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Publikationen

Suchbegriffe: CARCINOMA, HEPATOCELLULAR - METABOLISM , . Treffer: 40

2022

Galhuber, M; Michenthaler, H; Heininger, C; Reinisch, I; Nössing, C; Krstic, J; Kupper, N; Moyschewitz, E; Auer, M; Heitzer, E; Ulz, P; Birner-Gruenberger, R; Liesinger, L; Lenihan-Geels, GN; Oster, M; Spreitzer, E; Zenezini, Chiozzi, R; Schulz, TJ; Schupp, M; Madl, T; Heck, AJR; Prokesch, A Complementary omics strategies to dissect p53 signaling networks under nutrient stress.
Cell Mol Life Sci. 2022; 79(6):326 Doi: 10.1007/s00018-022-04345-8 [OPEN ACCESS]
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2018

Li, M; Su, Y; Zhang, F; Chen, K; Xu, X; Xu, L; Zhou, J; Wang, W A dual-targeting reconstituted high density lipoprotein leveraging the synergy of sorafenib and antimiRNA21 for enhanced hepatocellular carcinoma therapy.
Acta Biomater. 2018; 75(10):413-426 Doi: 10.1016/j.actbio.2018.05.049
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2017

Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610 Doi: 10.1111/liv.13325
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Golob-Schwarzl, N; Krassnig, S; Toeglhofer, AM; Park, YN; Gogg-Kamerer, M; Vierlinger, K; Schröder, F; Rhee, H; Schicho, R; Fickert, P; Haybaeck, J New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Eur J Cancer. 2017; 83(60):56-70 Doi: 10.1016/j.ejca.2017.06.003
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Görtz, M; Galli, U; Longerich, T; Zöller, M; Erb, U; Schemmer, P De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells.
Oncol Rep. 2017; 38(5):2697-2704 Doi: 10.3892/or.2017.5980 [OPEN ACCESS]
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Lin, S; Hoffmann, K; Gao, C; Petrulionis, M; Herr, I; Schemmer, P Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.
J PINEAL RES. 2017; 62(3): Doi: 10.1111/jpi.12398
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Nelson, ME; Lahiri, S; Chow, JD; Byrne, FL; Hargett, SR; Breen, DS; Olzomer, EM; Wu, LE; Cooney, GJ; Turner, N; James, DE; Slack-Davis, JK; Lackner, C; Caldwell, SH; Hoehn, KL Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nat Commun. 2017; 8(6):14689-14689 Doi: 10.1038/ncomms14689 [OPEN ACCESS]
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Richtig, G; Aigelsreiter, A; Schwarzenbacher, D; Ress, AL; Adiprasito, JB; Stiegelbauer, V; Hoefler, G; Schauer, S; Kiesslich, T; Kornprat, P; Winder, T; Eisner, F; Gerger, A; Stoeger, H; Stauber, R; Lackner, C; Pichler, M SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
PLoS One. 2017; 12(11):e0187814-e0187814 Doi: 10.1371/journal.pone.0187814 [OPEN ACCESS]
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2016

Jeric, I; Maurer, G; Cavallo, AL; Raguz, J; Desideri, E; Tarkowski, B; Parrini, M; Fischer, I; Zatloukal, K; Baccarini, M A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nat Commun. 2016; 7(12):13781-13781 Doi: 10.1038/ncomms13781 [OPEN ACCESS]
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Trierweiler, C; Hockenjos, B; Zatloukal, K; Thimme, R; Blum, HE; Wagner, EF; Hasselblatt, P The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.
Cell Death Differ. 2016; 23(4):576-582 Doi: 10.1038/cdd.2015.121 [OPEN ACCESS]
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2015

Stotz, M; Gerger, A; Haybaeck, J; Kiesslich, T; Bullock, MD; Pichler, M Molecular Targeted Therapies in Hepatocellular Carcinoma: Past, Present and Future.
Anticancer Res. 2015; 35(11):5737-5744
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2014

