Medizinische Universität Graz - Research portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Hechenberger, S; Helmlinger, B; Ropele, S; Pirpamer, L; Bachmaier, G; Damulina, A; Pichler, A; Khalil, M; Enzinger, C; Pinter, D.
Information processing speed as a prognostic marker of physical impairment and progression in patients with multiple sclerosis.
Mult Scler Relat Disord. 2022; 57: 103353 Doi: 10.1016/j.msard.2021.103353
Web of Science PubMed FullText FullText_MUG


Leading authors Med Uni Graz
Hechenberger Stefanie Maria Charlotte
Pinter Daniela Theresia
Co-authors Med Uni Graz
Bachmaier Gerhard
Damulina Anna
Enzinger Christian
Helmlinger Birgit
Khalil Michael
Pichler Alexander
Pirpamer Lukas
Ropele Stefan

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

BACKGROUND: Prediction of disability progression in patients with MS (pwMS) is challenging. So far, scarce evidence exists suggesting knowledge about how cognitive performance may potentially improve prediction of physical impairment and disability progression in MS. Therefore, we wanted to assess the prognostic value of cognitive performance regarding physical impairment and disability progression in pwMS. METHODS: 85 patients (64% female; 60% relapse-remitting MS; mean age=36.78 ± 9.63 years) underwent clinical, neuropsychological (Brief Repeatable Battery for Neuropsychological Test (BRB-N)) and brain MRI (T1-weighted and T2-weighted FLAIR images) assessment at baseline and after an average of 7 years (SD=3.75) at follow-up. We assessed physical impairment and annualized disability progression (disability progression divided by follow-up duration) using the Expanded Disability Status Scale (EDSS). To compare patients with no or mild physical impairment (EDSS≤2.5) and patients with moderate to severe physical impairment (EDSS≥3.0), we used an EDSS score ≥3.0 as cut-off. Silent progression was defined by an EDSS worsening of at least 0.5 in the absence of relapses and inflammation in relapsing-remitting MS. RESULTS: In hierarchical regression models (method "STEPWISE", forward) performance in information processing speed was a significant and independent predictor of physical impairment (EDSS≥3.0) at follow-up (model R²=0.671, b=-1.46, OR=0.23, p=0.001) and annualized disability progression (adjusted model R²=0.257, β=-0.26, 95% CI: -0.066, -0.008, p=0.012), in addition to demographics (age, education, individual follow-up time), clinical (EDSS, disease duration, clinical phenotype, annualized-relapse-rate) and MRI measures (brain volumes and T2-lesion load). In a MANCOVA controlled for age, disease duration and individual follow-up time, worse baseline performance in information processing speed was found in patients with higher EDSS at follow-up (m=-1.91, SD=1.18, p<0.001) and silent progression (m=-2.19, SD=1.01, p=0.038). CONCLUSION: Performance in information processing speed might help to identify patients at risk for physical impairment. Therefore, neuropsychological assessment should be integrated in clinical standard care to support disease management in pwMS.

Find related publications in this database (Keywords)
Multiple sclerosis
Physical impairment
(Silent) progression
© Med Uni GrazImprint