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Publikationen

Suchbegriffe: LIVER - METABOLISM , . Treffer: 270

2022

Eisner, H; Riegler-Berket, L; Gamez, CFR; Sagmeister, T; Chalhoub, G; Darnhofer, B; Jazleena, PJ; Birner-Gruenberger, R; Pavkov-Keller, T; Haemmerle, G; Schoiswohl, G; Oberer, M The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1.
Int J Mol Sci. 2022; 23(21): Doi: 10.3390/ijms232113101 [OPEN ACCESS]
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Li, H; Perino, A; Huang, Q; Von, Alvensleben, GVG; Banaei-Esfahani, A; Velazquez-Villegas, LA; Gariani, K; Korbelius, M; Bou, Sleiman, M; Imbach, J; Sun, Y; Li, X; Bachmann, A; Goeminne, LJE; Gallart-Ayala, H; Williams, EG; Ivanisevic, J; Auwerx, J; Schoonjans, K Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis.
Cell Metab. 2022; 34(10): 1594-1610.e4. Doi: 10.1016/j.cmet.2022.08.015 [OPEN ACCESS]
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Oster, M; Galhuber, M; Krstic, J; Steinhoff, JS; Lenihan-Geels, G; Wulff, S; Kiefer, MF; Petricek, KM; Wowro, SJ; Flores, RE; Yang, N; Li, C; Meng, Y; Reinisch, I; Sommerfeld, M; Weger, S; Habisch, H; Madl, T; Schulz, TJ; Prokesch, A; Schupp, M Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
J Biol Chem. 2022; 298(9):102287 Doi: 10.1016/j.jbc.2022.102287 [OPEN ACCESS]
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Pixner, T; Stummer, N; Schneider, AM; Lukas, A; Gramlinger, K; Julian, V; Thivel, D; Mörwald, K; Mangge, H; Dalus, C; Aigner, E; Furthner, D; Weghuber, D; Maruszczak, K The relationship between glucose and the liver-alpha cell axis - A systematic review.
Front Endocrinol (Lausanne). 2022; 13:1061682 Doi: 10.3389/fendo.2022.1061682 [OPEN ACCESS]
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Zhou, Q; Zhang, F; Kerbl-Knapp, J; Korbelius, M; Kuentzel, KB; Vujić, N; Akhmetshina, A; Hörl, G; Paar, M; Steyrer, E; Kratky, D; Madl, T Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice.
BIOMOLECULES. 2022; 12(9): Doi: 10.3390/biom12091270 [OPEN ACCESS]
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2021

Pan, G; Diamanti, K; Cavalli, M; Lara, Gutiérrez, A; Komorowski, J; Wadelius, C Multifaceted regulation of hepatic lipid metabolism by YY1.
Life Sci Alliance. 2021; 4(7): Doi: 10.26508/lsa.202000928 [OPEN ACCESS]
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Sistilli, G; Kalendova, V; Cajka, T; Irodenko, I; Bardova, K; Oseeva, M; Zacek, P; Kroupova, P; Horakova, O; Lackner, K; Gastaldelli, A; Kuda, O; Kopecky, J; Rossmeisl, M Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity.
NUTRIENTS. 2021; 13(2): Doi: 10.3390/nu13020437 [OPEN ACCESS]
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2020

Alexopoulos, SJ; Chen, SY; Brandon, AE; Salamoun, JM; Byrne, FL; Garcia, CJ; Beretta, M; Olzomer, EM; Shah, DP; Philp, AM; Hargett, SR; Lawrence, RT; Lee, B; Sligar, J; Carrive, P; Tucker, SP; Philp, A; Lackner, C; Turner, N; Cooney, GJ; Santos, WL; Hoehn, KL Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.
Nat Commun. 2020; 11(1):2397-2397 Doi: 10.1038/s41467-020-16298-2 [OPEN ACCESS]
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Fellinger, P; Wolf, P; Pfleger, L; Krumpolec, P; Krssak, M; Klavins, K; Wolfsberger, S; Micko, A; Carey, P; Gürtl, B; Vila, G; Raber, W; Fürnsinn, C; Scherer, T; Trattnig, S; Kautzky-Willer, A; Krebs, M; Winhofer, Y Increased ATP synthesis might counteract hepatic lipid accumulation in acromegaly.
JCI Insight. 2020; 5(5): Doi: 10.1172/jci.insight.134638 [OPEN ACCESS]
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2019

