Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: CALCIUM CHANNELS - METABOLISM , . Treffer: 63

2019

Gottschalk, B; Klec, C; Leitinger, G; Bernhart, E; Rost, R; Bischof, H; Madreiter-Sokolowski, CT; Radulović, S; Eroglu, E; Sattler, W; Waldeck-Weiermair, M; Malli, R; Graier, WF MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex.
Nat Commun. 2019; 10(1):3732-3732 [OPEN ACCESS]
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2017

Charoensin, S; Eroglu, E; Opelt, M; Bischof, H; Madreiter-Sokolowski, CT; Kirsch, A; Depaoli, MR; Frank, S; Schrammel, A; Mayer, B; Waldeck-Weiermair, M; Graier, WF; Malli, R Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS).
Free Radic Biol Med. 2017; 102(1):248-259 [OPEN ACCESS]
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Fahrner, M; Schindl, R; Muik, M; Derler, I; Romanin, C The STIM-Orai Pathway: The Interactions Between STIM and Orai.
Adv Exp Med Biol. 2017; 993(14-15):59-81
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Groschner, K; Shrestha, N; Fameli, N Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention.
Adv Exp Med Biol. 2017; 993: 473-503.
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Malli, R; Graier, WF The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry.
Adv Exp Med Biol. 2017; 993(14-15):297-319
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2016

Derler, I; Jardin, I; Stathopulos, PB; Muik, M; Fahrner, M; Zayats, V; Pandey, SK; Poteser, M; Lackner, B; Absolonova, M; Schindl, R; Groschner, K; Ettrich, R; Ikura, M; Romanin, C Cholesterol modulates Orai1 channel function.
Sci Signal. 2016; 9(412):ra10-ra10 [OPEN ACCESS]
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Madreiter-Sokolowski, CT; Gottschalk, B; Parichatikanond, W; Eroglu, E; Klec, C; Waldeck-Weiermair, M; Malli, R; Graier, WF Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Cell Physiol Biochem. 2016; 39(4):1404-1420 [OPEN ACCESS]
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Madreiter-Sokolowski, CT; Klec, C; Parichatikanond, W; Stryeck, S; Gottschalk, B; Pulido, S; Rost, R; Eroglu, E; Hofmann, NA; Bondarenko, AI; Madl, T; Waldeck-Weiermair, M; Malli, R; Graier, WF PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.
Nat Commun. 2016; 7(4):12897-12897 [OPEN ACCESS]
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2015

Bondarenko, AI; Parichatikanond, W; Madreiter, CT; Rost, R; Waldeck-Weiermair, M; Malli, R; Graier, WF UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria.
Pflugers Arch. 2015; 467(12):2509-2518 [OPEN ACCESS]
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Didiasova, M; Zakrzewicz, D; Magdolen, V; Nagaraj, C; Bálint, Z; Rohde, M; Preissner, KT; Wygrecka, M STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.
J Biol Chem. 2015; 290(19):11983-11999 [OPEN ACCESS]
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2014

Bondarenko, AI; Jean-Quartier, C; Parichatikanond, W; Alam, MR; Waldeck-Weiermair, M; Malli, R; Graier, WF Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane.
Pflugers Arch. 2014; 466(7):1411-1420 [OPEN ACCESS]
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Deak, AT; Blass, S; Khan, MJ; Groschner, LN; Waldeck-Weiermair, M; Hallström, S; Graier, WF; Malli, R IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake.
J Cell Sci. 2014; 127(Pt 13):2944-2955 [OPEN ACCESS]
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Etemad, S; Obermair, GJ; Bindreither, D; Benedetti, A; Stanika, R; Di Biase, V; Burtscher, V; Koschak, A; Kofler, R; Geley, S; Wille, A; Lusser, A; Flockerzi, V; Flucher, BE Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
J Neurosci. 2014; 34(4):1446-1461 [OPEN ACCESS]
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Fahrner, M; Muik, M; Schindl, R; Butorac, C; Stathopulos, P; Zheng, L; Jardin, I; Ikura, M; Romanin, C A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).
J Biol Chem. 2014; 289(48): 33231-33244. [OPEN ACCESS]
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2013

