Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: BILE ACIDS AND SALTS - METABOLISM , . Treffer: 63

2022

Li, H; Perino, A; Huang, Q; Von, Alvensleben, GVG; Banaei-Esfahani, A; Velazquez-Villegas, LA; Gariani, K; Korbelius, M; Bou, Sleiman, M; Imbach, J; Sun, Y; Li, X; Bachmann, A; Goeminne, LJE; Gallart-Ayala, H; Williams, EG; Ivanisevic, J; Auwerx, J; Schoonjans, K Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis.
Cell Metab. 2022; 34(10): 1594-1610.e4. Doi: 10.1016/j.cmet.2022.08.015 [OPEN ACCESS]
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2020

Streidl, T; Karkossa, I; Segura, Muñoz, RR; Eberl, C; Zaufel, A; Plagge, J; Schmaltz, R; Schubert, K; Basic, M; Schneider, KM; Afify, M; Trautwein, C; Tolba, R; Stecher, B; Doden, HL; Ridlon, JM; Ecker, J; Moustafa, T; von, Bergen, M; Ramer-Tait, AE; Clavel, T The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice.
GUT MICROBES. 2020; 13(1): 1-21. Doi: 10.1080/19490976.2020.1854008 [OPEN ACCESS]
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2019

Liu, L; Panzitt, K; Racedo, S; Wagner, M; Platzer, W; Zaufel, A; Theiler-Schwetz, V; Obermayer-Pietsch, B; Müller, H; Höfler, G; Heinemann, A; Zollner, G; Fickert, P Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
Liver Int. 2019; 39(11):2112-2123 Doi: 10.1111/liv.14052 [OPEN ACCESS]
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Theiler-Schwetz, V; Zaufel, A; Schlager, H; Obermayer-Pietsch, B; Fickert, P; Zollner, G Bile acids and glucocorticoid metabolism in health and disease.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(1):243-251 Doi: 10.1016/j.bbadis.2018.08.001 [OPEN ACCESS]
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2018

Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 Doi: 10.1016/j.bbadis.2017.08.028 [OPEN ACCESS]
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Lembke, M; Pennetzdorfer, N; Tutz, S; Koller, M; Vorkapic, D; Zhu, J; Schild, S; Reidl, J Proteolysis of ToxR is controlled by cysteine-thiol redox state and bile salts in Vibrio cholerae.
Mol Microbiol. 2018; 110(5): 796-810. Doi: 10.1111/mmi.14125 [OPEN ACCESS]
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2017

Castellani, C; Singer, G; Kaiser, M; Kaiser, T; Huang, J; Sperl, D; Kashofer, K; Fauler, G; Guertl-Lackner, B; Höfler, G; Till, H Neuroblastoma causes alterations of the intestinal microbiome, gut hormones, inflammatory cytokines, and bile acid composition.
Pediatr Blood Cancer. 2017; 64(8): Doi: 10.1002/pbc.26425
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Fuchs, CD; Paumgartner, G; Wahlström, A; Schwabl, P; Reiberger, T; Leditznig, N; Stojakovic, T; Rohr-Udilova, N; Chiba, P; Marschall, HU; Trauner, M Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.
J Hepatol. 2017; 66(1):95-101 Doi: 10.1016/j.jhep.2016.08.017 [OPEN ACCESS]
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2016

Baghdasaryan, A; Fuchs, CD; Österreicher, CH; Lemberger, UJ; Halilbasic, E; Påhlman, I; Graffner, H; Krones, E; Fickert, P; Wahlström, A; Ståhlman, M; Paumgartner, G; Marschall, HU; Trauner, M Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.
J Hepatol. 2016; 64(3):674-681 Doi: 10.1016/j.jhep.2015.10.024 [OPEN ACCESS]
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Gomez-Ospina, N; Potter, CJ; Xiao, R; Manickam, K; Kim, MS; Kim, KH; Shneider, BL; Picarsic, JL; Jacobson, TA; Zhang, J; He, W; Liu, P; Knisely, AS; Finegold, MJ; Muzny, DM; Boerwinkle, E; Lupski, JR; Plon, SE; Gibbs, RA; Eng, CM; Yang, Y; Washington, GC; Porteus, MH; Berquist, WE; Kambham, N; Singh, RJ; Xia, F; Enns, GM; Moore, DD Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
NAT COMMUN. 2016; 7(2): 10713-10713. Doi: 10.1038/ncomms10713 [OPEN ACCESS]
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Lemberger, UJ; Fuchs, CD; Karer, M; Haas, S; Stojakovic, T; Schöfer, C; Marschall, HU; Wrba, F; Taketo, MM; Egger, G; Trauner, M; Österreicher, CH Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.
Oncotarget. 2016; 7(52):86985-86998 Doi: 10.18632/oncotarget.13521 [OPEN ACCESS]
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2015