Dengler, MA; Robin, AY; Gibson, L; Li, MX; Sandow, JJ; Iyer, S; Webb, AI; Westphal, D; Dewson, G; Adams, JM BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Cell Rep. 2019; 27(2):359-373 Doi: 10.1016/j.celrep.2019.03.040
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Pajed, L; Wagner, C; Taschler, U; Schreiber, R; Kolleritsch, S; Fawzy, N; Pototschnig, I; Schoiswohl, G; Pusch, LM; Wieser, BI; Vesely, P; Hoefler, G; Eichmann, TO; Zimmermann, R; Lass, A Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.
J Biol Chem. 2019; 294(23):9118-9133 Doi: 10.1074/jbc.RA118.007201 [OPEN ACCESS]
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Stumptner, C; Pabst, D; Loibner, M; Viertler, C; Zatloukal, K The impact of crosslinking and non-crosslinking fixatives on antigen retrieval and immunohistochemistry.
N Biotechnol. 2019; 52:69-83 Doi: 10.1016/j.nbt.2019.05.003
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Theiler-Schwetz, V; Zaufel, A; Schlager, H; Obermayer-Pietsch, B; Fickert, P; Zollner, G Bile acids and glucocorticoid metabolism in health and disease.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(1):243-251 Doi: 10.1016/j.bbadis.2018.08.001 [OPEN ACCESS]
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2018

Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 Doi: 10.1016/j.bbadis.2017.08.028 [OPEN ACCESS]
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Ramirez, T; Strigun, A; Verlohner, A; Huener, HA; Peter, E; Herold, M; Bordag, N; Mellert, W; Walk, T; Spitzer, M; Jiang, X; Sperber, S; Hofmann, T; Hartung, T; Kamp, H; van Ravenzwaay, B Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells.
Arch Toxicol. 2018; 92(2): 893-906. Doi: 10.1007/s00204-017-2079-6 [OPEN ACCESS]
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Tang, Y; Blomenkamp, KS; Fickert, P; Trauner, M; Teckman, JH NorUDCA promotes degradation of α1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway.
PLoS One. 2018; 13(8):e0200897-e0200897 Doi: 10.1371/journal.pone.0200897 [OPEN ACCESS]
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2017

Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610 Doi: 10.1111/liv.13325
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Boege, Y; Malehmir, M; Healy, ME; Bettermann, K; Lorentzen, A; Vucur, M; Ahuja, AK; Böhm, F; Mertens, JC; Shimizu, Y; Frick, L; Remouchamps, C; Mutreja, K; Kähne, T; Sundaravinayagam, D; Wolf, MJ; Rehrauer, H; Koppe, C; Speicher, T; Padrissa-Altés, S; Maire, R; Schattenberg, JM; Jeong, JS; Liu, L; Zwirner, S; Boger, R; Hüser, N; Davis, RJ; Müllhaupt, B; Moch, H; Schulze-Bergkamen, H; Clavien, PA; Werner, S; Borsig, L; Luther, SA; Jost, PJ; Weinlich, R; Unger, K; Behrens, A; Hillert, L; Dillon, C; Di Virgilio, M; Wallach, D; Dejardin, E; Zender, L; Naumann, M; Walczak, H; Green, DR; Lopes, M; Lavrik, I; Luedde, T; Heikenwalder, M; Weber, A A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer Cell. 2017; 32(3):342-359 Doi: 10.1016/j.ccell.2017.08.010 [OPEN ACCESS]
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Fuchs, CD; Claudel, T; Scharnagl, H; Stojakovic, T; Trauner, M FXR controls CHOP expression in steatohepatitis.
FEBS Lett. 2017; 591(20):3360-3368 Doi: 10.1002/1873-3468.12845 [OPEN ACCESS]
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Gong, JY; Setchell, KDR; Zhao, J; Zhang, W; Wolfe, B; Lu, Y; Lackner, K; Knisely, AS; Wang, NL; Hao, CZ; Zhang, MH; Wang, JS Severe Neonatal Cholestasis in Cerebrotendinous Xanthomatosis: Genetics, Immunostaining, Mass Spectrometry.
J Pediatr Gastroenterol Nutr. 2017; 65(5):561-568 Doi: 10.1097/MPG.0000000000001730
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Katanić, J; Matić, S; Pferschy-Wenzig, EM; Kretschmer, N; Boroja, T; Mihailović, V; Stanković, V; Stanković, N; Mladenović, M; Stanić, S; Mihailović, M; Bauer, R Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
Food Chem Toxicol. 2017; 99(2):86-102 Doi: 10.1016/j.fct.2016.11.018
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Lindquist, C; Bjørndal, B; Rossmann, CR; Tusubira, D; Svardal, A; Røsland, GV; Tronstad, KJ; Hallström, S; Berge, RK Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats.
J Lipid Res. 2017; 58(7):1362-1373 Doi: 10.1194/jlr.M074849 [OPEN ACCESS]
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Melvin, AJ; Warshaw, M; Compagnucci, A; Saidi, Y; Harrison, L; Turkova, A; Tudor-Williams, G; Tudor-Williams, G Hepatic, Renal, Hematologic, and Inflammatory Markers in HIV-Infected Children on Long-term Suppressive Antiretroviral Therapy.
J Pediatric Infect Dis Soc. 2017; 6(3):e109-e115-e109-e115 Doi: 10.1093/jpids/pix050 [OPEN ACCESS]
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Mueller, KM; Hartmann, K; Kaltenecker, D; Vettorazzi, S; Bauer, M; Mauser, L; Amann, S; Jall, S; Fischer, K; Esterbauer, H; Müller, TD; Tschöp, MH; Magnes, C; Haybaeck, J; Scherer, T; Bordag, N; Tuckermann, JP; Moriggl, R Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.
Diabetes. 2017; 66(2):272-286 Doi: 10.2337/db16-0381 [OPEN ACCESS]
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Nelson, ME; Lahiri, S; Chow, JD; Byrne, FL; Hargett, SR; Breen, DS; Olzomer, EM; Wu, LE; Cooney, GJ; Turner, N; James, DE; Slack-Davis, JK; Lackner, C; Caldwell, SH; Hoehn, KL Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nat Commun. 2017; 8(6):14689-14689 Doi: 10.1038/ncomms14689 [OPEN ACCESS]
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Prokesch, A; Graef, FA; Madl, T; Kahlhofer, J; Heidenreich, S; Schumann, A; Moyschewitz, E; Pristoynik, P; Blaschitz, A; Knauer, M; Muenzner, M; Bogner-Strauss, JG; Dohr, G; Schulz, TJ; Schupp, M Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.
FASEB J. 2017; 31(2):732-742 Doi: 10.1096/fj.201600845R [OPEN ACCESS]
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Qiu, YL; Gong, JY; Feng, JY; Wang, RX; Han, J; Liu, T; Lu, Y; Li, LT; Zhang, MH; Sheps, JA; Wang, NL; Yan, YY; Li, JQ; Chen, L; Borchers, CH; Sipos, B; Knisely, AS; Ling, V; Xing, QH; Wang, JS Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis.
Hepatology. 2017; 65(5):1655-1669 Doi: 10.1002/hep.29020 [OPEN ACCESS]
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Schrumpf, E; Jiang, X; Zeissig, S; Pollheimer, MJ; Anmarkrud, JA; Tan, C; Exley, MA; Karlsen, TH; Blumberg, RS; Melum, E The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.
Physiol Rep. 2017; 5(4): Doi: 10.14814/phy2.13117 [OPEN ACCESS]
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Vahdati Hassani, F; Mehri, S; Abnous, K; Birner-Gruenberger, R; Hosseinzadeh, H Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression.
Food Chem Toxicol. 2017; 107(Pt A):395-405 Doi: 10.1016/j.fct.2017.07.007
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Vujic, N; Korbelius, M; Leopold, C; Duta-Mare, M; Rainer, S; Schlager, S; Goeritzer, M; Kolb, D; Eichmann, TO; Diwoky, C; Zimmer, A; Zimmermann, R; Lass, A; Radovic, B; Kratky, D Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Oncotarget. 2017; 8(20):33122-33136 Doi: 10.18632/oncotarget.16529 [OPEN ACCESS]
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2016

