Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Uhl, B; Prochazka, KT; Pansy, K; Wenzl, K; Strobl, J; Baumgartner, C; Szmyra, MM; Waha, JE; Wolf, A; Tomazic, PV; Steinbauer, E; Steinwender, M; Friedl, S; Weniger, M; Küppers, R; Pichler, M; Greinix, HT; Stary, G; Ramsay, AG; Apollonio, B; Feichtinger, J; Beham-Schmid, C; Neumeister, P; Deutsch, AJ.
Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells.
Int J Mol Sci. 2022; 23(14): Doi: 10.3390/ijms23147874 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Deutsch Alexander
Neumeister Peter
Uhl Barbara
Co-authors Med Uni Graz
Baumgartner Claudia
Beham-Schmid Christine
Feichtinger Julia
Greinix Hildegard
Pansy Katrin
Pichler Martin
Prochazka Katharina
Tomazic Peter Valentin
Waha James Elvis
Wenzl Kerstin
Wolf Axel

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Chemokine receptors and their ligands have been identified as playing an important role in the development of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, and Richter syndrome (RS). Our aim was to investigate the different expression profiles in de novo DLBCL, transformed follicular lymphoma (tFL), and RS. Here, we profiled the mRNA expression levels of 18 chemokine receptors (CCR1-CCR9, CXCR1-CXCR7, CX3CR1 and XCR1) using RQ-PCR, as well as immunohistochemistry of seven chemokine receptors (CCR1, CCR4-CCR8 and CXCR2) in RS, de novo DLBCL, and tFL biopsy-derived tissues. Tonsil-derived germinal center B-cells (GC-B) served as non-neoplastic controls. The chemokine receptor expression profiles of de novo DLBCL and tFL substantially differed from those of GC-B, with at least 5-fold higher expression of 15 out of the 18 investigated chemokine receptors (CCR1-CCR9, CXCR1, CXCR2, CXCR6, CXCR7, CX3CR1 and XCR1) in these lymphoma subtypes. Interestingly, the de novo DLBCL and tFL exhibited at least 22-fold higher expression of CCR1, CCR5, CCR8, and CXCR6 compared with RS, whereas no significant difference in chemokine receptor expression profile was detected when comparing de novo DLBCL with tFL. Furthermore, in de novo DLBCL and tFLs, a high expression of CCR7 was associated with a poor overall survival in our study cohort, as well as in an independent patient cohort. Our data indicate that the chemokine receptor expression profile of RS differs substantially from that of de novo DLBCL and tFL. Thus, these multiple dysregulated chemokine receptors could represent novel clinical markers as diagnostic and prognostic tools. Moreover, this study highlights the relevance of chemokine signaling crosstalk in the tumor microenvironment of aggressive lymphomas.
Find related publications in this database (using NLM MeSH Indexing)
B-Lymphocytes - metabolism
Germinal Center - metabolism
Humans - administration & dosage
Leukemia, Lymphocytic, Chronic, B-Cell - administration & dosage
Lymphoma, Follicular - genetics, pathology
Lymphoma, Large B-Cell, Diffuse - pathology
Neoplasm Recurrence, Local - administration & dosage
Tumor Microenvironment - administration & dosage

Find related publications in this database (Keywords)
diffuse large B-cell lymphoma
Richter syndrome
transformed follicular lymphoma
chemokine receptors
© Med Uni GrazImprint