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Macher, S; Wagner, T; Rosskopf, K; Reiterer, F; Csapo, B; Schlenke, P; Klaritsch, P.
Severe case of fetal hemolytic disease caused by anti-C(w) requiring serial intrauterine transfusions complicated by pancytopenia and cholestasis.
Transfusion. 2016; 56(1):80-83 (- Case Report)
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Authors Med Uni Graz:
Csapo Bence
Klaritsch Philipp
Macher Susanne
Reiterer Friedrich
Rosskopf Konrad
Schlenke Peter
Wagner Thomas

Dimensions Citations:

Plum Analytics:
Anti-C(w) are rarely found as a source for severe fetal and neonatal hemolytic diseases. We report a case with serial intrauterine transfusions complicated by pancytopenia and cholestasis in the neonatal period. A 37-year-old woman revealed anti-C(w) with a titer of 512 in her fourth pregnancy. The fetus developed fetal anemia and a severe hydrops requiring three intrauterine red blood cell (RBC) transfusions. After birth at 33 + 0 weeks the newborn presented only transfused RBCs and suffered from anemia, thrombocytopenia, leukopenia, and a cholestatic liver disease. Blood counts improved after transfusion of 2 RBC units and one platelet concentrate and administration of hematopoietic growth factors. The symptoms of cholestasis improved slowly after therapy with ursodeoxycholic acid, vitamins, and medium-chain triglyceride-enriched formula feeding. Anti-C(w) may lead to severe fetal anemia and consecutive complications. Surveillance of affected pregnancies with high antibody titers using sonographic evaluation of the middle cerebral artery peak systolic velocity should be warranted, especially in multiparous women. © 2015 AABB.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Biomarkers - blood
Blood Transfusion, Intrauterine -
Cholestasis - etiology
Erythroblastosis, Fetal - blood
Erythroblastosis, Fetal - diagnosis
Erythroblastosis, Fetal - immunology
Erythrocyte Transfusion -
Female -
Humans -
Infant, Newborn -
Isoantibodies - blood
Pancytopenia - etiology
Pregnancy -

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