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SHR Neuro Cancer Cardio Lipid Metab Microb

Michaelis, S; Zelzer, S; Schneider, C; Schnedl, WJ; Baranyi, A; Meinitzer, A; Herrmann, M; Enko, D.
Alteration of the kynurenine pathway is inversely associated with the humoral immune response in patients with SARS-CoV-2.
Clin Chim Acta. 2022; 537: 77-79. Doi: 10.1016/j.cca.2022.10.005 [OPEN ACCESS]
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Co-authors Med Uni Graz
Baranyi Andreas
Enko Dietmar
Herrmann Markus
Meinitzer Andreas
Schnedl Wolfgang
Zelzer Sieglinde

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BACKGROUND: The scale and the course of antibody production in patients with SARS-CoV-2 is highly variable. Factors involved in the immune regulation during the infection may play a major role in the antibody response. We investigated the relationship between the inflammatory markers of the kynurenine pathway and the concentration of antibodies against SARS-CoV-2 in infected patients 8 - 11 days after admission. METHODS: The study included 72 SARS-CoV-2 - positive inpatients hospitalized between August 2020 and April 2021. The plasma concentrations of tryptophan, kynurenine, anti-SARS-CoV-2 antibodies and the leucocyte count were measured 8 - 11 days after admission. The kynurenine/tryptophan ratio (KYN/TRP ratio) was calculated. Tertiles based on the values for tryptophan, kynurenine, KYN/TRP ratio and the leucocytes were generated. RESULTS: Statistically significant correlations were observed between anti-SARS-CoV-2 antibodies and tryptophan, kynurenine, KYN/TRP ratio and the leucocytes (p-values < 0.001-0.007). The high kynurenine and KYN/TRP ratio tertiles showed significantly lower antibody titers compared to the low tertiles (p-values 0.017 and < 0.001). The low tryptophan and leucocytes tertiles showed significantly lower antibody titers compared to the high tertiles (p-values 0.001 and 0.008). CONCLUSION: Patients with higher activation levels of the kynurenine pathway tended to develop lower anti-SARS-CoV-2 antibody titers.

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