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Varga, EM; Jacobson, MR; Till, SJ; Masuyama, K; O'Brien, F; Rak, S; Lund, V; Scadding, GK; Hamid, QA; Durham, SR.
Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis.
Allergy. 1999; 54(4): 338-345. [OPEN ACCESS]
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Authors Med Uni Graz:
Varga Eva-Maria
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Abstract:
BACKGROUND: Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells. METHODS: Nasal biopsies from perennial allergic rhinitis patients and controls were analysed by immunocytochemistry for different cell populations and in situ hybridization for cytokine mRNA-expressing cells. RESULTS: Perennial allergic rhinitis was associated with increased numbers of submucosal CD3+ T cells (P=0.05), EG2+ activated eosinophils (P=0.01), and CD68+ macrophages (P=0.01) compared to controls. Epithelial, but not submucosal, tryptase-positive mast cells were also elevated in rhinitics compared to controls (P=0.01). The numbers of cells expressing interleukin (IL)-5 were higher (P=0.01) and the numbers of cells expressing IL-2 were lower (P=0.04) in rhinitic patients than controls. There were no significant differences for either IL-4 or interferon-gamma between the groups. CONCLUSIONS: Perennial allergic rhinitis is characterized by mast-cell migration into the epithelium; submucosal infiltration by T cells, eosinophils, and macrophages; and an imbalance in local T-cell cytokine production in favour of enhanced IL-5 and reduced IL-2 expression.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Antigens, CD3 - immunology
Cytokines - metabolism
Eosinophils - immunology
Female - immunology
Humans - immunology
Immunohistochemistry - immunology
In Situ Hybridization - immunology
Macrophages - immunology
Male - immunology
Mast Cells - immunology
Nasal Mucosa - immunology
RNA, Messenger - metabolism
Receptors, Interleukin-2 - immunology
Rhinitis, Allergic, Perennial - immunology
T-Lymphocytes - immunology

Find related publications in this database (Keywords)
cytokines
eosinophils
perennial allergic rhinitis
T cells
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