Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Lindenmann, J; Fediuk, M; Fink-Neuboeck, N; Mykoliuk, I; Taucher, E; Pichler, M; Smolle, J; Smolle-Juettner, FM.
The Prognostic Long-Term Impact of Chronic Obstructive Pulmonary Disease and Postoperative Mucostasis in Patients with Curatively Resected Non-Small Cell Lung Cancer.
Cells. 2023; 12(3):
Doi: 10.3390/cells12030480
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Web of Science
PubMed
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- Leading authors Med Uni Graz
- Fediuk Melanie
- Lindenmann Jörg
- Co-authors Med Uni Graz
- Fink-Neuböck Nicole
- Mykoliuk Iurii
- Pichler Martin
- Smolle Josef
- Smolle-Juettner Freyja-Maria
- Taucher Elisabeth Marie
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- Abstract:
- Chronic obstructive pulmonary disease (COPD) serves as risk factor for the development of lung cancer and seems to have a prognostic impact after surgery for non-small cell lung cancer (NSCLC). The aim was to investigate the impact of COPD and postoperative mucostasis on the long-term survival after resected NSCLC. We retrospectively reviewed the data from 342 patients with curatively resected NSCLC. The prognostic long-term impact of COPD and postoperative mucostasis on overall survival (OS), recurrence free survival (RFS) and cancer specific survival (CSS) was calculated using univariable and multivariable Cox regression analyses. We found that 52.3% suffered from COPD and 25.4% had postoperative mucostasis. COPD was significantly more common among smokers (59.9%) compared with non-smokers (21.3%), (p < 0.001). There was a significant relationship between COPD and postoperative mucostasis (p = 0.006) and between smoking and mucostasis (p = 0.023). Patients with postoperative mucostasis had a significantly worse OS (p < 0.001), RFS (p = 0.009) and CSS (p = 0.008). The present analysis demonstrated that postoperative mucostasis, but not COPD, was associated with both worse short- and long-term outcomes for OS, RFS and CSS in curatively resected NSCLC.
- Find related publications in this database (Keywords)
- mucostasis
- chronic obstructive pulmonary disease
- non-small cell lung cancer
- curative resection
- prognosis
- overall survival
- tumor-free survival
- cancer specific survival