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Publikationen

Suchbegriffe: ENZYME INHIBITORS - PHARMACOLOGY , . Treffer: 155

2023

Thomas, D; Wu, M; Nakauchi, Y; Zheng, M; Thompson-Peach, CAL; Lim, K; Landberg, N; Köhnke, T; Robinson, N; Kaur, S; Kutyna, M; Stafford, M; Hiwase, D; Reinisch, A; Peltz, G; Majeti, R Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability.
Cancer Discov. 2023; 13(2):496-515 Doi: 10.1158/2159-8290.CD-21-0218 [OPEN ACCESS]
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2017

Lebl, R; Thonhofer, M; Tysoe, C; Pabst, BM; Schalli, M; Weber, P; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.
Carbohydr Res. 2017; 442(15):31-40 Doi: 10.1016/j.carres.2017.03.003
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Plastira, I; Bernhart, E; Goeritzer, M; DeVaney, T; Reicher, H; Hammer, A; Lohberger, B; Wintersperger, A; Zucol, B; Graier, WF; Kratky, D; Malle, E; Sattler, W Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.
J Neuroinflammation. 2017; 14(1):253-253 Doi: 10.1186/s12974-017-1024-1 [OPEN ACCESS]
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Ruiz-Santaquiteria, M; Sánchez-Murcia, PA; Toro, MA; de Lucio, H; Gutiérrez, KJ; de Castro, S; Carneiro, FAC; Gago, F; Jiménez-Ruiz, A; Camarasa, MJ; Velázquez, S First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity^.
Eur J Med Chem. 2017; 135(19):49-59 Doi: 10.1016/j.ejmech.2017.04.020 [OPEN ACCESS]
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Schalli, M; Tysoe, C; Fischer, R; Pabst, BM; Thonhofer, M; Paschke, E; Rappitsch, T; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a G_M1-gangliosidosis related human lysosomal β-galactosidase mutant.
Carbohydr Res. 2017; 443-444(15):15-22 Doi: 10.1016/j.carres.2017.03.009
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Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG A new type of pharmacological chaperone for G_M1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.
Bioorg Med Chem Lett. 2017; 27(15):3431-3435 Doi: 10.1016/j.bmcl.2017.05.086
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2016

Bosche, B; Molcanyi, M; Noll, T; Rej, S; Zatschler, B; Doeppner, TR; Hescheler, J; Müller, DJ; Macdonald, RL; Härtel, FV A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation.
Prog Neuropsychopharmacol Biol Psychiatry. 2016; 67(4):98-106 Doi: 10.1016/j.pnpbp.2016.02.004
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Díez-Dacal, B; Sánchez-Gómez, FJ; Sánchez-Murcia, PA; Milackova, I; Zimmerman, T; Ballekova, J; García-Martín, E; Agúndez, JA; Gharbi, S; Gago, F; Stefek, M; Pérez-Sala, D Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins.
Mol Pharmacol. 2016; 89(1):42-52 Doi: 10.1124/mol.115.100693 [OPEN ACCESS]
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Suárez-Calvet, M; Neumann, M; Arzberger, T; Abou-Ajram, C; Funk, E; Hartmann, H; Edbauer, D; Kremmer, E; Göbl, C; Resch, M; Bourgeois, B; Madl, T; Reber, S; Jutzi, D; Ruepp, MD; Mackenzie, IR; Ansorge, O; Dormann, D; Haass, C Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
Acta Neuropathol. 2016; 131(4):587-604 Doi: 10.1007/s00401-016-1544-2 [OPEN ACCESS]
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Thonhofer, M; Gonzalez Santana, A; Fischer, R; Torvisco Gomez, A; Saf, R; Schalli, M; Stütz, AE; Withers, SG 5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease.
Carbohydr Res. 2016; 420(5): 6-12. Doi: 10.1016/j.carres.2015.10.009
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Thonhofer, M; Weber, P; Santana, AG; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Bioorg Med Chem Lett. 2016; 26(5):1438-1442 Doi: 10.1016/j.bmcl.2016.01.059
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2015

