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Tee, SI; Martínez-Escanamé, M; Zuriel, D; Fried, I; Wolf, I; Massone, C; Cerroni, L.
Acrodermatitis chronica atrophicans with pseudolymphomatous infiltrates.
Am J Dermatopathol. 2013; 35(3):338-342 Doi: 10.1097/DAD.0b013e31826b7487
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Leading authors Med Uni Graz
Cerroni Lorenzo
Co-authors Med Uni Graz
Fried Isabella
Massone Cesare
Wolf Ingrid

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In this study, we describe the clinicopathologic features of pseudolymphomatous infiltrates found within lesions of acrodermatitis chronica atrophicans (ACA). We studied 11 patients (10 females, 1 male, age range 60-88 years). The diagnosis of ACA in all cases was confirmed by clinicopathologic correlation and positive serology for Borrelia. Histopathologic examination revealed prominent, pseudolymphomatous inflammatory cell infiltrates in all cases, with 2 distinct patterns. Eight of 11 cases showed a band-like lymphocytic infiltrate, exocytosis of lymphocytes and a fibrotic papillary dermis, similar to features seen in mycosis fungoides. The other 3 cases showed dense, nodular-diffuse dermal infiltrates with many plasma cells and without germinal centers. The plasma cells expressed both kappa and lambda immunoglobulin light chains with a polyclonal pattern in all 3 cases. In conclusion, ACA may present with pseudolymphomatous infiltrates showing both a T-cell and, less frequently, a B-cell pattern. These lesions need to be distinguished from a cutaneous lymphoma. In the context of the knowledge of Borrelia-associated cutaneous lymphomas, follow-up seems advisable in these cases.
Find related publications in this database (using NLM MeSH Indexing)
Acrodermatitis - genetics Acrodermatitis - immunology Acrodermatitis - microbiology Acrodermatitis - pathology
Aged -
Aged, 80 and over -
Biological Markers - analysis
Biopsy -
Borrelia - genetics Borrelia - immunology
Borrelia Infections - genetics Borrelia Infections - immunology Borrelia Infections - microbiology Borrelia Infections - pathology
DNA, Bacterial - analysis
Diagnosis, Differential -
Female -
Gene Rearrangement, T-Lymphocyte -
Humans -
Immunoglobulin kappa-Chains - analysis
Immunoglobulin lambda-Chains - analysis
Immunohistochemistry -
Lymphocytes - immunology Lymphocytes - microbiology Lymphocytes - pathology
Male -
Middle Aged -
Plasma Cells - immunology Plasma Cells - microbiology Plasma Cells - pathology
Predictive Value of Tests -
Pseudolymphoma - genetics Pseudolymphoma - immunology Pseudolymphoma - microbiology Pseudolymphoma - pathology
Skin - immunology Skin - microbiology Skin - pathology

Find related publications in this database (Keywords)
acrodermatitis chronica atrophicans
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