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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofer, E; Pirpamer, L; Langkammer, C; Tinauer, C; Seshadri, S; Schmidt, H; Schmidt, R.
Heritability of R2* iron in the basal ganglia and cortex.
Aging (Albany NY). 2022; 14(16):6415-6426
Doi: 10.18632/aging.204212
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- Leading authors Med Uni Graz
- Hofer Edith
- Schmidt Reinhold
- Co-authors Med Uni Graz
- Langkammer Christian
- Pirpamer Lukas
- Schmidt Helena
- Tinauer Christian Gerhard
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- Abstract:
- BACKGROUND: While iron is essential for normal brain functioning, elevated concentrations are commonly found in neurodegenerative diseases and are associated with impaired cognition and neurological deficits. Currently, only little is known about genetic and environmental factors that influence brain iron concentrations. METHODS: Heritability and bivariate heritability of regional brain iron concentrations, assessed by R2* relaxometry at 3 Tesla MRI, were estimated with variance components models in 130 middle-aged to elderly participants of the Austrian Stroke Prevention Family Study. RESULTS: Heritability of R2* iron ranged from 0.46 to 0.82 in basal ganglia and from 0.65 to 0.76 in cortical lobes. Age and BMI explained up to 12% and 9% of the variance of R2* iron, while APOE ε4 carrier status, hypertension, diabetes, hypercholesterolemia, sex and smoking explained 5% or less. The genetic correlation of R2* iron among basal ganglionic nuclei and among cortical lobes ranged from 0.78 to 0.87 and from 0.65 to 0.97, respectively. R2* rates in basal ganglia and cortex were not genetically correlated. CONCLUSIONS: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Basal Ganglia - administration & dosage
- Brain - administration & dosage
- Cerebral Cortex - diagnostic imaging
- Humans - administration & dosage
- Iron - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- brain iron
- heritability
- magnetic resonance imaging
- genetic correlation
- genetic and environmental factors