Bartuzi, P; Billadeau, DD; Favier, R; Rong, S; Dekker, D; Fedoseienko, A; Fieten, H; Wijers, M; Levels, JH; Huijkman, N; Kloosterhuis, N; van der Molen, H; Brufau, G; Groen, AK; Elliott, AM; Kuivenhoven, JA; Plecko, B; Grangl, G; McGaughran, J; Horton, JD; Burstein, E; Hofker, MH; van de Sluis, B CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Nat Commun. 2016; 7(5):10961-10961 Doi: 10.1038/ncomms10961 [OPEN ACCESS]
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Fengler, VH; Macheiner, T; Kessler, SM; Czepukojc, B; Gemperlein, K; Müller, R; Kiemer, AK; Magnes, C; Haybaeck, J; Lackner, C; Sargsyan, K Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease.
PLoS One. 2016; 11(5):e0155163-e0155163 Doi: 10.1371/journal.pone.0155163 [OPEN ACCESS]
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Hartmann, P; Seebauer, CT; Mazagova, M; Horvath, A; Wang, L; Llorente, C; Varki, NM; Brandl, K; Ho, SB; Schnabl, B Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.
Am J Physiol Gastrointest Liver Physiol. 2016; 310(5):G310-G322 Doi: 10.1152/ajpgi.00094.2015 [OPEN ACCESS]
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Kawala, MA; Bohndorf, M; Graffmann, N; Wruck, W; Zatloukal, K; Adjaye, J Characterization of dermal fibroblast-derived iPSCs from a patient with high grade steatosis.
Stem Cell Res. 2016; 17(3):568-571 Doi: 10.1016/j.scr.2016.10.007 [OPEN ACCESS]
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Miller, HC; Frampton, AE; Malczewska, A; Ottaviani, S; Stronach, EA; Flora, R; Kaemmerer, D; Schwach, G; Pfragner, R; Faiz, O; Kos-Kudła, B; Hanna, GB; Stebbing, J; Castellano, L; Frilling, A MicroRNAs associated with small bowel neuroendocrine tumours and their metastases.
Endocr Relat Cancer. 2016; 23(9):711-726 Doi: 10.1530/ERC-16-0044 [OPEN ACCESS]
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Radović, B; Vujić, N; Leopold, C; Schlager, S; Goeritzer, M; Patankar, JV; Korbelius, M; Kolb, D; Reindl, J; Wegscheider, M; Tomin, T; Birner-Gruenberger, R; Schittmayer, M; Groschner, L; Magnes, C; Diwoky, C; Frank, S; Steyrer, E; Du, H; Graier, WF; Madl, T; Kratky, D Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Diabetologia. 2016; 59(8):1743-1752 Doi: 10.1007/s00125-016-3968-6 [OPEN ACCESS]
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Sachdev, V; Leopold, C; Bauer, R; Patankar, JV; Iqbal, J; Obrowsky, S; Boverhof, R; Doktorova, M; Scheicher, B; Goeritzer, M; Kolb, D; Turnbull, AV; Zimmer, A; Hoefler, G; Hussain, MM; Groen, AK; Kratky, D Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.
Biochim Biophys Acta. 2016; 1861(9 Pt A):1132-1141 Doi: 10.1016/j.bbalip.2016.06.014 [OPEN ACCESS]
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Scharinger, B; Messner, B; Türkcan, A; Schuster, D; Vuorinen, A; Pitterl, F; Heinz, K; Arnhard, K; Laufer, G; Grimm, M; Stuppner, H; Oberacher, H; Eller, P; Ritsch, A; Bernhard, D Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice.
J Mol Cell Cardiol. 2016; 99(7):35-46 Doi: 10.1016/j.yjmcc.2016.08.003 [OPEN ACCESS]
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Themanns, M; Mueller, KM; Kessler, SM; Golob-Schwarzl, N; Mohr, T; Kaltenecker, D; Bourgeais, J; Paier-Pourani, J; Friedbichler, K; Schneller, D; Schlederer, M; Zebedin-Brandl, E; Terracciano, LM; Han, X; Kenner, L; Wagner, KU; Mikulits, W; Kozlov, AV; Heim, MH; Gouilleux, F; Haybaeck, J; Moriggl, R Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.
Sci Rep. 2016; 6(4):34719-34719 Doi: 10.1038/srep34719 [OPEN ACCESS]
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Trieb, M; Horvath, A; Birner-Gruenberger, R; Spindelboeck, W; Stadlbauer, V; Taschler, U; Curcic, S; Stauber, RE; Holzer, M; Pasterk, L; Heinemann, A; Marsche, G Liver disease alters high-density lipoprotein composition, metabolism and function.
Biochim Biophys Acta. 2016; 1861(7):630-638 Doi: 10.1016/j.bbalip.2016.04.013 [OPEN ACCESS]
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Trierweiler, C; Hockenjos, B; Zatloukal, K; Thimme, R; Blum, HE; Wagner, EF; Hasselblatt, P The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.
Cell Death Differ. 2016; 23(4):576-582 Doi: 10.1038/cdd.2015.121 [OPEN ACCESS]
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Vinod, M; Patankar, JV; Sachdev, V; Frank, S; Graier, WF; Kratky, D; Kostner, GM MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.
Am J Physiol Endocrinol Metab. 2016; 311(1):E175-E185 Doi: 10.1152/ajpendo.00510.2015 [OPEN ACCESS]
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Wagner, M; Choi, S; Panzitt, K; Mamrosh, JL; Lee, JM; Zaufel, A; Xiao, R; Wooton-Kee, R; Ståhlman, M; Newgard, CB; Borén, J; Moore, DD Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.
Hepatology. 2016; 63(1):95-106 Doi: 10.1002/hep.28124 [OPEN ACCESS]
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Yang, H; Ni, HM; Guo, F; Ding, Y; Shi, YH; Lahiri, P; Fröhlich, LF; Rülicke, T; Smole, C; Schmidt, VC; Zatloukal, K; Cui, Y; Komatsu, M; Fan, J; Ding, WX Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 2016; 291(36):18663-18674 Doi: 10.1074/jbc.M116.739821 [OPEN ACCESS]
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2015