Berghold, VM; Gauster, M; Hemmings, DG; Moser, G; Kremshofer, J; Siwetz, M; Sundl, M; Huppertz, B Phospholipid scramblase 1 (PLSCR1) in villous trophoblast of the human placenta.
Histochem Cell Biol. 2015; 143(4):381-396 Doi: 10.1007/s00418-014-1294-y
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Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 Doi: 10.1016/j.bbalip.2015.06.005 [OPEN ACCESS]
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Scazzocchio, B; Varì, R; Filesi, C; Del Gaudio, I; D'Archivio, M; Santangelo, C; Iacovelli, A; Galvano, F; Pluchinotta, FR; Giovannini, C; Masella, R Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity.
Mol Nutr Food Res. 2015; 59(8):1472-1481 Doi: 10.1002/mnfr.201400816
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2014

Alkhani, H; Ase, AR; Grant, R; O'Donnell, D; Groschner, K; Séguéla, P Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.
Mol Pain. 2014; 10(6):43-43 Doi: 10.1186/1744-8069-10-43 [OPEN ACCESS]
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Loibl, M; Klein, I; Prattes, M; Schmidt, C; Kappel, L; Zisser, G; Gungl, A; Krieger, E; Pertschy, B; Bergler, H The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1.
J Biol Chem. 2014; 289(7): 3913-3922. Doi: 10.1074/jbc.M113.536110 [OPEN ACCESS]
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Quan, P; Moinfar, F; Kufferath, I; Absenger, M; Kueznik, T; Denk, H; Zatloukal, K; Haybaeck, J Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling.
Anticancer Res. 2014; 34(6):2883-2897
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Schulz, R; Murzabekova, G; Egemnazarov, B; Kraut, S; Eisele, HJ; Dumitrascu, R; Heitmann, J; Seimetz, M; Witzenrath, M; Ghofrani, HA; Schermuly, RT; Grimminger, F; Seeger, W; Weissmann, N Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.
J Hypertens. 2014; 32(2):300-305 Doi: 10.1097/HJH.0000000000000016
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2013

Lionetto, S; Little, A; Moriceau, G; Heymann, D; Decurtins, M; Plecko, M; Filgueira, L; Cadosch, D Pharmacological blocking of the osteoclastic biocorrosion of surgical stainless steel in vitro.
J Biomed Mater Res A. 2013; 101(4): 991-997. Doi: 10.1002/jbm.a.34402
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Robert, J; Lehner, M; Frank, S; Perisa, D; von Eckardstein, A; Rohrer, L Interleukin 6 stimulates endothelial binding and transport of high-density lipoprotein through induction of endothelial lipase.
Arterioscler Thromb Vasc Biol. 2013; 33(12):2699-2706 Doi: 10.1161/ATVBAHA.113.301363 [OPEN ACCESS]
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2012

Aflaki, E; Doddapattar, P; Radovic, B; Povoden, S; Kolb, D; Vujic, N; Wegscheider, M; Koefeler, H; Hornemann, T; Graier, WF; Malli, R; Madeo, F; Kratky, D C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.
Cell Death Dis. 2012; 3(6):e280-e280 Doi: 10.1038/cddis.2012.17 [OPEN ACCESS]
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Bondarenko, A; Panasiuk, O; Stepanenko, L; Goswami, N; Sagach, V Reduced hyperpolarization of endothelial cells following high dietary Na+: effects of enalapril and tempol.
Clin Exp Pharmacol Physiol. 2012; 39(7):608-613 Doi: 10.1111/j.1440-1681.2012.05718.x
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Fröhlich, JD; Huppertz, B; Abuja, PM; König, J; Desoye, G Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia.
Am J Pathol. 2012; 180(1): 153-164. Doi: 10.1016/j.ajpath.2011.09.012 [OPEN ACCESS]
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Ketabchi, F; Ghofrani, HA; Schermuly, RT; Seeger, W; Grimminger, F; Egemnazarov, B; Shid-Moosavi, SM; Dehghani, GA; Weissmann, N; Sommer, N Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.
Respir Res. 2012; 13(11):7-7 Doi: 10.1186/1465-9921-13-7 [OPEN ACCESS]
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Parichatikanond, W; Pinthong, D; Mangmool, S Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin.
Planta Med. 2012; 78(15):1626-1632 Doi: 10.1055/s-0032-1315198
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2011

