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SHR Neuro Cancer Cardio Lipid Metab Microb

Holzmann, C; Witt, M; Rolfs, A; Antipova, V; Wree, A.
Gender-Specific Effects of Two Treatment Strategies in a Mouse Model of Niemann-Pick Disease Type C1
INT J MOL SCI. 2021; 22(5): 2539 Doi: 10.3390/ijms22052539 [OPEN ACCESS]
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Leading authors Med Uni Graz: Antipova Veronica Alexandra
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Abstract:: In a mouse model of Niemann-Pick disease type C1 (NPC1), a combination therapy (COMBI) of miglustat (MIGLU), the neurosteroid allopregnanolone (ALLO) and the cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (HPßCD) has previously resulted in, among other things, significantly improved motor function. The present study was designed to compare the therapeutic effects of the COMBI therapy with that of MIGLU or HPßCD alone on body and brain weight and the behavior of NPC1^-/- mice in a larger cohort, with special reference to gender differences. A total of 117 NPC1^-/- and 123 NPC1^+/+ mice underwent either COMBI, MIGLU only, HPßCD only, or vehicle treatment (Sham), or received no treatment at all (None). In male and female NPC1^-/- mice, all treatments led to decreased loss of body weight and, partly, brain weight. Concerning motor coordination, as revealed by the accelerod test, male NPC1^-/- mice benefited from COMBI treatment, whereas female mice benefited from COMBI, MIGLU, and HPßCD treatment. As seen in the open field test, the reduced locomotor activity of male and female NPC1^-/- mice was not significantly ameliorated in either treatment group. Our results suggest that in NPC1^-/- mice, each drug treatment scheme had a beneficial effect on at least some of the parameters evaluated compared with Sham-treated mice. Only in COMBI-treated male and female NPC^+/+ mice were drug effects seen in reduced body and brain weights. Upon COMBI treatment, the increased dosage of drugs necessary for anesthesia in Sham-treated male and female NPC1^-/- mice was almost completely reduced only in the female groups.
Find related publications in this database (using NLM MeSH Indexing): 1-Deoxynojirimycin - analogs & derivatives, pharmacology; 2-Hydroxypropyl-beta-cyclodextrin - pharmacology; Animals - administration & dosage; Cyclodextrins - pharmacology; Disease Models, Animal - administration & dosage; Drug Therapy, Combination - methods; Female - administration & dosage; Male - administration & dosage; Mice - administration & dosage; Mice, Inbred BALB C - administration & dosage; Niemann-Pick Disease, Type C - drug therapy; Pregnanolone - pharmacology
Find related publications in this database (Keywords): NPC1; mouse; lipid storage disorder; treatment; miglustat; 2-hydroxypropyl-β -cyclodextrin; allopregnanolone; body weight; brain weight; anesthesia; behavior; accelerod test; open field test