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SHR Neuro Cancer Cardio Lipid Metab Microb

Tancevski, I; Wehinger, A; Demetz, E; Eller, P; Duwensee, K; Huber, J; Hochegger, K; Schgoer, W; Fievet, C; Stellaard, F; Rudling, M; Patsch, JR; Ritsch, A.
Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression.
Endocrinology. 2008; 149(7):3708-3712 Doi: 10.1210/en.2007-1387 [OPEN ACCESS]
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Co-authors Med Uni Graz: Eller Kathrin; Eller Philipp
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Abstract:: The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T(3) up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7alpha-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [(3)H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1.
Find related publications in this database (using NLM MeSH Indexing): ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism; Animals -; Bile - chemistry; Blotting, Western -; Cholesterol - metabolism; Cholesterol, HDL - blood; Feces - chemistry; Gene Expression -; Hyperthyroidism - blood Hyperthyroidism - metabolism Hyperthyroidism - physiopathology; Liver - metabolism; Male -; Mice -; Mice, Inbred BALB C -; Reverse Transcriptase Polymerase Chain Reaction -