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SHR Neuro Cancer Cardio Lipid Metab Microb

Lindenmann, J; Fediuk, M; Fink-Neuboeck, N; Mykoliuk, I; Taucher, E; Pichler, M; Smolle, J; Smolle-Juettner, FM.
The Prognostic Long-Term Impact of Chronic Obstructive Pulmonary Disease and Postoperative Mucostasis in Patients with Curatively Resected Non-Small Cell Lung Cancer.
Cells. 2023; 12(3): Doi: 10.3390/cells12030480 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Fediuk Melanie
Lindenmann Jörg
Co-authors Med Uni Graz
Fink-Neuböck Nicole
Mykoliuk Iurii
Pichler Martin
Smolle Josef
Smolle-Juettner Freyja-Maria
Taucher Elisabeth Marie

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Scite (citation analytics):

Chronic obstructive pulmonary disease (COPD) serves as risk factor for the development of lung cancer and seems to have a prognostic impact after surgery for non-small cell lung cancer (NSCLC). The aim was to investigate the impact of COPD and postoperative mucostasis on the long-term survival after resected NSCLC. We retrospectively reviewed the data from 342 patients with curatively resected NSCLC. The prognostic long-term impact of COPD and postoperative mucostasis on overall survival (OS), recurrence free survival (RFS) and cancer specific survival (CSS) was calculated using univariable and multivariable Cox regression analyses. We found that 52.3% suffered from COPD and 25.4% had postoperative mucostasis. COPD was significantly more common among smokers (59.9%) compared with non-smokers (21.3%), (p < 0.001). There was a significant relationship between COPD and postoperative mucostasis (p = 0.006) and between smoking and mucostasis (p = 0.023). Patients with postoperative mucostasis had a significantly worse OS (p < 0.001), RFS (p = 0.009) and CSS (p = 0.008). The present analysis demonstrated that postoperative mucostasis, but not COPD, was associated with both worse short- and long-term outcomes for OS, RFS and CSS in curatively resected NSCLC.

Find related publications in this database (Keywords)
chronic obstructive pulmonary disease
non-small cell lung cancer
curative resection
overall survival
tumor-free survival
cancer specific survival
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