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SHR Neuro Cancer Cardio Lipid Metab Microb

Trummer, O; Foessl, I; Schweighofer, N; Arifi, E; Haudum, CW; Reintar, S; Pilz, S; Theiler-Schwetz, V; Trummer, C; Zirlik, A; Schmidt, A; Colantonio, C; Kolesnik, E; Verheyen, N; Pieber, TR; Obermayer-Pietsch, B.
Expression Profiles of miR-22-5p and miR-142-3p Indicate Hashimoto's Disease and Are related to Thyroid Antibodies.
Genes (Basel). 2022; 13(2): Doi: 10.3390/genes13020171 [OPEN ACCESS]
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Leading authors Med Uni Graz

Fößl Ines

Trummer Olivia

Co-authors Med Uni Graz

Colantonio Caterina

Haudum Christoph

Kolesnik Ewald

Obermayer-Pietsch Barbara

Pieber Thomas

Pilz Stefan

Reintar Sharmaine

Schmidt Albrecht

Schweighofer Natascha

Theiler-Schwetz Verena

Trummer Christian

Verheyen Nicolas Dominik

Zirlik Andreas

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Abstract:

Hashimoto's thyroiditis (HT) is the most prevalent autoimmune disorder of the thyroid (AITD) and characterized by the presence of circulating autoantibodies evoked by a, to date, not fully understood dysregulation of the immune system. Autoreactive lymphocytes and inflammatory processes in the thyroid gland can impair or enhance thyroid hormone secretion. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present study was to evaluate whether the expression of 9 selected miRNAs related to immunological functions differ in patients with HT compared to healthy controls. MiRNA profiles were analysed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 24 patients with HT and 17 healthy controls. Systemic expressions of miR-21-5p, miR-22-3p, miR-22-5p, miR-142-3p, miR-146a-5p, miR-301-3p and miR-451 were significantly upregulated in patients with HT (p ≤ 0.01) and were suitable to discriminate between HT and healthy controls in AUC analysis. Altered expressions of miR-22-5p and miR-142-3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT.

Find related publications in this database (using NLM MeSH Indexing)

Autoantibodies - administration & dosage

Autoimmunity - administration & dosage

Hashimoto Disease - genetics

Humans - administration & dosage

MicroRNAs - genetics

Find related publications in this database (Keywords)

miRNA

autoimmune thyroid disease

AITD

Hashimoto's thyroiditis

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