Deak, AT; Groschner, LN; Alam, MR; Seles, E; Bondarenko, AI; Graier, WF; Malli, R The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1-Orai1 interaction.
J Cell Sci. 2013; 126(Pt 4):879-888 [OPEN ACCESS]
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Derler, I; Plenk, P; Fahrner, M; Muik, M; Jardin, I; Schindl, R; Gruber, HJ; Groschner, K; Romanin, C The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
J Biol Chem. 2013; 288(40):29025-29034 [OPEN ACCESS]
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Derler, I; Schindl, R; Fritsch, R; Heftberger, P; Riedl, MC; Begg, M; House, D; Romanin, C The action of selective CRAC channel blockers is affected by the Orai pore geometry.
Cell Calcium. 2013; 53(2): 139-151. [OPEN ACCESS]
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González-Cobos, JC; Zhang, X; Zhang, W; Ruhle, B; Motiani, RK; Schindl, R; Muik, M; Spinelli, AM; Bisaillon, JM; Shinde, AV; Fahrner, M; Singer, HA; Matrougui, K; Barroso, M; Romanin, C; Trebak, M Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.
Circ Res. 2013; 112(7): 1013-1025. [OPEN ACCESS]
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König, S; Browne, S; Doleschal, B; Schernthaner, M; Poteser, M; Mächler, H; Wittchow, E; Braune, M; Muik, M; Romanin, C; Groschner, K Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.
Am J Physiol Heart Circ Physiol. 2013; 305(11):H1646-H1657 [OPEN ACCESS]
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Stathopulos, PB; Schindl, R; Fahrner, M; Zheng, L; Gasmi-Seabrook, GM; Muik, M; Romanin, C; Ikura, M STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.
Nat Commun. 2013; 4(48): 2963-2963. [OPEN ACCESS]
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Zhang, X; González-Cobos, JC; Schindl, R; Muik, M; Ruhle, B; Motiani, RK; Bisaillon, JM; Zhang, W; Fahrner, M; Barroso, M; Matrougui, K; Romanin, C; Trebak, M Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
Mol Cell Biol. 2013; 33(18): 3715-3723. [OPEN ACCESS]
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2012

Alam, MR; Groschner, LN; Parichatikanond, W; Kuo, L; Bondarenko, AI; Rost, R; Waldeck-Weiermair, M; Malli, R; Graier, WF Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells.
J Biol Chem. 2012; 287(41):34445-34454 [OPEN ACCESS]
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Muik, M; Schindl, R; Fahrner, M; Romanin, C Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.
Cell Mol Life Sci. 2012; 69(24): 4163-4176. [OPEN ACCESS]
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Schindl, R; Fritsch, R; Jardin, I; Frischauf, I; Kahr, H; Muik, M; Riedl, MC; Groschner, K; Romanin, C Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.
J Biol Chem. 2012; 287(42):35612-35620 [OPEN ACCESS]
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Willer, EA; Malli, R; Bondarenko, AI; Zahler, S; Vollmar, AM; Graier, WF; Fürst, R The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway.
J Mol Cell Cardiol. 2012; 53(4):567-577
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2011

Bergsmann, J; Derler, I; Muik, M; Frischauf, I; Fahrner, M; Pollheimer, P; Schwarzinger, C; Gruber, HJ; Groschner, K; Romanin, C Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.
J Biol Chem. 2011; 286(36): 31565-31575. [OPEN ACCESS]
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Frischauf, I; Schindl, R; Bergsmann, J; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Lackner, B; Groschner, K; Romanin, C Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.
J Biol Chem. 2011; 286(10):8577-8584 [OPEN ACCESS]
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Gemes, G; Bangaru, ML; Wu, HE; Tang, Q; Weihrauch, D; Koopmeiners, AS; Cruikshank, JM; Kwok, WM; Hogan, QH Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury.
J Neurosci. 2011; 31(10):3536-3549 [OPEN ACCESS]
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Muik, M; Fahrner, M; Schindl, R; Stathopulos, P; Frischauf, I; Derler, I; Plenk, P; Lackner, B; Groschner, K; Ikura, M; Romanin, C STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.
EMBO J. 2011; 30(9): 1678-1689. [OPEN ACCESS]
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Zheng, L; Stathopulos, PB; Schindl, R; Li, GY; Romanin, C; Ikura, M Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
Proc Natl Acad Sci U S A. 2011; 108(4): 1337-1342. [OPEN ACCESS]
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2010

Naghdi, S; Waideck-Weiermair, M; Fertschai, I; Poteser, M; Graier, WF; Malli, R Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1-dependent store-operated Ca2+ entry.
J CELL SCI. 2010; 123(Pt 15): 2553-2564. [OPEN ACCESS]
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2009