Ravikumar, YS; Ray, U; Nandhitha, M; Perween, A; Raja Naika, H; Khanna, N; Das, S Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source.
Virus Res. 2011; 158(1-2): 89-97. Doi: 10.1016/j.virusres.2011.03.014
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Shalaby, A; Presneau, N; Ye, H; Halai, D; Berisha, F; Idowu, B; Leithner, A; Liegl, B; Briggs, TR; Bacsi, K; Kindblom, LG; Athanasou, N; Amary, MF; Hogendoorn, PC; Tirabosco, R; Flanagan, AM The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
J Pathol. 2011; 223(3): 336-346. Doi: 10.1002/path.2818
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2010

Fantur, K; Hofer, D; Schitter, G; Steiner, AJ; Pabst, BM; Wrodnigg, TM; Stütz, AE; Paschke, E DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts.
Mol Genet Metab. 2010; 100(3):262-268 Doi: 10.1016/j.ymgme.2010.03.019
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Frohlich, E; Kueznik, T; Samberger, C; Roblegg, E; Wrighton, C; Pieber, TR Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes.
TOXICOL APPL PHARMACOL. 2010; 242(3): 326-332. Doi: 10.1016/j.taap.2009.11.002
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Gauster, M; Siwetz, M; Orendi, K; Moser, G; Desoye, G; Huppertz, B Caspases rather than calpains mediate remodelling of the fodrin skeleton during human placental trophoblast fusion.
Cell Death Differ. 2010; 17(2): 336-345. Doi: 10.1038/cdd.2009.133 [OPEN ACCESS]
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Krstić, A; Santibanez, JF; Okić, I; Mojsilović, S; Kocić, J; Jovcić, G; Milenković, P; Bugarski, D Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice.
Acta Physiol (Oxf). 2010; 199(1): 31-41. Doi: 10.1111/j.1748-1716.2010.02082.x
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Santibáñez, JF; Kocić, J; Fabra, A; Cano, A; Quintanilla, M Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes.
FEBS Lett. 2010; 584(11): 2305-2310. Doi: 10.1016/j.febslet.2010.03.042 [OPEN ACCESS]
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Schellander, R; Donnerer, J Antidepressants: clinically relevant drug interactions to be considered.
Pharmacology. 2010; 86(4): 203-215. Doi: 10.1159/000319744
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Sedej, S; Heinzel, FR; Walther, S; Dybkova, N; Wakula, P; Groborz, J; Gronau, P; Maier, LS; Vos, MA; Lai, FA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovasc Res. 2010; 87(1):50-59 Doi: 10.1093/cvr/cvq007 [OPEN ACCESS]
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2009

Berna, MJ; Tapia, JA; Sancho, V; Thill, M; Pace, A; Hoffmann, KM; Gonzalez-Fernandez, L; Jensen, RT Gastrointestinal growth factors and hormones have divergent effects on Akt activation.
Cell Signal. 2009; 21(4): 622-638. Doi: 10.1016/j.cellsig.2009.01.003 [OPEN ACCESS]
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Chandak, PG; Gaikwad, AB; Tikoo, K Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP.
Phytother Res. 2009; 23(1):72-77 Doi: 10.1002/ptr.2559
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Racedo, SE; Branzini, MC; Salamone, D; Wójcik, C; Rawe, VY; Niemann, H Dynamics of microtubules, motor proteins and 20S proteasomes during bovine oocyte IVM.
Reprod Fertil Dev. 2009; 21(2):304-312 Doi: 10.1071/RD08111
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Riederer, M; Erwa, W; Zimmermann, R; Frank, S; Zechner, R Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Atherosclerosis. 2009; 204(2):412-417 Doi: 10.1016/j.atherosclerosis.2008.09.015
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von Lewinski, D; Kockskamper, J; Zhu, D; Post, H; Elgner, A; Pieske, B Reduced Stretch-Induced Force Response in Failing Human Myocardium Caused by Impaired Na+-Contraction Coupling
CIRC-HEART FAIL. 2009; 2(1): 47-55. Doi: 10.1161/CIRCHEARTFAILURE.108.794065 [OPEN ACCESS]
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2008

