Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: BILE ACIDS AND SALTS - METABOLISM , . Treffer: 56

2018

Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 [OPEN ACCESS]
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2017

Castellani, C; Singer, G; Kaiser, M; Kaiser, T; Huang, J; Sperl, D; Kashofer, K; Fauler, G; Guertl-Lackner, B; Höfler, G; Till, H Neuroblastoma causes alterations of the intestinal microbiome, gut hormones, inflammatory cytokines, and bile acid composition.
Pediatr Blood Cancer. 2017; 64(8):
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2016

Baghdasaryan, A; Fuchs, CD; Österreicher, CH; Lemberger, UJ; Halilbasic, E; Påhlman, I; Graffner, H; Krones, E; Fickert, P; Wahlström, A; Ståhlman, M; Paumgartner, G; Marschall, HU; Trauner, M Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.
J Hepatol. 2016; 64(3):674-681 [OPEN ACCESS]
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Gomez-Ospina, N; Potter, CJ; Xiao, R; Manickam, K; Kim, MS; Kim, KH; Shneider, BL; Picarsic, JL; Jacobson, TA; Zhang, J; He, W; Liu, P; Knisely, AS; Finegold, MJ; Muzny, DM; Boerwinkle, E; Lupski, JR; Plon, SE; Gibbs, RA; Eng, CM; Yang, Y; Washington, GC; Porteus, MH; Berquist, WE; Kambham, N; Singh, RJ; Xia, F; Enns, GM; Moore, DD Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
NAT COMMUN. 2016; 7(2): 10713-10713. [OPEN ACCESS]
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Lemberger, UJ; Fuchs, CD; Karer, M; Haas, S; Stojakovic, T; Schöfer, C; Marschall, HU; Wrba, F; Taketo, MM; Egger, G; Trauner, M; Österreicher, CH Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.
Oncotarget. 2016; 7(52):86985-86998 [OPEN ACCESS]
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2015

Krones, E; Wagner, M; Eller, K; Rosenkranz, AR; Trauner, M; Fickert, P Bile acid-induced cholemic nephropathy.
Dig Dis. 2015; 33(3):367-375
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Mueller, M; Thorell, A; Claudel, T; Jha, P; Koefeler, H; Lackner, C; Hoesel, B; Fauler, G; Stojakovic, T; Einarsson, C; Marschall, HU; Trauner, M Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.
J Hepatol. 2015; 62(6):1398-1404 [OPEN ACCESS]
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Out, C; Patankar, JV; Doktorova, M; Boesjes, M; Bos, T; de Boer, S; Havinga, R; Wolters, H; Boverhof, R; van Dijk, TH; Smoczek, A; Bleich, A; Sachdev, V; Kratky, D; Kuipers, F; Verkade, HJ; Groen, AK Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
J Hepatol. 2015; 63(3):697-704 [OPEN ACCESS]
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Stadlbauer, V; Leber, B; Lemesch, S; Trajanoski, S; Bashir, M; Horvath, A; Tawdrous, M; Stojakovic, T; Fauler, G; Fickert, P; Högenauer, C; Klymiuk, I; Stiegler, P; Lamprecht, M; Pieber, TR; Tripolt, NJ; Sourij, H Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.
PLoS One. 2015; 10(10):e0141399-e0141399 [OPEN ACCESS]
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Stiedl, P; McMahon, R; Blaas, L; Stanek, V; Svinka, J; Grabner, B; Zollner, G; Kessler, SM; Claudel, T; Müller, M; Mikulits, W; Bilban, M; Esterbauer, H; Eferl, R; Haybaeck, J; Trauner, M; Casanova, E Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.
Hepatology. 2015; 61(2):613-626 [OPEN ACCESS]
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2014

