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Schnedl, WJ; Schenk, M; Lackner, S; Holasek, SJ; Mangge, H.
β-thalassemia minor, carbohydrate malabsorption and histamine intolerance.
J Community Hosp Intern Med Perspect. 2017; 7(4):227-229 [OPEN ACCESS]
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Authors Med Uni Graz:
Lackner Sonja
Mangge Harald
Schenk Michael
Schnedl Wolfgang
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Abstract:
Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines (histamine), or proteins (gluten). Objectives: We report on two patients with β-thalassemia minor suffering nonspecific abdominal symptoms due to a carbohydrate and histamine malabsorption. Design/methods: The diagnosis of β-thalassemia minorwas done with peripheral blood smear and cellulose acetate electrophoresis. Carbohydrate malabsorption was diagnosed with hydrogen breath tests and, histamine intolerance (HIT) with a serum diamine oxidase value <10 U/ml and more than two gastrointestinal symptoms described for HIT. Conclusion: The symptoms of gastrointestinal malabsorption in these two patients with β-thalassemia minor were treated successfully with an individually-tailored diet free of symptom causing carbohydrates and histamine.

Find related publications in this database (Keywords)
beta-thalassemia minor
lactose intolerance
fructose malabsorption
histamine intolerance
nonspecific abdominal complaints
diet
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