Abuja, PM; Ehrhart, F; Schoen, U; Schmidt, T; Stracke, F; Dallmann, G; Friedrich, T; Zimmermann, H; Zatloukal, K Alterations in Human Liver Metabolome during Prolonged Cryostorage.
J Proteome Res. 2015; 14(7):2758-2768 Doi: 10.1021/acs.jproteome.5b00025
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Beilfuss, A; Sowa, JP; Sydor, S; Beste, M; Bechmann, LP; Schlattjan, M; Syn, WK; Wedemeyer, I; Mathé, Z; Jochum, C; Gerken, G; Gieseler, RK; Canbay, A Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently.
Gut. 2015; 64(5):791-799 Doi: 10.1136/gutjnl-2014-307024
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Chen, Y; Guldiken, N; Spurny, M; Mohammed, HH; Haybaeck, J; Pollheimer, MJ; Fickert, P; Gassler, N; Jeon, MK; Trautwein, C; Strnad, P Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.
J Pathol. 2015; 237(3):343-354 Doi: 10.1002/path.4580
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Chmelík, M; Valkovič, L; Wolf, P; Bogner, W; Gajdošík, M; Halilbasic, E; Gruber, S; Trauner, M; Krebs, M; Trattnig, S; Krššák, M Phosphatidylcholine contributes to in vivo (31)P MRS signal from the human liver.
Eur Radiol. 2015; 25(7):2059-2066 Doi: 10.1007/s00330-014-3578-y
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Dražić, T; Sachdev, V; Leopold, C; Patankar, JV; Malnar, M; Hećimović, S; Levak-Frank, S; Habuš, I; Kratky, D Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem. 2015; 23(10):2353-2359 Doi: 10.1016/j.bmc.2015.03.067 [OPEN ACCESS]
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Fritsch, M; Koliaki, C; Livingstone, R; Phielix, E; Bierwagen, A; Meisinger, M; Jelenik, T; Strassburger, K; Zimmermann, S; Brockmann, K; Wolff, C; Hwang, JH; Szendroedi, J; Roden, M Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients.
Am J Clin Nutr. 2015; 102(5): 1051-1058. Doi: 10.3945/ajcn.115.107599 [OPEN ACCESS]
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