Baghdasaryan, A; Chiba, P; Trauner, M Clinical application of transcriptional activators of bile salt transporters.
Mol Aspects Med. 2014; 37:57-76 [OPEN ACCESS]
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Demetz, E; Schroll, A; Auer, K; Heim, C; Patsch, JR; Eller, P; Theurl, M; Theurl, I; Theurl, M; Seifert, M; Lener, D; Stanzl, U; Haschka, D; Asshoff, M; Dichtl, S; Nairz, M; Huber, E; Stadlinger, M; Moschen, AR; Li, X; Pallweber, P; Scharnagl, H; Stojakovic, T; März, W; Kleber, ME; Garlaschelli, K; Uboldi, P; Catapano, AL; Stellaard, F; Rudling, M; Kuba, K; Imai, Y; Arita, M; Schuetz, JD; Pramstaller, PP; Tietge, UJF; Trauner, M; Norata, GD; Claudel, T; Hicks, AA; Weiss, G; Tancevski, I The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.
Cell Metab. 2014; 20(5):787-798 [OPEN ACCESS]
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García-Rodríguez, JL; Barbier-Torres, L; Fernández-Álvarez, S; Gutiérrez-de Juan, V; Monte, MJ; Halilbasic, E; Herranz, D; Álvarez, L; Aspichueta, P; Marín, JJ; Trauner, M; Mato, JM; Serrano, M; Beraza, N; Martínez-Chantar, ML SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
Hepatology. 2014; 59(5):1972-1983 [OPEN ACCESS]
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Jahnel, J; Fickert, P; Hauer, AC; Högenauer, C; Avian, A; Trauner, M Inflammatory bowel disease alters intestinal bile acid transporter expression.
Drug Metab Dispos. 2014; 42(9):1423-1431 [OPEN ACCESS]
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Schaap, FG; Trauner, M; Jansen, PL Bile acid receptors as targets for drug development.
Nat Rev Gastroenterol Hepatol. 2014; 11(1):55-67
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Schiller, LR; Pardi, DS; Spiller, R; Semrad, CE; Surawicz, CM; Giannella, RA; Krejs, GJ; Farthing, MJ; Sellin, JH Gastro 2013 APDW/WCOG Shanghai working party report: chronic diarrhea: definition, classification, diagnosis.
J Gastroenterol Hepatol. 2014; 29(1):6-25 [OPEN ACCESS]
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Woolbright, BL; Li, F; Xie, Y; Farhood, A; Fickert, P; Trauner, M; Jaeschke, H Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.
Toxicol Lett. 2014; 228(1):56-66 [OPEN ACCESS]
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2013

Fuchs, C; Claudel, T; Trauner, M Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342
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2012

Modica, S; Petruzzelli, M; Bellafante, E; Murzilli, S; Salvatore, L; Celli, N; Di Tullio, G; Palasciano, G; Moustafa, T; Halilbasic, E; Trauner, M; Moschetta, A Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
Gastroenterology. 2012; 142(2):355-65.e1-355-65.e4
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Moustafa, T; Fickert, P; Magnes, C; Guelly, C; Thueringer, A; Frank, S; Kratky, D; Sattler, W; Reicher, H; Sinner, F; Gumhold, J; Silbert, D; Fauler, G; Höfler, G; Lass, A; Zechner, R; Trauner, M Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Gastroenterology. 2012; 142(1):140-151
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2011

Baghdasaryan, A; Claudel, T; Gumhold, J; Silbert, D; Adorini, L; Roda, A; Vecchiotti, S; Gonzalez, FJ; Schoonjans, K; Strazzabosco, M; Fickert, P; Trauner, M Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Hepatology. 2011; 54(4):1303-1312 [OPEN ACCESS]
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Claudel, T; Zollner, G; Wagner, M; Trauner, M Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.
Biochim Biophys Acta. 2011; 1812(8):867-878 [OPEN ACCESS]
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Tancevski, I; Demetz, E; Eller, P Sobetirome: a selective thyromimetic for the treatment of dyslipidemia.
Recent Pat Cardiovasc Drug Discov. 2011; 6(1):16-19
PubMed

 

Trauner, M; Baghdasaryan, A; Claudel, T; Fickert, P; Halilbasic, E; Moustafa, T; Zollner, G Targeting nuclear bile acid receptors for liver disease.
Dig Dis. 2011; 29(1):98-102
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2010

Denk, GU; Maitz, S; Wimmer, R; Rust, C; Invernizzi, P; Ferdinandusse, S; Kulik, W; Fuchsbichler, A; Fickert, P; Trauner, M; Hofmann, AF; Beuers, U Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
Hepatology. 2010; 52(5): 1758-1768. [OPEN ACCESS]
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Wagner, M; Zollner, G; Trauner, M Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis.
SEMIN LIVER DIS. 2010; 30(2): 160-177. [OPEN ACCESS]
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2009

Klein, K; Kullak-Ublick, GA; Wagner, M; Trauner, M; Eloranta, JJ Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.
Am J Physiol Gastrointest Liver Physiol. 2009; 296(4): G936-G947. [OPEN ACCESS]
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Zollner, G; Trauner, M Nuclear receptors as therapeutic targets in cholestatic liver diseases.
Br J Pharmacol. 2009; 156(1):7-27 [OPEN ACCESS]
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2008

Wagner, M; Zollner, G; Trauner, M Nuclear bile acid receptor farnesoid X receptor meets nuclear factor-kappaB: new insights into hepatic inflammation.
Hepatology. 2008; 48(5):1383-1386 [OPEN ACCESS]
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2007

