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Palchik, AB; Einspieler, C; Evstafeyeva, IV; Talisa, VB; Marschik, PB.
Intra-uterine exposure to maternal opiate abuse and HIV: The impact on the developing nervous system.
Early Hum Dev. 2013; 89(4):229-235
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Authors Med Uni Graz:
Einspieler Christa
Marschik Peter
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Abstract:
Background: Both intra-uterine exposure to maternal drugs and HIV are known to adversely affect the developing central nervous system. Aims: (1) To describe the quality of GMs in infants who were intra-uterinely exposed to maternal opiate abuse and HIV; and (2) to analyze to what extent (a) perinatal events, (b) status of HIV-infection, and (c) the quality of GMs are associated with the neurodevelopmental outcome at 2 to 3 years of age. Patients and method: Seventy-seven children intra-uterinely exposed to both maternal opiate abuse and HIV in utero (41 boys and 36 girls; 39 born preterm) were videoed twice: first during the first 2 months after term (writhing GMs) and again at 3-5 months (fidgety GMs). Neurodevelopmental outcome was assessed at 2-3 years of age. Results: Thirty-eight infants showed abnormal writhing GMs; 25 infants had abnormal or absent fidgety movements; 22 children had an adverse neurodevelopmental outcome. The association between GM trajectories and outcome revealed a Cramer-V=0.75 (p<0.001). Those infants with active HIV-infection (n=10) did not differ from the 67 infants who were HIV-exposed but uninfected with respect to their GM quality or outcome. Conclusions: Serial assessment of GMs in infants who were intra-uterinely exposed to maternal opiates and to HIV can be utilized for early identification of infants at a higher risk for later deficits and needing early intervention. (C) 2013 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Child Development - drug effects
Developmental Disabilities - etiology
Female -
HIV Infections - complications
Heroin - toxicity
Humans -
Infant, Newborn -
Infant, Premature -
Male -
Maternal-Fetal Exchange -
Movement Disorders - etiology
Narcotics - toxicity
Opioid-Related Disorders - complications
Pregnancy -
Pregnancy Complications, Infectious -
Prenatal Exposure Delayed Effects - diagnosis Prenatal Exposure Delayed Effects - etiology

Find related publications in this database (Keywords)
Development
Fidgety movements
General movements
HIV-exposure
HIV-infection
Infant
Maternal opiate abuse
Neurodevelopmental outcome
Social deprivation
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