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Cserni, G; Floris, G; Koufopoulos, N; Kovács, A; Nonni, A; Regitnig, P; Stahls, A; Varga, Z.
Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases.
Virchows Arch. 2017; 471(1):3-12
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Authors Med Uni Graz:
Regitnig Peter
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Abstract:
Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation. All but one of the eight cases occurred in postmenopausal patients. Extracellular mucin production was present in 5 to 50% of the tumour samples and rarely also appeared in nodal and distant metastases. The tumours were completely E-cadherin negative and showed cytoplasmic p120 positivity. The majority (n = 6/8) was also completely negative for β-catenin, but two tumours displayed focal β-catenin positivity in the mucinous area. MUC1 and MUC2 expression was observed in all and 7/8 tumours, respectively; neuroendocrine differentiation was present in only one. Invasive lobular carcinoma with extracellular mucin formation is a rare morphologic variant of lobular carcinoma prone to be misdiagnosed and warranting further studies.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Biomarkers, Tumor - analysis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - pathology
Female -
Humans -
Middle Aged -
Mucin-1 - biosynthesis
Mucin-2 - biosynthesis

Find related publications in this database (Keywords)
Breast cancer
E-cadherin
Extracellular mucin
Lobular carcinoma
Mucinous carcinoma
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