Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Publikationen
Suchbegriffe: CRISPR, . Treffer: 23
2023
Crowther, LM; Poms, M; Zandl-Lang, M; Abela, L; Hartmann, H; Seiler, M; Mathis, D; Plecko, B
Metabolomics analysis of antiquitin deficiency in cultured human cells and plasma: Relevance to pyridoxine-dependent epilepsy.
J Inherit Metab Dis. 2023; 46(1): 129-142.
Doi: 10.1002/jimd.12569
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Dinter, J; Friedrich, RP; Yang, H; Pilarsky, C; Mangge, H; Pöttler, M; Janko, C; Alexiou, C; Lyer, S
Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids.
Materials (Basel). 2023; 16(7):
Doi: 10.3390/ma16072906
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Foßelteder, J; Pabst, G; Sconocchia, T; Schlacher, A; Auinger, L; Kashofer, K; Beham-Schmid, C; Trajanoski, S; Waskow, C; Schöll, W; Sill, H; Zebisch, A; Wölfler, A; Thomas, D; Reinisch, A
Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities.
Leukemia. 2023;
Doi: 10.1038/s41375-023-01848-6
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Sconocchia, T; Foßelteder, J; Köhnke, T; Majeti, R; Reinisch, A
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells.
J Vis Exp. 2023;
Doi: 10.3791/64558
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2022
Boos, SL; Loevenich, LP; Vosberg, S; Engleitner, T; Öllinger, R; Kumbrink, J; Rokavec, M; Michl, M; Greif, PA; Jung, A; Hermeking, H; Neumann, J; Kirchner, T; Rad, R; Jung, P
Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer.
Cell Mol Gastroenterol Hepatol. 2022; 13(2): 517-540.
Doi: 10.1016/j.jcmgh.2021.10.008
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Kumar, V; Pouw, RB; Autio, MI; Sagmeister, MG; Phua, ZY; Borghini, L; Wright, VJ; Hoggart, C; Pan, B; Tan, AKY; Binder, A; Brouwer, MC; Pinnock, E; De, Groot, R; Hazelzet, J; Emonts, M; Van, Der, Flier, M; Reiter, K; Nöthen, MM; Hoffmann, P; Schlapbach, LJ; Bellos, E; Anderson, S; Secka, F; Martinón-Torres, F; Salas, A; Fink, C; Carrol, ED; Pollard, AJ; Coin, LJ; Zenz, W; Wouters, D; Ang, LT; Hibberd, ML; Levin, M; Kuijpers, TW; Davila, S, , EUCLIDS, consortium
Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations.
Am J Hum Genet. 2022; 109(9): 1680-1691.
Doi: 10.1016/j.ajhg.2022.08.001
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Nakauchi, Y; Azizi, A; Thomas, D; Corces, MR; Reinisch, A; Sharma, R; Cruz, Hernandez, D; Köhnke, T; Karigane, D; Fan, A; Martinez-Krams, D; Stafford, M; Kaur, S; Dutta, R; Phan, P; Ediriwickrema, A; McCarthy, E; Ning, Y; Phillips, T; Ellison, CK; Guler, GD; Bergamaschi, A; Ku, CJ; Levy, S; Majeti, R
The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia.
Blood Cancer Discov. 2022; 3(4):346-367
Doi: 10.1158/2643-3230.BCD-21-0143
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Wirth, AK; Wange, L; Vosberg, S; Henrich, KO; Rausch, C; Özdemir, E; Zeller, CM; Richter, D; Feuchtinger, T; Kaller, M; Hermeking, H; Greif, PA; Senft, D; Jurinovic, V; Bahrami, E; Jayavelu, AK; Westermann, F; Mann, M; Enard, W; Herold, T; Jeremias, I
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
Leukemia. 2022; 36(12):2863-2874
Doi: 10.1038/s41375-022-01726-7
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2021
Berg, JL; Perfler, B; Hatzl, S; Mayer, MC; Wurm, S; Uhl, B; Reinisch, A; Klymiuk, I; Tierling, S; Pregartner, G; Bachmaier, G; Berghold, A; Geissler, K; Pichler, M; Hoefler, G; Strobl, H; Wölfler, A; Sill, H; Zebisch, A
Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia.
Clin Epigenetics. 2021; 13(1): 1-1.
Doi: 10.1186/s13148-020-00979-2
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Jensen, TI; Mikkelsen, NS; Gao, Z; Foßelteder, J; Pabst, G; Axelgaard, E; Laustsen, A; König, S; Reinisch, A; Bak, RO
Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi.
Genome Res. 2021; 31(11):2120-2130
Doi: 10.1101/gr.275607.121
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Krüger, C; Waldeck-Weiermair, M; Kaynert, J; Pokrant, T; Komaragiri, Y; Otto, O; Michel, T; Elsner, M
AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells.
Redox Biol. 2021; 43: 101962
Doi: 10.1016/j.redox.2021.101962
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2020
Dengler, MA; Teh, CE; Thijssen, R; Gangoda, L; Lan, P; Herold, MJ; Gray, DH; Kelly, GL; Roberts, AW; Adams, JM
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Oncogene. 2020; 39(9):2009-2023
Doi: 10.1038/s41388-019-1122-x
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Reicher, A; Harris, AL; Prinz, F; Kiesslich, T; Wei, M; Öllinger, R; Rad, R; Pichler, M; Kwong, LN
Generation of An Endogenous FGFR2-BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells.
Int J Mol Sci. 2020; 21(7): 2460
Doi: 10.3390/ijms21072460
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Reichmann, F; Rimmer, N; Tilley, CA; Dalla, Vecchia, E; Pinion, J; Al, Oustah, A; Carreño, Gutiérrez, H; Young, AMJ; McDearmid, JR; Winter, MJ; Norton, WHJ
The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity.