Krones, E; Wagner, M; Eller, K; Rosenkranz, AR; Trauner, M; Fickert, P Bile acid-induced cholemic nephropathy.
Dig Dis. 2015; 33(3):367-375 Doi: 10.1159/000371689
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Mueller, M; Thorell, A; Claudel, T; Jha, P; Koefeler, H; Lackner, C; Hoesel, B; Fauler, G; Stojakovic, T; Einarsson, C; Marschall, HU; Trauner, M Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.
J Hepatol. 2015; 62(6):1398-1404 Doi: 10.1016/j.jhep.2014.12.034 [OPEN ACCESS]
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Out, C; Patankar, JV; Doktorova, M; Boesjes, M; Bos, T; de Boer, S; Havinga, R; Wolters, H; Boverhof, R; van Dijk, TH; Smoczek, A; Bleich, A; Sachdev, V; Kratky, D; Kuipers, F; Verkade, HJ; Groen, AK Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
J Hepatol. 2015; 63(3):697-704 Doi: 10.1016/j.jhep.2015.04.030 [OPEN ACCESS]
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Stadlbauer, V; Leber, B; Lemesch, S; Trajanoski, S; Bashir, M; Horvath, A; Tawdrous, M; Stojakovic, T; Fauler, G; Fickert, P; Högenauer, C; Klymiuk, I; Stiegler, P; Lamprecht, M; Pieber, TR; Tripolt, NJ; Sourij, H Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.
PLoS One. 2015; 10(10):e0141399-e0141399 Doi: 10.1371/journal.pone.0141399 [OPEN ACCESS]
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Stiedl, P; McMahon, R; Blaas, L; Stanek, V; Svinka, J; Grabner, B; Zollner, G; Kessler, SM; Claudel, T; Müller, M; Mikulits, W; Bilban, M; Esterbauer, H; Eferl, R; Haybaeck, J; Trauner, M; Casanova, E Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.
Hepatology. 2015; 61(2):613-626 Doi: 10.1002/hep.27408 [OPEN ACCESS]
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2014

Baghdasaryan, A; Chiba, P; Trauner, M Clinical application of transcriptional activators of bile salt transporters.
Mol Aspects Med. 2014; 37:57-76 Doi: 10.1016/j.mam.2013.12.001 [OPEN ACCESS]
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Demetz, E; Schroll, A; Auer, K; Heim, C; Patsch, JR; Eller, P; Theurl, M; Theurl, I; Theurl, M; Seifert, M; Lener, D; Stanzl, U; Haschka, D; Asshoff, M; Dichtl, S; Nairz, M; Huber, E; Stadlinger, M; Moschen, AR; Li, X; Pallweber, P; Scharnagl, H; Stojakovic, T; März, W; Kleber, ME; Garlaschelli, K; Uboldi, P; Catapano, AL; Stellaard, F; Rudling, M; Kuba, K; Imai, Y; Arita, M; Schuetz, JD; Pramstaller, PP; Tietge, UJF; Trauner, M; Norata, GD; Claudel, T; Hicks, AA; Weiss, G; Tancevski, I The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.
Cell Metab. 2014; 20(5):787-798 Doi: 10.1016/j.cmet.2014.09.004 [OPEN ACCESS]
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García-Rodríguez, JL; Barbier-Torres, L; Fernández-Álvarez, S; Gutiérrez-de Juan, V; Monte, MJ; Halilbasic, E; Herranz, D; Álvarez, L; Aspichueta, P; Marín, JJ; Trauner, M; Mato, JM; Serrano, M; Beraza, N; Martínez-Chantar, ML SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Hepatology. 2014; 59(5):1972-1983 Doi: 10.1002/hep.26971 [OPEN ACCESS]
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Jahnel, J; Fickert, P; Hauer, AC; Högenauer, C; Avian, A; Trauner, M Inflammatory bowel disease alters intestinal bile acid transporter expression.
Drug Metab Dispos. 2014; 42(9):1423-1431 Doi: 10.1124/dmd.114.058065 [OPEN ACCESS]
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Schaap, FG; Trauner, M; Jansen, PL Bile acid receptors as targets for drug development.
Nat Rev Gastroenterol Hepatol. 2014; 11(1):55-67 Doi: 10.1038/nrgastro.2013.151 [OPEN ACCESS]
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Schiller, LR; Pardi, DS; Spiller, R; Semrad, CE; Surawicz, CM; Giannella, RA; Krejs, GJ; Farthing, MJ; Sellin, JH Gastro 2013 APDW/WCOG Shanghai working party report: chronic diarrhea: definition, classification, diagnosis.
J Gastroenterol Hepatol. 2014; 29(1):6-25 Doi: 10.1111/jgh.12392 [OPEN ACCESS]
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Woolbright, BL; Li, F; Xie, Y; Farhood, A; Fickert, P; Trauner, M; Jaeschke, H Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.
Toxicol Lett. 2014; 228(1):56-66 Doi: 10.1016/j.toxlet.2014.04.001 [OPEN ACCESS]
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2013

