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SHR Neuro Cancer Cardio Lipid

Rosenberg, GA; Wallin, A; Wardlaw, JM; Markus, HS; Montaner, J; Wolfson, L; Iadecola, C; Zlokovic, BV; Joutel, A; Dichgans, M; Duering, M; Schmidt, R; Korczyn, AD; Grinberg, LT; Chui, HC; Hachinski, V.
Consensus statement for diagnosis of subcortical small vessel disease
J CEREBR BLOOD F MET. 2016; 36(1): 6-25. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Authors Med Uni Graz:
Schmidt Reinhold
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Abstract:
Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger's disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger's disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood-brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.
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Binswanger's disease
blood-brain barrier permeability
cerebrospinal fluid
inflammation
leukoaraiosis
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