Derler, I; Fahrner, M; Muik, M; Lackner, B; Schindl, R; Groschner, K; Romanin, C A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.
J Biol Chem. 2009; 284(37): 24933-24938. [OPEN ACCESS]
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Donnerer, J; Liebmann, I; Schuligoi, R Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.
Basic Clin Pharmacol Toxicol. 2009; 104(1):11-16 [OPEN ACCESS]
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Fahrner, M; Muik, M; Derler, I; Schindl, R; Fritsch, R; Frischauf, I; Romanin, C Mechanistic view on domains mediating STIM1-Orai coupling.
Immunol Rev. 2009; 231(1): 99-112.
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Frischauf, I; Muik, M; Derler, I; Bergsmann, J; Fahrner, M; Schindl, R; Groschner, K; Romanin, C Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
J Biol Chem. 2009; 284(32): 21696-21706. [OPEN ACCESS]
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Muik, M; Fahrner, M; Derler, I; Schindl, R; Bergsmann, J; Frischauf, I; Groschner, K; Romanin, C A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
J Biol Chem. 2009; 284(13):8421-8426 [OPEN ACCESS]
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Schindl, R; Frischauf, I; Bergsmann, J; Muik, M; Derler, I; Lackner, B; Groschner, K; Romanin, C Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.
Proc Natl Acad Sci U S A. 2009; 106(46): 19623-19628. [OPEN ACCESS]
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Schindl, R; Muik, M; Fahrner, M; Derler, I; Fritsch, R; Bergsmann, J; Romanin, C Recent progress on STIM1 domains controlling Orai activation.
Cell Calcium. 2009; 46(4): 227-232.
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2008

Antoons, G; Sipido, KR Targeting calcium handling in arrhythmias.
Europace. 2008; 10(12):1364-1369 [OPEN ACCESS]
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Frischauf, I; Schindl, R; Derler, I; Bergsmann, J; Fahrner, M; Romanin, C The STIM/Orai coupling machinery.
Channels (Austin). 2008; 2(4): 261-268. [OPEN ACCESS]
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Jousset, H; Malli, R; Girardin, N; Graier, WF; Demaurex, N; Frieden, M Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2) store depletion in endothelial cells.
Cell Calcium. 2008; 43(1): 83-94.
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Muik, M; Frischauf, I; Derler, I; Fahrner, M; Bergsmann, J; Eder, P; Schindl, R; Hesch, C; Polzinger, B; Fritsch, R; Kahr, H; Madl, J; Gruber, H; Groschner, K; Romanin, C Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
J Biol Chem. 2008; 283(12):8014-8022 [OPEN ACCESS]
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Schindl, R; Bergsmann, J; Frischauf, I; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Groschner, K; Romanin, C 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
J Biol Chem. 2008; 283(29):20261-20267 [OPEN ACCESS]
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2006

Jost, B; Grabert, J; Patz, S; Schmidt, M; Wahle, P GABAC receptor subunit mRNA expression in the rat superior colliculus is regulated by calcium channels, neurotrophins, and GABAC receptor activity.
Brain Cell Biol. 2006; 35(4-6): 251-266.
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2005

Di Biase, V; Franzini-Armstrong, C Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery.
J Cell Biol. 2005; 171(4):695-704 [OPEN ACCESS]
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2004

Liu, X; Groschner, K; Ambudkar, IS Distinct Ca(2+)-permeable cation currents are activated by internal Ca(2+)-store depletion in RBL-2H3 cells and human salivary gland cells, HSG and HSY.
J Membr Biol. 2004; 200(2):93-104
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2003

Diem, R; Hobom, M; Maier, K; Weissert, R; Storch, MK; Meyer, R; Bähr, M Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway.
J Neurosci. 2003; 23(18):6993-7000 [OPEN ACCESS]
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Zhong, Z; Wheeler, MD; Li, X; Froh, M; Schemmer, P; Yin, M; Bunzendaul, H; Bradford, B; Lemasters, JJ L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.
Curr Opin Clin Nutr Metab Care. 2003; 6(2):229-240
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2002

Groschner, K Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity.
Cardiovasc Res. 2002; 53(1):9-11 [OPEN ACCESS]
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Schindl, R; Kahr, H; Graz, I; Groschner, K; Romanin, C Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels.
J Biol Chem. 2002; 277(30):26950-26958 [OPEN ACCESS]
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