Fickert, P; Stöger, U; Fuchsbichler, A; Moustafa, T; Marschall, HU; Weiglein, AH; Tsybrovskyy, O; Jaeschke, H; Zatloukal, K; Denk, H; Trauner, M A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Am J Pathol. 2007; 171(2):525-536 [OPEN ACCESS]
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Zollner, G; Wagner, M; Fickert, P; Silbert, D; Gumhold, J; Zatloukal, K; Denk, H; Trauner, M Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.
Liver Int. 2007; 27(7):920-929
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2006

Fickert, P; Fuchsbichler, A; Marschall, HU; Wagner, M; Zollner, G; Krause, R; Zatloukal, K; Jaeschke, H; Denk, H; Trauner, M Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
Am J Pathol. 2006; 168(2):410-422 [OPEN ACCESS]
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Marschall, HU; Wagner, M; Bodin, K; Zollner, G; Fickert, P; Gumhold, J; Silbert, D; Fuchsbichler, A; Sjövall, J; Trauner, M Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.
J Lipid Res. 2006; 47(3):582-592 [OPEN ACCESS]
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Zollner, G; Marschall, HU; Wagner, M; Trauner, M Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.
Mol Pharm. 2006; 3(3): 231-251.
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Zollner, G; Trauner, M Molecular mechanisms of cholestasis.
Wien Med Wochenschr. 2006; 156(13-14):380-385
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Zollner, G; Wagner, M; Moustafa, T; Fickert, P; Silbert, D; Gumhold, J; Fuchsbichler, A; Halilbasic, E; Denk, H; Marschall, HU; Trauner, M Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G923-G932 [OPEN ACCESS]
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2005

Claudel, T; Staels, B; Kuipers, F The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.
Arterioscler Thromb Vasc Biol. 2005; 25(10): 2020-2030. [OPEN ACCESS]
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Trauner, M; Wagner, M; Fickert, P; Zollner, G Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis.
J Clin Gastroenterol. 2005; 39(4 Suppl 2):S111-S124 [OPEN ACCESS]
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Wagner, M; Halilbasic, E; Marschall, HU; Zollner, G; Fickert, P; Langner, C; Zatloukal, K; Denk, H; Trauner, M CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
Hepatology. 2005; 42(2):420-430 [OPEN ACCESS]
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Wagner, M; Trauner, M Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis.
Ann Hepatol. 2005; 4(2): 77-99.
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2004

Stauber, RE; Krisper, P; Zollner, G; Iberer, F; Beuers, U; Trauner, M Extracorporeal albumin dialysis in a patient with primary sclerosing cholangitis: effect on pruritus and bile acid profile.
Int J Artif Organs. 2004; 27(4):342-344 (- Case Report)
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2003

Arrese, M; Trauner, M Molecular aspects of bile formation and cholestasis.
Trends Mol Med. 2003; 9(12):558-564
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Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins.
J Hepatol. 2003; 38(4):387-394
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Pineda Torra, I; Claudel, T; Duval, C; Kosykh, V; Fruchart, JC; Staels, B Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Mol Endocrinol. 2003; 17(2):259-272 [OPEN ACCESS]
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Trauner, M; Boyer, JL Bile salt transporters: molecular characterization, function, and regulation.
Physiol Rev. 2003; 83(2):633-671 [OPEN ACCESS]
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Zollner, G; Fickert, P; Silbert, D; Fuchsbichler, A; Marschall, HU; Zatloukal, K; Denk, H; Trauner, M Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.
J Hepatol. 2003; 38(6):717-727
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2002

Claudel, T; Sturm, E; Duez, H; Torra, IP; Sirvent, A; Kosykh, V; Fruchart, JC; Dallongeville, J; Hum, DW; Kuipers, F; Staels, B Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
J Clin Invest. 2002; 109(7):961-971 [OPEN ACCESS]
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Fickert, P; Trauner, M; Fuchsbichler, A; Stumptner, C; Zatloukal, K; Denk, H Bile acid-induced Mallory body formation in drug-primed mouse liver.
Am J Pathol. 2002; 161(6):2019-2026 [OPEN ACCESS]
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Fickert, P; Zollner, G; Fuchsbichler, A; Stumptner, C; Weiglein, AH; Lammert, F; Marschall, HU; Tsybrovskyy, O; Zatloukal, K; Denk, H; Trauner, M Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles.
Gastroenterology. 2002; 123(4):1238-1251
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2001

Trauner, M; Fickert, P; Zollner, G Abnormal hepatic sinusoidal bile acid transport: new insights into the pathogenesis of cholestasis?
Gastroenterology. 2001; 120(1):321-323
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