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Valko, PO; Gavrilov, YV; Yamamoto, M; Finn, K; Reddy, H; Haybaeck, J; Weis, S; Scammell, TE; Baumann, CR.
Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury.
Ann Neurol. 2015; 77(1):177-182 [OPEN ACCESS]
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Authors Med Uni Graz:
Haybäck Johannes
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Abstract:
The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions. © 2014 American Neurological Association.
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Brain Injuries - pathology
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Glial Fibrillary Acidic Protein - metabolism
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