Bruns, H; Petrulionis, M; Schultze, D; Al Saeedi, M; Lin, S; Yamanaka, K; Ambrazevičius, M; Strupas, K; Schemmer, P Glycine inhibits angiogenic signaling in human hepatocellular carcinoma cells.
Amino Acids. 2014; 46(4):969-976 Doi: 10.1007/s00726-013-1662-2
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Hucke, F; Pinter, M; Graziadei, I; Bota, S; Vogel, W; Müller, C; Heinzl, H; Waneck, F; Trauner, M; Peck-Radosavljevic, M; Sieghart, W How to STATE suitability and START transarterial chemoembolization in patients with intermediate stage hepatocellular carcinoma.
J Hepatol. 2014; 61(6):1287-1296 Doi: 10.1016/j.jhep.2014.07.002
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Kessler, SM; Simon, Y; Gemperlein, K; Gianmoena, K; Cadenas, C; Zimmer, V; Pokorny, J; Barghash, A; Helms, V; van Rooijen, N; Bohle, RM; Lammert, F; Hengstler, JG; Mueller, R; Haybaeck, J; Kiemer, AK Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Int J Mol Sci. 2014; 15(4):5762-5773 Doi: 10.3390/ijms15045762 [OPEN ACCESS]
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Lanaya, H; Natarajan, A; Komposch, K; Li, L; Amberg, N; Chen, L; Wculek, SK; Hammer, M; Zenz, R; Peck-Radosavljevic, M; Sieghart, W; Trauner, M; Wang, H; Sibilia, M EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.
Nat Cell Biol. 2014; 16(10): 1- 7. Doi: 10.1038/ncb3031 [OPEN ACCESS]
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Thomann, S; Longerich, T; Bazhin, AV; Mier, W; Schemmer, P; Ryschich, E Selective targeting of liver cancer with the endothelial marker CD146.
Oncotarget. 2014; 5(18):8614-8624 Doi: 10.18632/oncotarget.2345 [OPEN ACCESS]
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2013

Aigelsreiter, A; Ress, AL; Bettermann, K; Schauer, S; Koller, K; Eisner, F; Kiesslich, T; Stojakovic, T; Samonigg, H; Kornprat, P; Lackner, C; Haybaeck, J; Pichler, M Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma.
Br J Cancer. 2013; 108(9):1830-1837 Doi: 10.1038/bjc.2013.165 [OPEN ACCESS]
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Koschny, R; Brost, S; Hinz, U; Sykora, J; Batke, EM; Singer, S; Breuhahn, K; Stremmel, W; Walczak, H; Schemmer, P; Schirmacher, P; Ganten, TM Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.
BMC Cancer. 2013; 13(5):532-532 Doi: 10.1186/1471-2407-13-532 [OPEN ACCESS]
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2012

Aigelsreiter, A; Haybaeck, J; Schauer, S; Kiesslich, T; Bettermann, K; Griessbacher, A; Stojakovic, T; Bauernhofer, T; Samonigg, H; Kornprat, P; Lackner, C; Pichler, M NEMO expression in human hepatocellular carcinoma and its association with clinical outcome.
Hum Pathol. 2012; 43(7):1012-1019 Doi: 10.1016/j.humpath.2011.08.009
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Radnai, B; Antus, C; Racz, B; Engelmann, P; Priber, JK; Tucsek, Z; Veres, B; Turi, Z; Lorand, T; Sumegi, B; Gallyas, F Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Mol Cancer. 2012; 11(5): 34-34. Doi: 10.1186/1476-4598-11-34 [OPEN ACCESS]
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Zachau, L; Zeckey, C; Schlue, J; Sander, J; Meyer-Heithuis, C; Winkler, M; Klempnauer, J; Schrem, H Haematogenous abdominal wall metastasis of differentiated, alpha-fetoprotein-negative hepatocellular carcinoma after previous antiandrogen therapy within a site of lipoma manifestation since childhood.
World J Surg Oncol. 2012; 10(2): 98-98. Doi: 10.1186/1477-7819-10-98 (- Case Report) [OPEN ACCESS]
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2011

Hoffmann, K; Shibo, L; Xiao, Z; Longerich, T; Büchler, MW; Schemmer, P Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma.
Anticancer Res. 2011; 31(11):3883-3890
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Mahajan, V; Klingstedt, T; Simon, R; Nilsson, KP; Thueringer, A; Kashofer, K; Haybaeck, J; Denk, H; Abuja, PM; Zatloukal, K Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.
Gastroenterology. 2011; 141(3):1080-1090.e1-1080-1090.e7 Doi: 10.1053/j.gastro.2011.05.039
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Mayrhauser, U; Stiegler, P; Stadlbauer, V; Koestenbauer, S; Leber, B; Konrad, K; Iberer, F; Portugaller, RH; Tscheliessnigg, K Effect of hyperthermia on liver cell lines: important findings for thermal therapy in hepatocellular carcinoma.
Anticancer Res. 2011; 31(5):1583-1588
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Mayrhauser, U; Stiegler, P; Stadlbauer, V; Koestenbauer, S; Leber, B; Konrad, K; Iberer, F; Tscheliessnigg, K Cell to cell interactions influence sensitivity of liver cell lines during hyperthermia.
Anticancer Res. 2011; 31(11):3713-3717
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Mueller, KM; Kornfeld, JW; Friedbichler, K; Blaas, L; Egger, G; Esterbauer, H; Hasselblatt, P; Schlederer, M; Haindl, S; Wagner, KU; Engblom, D; Haemmerle, G; Kratky, D; Sexl, V; Kenner, L; Kozlov, AV; Terracciano, L; Zechner, R; Schuetz, G; Casanova, E; Pospisilik, JA; Heim, MH; Moriggl, R Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
Hepatology. 2011; 54(4):1398-1409 Doi: 10.1002/hep.24509 [OPEN ACCESS]
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2010