Fuchs, C; Claudel, T; Trauner, M Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342 Doi: 10.1055/s-0033-1358520
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2012

Modica, S; Petruzzelli, M; Bellafante, E; Murzilli, S; Salvatore, L; Celli, N; Di Tullio, G; Palasciano, G; Moustafa, T; Halilbasic, E; Trauner, M; Moschetta, A Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
Gastroenterology. 2012; 142(2):355-65.e1-355-65.e4 Doi: 10.1053/j.gastro.2011.10.028 [OPEN ACCESS]
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Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151 Doi: 10.1053/j.gastro.2011.09.051
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Schreiter, T; Marquitan, G; Darnell, M; Sowa, JP; Bröcker-Preuss, M; Andersson, TB; Baba, HA; Furch, M; Arteel, GE; Mathé, Z; Treckmann, J; Gerken, G; Gieseler, RK; Canbay, A An ex vivo perfusion system emulating in vivo conditions in noncirrhotic and cirrhotic human liver.
J Pharmacol Exp Ther. 2012; 342(3):730-741 Doi: 10.1124/jpet.112.194167
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2011

Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Adorini, L; Roda, A; Vecchiotti, S; Gonzalez, FJ; Schoonjans, K; Strazzabosco, M; Fickert, P; Trauner, M Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Hepatology. 2011; 54(4):1303-1312 Doi: 10.1002/hep.24537 [OPEN ACCESS]
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Claudel, T; Zollner, G; Wagner, M; Trauner, M Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.
Biochim Biophys Acta. 2011; 1812(8):867-878 Doi: 10.1016/j.bbadis.2010.12.021 [OPEN ACCESS]
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Tancevski, I; Demetz, E; Eller, P Sobetirome: a selective thyromimetic for the treatment of dyslipidemia.
Recent Pat Cardiovasc Drug Discov. 2011; 6(1):16-19 Doi: 10.2174/157489011794578473
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Trauner, M; Baghdasaryan, A; Claudel, T; Fickert, P; Halilbasic, E; Moustafa, T; Zollner, G Targeting nuclear bile acid receptors for liver disease.
Dig Dis. 2011; 29(1):98-102 Doi: 10.1159/000324141
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2010

Denk, GU; Maitz, S; Wimmer, R; Rust, C; Invernizzi, P; Ferdinandusse, S; Kulik, W; Fuchsbichler, A; Fickert, P; Trauner, M; Hofmann, AF; Beuers, U Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
Hepatology. 2010; 52(5): 1758-1768. Doi: 10.1002/hep.23911 [OPEN ACCESS]
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Wagner, M; Zollner, G; Trauner, M Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis.
SEMIN LIVER DIS. 2010; 30(2): 160-177. Doi: 10.1055/s-0030-1253225 [OPEN ACCESS]
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2009

