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Szurian, K; Till, H; Amerstorfer, E; Hinteregger, N; Mischinger, HJ; Liegl-Atzwanger, B; Brcic, I.
Rarity among benign gastric tumors: Plexiform fibromyxoma - Report of two cases.
World J Gastroenterol. 2017; 23(31):5817-5822 (- Case Report) [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Authors Med Uni Graz:
Amerstorfer Eva Elisa
Brcic Iva
Hinteregger Nicole
Liegl-Atzwanger Bernadette
Mischinger Hans-Joerg
Szurian Kinga
Till Holger

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Number of Figures: 3
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Plexiform fibromyxoma is a very rare mesenchymal tumor of the stomach, found almost exclusively in the antrum/pylorus region. The most common presenting symptoms are anemia, hematemesis, nausea and unintentional weight loss, without sex or age predilection. We describe here two cases of plexiform fibromyxoma, involving a 16-year-old female and a 34-year-old male. Both patients underwent complete resection (R0) by distal gastrectomy and retrocolic gastrojejunostomy (according to Billroth 2); for both, the postoperative course was uneventful. Histology showed multiple intramural and subserosal nodules with characteristic plexiform growth, featuring bland spindle cells situated in an abundant myxoid stroma with low mitotic activity. Immunohistochemistry showed α-smooth muscle actin-positive spindle cells, focal positivity for CD10, and negative staining for KIT, DOG1, CD34, S100, β-catenin, STAT-6 and anaplastic lymphoma kinase. One of the cases showed focal positivity for h-caldesmon and desmin. Upon follow-up, no sign of disease was found. In the differential diagnosis of plexiform fibromyxoma, it is important to exclude the more common gastrointestinal stromal tumors as they have greater potential for aggressive behavior. Other lesions, like neuronal and vascular tumors, inflammatory fibroid polyps, abdominal desmoid-type fibromatosis, solitary fibrous tumors and smooth muscle tumors, must also be excluded.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Anoctamin-1 - metabolism
Biomarkers, Tumor - metabolism
Calmodulin-Binding Proteins - metabolism
Diagnosis, Differential -
Female -
Fibroma - diagnosis
Fibroma - pathology
Fibroma - surgery
Gastrectomy -
Gastric Bypass -
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - pathology
Humans -
Magnetic Resonance Imaging -
Male -
Neoplasm Proteins - metabolism
Positron Emission Tomography Computed Tomography -
Proto-Oncogene Proteins c-kit - metabolism
Stomach - pathology
Stomach - surgery
Stomach Neoplasms - diagnosis
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery

Find related publications in this database (Keywords)
Plexiform fibromyxoma
Plexiform angiomyxoid myofibroblastic tumor
Gastrointestinal stromal tumor
Benign gastric tumor
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