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SHR Neuro Cancer Cardio Lipid

Bagga, D; Reichert, JL; Koschutnig, K; Aigner, CS; Holzer, P; Koskinen, K; Moissl-Eichinger, C; Schöpf, V.
Probiotics drive gut microbiome triggering emotional brain signatures.
Gut Microbes. 2018; 9(6): 486-496. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Authors Med Uni Graz:
Holzer Peter
Koschutnig Karl
Koskinen Kaisa
Moissl-Eichinger Christine
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Number of Figures: 6
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Abstract:
Experimental manipulation of the gut microbiome was found to modify emotional and cognitive behavior, neurotransmitter expression and brain function in rodents, but corresponding human data remain scarce. The present double-blind, placebo-controlled randomised study aimed at investigating the effects of 4 weeks' probiotic administration on behavior, brain function and gut microbial composition in healthy volunteers. Forty-five healthy participants divided equally into three groups (probiotic, placebo and no intervention) underwent functional MRI (emotional decision-making and emotional recognition memory tasks). In addition, stool samples were collected to investigate the gut microbial composition. Probiotic administration for 4 weeks was associated with changes in brain activation patterns in response to emotional memory and emotional decision-making tasks, which were also accompanied by subtle shifts in gut microbiome profile. Microbiome composition mirrored self-reported behavioral measures and memory performance. This is the first study reporting a distinct influence of probiotic administration at behavioral, neural, and microbiome levels at the same time in healthy volunteers. The findings provide a basis for future investigations into the role of the gut microbiota and potential therapeutic application of probiotics.

Find related publications in this database (Keywords)
behavior
Emotional decision
fMRI
microbiome
probiotics
recognition
memory
stool
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