Klein, K; Kullak-Ublick, GA; Wagner, M; Trauner, M; Eloranta, JJ Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.
Am J Physiol Gastrointest Liver Physiol. 2009; 296(4): G936-G947. Doi: 10.1152/ajpgi.90678.2008 [OPEN ACCESS]
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Zollner, G; Trauner, M Nuclear receptors as therapeutic targets in cholestatic liver diseases.
Br J Pharmacol. 2009; 156(1):7-27 Doi: 10.1111/j.1476-5381.2008.00030.x [OPEN ACCESS]
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2008

Wagner, M; Zollner, G; Trauner, M Nuclear bile acid receptor farnesoid X receptor meets nuclear factor-kappaB: new insights into hepatic inflammation.
Hepatology. 2008; 48(5):1383-1386 Doi: 10.1002/hep.22668 [OPEN ACCESS]
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2007

Fickert, P; Stöger, U; Fuchsbichler, A; Moustafa, T; Marschall, HU; Weiglein, AH; Tsybrovskyy, O; Jaeschke, H; Zatloukal, K; Denk, H; Trauner, M A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Am J Pathol. 2007; 171(2):525-536 Doi: 10.2353/ajpath.2007.061133 [OPEN ACCESS]
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Zollner, G; Wagner, M; Fickert, P; Silbert, D; Gumhold, J; Zatloukal, K; Denk, H; Trauner, M Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.
Liver Int. 2007; 27(7):920-929 Doi: 10.1111/j.1478-3231.2007.01506.x
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2006

Fickert, P; Fuchsbichler, A; Marschall, HU; Wagner, M; Zollner, G; Krause, R; Zatloukal, K; Jaeschke, H; Denk, H; Trauner, M Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
Am J Pathol. 2006; 168(2):410-422 Doi: 10.2353/ajpath.2006.050404 [OPEN ACCESS]
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Marschall, HU; Wagner, M; Bodin, K; Zollner, G; Fickert, P; Gumhold, J; Silbert, D; Fuchsbichler, A; Sjövall, J; Trauner, M Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.
J Lipid Res. 2006; 47(3):582-592 Doi: 10.1194/jlr.M500427-JLR200 [OPEN ACCESS]
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Zollner, G; Marschall, HU; Wagner, M; Trauner, M Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.
Mol Pharm. 2006; 3(3): 231-251. Doi: 10.1021/mp060010s
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Zollner, G; Trauner, M Molecular mechanisms of cholestasis.
Wien Med Wochenschr. 2006; 156(13-14):380-385 Doi: 10.1007/s10354-006-0312-7
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Zollner, G; Wagner, M; Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Halilbasic, E; Denk, H; Marschall, HU; Trauner, M Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G923-G932 Doi: 10.1152/ajpgi.00490.2005 [OPEN ACCESS]
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2005

Claudel, T; Staels, B; Kuipers, F The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.
Arterioscler Thromb Vasc Biol. 2005; 25(10): 2020-2030. Doi: 10.1161/01.ATV.0000178994.21828.a7 [OPEN ACCESS]
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Trauner, M; Wagner, M; Fickert, P; Zollner, G Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis.
J Clin Gastroenterol. 2005; 39(4 Suppl 2):S111-S124 Doi: 10.1097/01.mcg.0000155551.37266.26 [OPEN ACCESS]
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Wagner, M; Halilbasic, E; Marschall, HU; Zollner, G; Fickert, P; Langner, C; Zatloukal, K; Denk, H; Trauner, M CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
Hepatology. 2005; 42(2):420-430 Doi: 10.1002/hep.20784 [OPEN ACCESS]
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Wagner, M; Trauner, M Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis.
Ann Hepatol. 2005; 4(2): 77-99. Doi: 10.1016/S1665-2681(19)32071-X
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2004

Stauber, RE; Krisper, P; Zollner, G; Iberer, F; Beuers, U; Trauner, M Extracorporeal albumin dialysis in a patient with primary sclerosing cholangitis: effect on pruritus and bile acid profile.
Int J Artif Organs. 2004; 27(4):342-344 Doi: 10.1177/039139880402700411 (- Case Report)
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2003

Arrese, M; Trauner, M Molecular aspects of bile formation and cholestasis.
Trends Mol Med. 2003; 9(12):558-564 Doi: 10.1016/j.molmed.2003.10.002
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Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins.
J Hepatol. 2003; 38(4):387-394 Doi: 10.1016/S0168-8278(02)00439-7
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