Acta Physiol (Oxf). 2020; 230(4):e13543
Doi: 10.1111/apha.13543
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Weber, RA; Yen, FS; Nicholson, SPV; Alwaseem, H; Bayraktar, EC; Alam, M; Timson, RC; La, K; Abu-Remaileh, M; Molina, H; Birsoy, K
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Mol Cell. 2020; 77(3):645-655
Doi: 10.1016/j.molcel.2020.01.003
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2019
Rhodes, CJ; Batai, K; Bleda, M; Haimel, M; Southgate, L; Germain, M; Pauciulo, MW; Hadinnapola, C; Aman, J; Girerd, B; Arora, A; Knight, J; Hanscombe, KB; Karnes, JH; Kaakinen, M; Gall, H; Ulrich, A; Harbaum, L; Cebola, I; Ferrer, J; Lutz, K; Swietlik, EM; Ahmad, F; Amouyel, P; Archer, SL; Argula, R; Austin, ED; Badesch, D; Bakshi, S; Barnett, C; Benza, R; Bhatt, N; Bogaard, HJ; Burger, CD; Chakinala, M; Church, C; Coghlan, JG; Condliffe, R; Corris, PA; Danesino, C; Debette, S; Elliott, CG; Elwing, J; Eyries, M; Fortin, T; Franke, A; Frantz, RP; Frost, A; Garcia, JGN; Ghio, S; Ghofrani, HA; Gibbs, JSR; Harley, J; He, H; Hill, NS; Hirsch, R; Houweling, AC; Howard, LS; Ivy, D; Kiely, DG; Klinger, J; Kovacs, G; Lahm, T; Laudes, M; Machado, RD; MacKenzie Ross, RV; Marsolo, K; Martin, LJ; Moledina, S; Montani, D; Nathan, SD; Newnham, M; Olschewski, A; Olschewski, H; Oudiz, RJ; Ouwehand, WH; Peacock, AJ; Pepke-Zaba, J; Rehman, Z; Robbins, I; Roden, DM; Rosenzweig, EB; Saydain, G; Scelsi, L; Schilz, R; Seeger, W; Shaffer, CM; Simms, RW; Simon, M; Sitbon, O; Suntharalingam, J; Tang, H; Tchourbanov, AY; Thenappan, T; Torres, F; Toshner, MR; Treacy, CM; Vonk Noordegraaf, A; Waisfisz, Q; Walsworth, AK; Walter, RE; Wharton, J; White, RJ; Wilt, J; Wort, SJ; Yung, D; Lawrie, A; Humbert, M; Soubrier, F; Trégouët, DA; Prokopenko, I; Kittles, R; Gräf, S; Nichols, WC; Trembath, RC; Desai, AA; Morrell, NW; Wilkins, MR; UK NIHR BioResource Rare Diseases Consortium; UK PAH Cohort Study Consortium; US PAH Biobank Consortium
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
Lancet Respir Med. 2019; 7(3):227-238
Doi: 10.1016/S2213-2600(18)30409-0
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Strell, C; Paulsson, J; Jin, SB; Tobin, NP; Mezheyeuski, A; Roswall, P; Mutgan, C; Mitsios, N; Johansson, H; Wickberg, SM; Svedlund, J; Nilsson, M; Hall, P; Mulder, J; Radisky, DC; Pietras, K; Bergh, J; Lendahl, U; Wärnberg, F; Östman, A
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.
J Natl Cancer Inst. 2019; 111(9):983-995
Doi: 10.1093/jnci/djy234
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Werthebach, M; Stewart, FA; Gahlen, A; Mettler-Altmann, T; Akhtar, I; Maas-Enriquez, K; Droste, A; Eichmann, TO; Poschmann, G; Stühler, K; Beller, M
Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.
Cell Rep. 2019; 26(13): 3726-3740.e7.
Doi: 10.1016/j.celrep.2019.02.110
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Zhu, XG; Nicholson Puthenveedu, S; Shen, Y; La, K; Ozlu, C; Wang, T; Klompstra, D; Gultekin, Y; Chi, J; Fidelin, J; Peng, T; Molina, H; Hang, HC; Min, W; Birsoy, K
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.
MOL CELL. 2019; 74(1): 45-58.
Doi: 10.1016/j.molcel.2019.01.037
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2018
Tomin, T; Fritz, K; Gindlhuber, J; Waldherr, L; Pucher, B; Thallinger, GG; Nomura, DK; Schittmayer, M; Birner-Gruenberger, R
Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells.
J Proteome Res. 2018; 17(4):1415-1425
Doi: 10.1021/acs.jproteome.7b00782
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2017
Bak, RO; Dever, DP; Reinisch, A; Cruz Hernandez, D; Majeti, R; Porteus, MH
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6.
Elife. 2017; 6(10):
Doi: 10.7554/eLife.27873
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2016
Dever, DP; Bak, RO; Reinisch, A; Camarena, J; Washington, G; Nicolas, CE; Pavel-Dinu, M; Saxena, N; Wilkens, AB; Mantri, S; Uchida, N; Hendel, A; Narla, A; Majeti, R; Weinberg, KI; Porteus, MH
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells.
Nature. 2016; 539(7629): 384-389.
Doi: 10.1038/nature20134
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2015
Zuckermann, M; Hovestadt, V; Knobbe-Thomsen, CB; Zapatka, M; Northcott, PA; Schramm, K; Belic, J; Jones, DT; Tschida, B; Moriarity, B; Largaespada, D; Roussel, MF; Korshunov, A; Reifenberger, G; Pfister, SM; Lichter, P; Kawauchi, D; Gronych, J
Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.
Nat Commun. 2015; 6(3):7391-7391
Doi: 10.1038/ncomms8391
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