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SHR Neuro Cancer Cardio Lipid Metab Microb

Schrom, S; Hebesberger, T; Wallner, SA; Anders, I; Richtig, E; Brandl, W; Hirschmugl, B; Garofalo, M; Bernecker, C; Schlenke, P; Kashofer, K; Wadsack, C; Aigelsreiter, A; Heitzer, E; Riedl, S; Zweytick, D; Kretschmer, N; Richtig, G; Rinner, B.
MUG Mel3 Cell Lines Reflect Heterogeneity in Melanoma and Represent a Robust Model for Melanoma in Pregnancy.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111318 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Leading authors Med Uni Graz
Rinner Beate
Schrom Silke
Co-authors Med Uni Graz
Aigelsreiter Ariane
Anders Ines
Bernecker Claudia
Brandl Waltraud Theresia
Hebesberger Thomas
Heitzer Ellen
Hirschmugl Birgit
Kashofer Karl
Kretschmer Nadine
Richtig Erika
Richtig Georg
Riedl Sabrina
Schlenke Peter
Wadsack Christian
Wallner Stefanie Angela
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Abstract:
Melanomas are aggressive tumors with a high metastatic potential and an increasing incidence rate. They are known for their heterogeneity and propensity to easily develop therapy-resistance. Nowadays they are one of the most common cancers diagnosed during pregnancy. Due to the difficulty in balancing maternal needs and foetal safety, melanoma is challenging to treat. The aim of this study was to provide a potential model system for the study of melanoma in pregnancy and to illustrate melanoma heterogeneity. For this purpose, a pigmented and a non-pigmented section of a lymph node metastasis from a pregnant patient were cultured under different conditions and characterized in detail. All four culture conditions exhibited different phenotypic, genotypic as well as tumorigenic properties, and resulted in four newly established melanoma cell lines. To address treatment issues, especially in pregnant patients, the effect of synthetic human lactoferricin-derived peptides was tested successfully. These new BRAF-mutated MUG Mel3 cell lines represent a valuable model in melanoma heterogeneity and melanoma pregnancy research. Furthermore, treatment with anti-tumor peptides offers an alternative to conventionally used therapeutic options-especially during pregnancy.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Animals - administration & dosage
Cell Culture Techniques - methods
Cell Line - administration & dosage
Cell Line, Tumor - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Lactoferrin - pharmacology
Lymphatic Metastasis - administration & dosage
Melanoma - drug therapy, genetics, metabolism
Mice - administration & dosage
Mice, Inbred NOD - administration & dosage
Pregnancy - administration & dosage
Primary Cell Culture - administration & dosage
Proto-Oncogene Proteins B-raf - genetics
Skin Neoplasms - pathology
Xenograft Model Antitumor Assays - methods

Find related publications in this database (Keywords)
melanoma
tumor heterogeneity
pregnancy
anti-tumor peptides
in vitro model
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