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SHR Neuro Cancer Cardio Lipid Metab Microb

Zweiker, D; Pogran, E; Gargiulo, L; Abd, El-Razek, A; Lechner, I; Vosko, I; Rechberger, S; Bugger, H; Christ, G; Bonderman, D; Kunschitz, E; Czedik-Eysenberg, C; Roithinger, A; Weihs, V; Kaufmann, CC; Zirlik, A; Bauer, A; Metzler, B; Lambert, T; Steinwender, C; Huber, K.
Neutrophile-Lymphocyte Ratio and Outcome in Takotsubo Syndrome.
Biology (Basel). 2022; 11(8): Doi: 10.3390/biology11081154 [OPEN ACCESS]
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Leading authors Med Uni Graz: Zweiker David
Co-authors Med Uni Graz: Bugger Heiko Matthias; Vosko Ivan; Zirlik Andreas
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Abstract:: BACKGROUND: Takotsubo syndrome (TTS) is an important type of acute heart failure with significant risk of acute complications and death. In this analysis we sought to identify predictors for in-hospital clinical outcome in TTS patients and present long-term outcomes. METHODS: In this analysis from the Austrian national TTS registry, univariable and multivariable analyses were performed to identify significant predictors for severe in-hospital complications requiring immediate invasive treatment or leading to irreversible damage, such as cardiogenic shock, intubation, stroke, arrhythmias and death. Furthermore, the influence of independent predictors on long-term survival was evaluated. RESULTS: A total of 338 patients (median age 72 years, 86.9% female) from six centers were included. Severe in-hospital complications occurred in 14.5% of patients. In multivariable analysis, high neutrophile-lymphocyte-ratio (NLR; OR 1.04 [95% CI 1.02-1.07], p = 0.009) and low LVEF (OR 0.92 [0.90-0.95] per %, p < 0.001) were significant predictors of severe in-hospital complications. Both the highest NLR tercile and the lowest LVEF tercile were significantly associated with reduced 5-year survival. CONCLUSIONS: Low LVEF and high NLR at admission were independently associated with increased in-hospital complications and reduced long-term survival in TTS patients. NLR is a new easy-to-measure tool to predict worse short- and long-term outcome after TTS.
Find related publications in this database (Keywords): neutrophile-lymphocyte ratio; takotsubo syndrome; predictors; registry; LVEF; outcome