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SHR Neuro Cancer Cardio Lipid

Czapiewski, P; Bobowicz, M; Pęksa, R; Skrzypski, M; Gorczyński, A; Szczepańska-Michalska, K; Korwat, A; Jankowski, M; Zegarski, W; Szulgo-Paczkowska, A; Polec, T; Piątek, M; Skokowski, J; Haybaeck, J; Żaczek, A; Biernat, W.
Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma.
Pol J Pathol. 2017; 67(3):228-234 [OPEN ACCESS]
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Authors Med Uni Graz:
Haybäck Johannes
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Abstract:
Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN-, 85 cases). Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN- group. K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival. We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult -
Aged -
Aged, 80 and over -
Biomarkers, Tumor - analysis
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Disease-Free Survival -
Female -
Humans -
Immunohistochemistry -
Kaplan-Meier Estimate -
Keratin-7 - analysis
Keratin-7 - biosynthesis
Lymphatic Metastasis - pathology
Male -
Middle Aged -
Prognosis -
Proportional Hazards Models -
Tissue Array Analysis -

Find related publications in this database (Keywords)
keratin 7
metastasis
colon carcinoma
prognosis
lymph node metastases
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