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SHR Neuro Cancer Cardio Lipid

Olschewski, A; Berghausen, EM; Eichstaedt, CA; Fleischmann, BK; Grünig, E; Grünig, G; Hansmann, G; Harbaum, L; Hennigs, JK; Jonigk, D; Kuebler, WM; Kwapiszewska, G; Pullamsetti, SS; Stacher, E; Weissmann, N; Wenzel, D; Schermuly, RT.
Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.
Int J Cardiol. 2018; 272S(10): 4-10.
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Authors Med Uni Graz:
Kwapiszewska-Marsh Grazyna
Olschewski Andrea
Stacher-Priehse Elvira
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Abstract:
The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy. In addition to new insights in the pathobiology of this disease, this working group of the Cologne Consensus Conference also highlights novel concepts and potential new therapeutic targets to further improve the treatment options in PAH. Copyright © 2018. Published by Elsevier B.V.

Find related publications in this database (Keywords)
Pulmonary hypertension
Inflammation
Transcription factors
Ion channels/ion channel diseases
Hypoxic pulmonary vasoconstriction
Genetics/epigenetics
Metabolic dysfunction
And the potential future role of histopathology
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