Frohlich, E; Kueznik, T; Samberger, C; Roblegg, E; Wrighton, C; Pieber, TR Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes.
TOXICOL APPL PHARMACOL. 2010; 242(3): 326-332. Doi: 10.1016/j.taap.2009.11.002
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Tomuleasa, C; Soritau, O; Rus-Ciuca, D; Pop, T; Todea, D; Mosteanu, O; Pintea, B; Foris, V; Susman, S; Kacsó, G; Irimie, A Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma.
J Gastrointestin Liver Dis. 2010; 19(1):61-67 [OPEN ACCESS]
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2009

Aigelsreiter, A; Janig, E; Sostaric, J; Pichler, M; Unterthor, D; Halasz, J; Lackner, C; Zatloukal, K; Denk, H Clusterin expression in cholestasis, hepatocellular carcinoma and liver fibrosis.
Histopathology. 2009; 54(5): 561-570. Doi: 10.1111/j.1365-2559.2009.03258.x
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Salnikov, AV; Kusumawidjaja, G; Rausch, V; Bruns, H; Gross, W; Khamidjanov, A; Ryschich, E; Gebhard, MM; Moldenhauer, G; Büchler, MW; Schemmer, P; Herr, I Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter.
Cancer Lett. 2009; 275(2):185-193 Doi: 10.1016/j.canlet.2008.10.015
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2006

Denk, H; Stumptner, C; Fuchsbichler, A; Müller, T; Farr, G; Müller, W; Terracciano, L; Zatloukal, K Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
J PATHOL. 2006; 208: 653-661. Doi: 10.1002/path.1946
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2003

Wadsack, C; Hirschmugl, B; Hammer, A; Levak-Frank, S; Kozarsky, KF; Sattler, W; Malle, E Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins.
Int J Biochem Cell Biol. 2003; 35(4):441-454 Doi: 10.1016/S1357-2725(02)00272-8
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2002

Artl, A; Marsche, G; Pussinen, P; Knipping, G; Sattler, W; Malle, E Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line.
Int J Biochem Cell Biol. 2002; 34(4):370-381 Doi: 10.1016/S1357-2725(01)00132-7
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2001

Frank, S; Gauster, M; Strauss, J; Hrzenjak, A; Kostner, GM Adenovirus-mediated apo(a)-antisense-RNA expression efficiently inhibits apo(a) synthesis in vitro and in vivo.
Gene Ther. 2001; 8(6):425-430 Doi: 10.1038/sj.gt.3301434 [OPEN ACCESS]
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1999

Stumptner, C; Heid, H; Fuchsbichler, A; Hauser, H; Mischinger, HJ; Zatloukal, K; Denk, H Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent.
Am J Pathol. 1999; 154(6):1701-1710 Doi: 10.1016/S0002-9440(10)65426-0 (- Case Report) [OPEN ACCESS]
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1998

Goti, D; Reicher, H; Malle, E; Kostner, GM; Panzenboeck, U; Sattler, W High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles.
Biochem J. 1998; 332 ( Pt 1)(3):57-65 Doi: 10.1042/bj3320057 [OPEN ACCESS]
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Steiner, E; Kleinhappl, B; Gutschi, A; Marth, E Analysis of hsp70 mRNA levels in HepG2 cells exposed to various metals differing in toxicity
Toxicol Lett. 1998; 96-97(2):169-176 Doi: 10.1016%2FS0378-4274%2898%2900065-4
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1997

Hofer, G; Steyrer, E; Kostner, GM; Hermetter, A LDL-mediated interaction of Lpa with HepG2 cells: a novel fluorescence microscopy approach.
J LIPID RES 1997 38: 2411-2421. Doi: 10.1016/S0022-2275(20)30026-2 [OPEN ACCESS]
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1991

Watkins, PA; Ferrell, EV; Pedersen, JI; Hoefler, G Peroxisomal fatty acid beta-oxidation in HepG2 cells.
Arch Biochem Biophys. 1991; 289(2): 329-336. Doi: 10.1016/0003-9861(91)90419-J
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1987

Krempler, F; Kostner, GM; Friedl, W; Paulweber, B; Bauer, H; Sandhofer, F Lipoprotein binding to cultured human hepatoma cells.
J Clin Invest. 1987; 80(2):401-408 Doi: 10.1172/JCI113086 [OPEN ACCESS]
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