp(a) and of apo(a) with liver cells.
ARTERIOSCLER THROMB. 1993; 13(7): 1101-1109. Doi: 10.1161/01.ATV.13.7.1101 [OPEN ACCESS]
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1991

Watkins, PA; Ferrell, EV; Pedersen, JI; Hoefler, G Peroxisomal fatty acid beta-oxidation in HepG2 cells.
Arch Biochem Biophys. 1991; 289(2): 329-336. Doi: 10.1016/0003-9861(91)90419-J
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