Cohen, G; Raupachova, J; Wimmer, T; Deicher, R; Hörl, WH The uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients.
Nephrol Dial Transplant. 2008; 23(8):2512-2519 Doi: 10.1093/ndt/gfn098 [OPEN ACCESS]
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Delli, Gatti, C; Osto, E; Kouroedov, A; Eto, M; Shaw, S; Volpe, M; Lüscher, TF; Cosentino, F Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.
Clin Exp Hypertens. 2008; 30(7):616-27 Doi: 10.1080/10641960802443183
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Heinzel, FR; Gres, P; Boengler, K; Duschin, A; Konietzka, I; Rassaf, T; Snedovskaya, J; Meyer, S; Skyschally, A; Kelm, M; Heusch, G; Schulz, R Inducible nitric oxide synthase expression and cardiomyocyte dysfunction during sustained moderate ischemia in pigs.
Circ Res. 2008; 103(10): 1120-1127. Doi: 10.1161/CIRCRESAHA.108.186015 [OPEN ACCESS]
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Klicek, R; Sever, M; Radic, B; Drmic, D; Kocman, I; Zoricic, I; Vuksic, T; Ivica, M; Barisic, I; Ilic, S; Berkopic, L; Vrcic, H; Brcic, L; Blagaic, AB; Coric, M; Brcic, I; Rokotov, DS; Anic, T; Seiwerth, S; Sikiric, P Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.
J Pharmacol Sci. 2008; 108(1): 7-17. Doi: 10.1254/jphs.FP0072161 [OPEN ACCESS]
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Steiner, AJ; Schitter, G; Stütz, AE; Wrodnigg, TM; Tarling, CA; Withers, SG; Fantur, K; Mahuran, D; Paschke, E; Tropak, M 1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.
Bioorg Med Chem. 2008; 16(24):10216-10220 Doi: 10.1016/j.bmc.2008.10.054 [OPEN ACCESS]
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Sturm, EM; Schratl, P; Schuligoi, R; Konya, V; Sturm, GJ; Lippe, IT; Peskar, BA; Heinemann, A Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors.
J Immunol. 2008; 181(10): 7273-7283. Doi: 10.4049/jimmunol.181.10.7273 [OPEN ACCESS]
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2007

Houben, R; Ortmann, S; Schrama, D; Herold, MJ; Berberich, I; Reichardt, HM; Becker, JC Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.
J Invest Dermatol. 2007; 127(9):2116-2122 Doi: 10.1038/sj.jid.5700857 [OPEN ACCESS]
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Majumder, S; Tamilarasan, KP; Kolluru, GK; Muley, A; Nair, CM; Omanakuttan, A; Murty, KV; Chatterjee, S Activated pericyte attenuates endothelial functions: nitric oxide-cGMP rescues activated pericyte-associated endothelial dysfunctions.
Biochem Cell Biol. 2007; 85(6):709-720 Doi: 10.1139/o07-140
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Malle, E; Furtmüller, PG; Sattler, W; Obinger, C Myeloperoxidase: a target for new drug development?
Br J Pharmacol. 2007; 152(6): 838-854. Doi: 10.1038/sj.bjp.0707358 [OPEN ACCESS]
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Malli, R; Frieden, M; Hunkova, M; Trenker, M; Graier, WF Ca2+ refilling of the endoplasmic reticulum is largely preserved albeit reduced Ca2+ entry in endothelial cells.
Cell Calcium. 2007; 41(1): 63-76. Doi: 10.1016/j.ceca.2006.05.001 [OPEN ACCESS]
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Osto, E; Coppolino, G; Volpe, M; Cosentino, F Restoring the dysfunctional endothelium.
Curr Pharm Des. 2007; 13(10):1053-68 Doi: 10.2174/138161207780487566
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