Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid

Plomgaard, AM; van Oeveren, W; Petersen, TH; Alderliesten, T; Austin, T; van Bel, F; Benders, M; Claris, O; Dempsey, E; Franz, A; Fumagalli, M; Gluud, C; Hagmann, C; Hyttel-Sorensen, S; Lemmers, P; Pellicer, A; Pichler, G; Winkel, P; Greisen, G.
The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury.
Pediatr Res. 2016; 79(4):528-535 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Authors Med Uni Graz:
Pichler Gerhard

Dimensions Citations:

Plum Analytics:
Number of Figures: 2
| |
The SafeBoosC phase II multicentre randomized clinical trial investigated the benefits and harms of monitoring cerebral oxygenation by near-infrared spectroscopy (NIRS) combined with an evidence-based treatment guideline vs. no NIRS data and treatment as usual in the control group during the first 72 h of life. The trial demonstrated a significant reduction in the burden of cerebral hypoxia in the experimental group. We now report the blindly assessed and analyzed treatment effects on electroencephalographic (EEG) outcomes (burst rate and spectral edge frequency 95% (SEF95)) and blood biomarkers of brain injury (S100β, brain fatty acid-binding protein, and neuroketal). One hundred and sixty-six extremely preterm infants were randomized to either experimental or control group. EEG was recorded at 64 h of age and blood samples were collected at 6 and 64 h of age. One hundred and thirty-three EEGs were evaluated. The two groups did not differ regarding burst rates (experimental 7.2 vs. control 7.7 burst/min) or SEF95 (experimental 18.1 vs. control 18.0 Hz). The two groups did not differ regarding blood S100β, brain fatty acid-binding protein, and neuroketal concentrations at 6 and 64 h (n = 123 participants). Treatment guided by NIRS reduced the cerebral burden of hypoxia without affecting EEG or the selected blood biomarkers.
Find related publications in this database (using NLM MeSH Indexing)
Biomarkers - metabolism
Brain Injuries - metabolism
Electroencephalography -
Humans -
Hypoxia, Brain - metabolism
Hypoxia, Brain - physiopathology
Hypoxia, Brain - prevention & control
Infant, Newborn -
Spectroscopy, Near-Infrared - methods

© Meduni GrazImprint